DE2253927A1 - Indolderivate und verfahren zu deren herstellung - Google Patents

Indolderivate und verfahren zu deren herstellung

Info

Publication number
DE2253927A1
DE2253927A1 DE2253927A DE2253927A DE2253927A1 DE 2253927 A1 DE2253927 A1 DE 2253927A1 DE 2253927 A DE2253927 A DE 2253927A DE 2253927 A DE2253927 A DE 2253927A DE 2253927 A1 DE2253927 A1 DE 2253927A1
Authority
DE
Germany
Prior art keywords
radical
formula
acid
methoxy
compounds
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE2253927A
Other languages
German (de)
English (en)
Inventor
George Richard Birchall
Walter Hepworth
Stephen Collyer Smith
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Imperial Chemical Industries Ltd
Original Assignee
Imperial Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Imperial Chemical Industries Ltd filed Critical Imperial Chemical Industries Ltd
Publication of DE2253927A1 publication Critical patent/DE2253927A1/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE2253927A 1971-11-03 1972-11-03 Indolderivate und verfahren zu deren herstellung Pending DE2253927A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1811672A GB1356834A (en) 1971-11-03 1971-11-03 Indole derivatives
GB1811672 1972-04-19
GB3076772 1972-06-30

Publications (1)

Publication Number Publication Date
DE2253927A1 true DE2253927A1 (de) 1973-05-10

Family

ID=27257588

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2253927A Pending DE2253927A1 (de) 1971-11-03 1972-11-03 Indolderivate und verfahren zu deren herstellung

Country Status (17)

