DE19906310A1 - Arzneimittel zur Behandlung von Bluthochdruck - Google Patents

Arzneimittel zur Behandlung von Bluthochdruck

Info

Publication number
DE19906310A1
DE19906310A1 DE19906310A DE19906310A DE19906310A1 DE 19906310 A1 DE19906310 A1 DE 19906310A1 DE 19906310 A DE19906310 A DE 19906310A DE 19906310 A DE19906310 A DE 19906310A DE 19906310 A1 DE19906310 A1 DE 19906310A1
Authority
DE
Germany
Prior art keywords
phenyl
lower alkyl
group
blood pressure
high blood
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
DE19906310A
Other languages
German (de)
English (en)
Inventor
Martin R Wilkins
Dirk Thormaehlen
Harald Waldeck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Abbott Products GmbH
Original Assignee
Solvay Pharmaceuticals GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Solvay Pharmaceuticals GmbH filed Critical Solvay Pharmaceuticals GmbH
Priority to DE19906310A priority Critical patent/DE19906310A1/de
Priority to ARP000100257A priority patent/AR036864A1/es
Priority to TW089101041A priority patent/TWI221770B/zh
Priority to KR1020077001387A priority patent/KR100797665B1/ko
Priority to SK1082-2001A priority patent/SK287254B6/sk
Priority to JP2000599393A priority patent/JP2002537258A/ja
Priority to NZ514058A priority patent/NZ514058A/en
Priority to DE50010284T priority patent/DE50010284D1/de
Priority to PCT/EP2000/001068 priority patent/WO2000048601A1/de
Priority to ES00903681T priority patent/ES2238268T3/es
Priority to PL00350167A priority patent/PL195283B1/pl
Priority to BR0008260-0A priority patent/BR0008260A/pt
Priority to EP00903681A priority patent/EP1154777B1/de
Priority to AT00903681T priority patent/ATE295174T1/de
Priority to CZ20012672A priority patent/CZ301499B6/cs
Priority to PT00903681T priority patent/PT1154777E/pt
Priority to CNB008038236A priority patent/CN1198619C/zh
Priority to HU0105491A priority patent/HUP0105491A3/hu
Priority to TR2001/02386T priority patent/TR200102386T2/xx
Priority to RU2001124604/15A priority patent/RU2270679C2/ru
Priority to KR1020017009705A priority patent/KR20010101922A/ko
Priority to CA2362273A priority patent/CA2362273C/en
Priority to AU25476/00A priority patent/AU773240C/en
Priority to DZ000029A priority patent/DZ3014A1/xx
Publication of DE19906310A1 publication Critical patent/DE19906310A1/de
Priority to UA2001096336A priority patent/UA63032C2/uk
Priority to ZA200105828A priority patent/ZA200105828B/en
Priority to IL144622A priority patent/IL144622A/en
Priority to NO20013958A priority patent/NO329588B1/no
Priority to US09/930,186 priority patent/US6482820B2/en
Priority to HK02104121.2A priority patent/HK1042247B/zh
Ceased legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives

Landscapes

  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Cardiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19906310A 1999-02-16 1999-02-16 Arzneimittel zur Behandlung von Bluthochdruck Ceased DE19906310A1 (de)

Priority Applications (30)

