DE2146859C3 - Verfahren zum Herstellen von Überzügen aus Zucker auf Medikamente enthaltende Tablettenkerne - Google Patents
Verfahren zum Herstellen von Überzügen aus Zucker auf Medikamente enthaltende TablettenkerneInfo
- Publication number
- DE2146859C3 DE2146859C3 DE2146859A DE2146859A DE2146859C3 DE 2146859 C3 DE2146859 C3 DE 2146859C3 DE 2146859 A DE2146859 A DE 2146859A DE 2146859 A DE2146859 A DE 2146859A DE 2146859 C3 DE2146859 C3 DE 2146859C3
- Authority
- DE
- Germany
- Prior art keywords
- sugar
- tablets
- coating
- tablet cores
- calcium lactate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- 238000000034 method Methods 0.000 title claims description 26
- 238000000576 coating method Methods 0.000 title claims description 22
- 235000000346 sugar Nutrition 0.000 title claims description 15
- 238000004519 manufacturing process Methods 0.000 title claims description 9
- 230000008569 process Effects 0.000 title claims description 9
- 239000003814 drug Substances 0.000 title claims description 7
- 239000011248 coating agent Substances 0.000 claims description 34
- MKJXYGKVIBWPFZ-UHFFFAOYSA-L calcium lactate Chemical compound [Ca+2].CC(O)C([O-])=O.CC(O)C([O-])=O MKJXYGKVIBWPFZ-UHFFFAOYSA-L 0.000 claims description 21
- 239000001527 calcium lactate Substances 0.000 claims description 21
- 229960002401 calcium lactate Drugs 0.000 claims description 21
- 235000011086 calcium lactate Nutrition 0.000 claims description 21
- 238000002360 preparation method Methods 0.000 claims description 11
- 239000003826 tablet Substances 0.000 description 48
- 239000008298 dragée Substances 0.000 description 24
- 239000007940 sugar coated tablet Substances 0.000 description 24
- 239000000243 solution Substances 0.000 description 23
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 17
- 229930006000 Sucrose Natural products 0.000 description 17
- 229960004793 sucrose Drugs 0.000 description 17
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 15
- 239000012153 distilled water Substances 0.000 description 11
- 238000009495 sugar coating Methods 0.000 description 11
- 239000004149 tartrazine Substances 0.000 description 10
- UJMBCXLDXJUMFB-GLCFPVLVSA-K tartrazine Chemical compound [Na+].[Na+].[Na+].[O-]C(=O)C1=NN(C=2C=CC(=CC=2)S([O-])(=O)=O)C(=O)C1\N=N\C1=CC=C(S([O-])(=O)=O)C=C1 UJMBCXLDXJUMFB-GLCFPVLVSA-K 0.000 description 10
- 229960000943 tartrazine Drugs 0.000 description 10
- 235000012756 tartrazine Nutrition 0.000 description 10
- 239000000463 material Substances 0.000 description 6
- 238000003860 storage Methods 0.000 description 6
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 108010010803 Gelatin Proteins 0.000 description 4
- 239000008273 gelatin Substances 0.000 description 4
- 229920000159 gelatin Polymers 0.000 description 4
- 235000019322 gelatine Nutrition 0.000 description 4
- 235000011852 gelatine desserts Nutrition 0.000 description 4
- 239000007787 solid Substances 0.000 description 4
- 239000000454 talc Substances 0.000 description 4
- 229910052623 talc Inorganic materials 0.000 description 4
- 239000007864 aqueous solution Substances 0.000 description 3
- 230000015572 biosynthetic process Effects 0.000 description 3
- 239000011247 coating layer Substances 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 238000010438 heat treatment Methods 0.000 description 3
- 239000007791 liquid phase Substances 0.000 description 3
- 235000020374 simple syrup Nutrition 0.000 description 3
- 235000020357 syrup Nutrition 0.000 description 3
- 239000006188 syrup Substances 0.000 description 3
- 238000009492 tablet coating Methods 0.000 description 3