Country Link
US (1) US3884919A (enExample)
JP (1) JPS4856667A (enExample)
AR (3) AR198064A1 (enExample)
BE (1) BE790679A (enExample)
CA (1) CA983932A (enExample)
CH (1) CH577499A5 (enExample)
DD (1) DD105611A5 (enExample)
DE (1) DE2253927A1 (enExample)
EG (1) EG11358A (enExample)
ES (2) ES408226A1 (enExample)
FR (1) FR2158464B1 (enExample)
GB (1) GB1356834A (enExample)
HU (1) HU169711B (enExample)
IE (1) IE37998B1 (enExample)
IL (1) IL40521A (enExample)
NL (1) NL7214807A (enExample)
SE (1) SE384856B (enExample)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4022780A (en) * 1973-03-06 1977-05-10 Imperial Chemical Industries Limited Process for the manufacture of indole derivatives
FR2421900A1 (fr) * 1977-03-17 1979-11-02 Sauba Lab Piperazino-3-indoles, leur procede de preparation et leurs applications therapeutiques
US4316847A (en) * 1979-07-30 1982-02-23 Hoffmann-La Roche Inc. Pyrroles and pyrrolidines
US4459227A (en) * 1981-03-02 1984-07-10 Duke University Para-hydroxyphenylhydrazines as in situ precursors of iminoquinones and quinones
CA2183655C (en) * 1994-02-23 2001-03-06 Lee D. Arnold 4-polycyclic amino-substituted quinazoline derivatives
US6252084B1 (en) * 1994-03-15 2001-06-26 Eli Lilly And Company 1H-indole-3-acetamide sPLA2 inhibitors
GEP20032920B (en) * 1998-02-25 2003-03-25 Genetics Inst Inhibitors of Phospholipase Enzymes
US6500853B1 (en) 1998-02-28 2002-12-31 Genetics Institute, Llc Inhibitors of phospholipase enzymes
SE0200356D0 (sv) * 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
SE0200411D0 (sv) * 2002-02-05 2002-02-05 Astrazeneca Ab Novel use
SE0201635D0 (sv) * 2002-05-30 2002-05-30 Astrazeneca Ab Novel compounds
TW200307542A (en) 2002-05-30 2003-12-16 Astrazeneca Ab Novel compounds
SE0202241D0 (sv) 2002-07-17 2002-07-17 Astrazeneca Ab Novel Compounds
SE0301010D0 (sv) 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
SE0301009D0 (sv) * 2003-04-07 2003-04-07 Astrazeneca Ab Novel compounds
DE60303238T2 (de) 2003-04-25 2006-09-14 Actimis Pharmaceuticals, Inc., La Jolla Pyrimidin-Essigsäure Derivate geeignet zur Behandlung von CRTH2-bedingten Krankheiten
US20050009817A1 (en) * 2003-04-30 2005-01-13 Jennifer Savoy Substituted heteroaryls
SE0301569D0 (sv) 2003-05-27 2003-05-27 Astrazeneca Ab Novel compounds
SE0302232D0 (sv) 2003-08-18 2003-08-18 Astrazeneca Ab Novel Compounds
SA04250253B1 (ar) 2003-08-21 2009-11-10 استرازينيكا ايه بي احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن
GB0324763D0 (en) 2003-10-23 2003-11-26 Oxagen Ltd Use of compounds in therapy
SE0303180D0 (sv) 2003-11-26 2003-11-26 Astrazeneca Ab Novel compounds
DK1718649T3 (da) 2004-01-31 2009-08-24 Actimis Pharmaceuticals Inc Imidazo[1,2-c]pyrimidinyleddikesyrederivater
GB0415320D0 (en) 2004-07-08 2004-08-11 Astrazeneca Ab Novel compounds
GB0418830D0 (en) 2004-08-24 2004-09-22 Astrazeneca Ab Novel compounds
EP1817282B1 (en) 2004-11-23 2011-07-20 AstraZeneca AB Phenoxyacetic acid derivatives useful for treating respiratory diseases
GB0500604D0 (en) 2005-01-13 2005-02-16 Astrazeneca Ab Novel process
TW200745003A (en) 2005-10-06 2007-12-16 Astrazeneca Ab Novel compounds
EP1937632A1 (en) 2005-10-06 2008-07-02 Astra Zeneca AB Novel compounds
US7741360B2 (en) 2006-05-26 2010-06-22 Astrazeneca Ab Bi-aryl or aryl-heteroaryl substituted indoles
ES2391671T3 (es) 2006-07-22 2012-11-28 Oxagen Limited Compuestos con actividad antagonista de CRTH2
UA100983C2 (ru) 2007-07-05 2013-02-25 Астразенека Аб Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты
EP2205569B1 (en) 2007-09-25 2012-02-29 Actimis Pharmaceuticals, Inc., Alkylthio pyrimidines as crth2 antagonists
KR20100061746A (ko) 2007-09-25 2010-06-08 액티미스 파마수티컬스 인코포레이티드 Ｃｒｔｈ２ 길항제로서의 ２－ｓ－벤질 치환된 피리미딘
DK2250161T3 (da) 2008-01-18 2014-01-27 Atopix Therapeutics Ltd Forbindelser med CRTH2-antagonistaktivitet
US7750027B2 (en) 2008-01-18 2010-07-06 Oxagen Limited Compounds having CRTH2 antagonist activity
WO2009093026A1 (en) 2008-01-22 2009-07-30 Oxagen Limited Compounds having crth2 antagonist activity
EP2240444A1 (en) 2008-01-22 2010-10-20 Oxagen Limited Compounds having crth2 antagonist activity
GB201322273D0 (en) 2013-12-17 2014-01-29 Atopix Therapeutics Ltd Process
GB201407807D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
GB201407820D0 (en) 2014-05-02 2014-06-18 Atopix Therapeutics Ltd Polymorphic form
JOP20210060A1 (ar) * 2018-10-05 2023-01-30 Vertex Pharma معدلات لمضاد تريبسين ألفا-1
CN115697969B (zh) 2020-04-03 2026-08-11 弗特克斯药品有限公司 α-1抗胰蛋白酶调节剂
AU2021247285A1 (en) 2020-04-03 2022-10-27 Vertex Pharmaceuticals Incorporated Modulators of alpha-1 antitrypsin