Application Number Priority Date Filing Date Title
DE19906310A DE19906310A1 (de) 1999-02-16 1999-02-16 Arzneimittel zur Behandlung von Bluthochdruck
ARP000100257A AR036864A1 (es) 1999-02-16 2000-01-20 Uso de compuestos de acido benzacepin-n-acetico, y procedimiento para la preparacion de dichos compuestos
TW089101041A TWI221770B (en) 1999-02-16 2000-01-21 Medicament for treating hypertension
PT00903681T PT1154777E (pt) 1999-02-16 2000-02-10 Medicamento para o tratamento de hipertensao arterial
TR2001/02386T TR200102386T2 (tr) 1999-02-16 2000-02-10 Yüksek tansiyon tedavisi için ilaç.
JP2000599393A JP2002537258A (ja) 1999-02-16 2000-02-10 高血圧の治療のための医薬
NZ514058A NZ514058A (en) 1999-02-16 2000-02-10 Medicament for treating hypertension
DE50010284T DE50010284D1 (de) 1999-02-16 2000-02-10 Arzneimittel zur behandlung von bluthochdruck
PCT/EP2000/001068 WO2000048601A1 (de) 1999-02-16 2000-02-10 Arzneimittel zur behandlung von bluthochdruck
ES00903681T ES2238268T3 (es) 1999-02-16 2000-02-10 Medicamento para el tratamiento de la hipertension sanguinea.
PL00350167A PL195283B1 (pl) 1999-02-16 2000-02-10 Zastosowanie pochodnych kwasu benzazepino-N-octowego
BR0008260-0A BR0008260A (pt) 1999-02-16 2000-02-10 Medicamento para tratamento de hipertensão arterial
EP00903681A EP1154777B1 (de) 1999-02-16 2000-02-10 Arzneimittel zur behandlung von bluthochdruck
AT00903681T ATE295174T1 (de) 1999-02-16 2000-02-10 Arzneimittel zur behandlung von bluthochdruck
CZ20012672A CZ301499B6 (cs) 1999-02-16 2000-02-10 Lék pro lécbu vysokého krevního tlaku
KR1020077001387A KR100797665B1 (ko) 1999-02-16 2000-02-10 고혈압 치료를 위한 약제학적 조성물
CNB008038236A CN1198619C (zh) 1999-02-16 2000-02-10 苯并氮杂䓬－n－乙酸衍生物在制备治疗肺高血压的药物中的应用
HU0105491A HUP0105491A3 (en) 1999-02-16 2000-02-10 Use of 3-[1-(2-aralkyl-2-carboxyethyl)-1-cyclopentanecarboxamido]-2,3,4,5-tetrahydro-2-oxo-1h-benz(b)azepine-1-acetic acid derivatives for manufacture of a medicament for treating hypertension
SK1082-2001A SK287254B6 (sk) 1999-02-16 2000-02-10 Použitie derivátov benzazepín-N-kyseliny octovej na výrobu farmaceutických prípravkov na liečbu vysokého krvného tlaku
RU2001124604/15A RU2270679C2 (ru) 1999-02-16 2000-02-10 Лекарственное средство для лечения гипертензии
KR1020017009705A KR20010101922A (ko) 1999-02-16 2000-02-10 고혈압 치료를 위한 약제학적 조성물
CA2362273A CA2362273C (en) 1999-02-16 2000-02-10 Benzazepine-n-ethanoic acid derivatives for treating secondary hypertension
AU25476/00A AU773240C (en) 1999-02-16 2000-02-10 Medicament for treating hypertension
DZ000029A DZ3014A1 (fr) 1999-02-16 2000-02-13 Médicaments pour le traitement de l'hypertension.
UA2001096336A UA63032C2 (en) 1999-02-16 2000-10-02 Drug for treating hypertension
ZA200105828A ZA200105828B (en) 1999-02-16 2001-07-16 Medicament for treating hypertension.
IL144622A IL144622A (en) 1999-02-16 2001-07-30 A drug for the treatment of hypertension
NO20013958A NO329588B1 (no) 1999-02-16 2001-08-15 Anvendelse av benzazepin-N-eddiksyrederivater til fremstilling av farmasoytiske preparater for behandling av sekundaeformer av hypertensjon
US09/930,186 US6482820B2 (en) 1999-02-16 2001-08-16 Pharmaceutical compositions and method for the inhibition and treatment of secondary hypertension
HK02104121.2A HK1042247B (zh) 1999-02-16 2002-05-31 苯並氮雜䓬-n-乙酸衍生物在製備治療肺高血壓的藥物中的應用

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19906310A DE19906310A1 (de) 1999-02-16 1999-02-16 Arzneimittel zur Behandlung von Bluthochdruck

Publications (1)

Publication Number Publication Date
DE19906310A1 true DE19906310A1 (de) 2000-08-17

Family

ID=7897580

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19906310A Ceased DE19906310A1 (de) 1999-02-16 1999-02-16 Arzneimittel zur Behandlung von Bluthochdruck
DE50010284T Expired - Lifetime DE50010284D1 (de) 1999-02-16 2000-02-10 Arzneimittel zur behandlung von bluthochdruck

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE50010284T Expired - Lifetime DE50010284D1 (de) 1999-02-16 2000-02-10 Arzneimittel zur behandlung von bluthochdruck

Country Status (28)