- 239000002700 tablet coating Substances 0.000 description 3
- SWGJCIMEBVHMTA-UHFFFAOYSA-K trisodium;6-oxido-4-sulfo-5-[(4-sulfonatonaphthalen-1-yl)diazenyl]naphthalene-2-sulfonate Chemical compound [Na+].[Na+].[Na+].C1=CC=C2C(N=NC3=C4C(=CC(=CC4=CC=C3O)S([O-])(=O)=O)S([O-])(=O)=O)=CC=C(S([O-])(=O)=O)C2=C1 SWGJCIMEBVHMTA-UHFFFAOYSA-K 0.000 description 3
- 240000007594 Oryza sativa Species 0.000 description 2
- 235000007164 Oryza sativa Nutrition 0.000 description 2
- -1 Polytetrafluoroethylene Polymers 0.000 description 2
- 239000013543 active substance Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- OSGAYBCDTDRGGQ-UHFFFAOYSA-L calcium sulfate Chemical compound [Ca+2].[O-]S([O-])(=O)=O OSGAYBCDTDRGGQ-UHFFFAOYSA-L 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 238000004040 coloring Methods 0.000 description 2
- 238000007796 conventional method Methods 0.000 description 2
- 239000013078 crystal Substances 0.000 description 2
- 238000000354 decomposition reaction Methods 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 238000005562 fading Methods 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 239000010419 fine particle Substances 0.000 description 2
- 229940014259 gelatin Drugs 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- 238000009499 grossing Methods 0.000 description 2
- 239000010410 layer Substances 0.000 description 2
- 230000014759 maintenance of location Effects 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 229920001343 polytetrafluoroethylene Polymers 0.000 description 2
- 239000004810 polytetrafluoroethylene Substances 0.000 description 2
- 235000009566 rice Nutrition 0.000 description 2
- 239000007790 solid phase Substances 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 239000005720 sucrose Substances 0.000 description 2
- 238000009496 sugar coating process Methods 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- QTWJRLJHJPIABL-UHFFFAOYSA-N 2-methylphenol;3-methylphenol;4-methylphenol Chemical compound CC1=CC=C(O)C=C1.CC1=CC=CC(O)=C1.CC1=CC=CC=C1O QTWJRLJHJPIABL-UHFFFAOYSA-N 0.000 description 1
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 1
- 229930195725 Mannitol Natural products 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 240000008042 Zea mays Species 0.000 description 1
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 1
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 230000000996 additive effect Effects 0.000 description 1
- 230000032683 aging Effects 0.000 description 1
- 230000002421 anti-septic effect Effects 0.000 description 1
- 235000019568 aromas Nutrition 0.000 description 1
- 239000011230 binding agent Substances 0.000 description 1
- 239000001913 cellulose Substances 0.000 description 1
- 229920002678 cellulose Polymers 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 239000007795 chemical reaction product Substances 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000007891 compressed tablet Substances 0.000 description 1
- 238000001816 cooling Methods 0.000 description 1
- 235000005822 corn Nutrition 0.000 description 1
- 238000005336 cracking Methods 0.000 description 1
- 229930003836 cresol Natural products 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 230000002349 favourable effect Effects 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- 150000002605 large molecules Chemical class 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000000594 mannitol Substances 0.000 description 1
- 235000010355 mannitol Nutrition 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 210000004798 organs belonging to the digestive system Anatomy 0.000 description 1
