CA983932A - Indole derivatives - Google Patents
Indole derivativesInfo
- Publication number
- CA983932A CA983932A CA152,944A CA152944A CA983932A CA 983932 A CA983932 A CA 983932A CA 152944 A CA152944 A CA 152944A CA 983932 A CA983932 A CA 983932A
- Authority
- CA
- Canada
- Prior art keywords
- indole derivatives
- indole
- derivatives
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1811672A GB1356834A (en) | 1971-11-03 | 1971-11-03 | Indole derivatives |
| GB1811672 | 1972-04-19 | ||
| GB3076772 | 1972-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CA983932A true CA983932A (en) | 1976-02-17 |
Family
ID=27257588
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA152,944A Expired CA983932A (en) | 1971-11-03 | 1972-09-29 | Indole derivatives |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US3884919A (enExample) |
| JP (1) | JPS4856667A (enExample) |
| AR (3) | AR198064A1 (enExample) |
| BE (1) | BE790679A (enExample) |
| CA (1) | CA983932A (enExample) |
| CH (1) | CH577499A5 (enExample) |
| DD (1) | DD105611A5 (enExample) |
| DE (1) | DE2253927A1 (enExample) |
| EG (1) | EG11358A (enExample) |
| ES (2) | ES408226A1 (enExample) |
| FR (1) | FR2158464B1 (enExample) |
| GB (1) | GB1356834A (enExample) |
| HU (1) | HU169711B (enExample) |
| IE (1) | IE37998B1 (enExample) |
| IL (1) | IL40521A (enExample) |
| NL (1) | NL7214807A (enExample) |
| SE (1) | SE384856B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4022780A (en) * | 1973-03-06 | 1977-05-10 | Imperial Chemical Industries Limited | Process for the manufacture of indole derivatives |
| FR2421900A1 (fr) * | 1977-03-17 | 1979-11-02 | Sauba Lab | Piperazino-3-indoles, leur procede de preparation et leurs applications therapeutiques |
| US4316847A (en) * | 1979-07-30 | 1982-02-23 | Hoffmann-La Roche Inc. | Pyrroles and pyrrolidines |
| US4459227A (en) * | 1981-03-02 | 1984-07-10 | Duke University | Para-hydroxyphenylhydrazines as in situ precursors of iminoquinones and quinones |
| CA2183655C (en) * | 1994-02-23 | 2001-03-06 | Lee D. Arnold | 4-polycyclic amino-substituted quinazoline derivatives |
| US6252084B1 (en) * | 1994-03-15 | 2001-06-26 | Eli Lilly And Company | 1H-indole-3-acetamide sPLA2 inhibitors |
| GEP20032920B (en) * | 1998-02-25 | 2003-03-25 | Genetics Inst | Inhibitors of Phospholipase Enzymes |
| US6500853B1 (en) | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| SE0200356D0 (sv) * | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| SE0200411D0 (sv) * | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| SE0201635D0 (sv) * | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
| TW200307542A (en) | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
| SE0202241D0 (sv) | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
| SE0301010D0 (sv) | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SE0301009D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| DE60303238T2 (de) | 2003-04-25 | 2006-09-14 | Actimis Pharmaceuticals, Inc., La Jolla | Pyrimidin-Essigsäure Derivate geeignet zur Behandlung von CRTH2-bedingten Krankheiten |
| US20050009817A1 (en) * | 2003-04-30 | 2005-01-13 | Jennifer Savoy | Substituted heteroaryls |
| SE0301569D0 (sv) | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
| SE0302232D0 (sv) | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
| SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| SE0303180D0 (sv) | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
| DK1718649T3 (da) | 2004-01-31 | 2009-08-24 | Actimis Pharmaceuticals Inc | Imidazo[1,2-c]pyrimidinyleddikesyrederivater |
| GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| EP1817282B1 (en) | 2004-11-23 | 2011-07-20 | AstraZeneca AB | Phenoxyacetic acid derivatives useful for treating respiratory diseases |