Country Link
US (1) US6482820B2 (US06262066-20010717-C00315.png)
EP (1) EP1154777B1 (US06262066-20010717-C00315.png)
JP (1) JP2002537258A (US06262066-20010717-C00315.png)
KR (2) KR100797665B1 (US06262066-20010717-C00315.png)
CN (1) CN1198619C (US06262066-20010717-C00315.png)
AR (1) AR036864A1 (US06262066-20010717-C00315.png)
AT (1) ATE295174T1 (US06262066-20010717-C00315.png)
AU (1) AU773240C (US06262066-20010717-C00315.png)
BR (1) BR0008260A (US06262066-20010717-C00315.png)
CA (1) CA2362273C (US06262066-20010717-C00315.png)
CZ (1) CZ301499B6 (US06262066-20010717-C00315.png)
DE (2) DE19906310A1 (US06262066-20010717-C00315.png)
DZ (1) DZ3014A1 (US06262066-20010717-C00315.png)
ES (1) ES2238268T3 (US06262066-20010717-C00315.png)
HK (1) HK1042247B (US06262066-20010717-C00315.png)
HU (1) HUP0105491A3 (US06262066-20010717-C00315.png)
IL (1) IL144622A (US06262066-20010717-C00315.png)
NO (1) NO329588B1 (US06262066-20010717-C00315.png)
NZ (1) NZ514058A (US06262066-20010717-C00315.png)
PL (1) PL195283B1 (US06262066-20010717-C00315.png)
PT (1) PT1154777E (US06262066-20010717-C00315.png)
RU (1) RU2270679C2 (US06262066-20010717-C00315.png)
SK (1) SK287254B6 (US06262066-20010717-C00315.png)
TR (1) TR200102386T2 (US06262066-20010717-C00315.png)
TW (1) TWI221770B (US06262066-20010717-C00315.png)
UA (1) UA63032C2 (US06262066-20010717-C00315.png)
WO (1) WO2000048601A1 (US06262066-20010717-C00315.png)
ZA (1) ZA200105828B (US06262066-20010717-C00315.png)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19932555A1 (de) * 1999-07-13 2001-01-18 Solvay Pharm Gmbh Arzneimittel mit protektiver Wirkung gegen oxidativ-toxische und insbesondere gegen kardiotoxische Substanzen
EP1234025B1 (en) * 1999-11-19 2008-08-27 Solvay Pharmaceuticals B.V. Human enzymes of the metalloprotease family
CA2357833C (en) * 2000-10-04 2005-11-15 Warner-Lambert Company Treatment of pulmonary hypertension using vasopressin antagonist
RU2003136077A (ru) * 2001-05-18 2005-08-10 Зольвай Фармасьютиклз Гмбх (De) Применение соединений, обладающих совместной ингибирующей активностью в отношении nep (нейтральная эндопептидаза) и мр (металлопротеаза), для приготовления лекарственных средств
PT1448567E (pt) * 2001-09-10 2010-03-12 Tibotec Pharm Ltd Método de preparação de hexa-hidro-furo[2,3-b]furan-3-ol
RU2303041C2 (ru) 2002-01-16 2007-07-20 Солвей Фармасьютикалс Б.В. Твердые соли бензазепиновых соединений и их применение при получении фармацевтических соединений
AR038681A1 (es) * 2002-02-14 2005-01-26 Solvay Pharm Bv Formulacion oral de solucion solida de una sustancia activa pobremente soluble en agua
WO2004062692A1 (en) * 2003-01-13 2004-07-29 Solvay Pharmaceuticals B.V. Formulation of poorly water-soluble active substances
US7262184B2 (en) 2003-09-26 2007-08-28 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7452875B2 (en) 2003-09-26 2008-11-18 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl) cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
US7427611B2 (en) 2003-09-26 2008-09-23 Solvay Pharmaceuticals Gmbh Amidomethyl-substituted 1-(carboxyalkyl)-cyclopentyl-carbonylamino-benzazepine-N-acetic acid compounds, process and intermediate products for their preparation and pharmaceutical compositions containing them
SA04250283B1 (ar) * 2003-09-26 2008-05-26 سولفاي فارماسيتيكالز جي أم بي أتش مشتقات من amidomethy1-substituted1-(carboxyalkyl)-cyclopentylcarbonylamino-benzazepine-N-acetic acid
TWI344366B (en) 2003-11-18 2011-07-01 Solvay Pharm Gmbh Pharmaceutical compositions for the treatment of renal dysfunction, disease or disorder, in particular in diabetic patients
US20050267072A1 (en) * 2004-05-14 2005-12-01 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions containing dually acting inhibitors of neutral endopeptidase for the treatment of sexual dysfunction
US20050267124A1 (en) * 2004-05-14 2005-12-01 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous producing system and PDEV inhibiitors
US20050288272A1 (en) * 2004-06-23 2005-12-29 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and AT1 receptor antagonists
MX2007006279A (es) 2004-12-15 2007-06-14 Solvay Pharm Gmbh Composiciones farmaceuticas que comprenden inhibidores de nep, inhibidores del sistema de produccion de endotelina endogena, e inhibidores de hmg coa-reductasa.
US20060205625A1 (en) * 2005-02-18 2006-09-14 Solvay Pharmaceuticals Gmbh Pharmaceutical compositions comprising NEP-inhibitors, inhibitors of the endogenous endothelin producing system and diuretics
US20070292503A1 (en) * 2006-06-16 2007-12-20 Gorissen Henricus R Oral pharmaceutical composition of poorly water-soluble active substance
US20070299054A1 (en) * 2006-06-22 2007-12-27 Rajesh Jain Oral pharmaceutical composition of a poorly water-soluble active agent
KR20100135729A (ko) * 2008-01-31 2010-12-27 반더빌트유니버시티 폐의 용태에 따른 치료 방법

