DE2153260A1 - Antibiotische Zubereitungen - Google Patents
Antibiotische ZubereitungenInfo
- Publication number
- DE2153260A1 DE2153260A1 DE19712153260 DE2153260A DE2153260A1 DE 2153260 A1 DE2153260 A1 DE 2153260A1 DE 19712153260 DE19712153260 DE 19712153260 DE 2153260 A DE2153260 A DE 2153260A DE 2153260 A1 DE2153260 A1 DE 2153260A1
- Authority
- DE
- Germany
- Prior art keywords
- penicillin
- metampicillin
- sodium salt
- salt
- mixture
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 238000002360 preparation method Methods 0.000 title claims description 13
- 230000003115 biocidal effect Effects 0.000 title claims description 12
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 49
- 229940056360 penicillin g Drugs 0.000 claims description 22
- 229960003806 metampicillin Drugs 0.000 claims description 15
- FZECHKJQHUVANE-MCYUEQNJSA-N metampicillin Chemical compound C1([C@@H](N=C)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 FZECHKJQHUVANE-MCYUEQNJSA-N 0.000 claims description 15
- 159000000000 sodium salts Chemical class 0.000 claims description 15
- 150000003839 salts Chemical class 0.000 claims description 12
- 239000000203 mixture Substances 0.000 description 15
- 229930182555 Penicillin Natural products 0.000 description 7
- 229960000723 ampicillin Drugs 0.000 description 7
- AVKUERGKIZMTKX-NJBDSQKTSA-N ampicillin Chemical compound C1([C@@H](N)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 AVKUERGKIZMTKX-NJBDSQKTSA-N 0.000 description 7
- 210000000941 bile Anatomy 0.000 description 7
- 244000005700 microbiome Species 0.000 description 7
- 229940049954 penicillin Drugs 0.000 description 7
- 241000194032 Enterococcus faecalis Species 0.000 description 5
- 229960001585 dicloxacillin Drugs 0.000 description 5
- YFAGHNZHGGCZAX-JKIFEVAISA-N dicloxacillin Chemical compound N([C@@H]1C(N2[C@H](C(C)(C)S[C@@H]21)C(O)=O)=O)C(=O)C1=C(C)ON=C1C1=C(Cl)C=CC=C1Cl YFAGHNZHGGCZAX-JKIFEVAISA-N 0.000 description 5
- 230000002195 synergetic effect Effects 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 241001465754 Metazoa Species 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 241000588724 Escherichia coli Species 0.000 description 3
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 3
- 229940088710 antibiotic agent Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
- 230000010412 perfusion Effects 0.000 description 3
- 230000001681 protective effect Effects 0.000 description 3
- 238000001228 spectrum Methods 0.000 description 3
- 241000699670 Mus sp. Species 0.000 description 2
- 241000283973 Oryctolagus cuniculus Species 0.000 description 2
- 108010087702 Penicillinase Proteins 0.000 description 2
- 241000192023 Sarcina Species 0.000 description 2
- 241000191967 Staphylococcus aureus Species 0.000 description 2
- 229910052783 alkali metal Inorganic materials 0.000 description 2
- 150000001340 alkali metals Chemical class 0.000 description 2
- 230000000844 anti-bacterial effect Effects 0.000 description 2
- FCPVYOBCFFNJFS-LQDWTQKMSA-M benzylpenicillin sodium Chemical compound [Na+].N([C@H]1[C@H]2SC([C@@H](N2C1=O)C([O-])=O)(C)C)C(=O)CC1=CC=CC=C1 FCPVYOBCFFNJFS-LQDWTQKMSA-M 0.000 description 2
- 239000002609 medium Substances 0.000 description 2
- CRTBAVDGJWEWNJ-GKANRWTBSA-M metampicillin sodium Chemical compound [Na+].C1([C@@H](N=C)C(=O)N[C@H]2[C@H]3SC([C@@H](N3C2=O)C([O-])=O)(C)C)=CC=CC=C1 CRTBAVDGJWEWNJ-GKANRWTBSA-M 0.000 description 2
- 235000015097 nutrients Nutrition 0.000 description 2
- 229950009506 penicillinase Drugs 0.000 description 2
- 239000011780 sodium chloride Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 239000008215 water for injection Substances 0.000 description 2
- 229920001817 Agar Polymers 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 208000035473 Communicable disease Diseases 0.000 description 1
- 241000192125 Firmicutes Species 0.000 description 1
- 241000606790 Haemophilus Species 0.000 description 1
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
- 241000588915 Klebsiella aerogenes Species 0.000 description 1
- 241000194035 Lactococcus lactis Species 0.000 description 1
- 241000191938 Micrococcus luteus Species 0.000 description 1
