DE2141289A1 - Spray-Vakzinen - Google Patents
Spray-VakzinenInfo
- Publication number
- DE2141289A1 DE2141289A1 DE19712141289 DE2141289A DE2141289A1 DE 2141289 A1 DE2141289 A1 DE 2141289A1 DE 19712141289 DE19712141289 DE 19712141289 DE 2141289 A DE2141289 A DE 2141289A DE 2141289 A1 DE2141289 A1 DE 2141289A1
- Authority
- DE
- Germany
- Prior art keywords
- lecithin
- vaccines
- virus
- antigens
- dispersed
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 229960005486 vaccine Drugs 0.000 title claims description 24
- 239000007921 spray Substances 0.000 title claims description 10
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims description 18
- 229940067606 lecithin Drugs 0.000 claims description 18
- 235000010445 lecithin Nutrition 0.000 claims description 18
- 239000000787 lecithin Substances 0.000 claims description 18
- 239000000427 antigen Substances 0.000 claims description 16
- 102000036639 antigens Human genes 0.000 claims description 16
- 108091007433 antigens Proteins 0.000 claims description 16
- 239000007788 liquid Substances 0.000 claims description 14
- 239000003380 propellant Substances 0.000 claims description 9
- 238000000034 method Methods 0.000 claims description 7
- 239000012530 fluid Substances 0.000 claims description 5
- 208000015181 infectious disease Diseases 0.000 claims description 5
- 206010022000 influenza Diseases 0.000 claims description 3
- 210000002345 respiratory system Anatomy 0.000 claims description 3
- 241000700605 Viruses Species 0.000 description 18
- 235000013601 eggs Nutrition 0.000 description 11
- 239000000463 material Substances 0.000 description 10
- 239000007789 gas Substances 0.000 description 9
- 230000000890 antigenic effect Effects 0.000 description 6
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 6
- 238000005119 centrifugation Methods 0.000 description 5
- 238000004108 freeze drying Methods 0.000 description 5
- 241000894006 Bacteria Species 0.000 description 4
- 238000001035 drying Methods 0.000 description 4
- 239000000725 suspension Substances 0.000 description 4
- 241000712461 unidentified influenza virus Species 0.000 description 4
- 239000004338 Dichlorodifluoromethane Substances 0.000 description 3
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 description 3
- 239000000385 dialysis solution Substances 0.000 description 3
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 description 3
- 235000019404 dichlorodifluoromethane Nutrition 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 230000002779 inactivation Effects 0.000 description 3
- 238000011534 incubation Methods 0.000 description 3
- 239000000203 mixture Substances 0.000 description 3
- 239000008363 phosphate buffer Substances 0.000 description 3
- 229960000380 propiolactone Drugs 0.000 description 3
- 239000013049 sediment Substances 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- CYRMSUTZVYGINF-UHFFFAOYSA-N trichlorofluoromethane Chemical compound FC(Cl)(Cl)Cl CYRMSUTZVYGINF-UHFFFAOYSA-N 0.000 description 3
- 229940029284 trichlorofluoromethane Drugs 0.000 description 3
- 241000282693 Cercopithecidae Species 0.000 description 2
- XQFRJNBWHJMXHO-RRKCRQDMSA-N IDUR Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C(I)=C1 XQFRJNBWHJMXHO-RRKCRQDMSA-N 0.000 description 2
- ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 239000003814 drug Substances 0.000 description 2
- NNPPMTNAJDCUHE-UHFFFAOYSA-N isobutane Chemical compound CC(C)C NNPPMTNAJDCUHE-UHFFFAOYSA-N 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 229940124597 therapeutic agent Drugs 0.000 description 2