- 238000004806 packaging method and process Methods 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002203 pretreatment Methods 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/2873—Proteins, e.g. gelatin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J3/00—Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
- A61J3/005—Coating of tablets or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/282—Organic compounds, e.g. fats
- A61K9/2826—Sugars or sugar alcohols, e.g. sucrose; Derivatives thereof
Landscapes
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP45083917A JPS4837815B1 (enExample) | 1970-09-25 | 1970-09-25 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DE2146859A1 DE2146859A1 (de) | 1972-03-30 |
| DE2146859B2 DE2146859B2 (de) | 1976-10-07 |
| DE2146859C3 true DE2146859C3 (de) | 1980-10-23 |
Family
ID=13815937
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE2146859A Expired DE2146859C3 (de) | 1970-09-25 | 1971-09-20 | Verfahren zum Herstellen von Überzügen aus Zucker auf Medikamente enthaltende Tablettenkerne |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US3798054A (enExample) |
| JP (1) | JPS4837815B1 (enExample) |
| BE (1) | BE772957A (enExample) |
| CA (1) | CA968708A (enExample) |
| CH (1) | CH566137A5 (enExample) |
| DE (1) | DE2146859C3 (enExample) |
| DK (1) | DK128516B (enExample) |
| FR (1) | FR2108470A5 (enExample) |
| GB (1) | GB1346213A (enExample) |
| NL (1) | NL7113202A (enExample) |
| SE (1) | SE373498B (enExample) |
| SU (1) | SU522772A3 (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS54105223A (en) * | 1977-12-29 | 1979-08-18 | Yamanouchi Pharmaceut Co Ltd | Coating agent for solid medicine |
| DE2936040C2 (de) * | 1979-09-06 | 1982-05-19 | Meggle Milchindustrie Gmbh & Co Kg, 8094 Reitmehring | Dragierverfahren und Mittel zur Durchführung des Verfahrens, bestehend im wesentlichen aus Saccharose, wenigstens einem weiteren Zucker und Wasser |
| CA1168082A (en) * | 1979-10-17 | 1984-05-29 | Francis Devos | Hard coating process with sorbitol and products so-obtained |
| FR2467597A1 (fr) * | 1979-10-17 | 1981-04-30 | Roquette Freres | Procede de drageification dure au sorbitol et produits ainsi obtenus |
| DE3062775D1 (en) * | 1979-11-07 | 1983-05-19 | Tate & Lyle Plc | Tablets containing isomaltulose, their use and a method of producing them |
| DE3221425A1 (de) * | 1982-06-07 | 1983-12-08 | Boehringer Ingelheim KG, 6507 Ingelheim | Hydrolyseempfindlichen wirkstoff enthaltende, lagerstabile tablette |
| US4459280A (en) * | 1982-07-23 | 1984-07-10 | G. D. Searle & Co. | Psyllium hydrophilic mucilloid composition |
| US4548806A (en) * | 1982-07-23 | 1985-10-22 | G. D. Searle & Co. | Psyllium hydrophilic mucilloid composition |
| JPS6141901U (ja) * | 1984-08-13 | 1986-03-18 | エヌオーケー株式会社 | アキユムレ−タ |
| JPH01218573A (ja) * | 1988-02-25 | 1989-08-31 | Yoshio Tanaka | ドナリエラ藻体含有固形状食品の製造法 |
| US5126150A (en) * | 1990-10-01 | 1992-06-30 | The Procter & Gamble Company | Compositions containing psyllium |
| US5705183A (en) * | 1994-11-16 | 1998-01-06 | Phillips Company | Cotton candy coated medication and a method for making and administering the same |
| BR0011343A (pt) * | 1999-06-05 | 2002-03-12 | Innovata Biomed Ltd | Dispositivo de distribuição de medicamento,e,métodos de administrar um medicamento por inalação,e de,tratamento de um paciente com distúrbio respiratório |
| GB9920839D0 (en) | 1999-09-04 | 1999-11-10 | Innovata Biomed Ltd | Inhaler |
| AT500063A1 (de) * | 1999-11-23 | 2005-10-15 | Sandoz Ag | Beschichtete tablettenkerne |
