AR198064A1 - Sintesis de nuevos derivados del del acido heterociclico-indol-3-il-carboxilico - Google Patents
Sintesis de nuevos derivados del del acido heterociclico-indol-3-il-carboxilicoInfo
- Publication number
- AR198064A1 AR198064A1 AR244863A AR24486372A AR198064A1 AR 198064 A1 AR198064 A1 AR 198064A1 AR 244863 A AR244863 A AR 244863A AR 24486372 A AR24486372 A AR 24486372A AR 198064 A1 AR198064 A1 AR 198064A1
- Authority
- AR
- Argentina
- Prior art keywords
- indol
- carboxyl
- synthesis
- new derivatives
- heterocyclic acid
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D209/26—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with an acyl radical attached to the ring nitrogen atom
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB1811672A GB1356834A (en) | 1971-11-03 | 1971-11-03 | Indole derivatives |
| GB1811672 | 1972-04-19 | ||
| GB3076772 | 1972-06-30 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR198064A1 true AR198064A1 (es) | 1974-05-31 |
Family
ID=27257588
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR244863A AR198064A1 (es) | 1971-11-03 | 1972-10-27 | Sintesis de nuevos derivados del del acido heterociclico-indol-3-il-carboxilico |
| AR249382A AR203627A1 (es) | 1971-11-03 | 1973-07-31 | Sintesis de nuevos derivados del acido heterociclico-indol-3-ilacetico |
| AR249381A AR203626A1 (es) | 1971-11-03 | 1973-07-31 | Sintesis de nuevos acidos heterociclico-indol-3-ii-acetic |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AR249382A AR203627A1 (es) | 1971-11-03 | 1973-07-31 | Sintesis de nuevos derivados del acido heterociclico-indol-3-ilacetico |
| AR249381A AR203626A1 (es) | 1971-11-03 | 1973-07-31 | Sintesis de nuevos acidos heterociclico-indol-3-ii-acetic |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US3884919A (es) |
| JP (1) | JPS4856667A (es) |
| AR (3) | AR198064A1 (es) |
| BE (1) | BE790679A (es) |
| CA (1) | CA983932A (es) |
| CH (1) | CH577499A5 (es) |
| DD (1) | DD105611A5 (es) |
| DE (1) | DE2253927A1 (es) |
| EG (1) | EG11358A (es) |
| ES (2) | ES408226A1 (es) |
| FR (1) | FR2158464B1 (es) |
| GB (1) | GB1356834A (es) |
| HU (1) | HU169711B (es) |
| IE (1) | IE37998B1 (es) |
| IL (1) | IL40521A (es) |
| NL (1) | NL7214807A (es) |
| SE (1) | SE384856B (es) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4022780A (en) * | 1973-03-06 | 1977-05-10 | Imperial Chemical Industries Limited | Process for the manufacture of indole derivatives |
| FR2421900A1 (fr) * | 1977-03-17 | 1979-11-02 | Sauba Lab | Piperazino-3-indoles, leur procede de preparation et leurs applications therapeutiques |
| US4316847A (en) * | 1979-07-30 | 1982-02-23 | Hoffmann-La Roche Inc. | Pyrroles and pyrrolidines |
| US4459227A (en) * | 1981-03-02 | 1984-07-10 | Duke University | Para-hydroxyphenylhydrazines as in situ precursors of iminoquinones and quinones |
| AU686843B2 (en) * | 1994-02-23 | 1998-02-12 | Pfizer Inc. | 4-heterocyclyl-substituted quinazoline derivatives, processes for their preparation and their use as anti-cancer agents |