- 230000003612 virological effect Effects 0.000 description 2
- BOSAWIQFTJIYIS-UHFFFAOYSA-N 1,1,1-trichloro-2,2,2-trifluoroethane Chemical compound FC(F)(F)C(Cl)(Cl)Cl BOSAWIQFTJIYIS-UHFFFAOYSA-N 0.000 description 1
- NPNPZTNLOVBDOC-UHFFFAOYSA-N 1,1-difluoroethane Chemical compound CC(F)F NPNPZTNLOVBDOC-UHFFFAOYSA-N 0.000 description 1
- DDMOUSALMHHKOS-UHFFFAOYSA-N 1,2-dichloro-1,1,2,2-tetrafluoroethane Chemical compound FC(F)(Cl)C(F)(F)Cl DDMOUSALMHHKOS-UHFFFAOYSA-N 0.000 description 1
- PZNPLUBHRSSFHT-RRHRGVEJSA-N 1-hexadecanoyl-2-octadecanoyl-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCCCC(=O)O[C@@H](COP([O-])(=O)OCC[N+](C)(C)C)COC(=O)CCCCCCCCCCCCCCC PZNPLUBHRSSFHT-RRHRGVEJSA-N 0.000 description 1
- CYXIKYKBLDZZNW-UHFFFAOYSA-N 2-Chloro-1,1,1-trifluoroethane Chemical compound FC(F)(F)CCl CYXIKYKBLDZZNW-UHFFFAOYSA-N 0.000 description 1
- 241000120506 Bluetongue virus Species 0.000 description 1
- 241000283690 Bos taurus Species 0.000 description 1
- 241000712083 Canine morbillivirus Species 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- VOPWNXZWBYDODV-UHFFFAOYSA-N Chlorodifluoromethane Chemical compound FC(F)Cl VOPWNXZWBYDODV-UHFFFAOYSA-N 0.000 description 1
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 1
- 241000710777 Classical swine fever virus Species 0.000 description 1
- 241000186216 Corynebacterium Species 0.000 description 1
- 206010012735 Diarrhoea Diseases 0.000 description 1
- 241000709661 Enterovirus Species 0.000 description 1
- 241000991587 Enterovirus C Species 0.000 description 1
- 241000283073 Equus caballus Species 0.000 description 1
- 241000588722 Escherichia Species 0.000 description 1
- 241000282324 Felis Species 0.000 description 1
- 241000710198 Foot-and-mouth disease virus Species 0.000 description 1
- 241000287828 Gallus gallus Species 0.000 description 1
- 241000606790 Haemophilus Species 0.000 description 1
- 241000711450 Infectious bronchitis virus Species 0.000 description 1
- 241000701076 Macacine alphaherpesvirus 1 Species 0.000 description 1
- 241000712079 Measles morbillivirus Species 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 241000699666 Mus <mouse, genus> Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 241000588653 Neisseria Species 0.000 description 1
- 208000010359 Newcastle Disease Diseases 0.000 description 1
- 241000702244 Orthoreovirus Species 0.000 description 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 description 1
- 241000606856 Pasteurella multocida Species 0.000 description 1
- 201000005702 Pertussis Diseases 0.000 description 1
- 241000588769 Proteus <enterobacteria> Species 0.000 description 1
- 241000589516 Pseudomonas Species 0.000 description 1
- 241000711798 Rabies lyssavirus Species 0.000 description 1
- 241000831652 Salinivibrio sharmensis Species 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 241000191963 Staphylococcus epidermidis Species 0.000 description 1
- 241000194017 Streptococcus Species 0.000 description 1
- 206010043376 Tetanus Diseases 0.000 description 1
- 241000700618 Vaccinia virus Species 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 229940031416 bivalent vaccine Drugs 0.000 description 1
- 239000001273 butane Substances 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 238000000502 dialysis Methods 0.000 description 1
- 229940042935 dichlorodifluoromethane Drugs 0.000 description 1
- UMNKXPULIDJLSU-UHFFFAOYSA-N dichlorofluoromethane Chemical compound FC(Cl)Cl UMNKXPULIDJLSU-UHFFFAOYSA-N 0.000 description 1
