DE19633349A1 - Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten - Google Patents

Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten

Info

Publication number
DE19633349A1
DE19633349A1 DE19633349A DE19633349A DE19633349A1 DE 19633349 A1 DE19633349 A1 DE 19633349A1 DE 19633349 A DE19633349 A DE 19633349A DE 19633349 A DE19633349 A DE 19633349A DE 19633349 A1 DE19633349 A1 DE 19633349A1
Authority
DE
Germany
Prior art keywords
androstane
diol
dione
androstan
dimethylaminoethoxyimino
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
DE19633349A
Other languages
German (de)
English (en)
Inventor
Sergio De Munari
Elena Folpini
Marco Frigerio
Piero Melloni
Fulvio Serra
Simona Sputore
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sigma Tau Industrie Farmaceutiche Riunite SpA
Original Assignee
Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sigma Tau Industrie Farmaceutiche Riunite SpA filed Critical Sigma Tau Industrie Farmaceutiche Riunite SpA
Priority to DE19633349A priority Critical patent/DE19633349A1/de
Priority to AT97111651T priority patent/ATE196768T1/de
Priority to PT97111651T priority patent/PT825197E/pt
Priority to EP97111651A priority patent/EP0825197B1/en
Priority to DK97111651T priority patent/DK0825197T3/da
Priority to DE69703228T priority patent/DE69703228T2/de
Priority to ES97111651T priority patent/ES2151698T3/es
Priority to US08/891,030 priority patent/US5914324A/en
Priority to JP22285497A priority patent/JP4297994B2/ja
Publication of DE19633349A1 publication Critical patent/DE19633349A1/de
Priority to HK98109935.2A priority patent/HK1009139B/en
Priority to GR20000402508T priority patent/GR3034821T3/el
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0033—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005
    • C07J41/0038—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring not covered by C07J41/0005 with an androstane skeleton, including 18- or 19-substituted derivatives, 18-nor derivatives and also derivatives where position 17-beta is substituted by a carbon atom not directly bonded to a further carbon atom and not being part of an amide group
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
    • C07J41/0005—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring the nitrogen atom being directly linked to the cyclopenta(a)hydro phenanthrene skeleton
    • C07J41/0016—Oximes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J43/00—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C07J43/003—Normal steroids having a nitrogen-containing hetero ring spiro-condensed or not condensed with the cyclopenta(a)hydrophenanthrene skeleton not condensed

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
DE19633349A 1996-08-19 1996-08-19 Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten Withdrawn DE19633349A1 (de)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE19633349A DE19633349A1 (de) 1996-08-19 1996-08-19 Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten
DE69703228T DE69703228T2 (de) 1996-08-19 1997-07-09 Neue 6-Hydroxy und 6-Oxo-Androstan Verbindungen mit Kardioaktivität und pharmazeutische Präparate davon
PT97111651T PT825197E (pt) 1996-08-19 1997-07-09 Novos derivados de 6-hidroxi e 6-oxo-androstano com actividade sobre o sistema cardiovascular e composicoes farmaceuticas que os contem
EP97111651A EP0825197B1 (en) 1996-08-19 1997-07-09 New 6-hydroxy and 6-oxo-androstane derivatives active on the cardiovascular system and pharmaceutical compositions containing same
DK97111651T DK0825197T3 (da) 1996-08-19 1997-07-09 Nye 6-hydroxy- og 6-oxo-androstanderivater, der er aktive i forhold til det cardiovaskulære system, og farmaceutiske præpar
AT97111651T ATE196768T1 (de) 1996-08-19 1997-07-09 Neue 6-hydroxy und 6-oxo-androstan verbindungen mit kardioaktivität und pharmazeutische präparate davon
ES97111651T ES2151698T3 (es) 1996-08-19 1997-07-09 Nuevos derivados de 6-hidroxi y 6-oxo-androstan activos sobre el sistema cardiovascular y composiciones farmaceuticas que los contienen.
US08/891,030 US5914324A (en) 1996-08-19 1997-07-10 6-Hydroxy and 6-oxo-androstane derivatives active on the cardiovascular system and pharmaceutical compositions containing same
JP22285497A JP4297994B2 (ja) 1996-08-19 1997-08-19 心臓血管系に活性のある新規の６−ヒドロキシおよび６−オキソ−アンドロスタン誘導体およびそれらを含有する製薬用組成物
HK98109935.2A HK1009139B (en) 1996-08-19 1998-08-14 New 6-hydroxy and 6-oxo-androstane derivatives active on the cardiovascular system and pharmaceutical compositions containing same
GR20000402508T GR3034821T3 (en) 1996-08-19 2000-11-10 New 6-hydroxy and 6-oxo-anstro-stane derivatives active on the cardiovascular system and pharmaceutical compositions containing same