| GB0500604D0 (en) | 2005-01-13 | 2005-02-16 | Astrazeneca Ab | Novel process |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| EP1937632A1 (en) | 2005-10-06 | 2008-07-02 | Astra Zeneca AB | Novel compounds |
| US7741360B2 (en) | 2006-05-26 | 2010-06-22 | Astrazeneca Ab | Bi-aryl or aryl-heteroaryl substituted indoles |
| ES2391671T3 (es) | 2006-07-22 | 2012-11-28 | Oxagen Limited | Compuestos con actividad antagonista de CRTH2 |
| UA100983C2 (ru) | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
| EP2205569B1 (en) | 2007-09-25 | 2012-02-29 | Actimis Pharmaceuticals, Inc., | Alkylthio pyrimidines as crth2 antagonists |
| KR20100061746A (ko) | 2007-09-25 | 2010-06-08 | 액티미스 파마수티컬스 인코포레이티드 | Ｃｒｔｈ２ 길항제로서의 ２－ｓ－벤질 치환된 피리미딘 |
| DK2250161T3 (da) | 2008-01-18 | 2014-01-27 | Atopix Therapeutics Ltd | Forbindelser med CRTH2-antagonistaktivitet |
| US7750027B2 (en) | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
| WO2009093026A1 (en) | 2008-01-22 | 2009-07-30 | Oxagen Limited | Compounds having crth2 antagonist activity |
| EP2240444A1 (en) | 2008-01-22 | 2010-10-20 | Oxagen Limited | Compounds having crth2 antagonist activity |
| GB201322273D0 (en) | 2013-12-17 | 2014-01-29 | Atopix Therapeutics Ltd | Process |
| GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| GB201407820D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| JOP20210060A1 (ar) * | 2018-10-05 | 2023-01-30 | Vertex Pharma | معدلات لمضاد تريبسين ألفا-1 |
| CN115697969B (zh) | 2020-04-03 | 2026-08-11 | 弗特克斯药品有限公司 | α-1抗胰蛋白酶调节剂 |
| AU2021247285A1 (en) | 2020-04-03 | 2022-10-27 | Vertex Pharmaceuticals Incorporated | Modulators of alpha-1 antitrypsin |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL125443C (enExample) * | 1963-06-06 | |||
| US3679692A (en) * | 1969-10-01 | 1972-07-25 | Mead Johnson & Co | Iminomethylindolines |
-
0
- BE BE790679D patent/BE790679A/xx unknown
-
1971
- 1971-11-03 GB GB1811672A patent/GB1356834A/en not_active Expired
-
1972
- 1972-09-28 IE IE1320/72A patent/IE37998B1/xx unknown
- 1972-09-29 CA CA152,944A patent/CA983932A/en not_active Expired
- 1972-10-06 IL IL40521A patent/IL40521A/xx unknown
- 1972-10-10 US US296202A patent/US3884919A/en not_active Expired - Lifetime
- 1972-10-27 AR AR244863A patent/AR198064A1/es active
- 1972-10-29 EG EG446/72A patent/EG11358A/xx active
- 1972-11-02 FR FR7238836A patent/FR2158464B1/fr not_active Expired
- 1972-11-02 CH CH1597672A patent/CH577499A5/xx not_active IP Right Cessation
- 1972-11-02 NL NL7214807A patent/NL7214807A/xx unknown
- 1972-11-02 JP JP47110172A patent/JPS4856667A/ja active Pending
- 1972-11-02 SE SE7214215A patent/SE384856B/xx unknown
- 1972-11-02 DD DD166646A patent/DD105611A5/xx unknown
- 1972-11-03 HU HUIE540A patent/HU169711B/hu unknown
- 1972-11-03 ES ES408226A patent/ES408226A1/es not_active Expired
- 1972-11-03 DE DE2253927A patent/DE2253927A1/de active Pending
-
1973
- 1973-07-31 AR AR249382A patent/AR203627A1/es active
- 1973-07-31 AR AR249381A patent/AR203626A1/es active
-
1975
- 1975-04-30 ES ES437331A patent/ES437311A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| EG11358A (en) | 1977-02-28 |
| AR203627A1 (es) | 1975-09-30 |
| GB1356834A (en) | 1974-06-19 |
| IL40521A0 (en) | 1972-12-29 |
| DE2253927A1 (de) | 1973-05-10 |
| US3884919A (en) | 1975-05-20 |
| DD105611A5 (enExample) | 1974-05-05 |
| HU169711B (enExample) | 1977-02-28 |
| IE37998B1 (en) | 1977-12-07 |
| NL7214807A (enExample) | 1973-05-07 |
| ES437311A1 (es) | 1977-04-01 |
| FR2158464A1 (enExample) | 1973-06-15 |
| BE790679A (fr) | 1973-04-27 |
| AR198064A1 (es) | 1974-05-31 |
| FR2158464B1 (enExample) | 1976-07-02 |
| AR203626A1 (es) | 1975-09-30 |
| IE37998L (en) | 1973-05-03 |
| CH577499A5 (enExample) | 1976-07-15 |
| IL40521A (en) | 1975-06-25 |
| JPS4856667A (enExample) | 1973-08-09 |
| ES408226A1 (es) | 1976-02-01 |
| SE384856B (sv) | 1976-05-24 |
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