IE37131B1 - Insulin derivatives - Google Patents
Insulin derivativesInfo
- Publication number
- IE37131B1 IE37131B1 IE1539/72A IE153972A IE37131B1 IE 37131 B1 IE37131 B1 IE 37131B1 IE 1539/72 A IE1539/72 A IE 1539/72A IE 153972 A IE153972 A IE 153972A IE 37131 B1 IE37131 B1 IE 37131B1
- Authority
- IE
- Ireland
- Prior art keywords
- insulins
- primary amino
- phenylalanine
- nov
- physiologically acceptable
- Prior art date
Links
- NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical class N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 3
- 102000004877 Insulin Human genes 0.000 abstract 5
- 108090001061 Insulin Proteins 0.000 abstract 5
- 239000004026 insulin derivative Substances 0.000 abstract 4
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 abstract 3
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 abstract 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 abstract 2
- 150000001413 amino acids Chemical group 0.000 abstract 2
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 abstract 2
- 239000004471 Glycine Substances 0.000 abstract 1
- 239000004472 Lysine Substances 0.000 abstract 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 abstract 1
- 229910052783 alkali metal Inorganic materials 0.000 abstract 1
- -1 alkali metal cyanates Chemical class 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 230000002252 carbamoylating effect Effects 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940125396 insulin Drugs 0.000 abstract 1
- 239000011541 reaction mixture Substances 0.000 abstract 1
- 238000006467 substitution reaction Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/62—Insulins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Endocrinology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Diabetes (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5362371 | 1971-11-18 | ||
| GB5362271A GB1408757A (en) | 1971-11-18 | 1971-11-18 | Insulin derivatives 35and hydrocarbons including normal paraffins a gasoline product of higher octane number than said gasoline |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IE37131L IE37131L (en) | 1973-05-18 |
| IE37131B1 true IE37131B1 (en) | 1977-05-11 |
Family
ID=26267305
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IE1539/72A IE37131B1 (en) | 1971-11-18 | 1972-11-10 | Insulin derivatives |
Country Status (11)
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2141679A (en) * | 1983-04-23 | 1985-01-03 | William Brydson | Motor vehicle turntable |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IE36225B1 (en) * | 1971-01-28 | 1976-09-15 | Nat Res Dev | Improvements relating to insulin derivatives |
-
0
- BE BE791585D patent/BE791585A/xx unknown
-
1971
- 1971-11-18 GB GB5362271A patent/GB1408757A/en not_active Expired
-
1972
- 1972-11-10 IE IE1539/72A patent/IE37131B1/xx unknown
- 1972-11-15 AU AU48872/72A patent/AU475066B2/en not_active Expired
- 1972-11-17 NL NL7215599A patent/NL7215599A/xx unknown
- 1972-11-17 CH CH1677972A patent/CH564519A5/xx not_active IP Right Cessation
- 1972-11-17 SE SE7215023A patent/SE396947B/xx unknown
- 1972-11-17 JP JP47115486A patent/JPS4861493A/ja active Pending
- 1972-11-17 DE DE2256574A patent/DE2256574A1/de active Pending
- 1972-11-17 CH CH1677774A patent/CH574393A5/xx not_active IP Right Cessation
- 1972-11-17 CA CA156,852A patent/CA1002517A/en not_active Expired
- 1972-11-17 FR FR7240950A patent/FR2160619B1/fr not_active Expired
-
1975
- 1975-10-17 SE SE7511703A patent/SE7511703L/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| FR2160619B1 (enrdf_load_stackoverflow) | 1977-04-15 |
| IE37131L (en) | 1973-05-18 |
| JPS4861493A (enrdf_load_stackoverflow) | 1973-08-28 |
| BE791585A (fr) | 1973-05-17 |
| SE7511703L (sv) | 1975-10-17 |
| SE396947B (sv) | 1977-10-10 |
| GB1408757A (en) | 1975-10-01 |
| CA1002517A (en) | 1976-12-28 |
| NL7215599A (enrdf_load_stackoverflow) | 1973-05-22 |
| DE2256574A1 (de) | 1973-05-30 |
| AU4887272A (en) | 1974-05-16 |
| CH574393A5 (enrdf_load_stackoverflow) | 1976-04-15 |
| AU475066B2 (en) | 1976-08-12 |
| FR2160619A1 (enrdf_load_stackoverflow) | 1973-06-29 |
| CH564519A5 (enrdf_load_stackoverflow) | 1975-07-31 |
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