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19633349A DE19633349A1 (de) 1996-08-19 1996-08-19 Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten

Publications (1)

Publication Number Publication Date
DE19633349A1 true DE19633349A1 (de) 1998-02-26

Family

ID=7802998

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19633349A Withdrawn DE19633349A1 (de) 1996-08-19 1996-08-19 Neue 6-Hydroxy- und 6-Oxo-androstan-Derivate, die auf das kardiovaskuläre System wirken und pharmazeutische Zusammensetzungen, die diese enthalten
DE69703228T Expired - Lifetime DE69703228T2 (de) 1996-08-19 1997-07-09 Neue 6-Hydroxy und 6-Oxo-Androstan Verbindungen mit Kardioaktivität und pharmazeutische Präparate davon

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69703228T Expired - Lifetime DE69703228T2 (de) 1996-08-19 1997-07-09 Neue 6-Hydroxy und 6-Oxo-Androstan Verbindungen mit Kardioaktivität und pharmazeutische Präparate davon

Country Status (9)

Country Link
US (1) US5914324A (cg-RX-API-DMAC7.html)
EP (1) EP0825197B1 (cg-RX-API-DMAC7.html)
JP (1) JP4297994B2 (cg-RX-API-DMAC7.html)
AT (1) ATE196768T1 (cg-RX-API-DMAC7.html)
DE (2) DE19633349A1 (cg-RX-API-DMAC7.html)
DK (1) DK0825197T3 (cg-RX-API-DMAC7.html)
ES (1) ES2151698T3 (cg-RX-API-DMAC7.html)
GR (1) GR3034821T3 (cg-RX-API-DMAC7.html)
PT (1) PT825197E (cg-RX-API-DMAC7.html)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1317031B1 (it) * 2000-05-17 2003-05-26 Sigma Tau Ind Farmaceuti Procedimento migliorato per la preparazione di (e,z)3-(2-amminoetossimmino)-androstano-6, 17-dione e di suoi analoghi.
US20080119447A1 (en) * 2005-09-30 2008-05-22 James Yarger 6-alkoxyalkyl estradiol derivatives and methods of use
US10174070B2 (en) * 2005-09-30 2019-01-08 Endece Llc 6-substituted estradiol derivatives and methods of use
US8168621B2 (en) 2005-09-30 2012-05-01 Endece, Llc 6-substituted estradiol derivatives and methods of use
TWI389917B (zh) 2006-04-13 2013-03-21 Sigma Tau Ind Farmaceuti 作為心血管疾病治療藥物的雄甾烷與雄甾烯之氮雜環烷基衍生物
TWI392682B (zh) * 2006-04-13 2013-04-11 Sigma Tau Ind Farmaceuti 作為心血管疾病的治療藥物之雄甾烷和雄甾烯的胺基衍生物
TWI372762B (en) * 2006-06-23 2012-09-21 Sigma Tau Ind Farmaceuti Amino derivatives of b-homoandrostanes and b-heteroandrostanes
BRPI0721050A2 (pt) 2006-11-29 2014-07-29 Endece Llc Derivados de 6-alquoxialquil estradiol e métodos de uso
JP5436432B2 (ja) * 2007-10-12 2014-03-05 シグマ−タウ・インドゥストリエ・ファルマチェウチケ・リウニテ・ソシエタ・ペル・アチオニ 心臓血管疾患のための医薬としての、２−および／または４−置換のアンドロスタンおよびアンドロステンのアミノオキシム誘導体
WO2010149666A1 (en) 2009-06-22 2010-12-29 Medexis S.A. Methods for treating neoplasia
US20130303500A1 (en) * 2010-07-30 2013-11-14 Medexis S.A. Compounds and methods for treating neoplasia
BR112013005843A2 (pt) 2010-09-14 2019-12-10 Endece Llc derivativos de er-beta 6-substituído por desmetil-estradiol
CN103315968B (zh) * 2013-06-26 2015-04-01 中国生命药物治疗有限公司 一种注射用粉针剂及其制备方法
CN103360457B (zh) * 2013-07-31 2015-10-07 中国生命药物治疗有限公司 一种雄甾烷二酮衍生物晶型及其制备方法
EP3599243B1 (en) 2018-07-26 2023-04-12 CVIE Therapeutics Limited 17beta-heterocyclyl-digitalis like compounds for the treatment of heart failure
KR20210136048A (ko) 2019-03-05 2021-11-16 윈드트리 세라퓨틱스, 인크. 급성 심부전 (ahf)의 치료를 위한 이스타록심-함유 정맥내 제형
EP3805243B1 (en) 2019-10-09 2023-11-15 Windtree Therapeutics, Inc. Androstane derivatives with activity as pure or predominantly pure stimulators of serca2a for the treatment of heart failure

