DE2166444A1 - 1,3-dihydro-2h-1,4-benzodiazepin-2on-verbindungen, ihre salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate - Google Patents

1,3-dihydro-2h-1,4-benzodiazepin-2on-verbindungen, ihre salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate

Info

Publication number
DE2166444A1
DE2166444A1 DE19712166444 DE2166444A DE2166444A1 DE 2166444 A1 DE2166444 A1 DE 2166444A1 DE 19712166444 DE19712166444 DE 19712166444 DE 2166444 A DE2166444 A DE 2166444A DE 2166444 A1 DE2166444 A1 DE 2166444A1
Authority
DE
Germany
Prior art keywords
general formula
compounds
dihydro
group
salts
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19712166444
Other languages
German (de)
English (en)
Inventor
Misuhiro Akatsu
Toshiyuki Hirohashi
Shigeho Inaba
Takahiro Izumi
Shigeru Sakai
Hisao Yamamoto
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sumitomo Chemical Co Ltd
Original Assignee
Sumitomo Chemical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP45035735A external-priority patent/JPS494226B1/ja
Priority claimed from JP4149970A external-priority patent/JPS4911238B1/ja
Priority claimed from JP4149870A external-priority patent/JPS499474B1/ja
Application filed by Sumitomo Chemical Co Ltd filed Critical Sumitomo Chemical Co Ltd
Publication of DE2166444A1 publication Critical patent/DE2166444A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/26—Preparation from compounds already containing the benzodiazepine skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/28—Preparation including building-up the benzodiazepine skeleton from compounds containing no hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D243/00—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms
    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/24—Oxygen atoms
    • C07D243/30—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings
    • C07D243/32—Preparation including building-up the benzodiazepine skeleton from compounds already containing hetero rings containing a phthalimide or hydrogenated phthalimide ring system
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Package Closures (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE19712166444 1970-04-23 1971-04-22 1,3-dihydro-2h-1,4-benzodiazepin-2on-verbindungen, ihre salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate Pending DE2166444A1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP45035735A JPS494226B1 (enrdf_load_stackoverflow) 1970-04-23 1970-04-23
JP4149970A JPS4911238B1 (enrdf_load_stackoverflow) 1970-05-14 1970-05-14
JP4149870A JPS499474B1 (enrdf_load_stackoverflow) 1970-05-14 1970-05-14

Publications (1)

Publication Number Publication Date
DE2166444A1 true DE2166444A1 (de) 1974-02-21

Family

ID=27288853

Family Applications (1)

Application Number Title Priority Date Filing Date
DE19712166444 Pending DE2166444A1 (de) 1970-04-23 1971-04-22 1,3-dihydro-2h-1,4-benzodiazepin-2on-verbindungen, ihre salze, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneipraeparate

Country Status (7)

Country Link
BE (1) BE766098A (enrdf_load_stackoverflow)
DE (1) DE2166444A1 (enrdf_load_stackoverflow)
FR (1) FR2092074B1 (enrdf_load_stackoverflow)
GB (1) GB1307144A (enrdf_load_stackoverflow)
IL (1) IL36671A (enrdf_load_stackoverflow)
NL (1) NL7105495A (enrdf_load_stackoverflow)
NO (1) NO132869C (enrdf_load_stackoverflow)

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL138936B (nl) * 1967-12-06 1973-05-15 Sumitomo Chemical Co Werkwijze voor het bereiden van benzodiazepinederivaten, alsmede hieruit bereid farmaceutisch preparaat.
US3778433A (en) * 1969-04-18 1973-12-11 Sumitomo Chemical Co Process for producing benzodiazepine derivatives

Also Published As

Publication number Publication date
IL36671A0 (en) 1971-06-23
FR2092074A1 (enrdf_load_stackoverflow) 1972-01-21
IL36671A (en) 1975-02-10
NO132869B (enrdf_load_stackoverflow) 1975-10-13
BE766098A (fr) 1971-09-16
FR2092074B1 (enrdf_load_stackoverflow) 1974-10-18
NL7105495A (enrdf_load_stackoverflow) 1971-10-26
GB1307144A (en) 1973-02-14
NO132869C (enrdf_load_stackoverflow) 1976-01-21

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