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4749688A (en) * 1986-06-20 1988-06-07 Schering Corporation Use of neutral metalloendopeptidase inhibitors in the treatment of hypertension
EP0254032A3 (en) * 1986-06-20 1990-09-05 Schering Corporation Neutral metalloendopeptidase inhibitors in the treatment of hypertension
CA1337400C (en) * 1987-06-08 1995-10-24 Norma G. Delaney Inhibitors of neutral endopeptidase
US5362727A (en) * 1993-07-26 1994-11-08 Bristol-Myers Squibb Substituted azepino[2,1-a]isoquinoline compounds
DE19510566A1 (de) 1995-03-23 1996-09-26 Kali Chemie Pharma Gmbh Benzazepin-, Benzoxazepin- und Benzothiazepin-N-essigsäurederivate sowie Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel
DE19638020A1 (de) * 1996-09-18 1998-03-19 Solvay Pharm Gmbh Die gastrointestinale Durchblutung fördernde Arzneimittel

Also Published As

Publication number Publication date
TR200102386T2 (tr) 2002-01-21
TWI221770B (en) 2004-10-11
NZ514058A (en) 2001-09-28
BR0008260A (pt) 2001-11-06
HK1042247A1 (en) 2002-08-09
WO2000048601A1 (de) 2000-08-24
SK287254B6 (sk) 2010-04-07
CA2362273C (en) 2010-05-25
HK1042247B (zh) 2005-09-23
DZ3014A1 (fr) 2004-03-27
CZ301499B6 (cs) 2010-03-24
HUP0105491A2 (en) 2002-06-29
ZA200105828B (en) 2002-07-15
CZ20012672A3 (cs) 2002-02-13
EP1154777B1 (de) 2005-05-11
SK10822001A3 (sk) 2002-03-05
UA63032C2 (en) 2004-01-15
CN1339966A (zh) 2002-03-13
PL195283B1 (pl) 2007-08-31
KR100797665B1 (ko) 2008-01-23
RU2270679C2 (ru) 2006-02-27
JP2002537258A (ja) 2002-11-05
PL350167A1 (en) 2002-11-18
AU773240C (en) 2004-11-18
US6482820B2 (en) 2002-11-19
NO329588B1 (no) 2010-11-15
KR20070027719A (ko) 2007-03-09
US20020052361A1 (en) 2002-05-02
DE50010284D1 (de) 2005-06-16
ES2238268T3 (es) 2005-09-01
PT1154777E (pt) 2005-07-29
AU2547600A (en) 2000-09-04
KR20010101922A (ko) 2001-11-15
NO20013958L (no) 2001-10-15
HUP0105491A3 (en) 2002-08-28
AR036864A1 (es) 2004-10-13
CN1198619C (zh) 2005-04-27
NO20013958D0 (no) 2001-08-15
CA2362273A1 (en) 2000-08-24
IL144622A (en) 2006-08-20
EP1154777A1 (de) 2001-11-21
AU773240B2 (en) 2004-05-20
ATE295174T1 (de) 2005-05-15

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Legal Events

Date Code Title Description
8110 Request for examination paragraph 44
8131 Rejection