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL125443C (enExample) * 1963-06-06
US3679692A (en) * 1969-10-01 1972-07-25 Mead Johnson & Co Iminomethylindolines

Also Published As

Publication number Publication date
EG11358A (en) 1977-02-28
AR203627A1 (es) 1975-09-30
GB1356834A (en) 1974-06-19
IL40521A0 (en) 1972-12-29
US3884919A (en) 1975-05-20
DD105611A5 (enExample) 1974-05-05
HU169711B (enExample) 1977-02-28
IE37998B1 (en) 1977-12-07
NL7214807A (enExample) 1973-05-07
ES437311A1 (es) 1977-04-01
FR2158464A1 (enExample) 1973-06-15
BE790679A (fr) 1973-04-27
CA983932A (en) 1976-02-17
AR198064A1 (es) 1974-05-31
FR2158464B1 (enExample) 1976-07-02
AR203626A1 (es) 1975-09-30
IE37998L (en) 1973-05-03
CH577499A5 (enExample) 1976-07-15
IL40521A (en) 1975-06-25
JPS4856667A (enExample) 1973-08-09
ES408226A1 (es) 1976-02-01
SE384856B (sv) 1976-05-24

Similar Documents

Publication Publication Date Title
EP0397060B1 (de) Maleinimid-Derivate und deren Verwendung als Arzneimittel
DE1445151A1 (de) Verfahren zur Herstellung chemischer Verbindungen
DE1620262A1 (de) Verfahren zur Herstellung von neuen Spiro[4,5]decanderivaten
DE3132882A1 (de) Neue piperazinone, ihre herstellung und verwendung
DE1545551A1 (de) Neue Chinazolinonderivate und ihre Herstellung
WO1980000152A1 (fr) Derives d'un 3-aminopropoxy-aryle, leur preparation et utilisation
DE2226703A1 (de) Neue tetrahydrocarbazolderivate und verfahren zu ihrer herstellung
DD143906A5 (de) Trianzin-derivate
US4012513A (en) Indole derivatives for providing analgesic and anti-inflammatory effects
DE1620442C3 (de) Verfahren zur Herstellung von 1-Acylindolverbindungen
DD158401A5 (de) Verfahren zur herstellung eines 1-substituierten spiro[imidazolidin-4,3'-indolin]-2,2',5-trions
DE69318920T2 (de) Ellipticinderivate mit Antitumorwirkung
DE2313227A1 (de) Neue isoindolinderivate, ihre herstellung und die medizinischen zusammensetzungen, die sie enthalten
DE2118315C3 (de) 2-(1H)-Chinazolinonderivate, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE69501791T2 (de) Indol-derivate als 5-ht1-like agonisten
DE2841644A1 (de) 3(tetrazol-5-yl)-1-azaxanthone, verfahren zu ihrer herstellung und sie enthaltende arzneimittel
DE3814057A1 (de) 6-oxo-pyridazinderivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel
EP0025501B1 (de) Neue N-Aminoalkylindol-Derivate und ihre Salze; Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel
DE1115259B (de) Verfahren zur Herstellung von Iminodibenzylen
DD202541A5 (de) Verfahren zur herstellung neuer indol-derivate
CH641800A5 (de) Pyrido-pyrimidine, verfahren zu ihrer herstellung und die diese verbindungen enthaltenden arzneimittel.
CH482697A (de) Verfahren zur Herstellung von neuen, kondensierten heterocyclischen Verbindungen
DE2162327A1 (de) Verfahren zur Herstellung von Chinazolinonen; neue Chinazolinone und diese Verbindungen enthaltende Arzneimittel
AT328431B (de) Verfahren zur herstellung von neuen indolderivaten und von deren pharmazeutisch zulassigen salzen
AT235289B (de) Verfahren zur Herstellung von neuen Triazolidinen

Legal Events

Date Code Title Description
OHA Expiration of time for request for examination