| BR0207062A (pt) * | 2001-02-06 | 2004-10-05 | Innovata Biomed Ltd | Composição farmacêutica bimodal, inalador para pó seco, método de aplicação de uma quantidade terapeuticamente eficaz de um ingrediente ativo substancialmente fino aos pulmões de um paciente, método de tratamento de um distúrbio respiratório, método de tratamento de doença pulmonar obstrutiva crÈnica (copd), uso de um agente antiinflamatório, uso de um broncodilatador, uso de uma mistura de um agente antiinflamatório e de um broncodilatador, e, processo para a fabricação de uma composição farmacêutica bimodal |
| GB0128148D0 (en) | 2001-11-23 | 2002-01-16 | Innovata Biomed Ltd | Assembly |
| WO2004054619A1 (ja) * | 2002-12-17 | 2004-07-01 | Wakunaga Pharmaceutical Co., Ltd. | 遮光剤及び皮膜組成物 |
| EP1744800B1 (en) * | 2004-04-21 | 2016-06-22 | Innovata Biomed Limited | Inhaler |
| GB0409197D0 (en) | 2004-04-24 | 2004-05-26 | Innovata Biomed Ltd | Device |
| CA2580117A1 (en) * | 2004-09-23 | 2006-03-30 | Fmc Corporation | Coating composition |
| US20070128268A1 (en) * | 2005-12-07 | 2007-06-07 | Herwig Jennewein | Pharmaceutical compositions comprising an antibiotic |
| MX342107B (es) * | 2006-04-21 | 2016-09-14 | Intercontinental Great Brands Llc | Composiciones de recubrimiento, composiciones de confiteria y goma de mascar y metodos. |
| WO2008081835A1 (ja) * | 2006-12-28 | 2008-07-10 | Qualicaps Co., Ltd. | 水濡れインジケーターおよびタイムインジケーター |
| JP5684729B2 (ja) * | 2009-01-20 | 2015-03-18 | メッド コート エービーＭｅｄ Ｃｏａｔ Ａｂ | 新規コーティング組成物とその使用 |
| EP2604124A1 (en) * | 2011-12-16 | 2013-06-19 | Nestec S.A. | Soluble non-dairy creamer tablet surface-treated with carbohydrate |
| KR20180062063A (ko) * | 2016-11-30 | 2018-06-08 | (주) 메티메디제약 | 서방형 항암용 약학 조성물 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US1829947A (en) * | 1927-08-25 | 1931-11-03 | Maximilian A Schneller | Dosage of substances |
| US2693436A (en) * | 1951-02-27 | 1954-11-02 | Upjohn Co | Coating material for tablets and coated tablets |
| US2693437A (en) * | 1951-02-27 | 1954-11-02 | Upjohn Co | Coating material for tablets and coated tablets |
| US3384493A (en) * | 1964-11-04 | 1968-05-21 | Agriculture Usa | Coated rice and method of preparing same |
-
1970
- 1970-09-25 JP JP45083917A patent/JPS4837815B1/ja active Pending
-
1971
- 1971-09-17 GB GB4354371A patent/GB1346213A/en not_active Expired
- 1971-09-20 DE DE2146859A patent/DE2146859C3/de not_active Expired
- 1971-09-20 CH CH1373871A patent/CH566137A5/xx not_active IP Right Cessation
- 1971-09-21 CA CA123292A patent/CA968708A/en not_active Expired
- 1971-09-23 BE BE772957A patent/BE772957A/xx unknown
- 1971-09-23 FR FR7134283A patent/FR2108470A5/fr not_active Expired
- 1971-09-24 SU SU1703324A patent/SU522772A3/ru active
- 1971-09-24 US US00183635A patent/US3798054A/en not_active Expired - Lifetime
- 1971-09-24 SE SE7112099A patent/SE373498B/xx unknown
- 1971-09-24 DK DK466671AA patent/DK128516B/da unknown
- 1971-09-24 NL NL7113202A patent/NL7113202A/xx not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JPS4837815B1 (enExample) | 1973-11-14 |
| GB1346213A (en) | 1974-02-06 |
| CA968708A (en) | 1975-06-03 |
| CH566137A5 (enExample) | 1975-09-15 |
| BE772957A (fr) | 1972-01-17 |
| DK128516B (da) | 1974-05-20 |
| FR2108470A5 (enExample) | 1972-05-19 |
| SU522772A3 (ru) | 1976-07-25 |
| US3798054A (en) | 1974-03-19 |
| SE373498B (sv) | 1975-02-10 |
| DE2146859B2 (de) | 1976-10-07 |
| DE2146859A1 (de) | 1972-03-30 |
| NL7113202A (enExample) | 1972-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C3 | Grant after two publication steps (3rd publication) | ||
| 8339 | Ceased/non-payment of the annual fee |