- 229940099364 dichlorofluoromethane Drugs 0.000 description 1
- 229940087091 dichlorotetrafluoroethane Drugs 0.000 description 1
- 206010013023 diphtheria Diseases 0.000 description 1
- 239000006185 dispersion Substances 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000001963 growth medium Substances 0.000 description 1
- 150000008282 halocarbons Chemical class 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 239000003230 hygroscopic agent Substances 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
- 229960003971 influenza vaccine Drugs 0.000 description 1
- 239000011872 intimate mixture Substances 0.000 description 1
- 239000001282 iso-butane Substances 0.000 description 1
- WSFSSNUMVMOOMR-NJFSPNSNSA-N methanone Chemical compound O=[14CH2] WSFSSNUMVMOOMR-NJFSPNSNSA-N 0.000 description 1
- 229940031348 multivalent vaccine Drugs 0.000 description 1
- IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
- OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
- 210000001989 nasopharynx Anatomy 0.000 description 1
- 239000006199 nebulizer Substances 0.000 description 1
- 239000002736 nonionic surfactant Substances 0.000 description 1
- 210000000056 organ Anatomy 0.000 description 1
- 229940051027 pasteurella multocida Drugs 0.000 description 1
- 239000001294 propane Substances 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- 230000000241 respiratory effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 239000008347 soybean phospholipid Substances 0.000 description 1
- QAOWNCQODCNURD-UHFFFAOYSA-N sulfuric acid Substances OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL7012832A NL7012832A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1970-08-29 | 1970-08-29 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE2141289A1 true DE2141289A1 (de) | 1972-03-09 |
Family
ID=19810895
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19712141289 Withdrawn DE2141289A1 (de) | 1970-08-29 | 1971-08-18 | Spray-Vakzinen |
Country Status (7)
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1502774A (en) * | 1974-06-25 | 1978-03-01 | Nat Res Dev | Immunological preparations |
| FR2423217A2 (fr) * | 1978-03-10 | 1979-11-16 | Anvar | Procede de vaccination contre la myxomatose |
| US4223014A (en) * | 1978-05-08 | 1980-09-16 | The United States Of America As Represented By The Secretary Of The Interior | Spray immunization of fish |
| EP0009277B1 (en) * | 1978-09-14 | 1984-04-18 | Gist-Brocades N.V. | Combined vaccine active against newcastle disease and egg production drop caused by adeno-like viruses, process for preparing it, adeno-like and newcastle disease virus strains |
| US4225583A (en) * | 1978-12-07 | 1980-09-30 | Iowa State University Research Foundation, Inc. | Intra-respiratory vaccine for prevention of Bordetella bronchiseptica infection and method of use |
| NL7812359A (nl) * | 1978-12-20 | 1980-06-24 | Gist Brocades Nv | Vaccins tegen door reo virus veroorzaakte ziektever- schijnselen en werkwijze voor het bereiden van deze vaccins. |
| NL8102786A (nl) * | 1981-06-10 | 1983-01-03 | Duphar Int Res | Werkwijze voor het immuniseren van varkens tegen de ziekte van aujeszky. |
| JPS59163313A (ja) * | 1983-03-09 | 1984-09-14 | Teijin Ltd | 経鼻投与用ペプチドホルモン類組成物 |
| US4622219A (en) * | 1983-06-17 | 1986-11-11 | Haynes Duncan H | Method of inducing local anesthesia using microdroplets of a general anesthetic |
| GB8322178D0 (en) * | 1983-08-17 | 1983-09-21 | Sterwin Ag | Preparing aerosol compositions |
