DE2003486C3 - Verfahren zur Spaltung von racemisehen organischen Aminen durch die ( )-Di-O-isopropyliden-2-keto-L-gulonsäure - Google Patents

Verfahren zur Spaltung von racemisehen organischen Aminen durch die ( )-Di-O-isopropyliden-2-keto-L-gulonsäure

Info

Publication number
DE2003486C3
DE2003486C3 DE2003486A DE2003486A DE2003486C3 DE 2003486 C3 DE2003486 C3 DE 2003486C3 DE 2003486 A DE2003486 A DE 2003486A DE 2003486 A DE2003486 A DE 2003486A DE 2003486 C3 DE2003486 C3 DE 2003486C3
Authority
DE
Germany
Prior art keywords
keto
isopropylidene
isolated
gulonate
racemic amine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DE2003486A
Other languages
German (de)
English (en)
Other versions
DE2003486A1 (de
DE2003486B2 (de
Inventor
Charles William Den Midland Park Hollander
Willy Montclair Leimgruber
Ernest Nutley Mohacsi
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
F Hoffmann La Roche AG
Original Assignee
F Hoffmann La Roche AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F Hoffmann La Roche AG filed Critical F Hoffmann La Roche AG
Publication of DE2003486A1 publication Critical patent/DE2003486A1/de
Publication of DE2003486B2 publication Critical patent/DE2003486B2/de
Application granted granted Critical
Publication of DE2003486C3 publication Critical patent/DE2003486C3/de
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
    • C07D217/12—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with radicals, substituted by hetero atoms, attached to carbon atoms of the nitrogen-containing ring
    • C07D217/18—Aralkyl radicals
    • C07D217/20—Aralkyl radicals with oxygen atoms directly attached to the aromatic ring of said aralkyl radical, e.g. papaverine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C215/00—Compounds containing amino and hydroxy groups bound to the same carbon skeleton
    • C07C215/02—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C215/04—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated
    • C07C215/06—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic
    • C07C215/08—Compounds containing amino and hydroxy groups bound to the same carbon skeleton having hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being saturated and acyclic with only one hydroxy group and one amino group bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D221/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00
    • C07D221/02—Heterocyclic compounds containing six-membered rings having one nitrogen atom as the only ring hetero atom, not provided for by groups C07D211/00 - C07D219/00 condensed with carbocyclic rings or ring systems
    • C07D221/22—Bridged ring systems
    • C07D221/28—Morphinans

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
DE2003486A 1969-01-30 1970-01-27 Verfahren zur Spaltung von racemisehen organischen Aminen durch die ( )-Di-O-isopropyliden-2-keto-L-gulonsäure Expired DE2003486C3 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79533369A 1969-01-30 1969-01-30

Publications (3)

Publication Number Publication Date
DE2003486A1 DE2003486A1 (de) 1970-08-13
DE2003486B2 DE2003486B2 (de) 1978-08-24
DE2003486C3 true DE2003486C3 (de) 1979-04-26

Family

ID=25165275

Family Applications (1)

Application Number Title Priority Date Filing Date
DE2003486A Expired DE2003486C3 (de) 1969-01-30 1970-01-27 Verfahren zur Spaltung von racemisehen organischen Aminen durch die ( )-Di-O-isopropyliden-2-keto-L-gulonsäure

Country Status (10)

Country Link
US (1) US3682925A (https=)
JP (1) JPS5039652B1 (https=)
BE (1) BE745032A (https=)
CH (1) CH526486A (https=)
DE (1) DE2003486C3 (https=)
DK (1) DK126422B (https=)
FR (1) FR2029706A1 (https=)
GB (1) GB1288205A (https=)
NL (1) NL152233B (https=)
SE (1) SE361168B (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4283340A (en) * 1977-06-13 1981-08-11 Pfizer Inc. Ascorbic acid intermediates
DE3436179A1 (de) * 1984-10-03 1986-04-10 Merck Patent Gmbh, 6100 Darmstadt Verfahren zur herstellung optisch aktiver amine
US5039801A (en) * 1985-12-20 1991-08-13 The United States Of America As Represented By The Department Of Health & Human Services Thermal fragmentation of methylbenzylurea disastereomers or secondary amines and preparation of optically active secondary amines
DE19927412A1 (de) * 1999-06-16 2000-12-21 Bayer Ag Verfahren zur Enantiomerenanreicherung von cis-8-Benzyl-7,9-dioxo-2,8-diazabicyclo [4.3.0]nonan
WO2004005307A1 (en) * 2002-07-09 2004-01-15 Lonza Ag Process for the preparation of optically active 3-n-methylamino-1-(2-thienyl)-1-propanol
WO2004031168A2 (en) * 2002-10-07 2004-04-15 Lonza Ag Processes and intermediates for the preparation of optically active 3-amino-1-(2-thienyl)-1-propanol derivatives
US8148527B1 (en) 2011-01-18 2012-04-03 Divi's Laboratories, Ltd. Resolution of 1-(4-methoxybenzyl)-octahydro-isoquinoline
CN103319406A (zh) * 2012-03-20 2013-09-25 迪维斯实验室有限公司 1-(4-甲氧苄基)-八氢-异喹啉的拆分
AR110150A1 (es) * 2016-11-09 2019-02-27 Roivant Sciences Gmbh Procesos para la preparación de inhibidores de tph1
CN112707901B (zh) * 2020-12-07 2022-03-22 泰安汉威集团有限公司 一种化合物a的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB707903A (en) * 1951-05-10 1954-04-28 British Drug Houses Ltd Improvements in or relating to the resolution of isomeric mixtures of 1-p-nitrophenyl-2-aminopropane-1,3-diol
GB738064A (en) * 1953-07-15 1955-10-05 Lepetit Spa Process for the resolution of racemic threo-1-phenyl-2-amino-1,3-propanediol
US2957886A (en) * 1956-10-19 1960-10-25 Monsanto Chemicals Resolution procedures and apparatus therefor

Also Published As

Publication number Publication date
BE745032A (fr) 1970-07-28
DK126422B (da) 1973-07-16
US3682925A (en) 1972-08-08
JPS5039652B1 (https=) 1975-12-18
GB1288205A (https=) 1972-09-06
NL152233B (nl) 1977-02-15
DE2003486A1 (de) 1970-08-13
SE361168B (https=) 1973-10-22
DE2003486B2 (de) 1978-08-24
FR2029706A1 (https=) 1970-10-23
CH526486A (de) 1972-08-15
NL7001366A (https=) 1970-08-03

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Legal Events

Date Code Title Description
C3 Grant after two publication steps (3rd publication)
EHJ Ceased/non-payment of the annual fee