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2863885A (en) * 1958-02-10 1958-12-09 Upjohn Co 17-isonitrosoandrostanes
FR7725M (cg-RX-API-DMAC7.html) * 1967-06-22 1970-03-02
CH504427A (de) * 1967-12-06 1971-03-15 Ciba Geigy Ag Verfahren zur Herstellung neuer 4-Imino-19-nor-A-homosteroid-triene
US5144017A (en) * 1988-07-13 1992-09-01 University Of Manitoba Compounds that bind to digitalis receptor
GB9201224D0 (en) * 1992-01-21 1992-03-11 Erba Carlo Spa Difluoromethylenandrostenone derivatives and process for their preparation
DE4227605C2 (de) * 1992-08-20 1995-02-16 Sigma Tau Ind Farmaceuti 17-Hydroxyiminomethyl-14beta-hydroxy-5ß-androstan-Derivate, Verfahren zu deren Herstellung und pharmazeutische Zusammensetzungen, die dieselben enthalten
DE4232656C2 (de) * 1992-09-29 1995-01-12 Sigma Tau Ind Farmaceuti Cyclopentanperhydrophenanthren-17-furyl-3ß-derivate, Verfahren zu deren Herstellung und diese enthaltende pharmazeutischen Zusammensetzungen
DE4344236A1 (de) * 1993-12-23 1995-06-29 Sigma Tau Ind Farmaceuti Neue 17-Iminomethylalkenyl-5beta,14beta-androstan- und 17-Iminoalkyl-5beta,14beta-androstan-Derivate , die auf das kardiovaskuläre System wirken, Verfahren zu ihrer Herstellung und pharmazeutische Zusammensetzungen, die sie enthalten

Also Published As

Publication number Publication date
EP0825197B1 (en) 2000-10-04
EP0825197A2 (en) 1998-02-25
DE69703228D1 (de) 2000-11-09
JP4297994B2 (ja) 2009-07-15
JPH1077292A (ja) 1998-03-24
PT825197E (pt) 2001-01-31
DK0825197T3 (da) 2000-10-30
ES2151698T3 (es) 2001-01-01
HK1009139A1 (en) 1999-05-28
GR3034821T3 (en) 2001-02-28
US5914324A (en) 1999-06-22
ATE196768T1 (de) 2000-10-15
DE69703228T2 (de) 2001-02-22
EP0825197A3 (en) 1999-04-14

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8139 Disposal/non-payment of the annual fee