| US6252084B1 (en) * | 1994-03-15 | 2001-06-26 | Eli Lilly And Company | 1H-indole-3-acetamide sPLA2 inhibitors |
| CN1310706A (zh) * | 1998-02-25 | 2001-08-29 | 遗传研究所有限公司 | 磷脂酶抑制剂 |
| US6500853B1 (en) | 1998-02-28 | 2002-12-31 | Genetics Institute, Llc | Inhibitors of phospholipase enzymes |
| SE0200356D0 (sv) * | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| SE0200411D0 (sv) * | 2002-02-05 | 2002-02-05 | Astrazeneca Ab | Novel use |
| TW200307542A (en) * | 2002-05-30 | 2003-12-16 | Astrazeneca Ab | Novel compounds |
| SE0201635D0 (sv) * | 2002-05-30 | 2002-05-30 | Astrazeneca Ab | Novel compounds |
| SE0202241D0 (sv) | 2002-07-17 | 2002-07-17 | Astrazeneca Ab | Novel Compounds |
| SE0301009D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| SE0301010D0 (sv) * | 2003-04-07 | 2003-04-07 | Astrazeneca Ab | Novel compounds |
| EP1471057B1 (en) | 2003-04-25 | 2006-01-18 | Actimis Pharmaceuticals, Inc. | Pyrimidinylacetic acid derivatives useful for the treatment of diseases mediated by CRTH2 |
| CA2524221A1 (en) * | 2003-04-30 | 2004-11-18 | The Institutes For Pharmaceutical Discovery, Llc | Substituted heteroaryls as inhibitors of protein tyrosine phosphatases |
| SE0301569D0 (sv) | 2003-05-27 | 2003-05-27 | Astrazeneca Ab | Novel compounds |
| SE0302232D0 (sv) | 2003-08-18 | 2003-08-18 | Astrazeneca Ab | Novel Compounds |
| SA04250253B1 (ar) | 2003-08-21 | 2009-11-10 | استرازينيكا ايه بي | احماض فينوكسي اسيتيك مستبدلة باعتبارها مركبات صيدلانية لعلاج الامراض التنفسية مثل الربو ومرض الانسداد الرئوي المزمن |
| GB0324763D0 (en) | 2003-10-23 | 2003-11-26 | Oxagen Ltd | Use of compounds in therapy |
| SE0303180D0 (sv) | 2003-11-26 | 2003-11-26 | Astrazeneca Ab | Novel compounds |
| DK1718649T3 (da) | 2004-01-31 | 2009-08-24 | Actimis Pharmaceuticals Inc | Imidazo[1,2-c]pyrimidinyleddikesyrederivater |
| GB0415320D0 (en) | 2004-07-08 | 2004-08-11 | Astrazeneca Ab | Novel compounds |
| GB0418830D0 (en) | 2004-08-24 | 2004-09-22 | Astrazeneca Ab | Novel compounds |
| PT1817282E (pt) | 2004-11-23 | 2011-09-19 | Astrazeneca Ab | Derivados do ácido fenoxiacético úteis para tratar doenças respiratórias |
| GB0500604D0 (en) | 2005-01-13 | 2005-02-16 | Astrazeneca Ab | Novel process |
| US8148572B2 (en) | 2005-10-06 | 2012-04-03 | Astrazeneca Ab | Compounds |
| TW200745003A (en) | 2005-10-06 | 2007-12-16 | Astrazeneca Ab | Novel compounds |
| WO2007138282A2 (en) | 2006-05-26 | 2007-12-06 | Astrazeneca Ab | Bi-aryl or aryl-heteroaryl substituted indoles |
| KR20090042808A (ko) | 2006-07-22 | 2009-04-30 | 옥사겐 리미티드 | 씨알티에이치2 길항제 활성을 갖는 화합물 |
| UA100983C2 (ru) | 2007-07-05 | 2013-02-25 | Астразенека Аб | Бифенилоксипропановая кислота как модулятор crth2 и интермедиаты |
| WO2009042138A1 (en) | 2007-09-25 | 2009-04-02 | Actimis Pharmaceuticals, Inc. | Alkylthio pyrimidines as crth2 antagonists |
| CL2008002827A1 (es) | 2007-09-25 | 2009-11-27 | Actimis Pharmaceuticals Inc | Compuestos derivados de 2-s-bencil pirimidina, antagonistas del receptor crth2; composicion farmaceutica que los comprende; y su uso en el tratamiento de enfermedades alergicas mediadas por eosinofilos y basofilos, tales como asma, rinitis alergica, dermatitis atopica, conjuntivitis alergica, sinusitis y psoriasis, entre otras |