- 206010033109 Ototoxicity Diseases 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 241001076189 Proteus hauseri Species 0.000 description 1
- 241000293871 Salmonella enterica subsp. enterica serovar Typhi Species 0.000 description 1
- 241000607764 Shigella dysenteriae Species 0.000 description 1
- 241000607762 Shigella flexneri Species 0.000 description 1
- 241000295644 Staphylococcaceae Species 0.000 description 1
- 241000191940 Staphylococcus Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 235000014897 Streptococcus lactis Nutrition 0.000 description 1
- 241000193996 Streptococcus pyogenes Species 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 229910052784 alkaline earth metal Inorganic materials 0.000 description 1
- 150000001342 alkaline earth metals Chemical class 0.000 description 1
- 239000003708 ampul Substances 0.000 description 1
- 210000001367 artery Anatomy 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000000013 bile duct Anatomy 0.000 description 1
- 159000000007 calcium salts Chemical class 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000009833 condensation Methods 0.000 description 1
- 230000005494 condensation Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000009849 deactivation Effects 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 210000000232 gallbladder Anatomy 0.000 description 1
- 229960003884 hetacillin Drugs 0.000 description 1
- DXVUYOAEDJXBPY-NFFDBFGFSA-N hetacillin Chemical compound C1([C@@H]2C(=O)N(C(N2)(C)C)[C@H]2[C@H]3SC([C@@H](N3C2=O)C(O)=O)(C)C)=CC=CC=C1 DXVUYOAEDJXBPY-NFFDBFGFSA-N 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 238000010253 intravenous injection Methods 0.000 description 1
- 238000002350 laparotomy Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000013048 microbiological method Methods 0.000 description 1
- 230000001459 mortal effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 231100000262 ototoxicity Toxicity 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- -1 polyethylene Polymers 0.000 description 1
- 229920000573 polyethylene Polymers 0.000 description 1
- XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 description 1
- 229940007046 shigella dysenteriae Drugs 0.000 description 1
- 229910052708 sodium Inorganic materials 0.000 description 1
- 239000011734 sodium Substances 0.000 description 1
- 239000011885 synergistic combination Substances 0.000 description 1
- 239000007143 thioglycolate medium Substances 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 230000010415 tropism Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR7038890A FR2108991B1 (cg-RX-API-DMAC7.html) | 1970-10-28 | 1970-10-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2153260A1 true DE2153260A1 (de) | 1972-05-04 |
Family
ID=9063409
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712153260 Pending DE2153260A1 (de) | 1970-10-28 | 1971-10-26 | Antibiotische Zubereitungen |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US3729555A (cg-RX-API-DMAC7.html) |
| AU (1) | AU3503471A (cg-RX-API-DMAC7.html) |
| BE (1) | BE774122A (cg-RX-API-DMAC7.html) |
| DE (1) | DE2153260A1 (cg-RX-API-DMAC7.html) |
| FR (1) | FR2108991B1 (cg-RX-API-DMAC7.html) |
| NL (1) | NL7114811A (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA717037B (cg-RX-API-DMAC7.html) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ZA939117B (en) * | 1992-12-04 | 1994-08-05 | Susanna Elizabeth Chalmers | Pharmaceutical product |
-
1970
- 1970-10-28 FR FR7038890A patent/FR2108991B1/fr not_active Expired
-
1971
- 1971-10-19 BE BE774122A patent/BE774122A/xx unknown
- 1971-10-21 ZA ZA717037A patent/ZA717037B/xx unknown
- 1971-10-22 US US00191792A patent/US3729555A/en not_active Expired - Lifetime
- 1971-10-26 DE DE19712153260 patent/DE2153260A1/de active Pending
- 1971-10-27 NL NL7114811A patent/NL7114811A/xx unknown
- 1971-10-27 AU AU35034/71A patent/AU3503471A/en not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| NL7114811A (cg-RX-API-DMAC7.html) | 1972-05-03 |
| ZA717037B (en) | 1972-07-26 |
| BE774122A (fr) | 1972-02-14 |
| FR2108991B1 (cg-RX-API-DMAC7.html) | 1974-02-01 |
| US3729555A (en) | 1973-04-24 |
| AU3503471A (en) | 1973-05-03 |
| FR2108991A1 (cg-RX-API-DMAC7.html) | 1972-05-26 |
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