| GB8502892D0 (en) * | 1985-02-05 | 1985-03-06 | Sterwin Ag | Aerosol composition |
| WO1986006959A1 (en) * | 1985-05-22 | 1986-12-04 | Liposome Technology, Inc. | Liposome inhalation method and system |
| CA2097830C (en) * | 1990-12-04 | 2000-02-01 | Stephen G. Newman | Spray-dried antigenic products and method of preparation |
| US6576264B1 (en) | 1995-10-17 | 2003-06-10 | Skyepharma Canada Inc. | Insoluble drug delivery |
| US6465016B2 (en) | 1996-08-22 | 2002-10-15 | Research Triangle Pharmaceuticals | Cyclosporiine particles |
| US7255877B2 (en) * | 1996-08-22 | 2007-08-14 | Jagotec Ag | Fenofibrate microparticles |
| ATE241363T1 (de) * | 1998-02-11 | 2003-06-15 | Rtp Pharma Corp | Ungesättigte fettsäure und steroide enthaltende kombinationspräparate zur behandlung von entzündungen |
| US6979456B1 (en) | 1998-04-01 | 2005-12-27 | Jagotec Ag | Anticancer compositions |
| DE69914742T2 (de) | 1998-05-29 | 2004-11-25 | Skyepharma Canada Inc., Verdun | Gegen hitzeeinwirkung geschützte mikropartikel und verfahren zur terminalen dampfsterilisation derselben |
| EP1105096B1 (en) | 1998-08-19 | 2003-10-29 | Skyepharma Canada Inc. | Injectable aqueous dispersions of propofol |
| HUP0105089A3 (en) | 1998-11-20 | 2002-09-30 | Skyepharma Canada Inc | Compositions containing the active ingredient in form dispersible phospholipid stabilized microparticles |
| CA2383233C (en) * | 1999-09-21 | 2010-06-08 | Rtp Pharma Inc. | Surface modified particulate compositions of biologically active substances |
| US6682761B2 (en) | 2000-04-20 | 2004-01-27 | Rtp Pharma, Inc. | Water-insoluble drug particle process |
| DE60137943D1 (de) | 2000-08-31 | 2009-04-23 | Jagotec Ag | Gemahlene partikel |
| US8586094B2 (en) | 2000-09-20 | 2013-11-19 | Jagotec Ag | Coated tablets |
| ATE357216T1 (de) * | 2001-02-22 | 2007-04-15 | Jagotec Ag | Fibrat-statin kombinationen mit verminderten von der nahrungsaufnahme abhängigen auswirkungen |
| WO2003072016A2 (en) * | 2001-11-19 | 2003-09-04 | Becton, Dickinson And Company | Pharmaceutical compositions in particulate form |
| AU2003255275A1 (en) * | 2003-02-13 | 2004-09-09 | Becton, Dickinson And Company | Improved anthrax vaccines and delivery methods |
| US9827299B2 (en) * | 2009-10-09 | 2017-11-28 | Children's Medical Center Corporation | Selectively disrupted whole-cell vaccine |
| CN103386125A (zh) * | 2012-05-08 | 2013-11-13 | 刘江秋 | 肾综合征出血热鼻黏膜免疫气溶胶疫苗的研制 |
| CN107475204A (zh) * | 2017-08-03 | 2017-12-15 | 中国人民解放军军事医学科学院军事兽医研究所 | 一种囊膜病毒保护剂及其制备方法 |
-
1970
- 1970-08-29 NL NL7012832A patent/NL7012832A/xx not_active Application Discontinuation
-
1971
- 1971-08-18 DE DE19712141289 patent/DE2141289A1/de not_active Withdrawn
- 1971-08-26 FR FR7131004A patent/FR2103608B1/fr not_active Expired
- 1971-08-26 GB GB4009571A patent/GB1302671A/en not_active Expired
- 1971-08-26 CA CA121,390A patent/CA971480A/en not_active Expired
- 1971-08-27 BE BE771918A patent/BE771918A/xx unknown
- 1971-08-27 US US00175778A patent/US3755557A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| GB1302671A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1973-01-10 |
| NL7012832A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1972-03-02 |
| US3755557A (en) | 1973-08-28 |
| FR2103608A1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1972-04-14 |
| CA971480A (en) | 1975-07-22 |
| FR2103608B1 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1975-02-07 |
| BE771918A (fr) | 1972-02-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| OD | Request for examination | ||
| 8139 | Disposal/non-payment of the annual fee |