| US7750027B2 (en) | 2008-01-18 | 2010-07-06 | Oxagen Limited | Compounds having CRTH2 antagonist activity |
| CN101932571B (zh) | 2008-01-18 | 2014-04-23 | 奥克萨根有限公司 | 具有crth2拮抗活性的化合物 |
| EP2265581A1 (en) | 2008-01-22 | 2010-12-29 | Oxagen Limited | Compounds having crth2 antagonist activity |
| EP2240444A1 (en) | 2008-01-22 | 2010-10-20 | Oxagen Limited | Compounds having crth2 antagonist activity |
| GB201322273D0 (en) | 2013-12-17 | 2014-01-29 | Atopix Therapeutics Ltd | Process |
| GB201407820D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| GB201407807D0 (en) | 2014-05-02 | 2014-06-18 | Atopix Therapeutics Ltd | Polymorphic form |
| KR20210089656A (ko) * | 2018-10-05 | 2021-07-16 | 버텍스 파마슈티칼스 인코포레이티드 | 알파-1 항트립신 조절제 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL125443C (es) * | 1963-06-06 | |||
| US3679692A (en) * | 1969-10-01 | 1972-07-25 | Mead Johnson & Co | Iminomethylindolines |
-
0
- BE BE790679D patent/BE790679A/xx unknown
-
1971
- 1971-11-03 GB GB1811672A patent/GB1356834A/en not_active Expired
-
1972
- 1972-09-28 IE IE1320/72A patent/IE37998B1/xx unknown
- 1972-09-29 CA CA152,944A patent/CA983932A/en not_active Expired
- 1972-10-06 IL IL40521A patent/IL40521A/xx unknown
- 1972-10-10 US US296202A patent/US3884919A/en not_active Expired - Lifetime
- 1972-10-27 AR AR244863A patent/AR198064A1/es active
- 1972-10-29 EG EG446/72A patent/EG11358A/xx active
- 1972-11-02 DD DD166646A patent/DD105611A5/xx unknown
- 1972-11-02 SE SE7214215A patent/SE384856B/xx unknown
- 1972-11-02 CH CH1597672A patent/CH577499A5/xx unknown
- 1972-11-02 JP JP47110172A patent/JPS4856667A/ja active Pending
- 1972-11-02 NL NL7214807A patent/NL7214807A/xx unknown
- 1972-11-02 FR FR7238836A patent/FR2158464B1/fr not_active Expired
- 1972-11-03 DE DE2253927A patent/DE2253927A1/de active Pending
- 1972-11-03 ES ES408226A patent/ES408226A1/es not_active Expired
- 1972-11-03 HU HUIE540A patent/HU169711B/hu unknown
-
1973
- 1973-07-31 AR AR249382A patent/AR203627A1/es active
- 1973-07-31 AR AR249381A patent/AR203626A1/es active
-
1975
- 1975-04-30 ES ES437331A patent/ES437311A1/es not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| GB1356834A (en) | 1974-06-19 |
| ES408226A1 (es) | 1976-02-01 |
| EG11358A (en) | 1977-02-28 |
| BE790679A (fr) | 1973-04-27 |
| SE384856B (sv) | 1976-05-24 |
| US3884919A (en) | 1975-05-20 |
| CA983932A (en) | 1976-02-17 |
| AR203626A1 (es) | 1975-09-30 |
| NL7214807A (es) | 1973-05-07 |
| FR2158464B1 (es) | 1976-07-02 |
| IE37998B1 (en) | 1977-12-07 |
| CH577499A5 (es) | 1976-07-15 |
| ES437311A1 (es) | 1977-04-01 |
| IE37998L (en) | 1973-05-03 |
| FR2158464A1 (es) | 1973-06-15 |
| IL40521A0 (en) | 1972-12-29 |
| HU169711B (es) | 1977-02-28 |
| DE2253927A1 (de) | 1973-05-10 |
| IL40521A (en) | 1975-06-25 |
| AR203627A1 (es) | 1975-09-30 |
| JPS4856667A (es) | 1973-08-09 |
| DD105611A5 (es) | 1974-05-05 |
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