DE1768470A1 - 1,2-O-Isopropylidin-5-O-benzoyl-3-methyl-alpha-D-ribofuranose und Verfahren zu ihrer Herstellung - Google Patents

1,2-O-Isopropylidin-5-O-benzoyl-3-methyl-alpha-D-ribofuranose und Verfahren zu ihrer Herstellung

Info

Publication number
DE1768470A1
DE1768470A1 DE19661768470 DE1768470A DE1768470A1 DE 1768470 A1 DE1768470 A1 DE 1768470A1 DE 19661768470 DE19661768470 DE 19661768470 DE 1768470 A DE1768470 A DE 1768470A DE 1768470 A1 DE1768470 A1 DE 1768470A1
Authority
DE
Germany
Prior art keywords
benzoyl
methyl
preparation
ribofuranose
isopropylidine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE19661768470
Other languages
German (de)
English (en)
Inventor
Edward Walton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE1768470A1 publication Critical patent/DE1768470A1/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H9/00—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical
    • C07H9/02—Compounds containing a hetero ring sharing at least two hetero atoms with a saccharide radical the hetero ring containing only oxygen as ring hetero atoms
    • C07H9/04—Cyclic acetals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H13/00—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids
    • C07H13/02—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids
    • C07H13/08—Compounds containing saccharide radicals esterified by carbonic acid or derivatives thereof, or by organic acids, e.g. phosphonic acids by carboxylic acids having the esterifying carboxyl radicals directly attached to carbocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/02—Acyclic radicals, not substituted by cyclic structures
    • C07H15/04—Acyclic radicals, not substituted by cyclic structures attached to an oxygen atom of the saccharide radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H7/00—Compounds containing non-saccharide radicals linked to saccharide radicals by a carbon-to-carbon bond
    • C07H7/02—Acyclic radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Saccharide Compounds (AREA)
DE19661768470 1965-11-15 1966-11-14 1,2-O-Isopropylidin-5-O-benzoyl-3-methyl-alpha-D-ribofuranose und Verfahren zu ihrer Herstellung Pending DE1768470A1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US50769765A 1965-11-15 1965-11-15

Publications (1)

Publication Number Publication Date
DE1768470A1 true DE1768470A1 (de) 1971-05-13

Family

ID=24019753

Family Applications (2)

Application Number Title Priority Date Filing Date
DE19661768470 Pending DE1768470A1 (de) 1965-11-15 1966-11-14 1,2-O-Isopropylidin-5-O-benzoyl-3-methyl-alpha-D-ribofuranose und Verfahren zu ihrer Herstellung
DE19661593110 Pending DE1593110A1 (de) 1965-11-15 1966-11-14 Ribofuranosen und Verfahren zu deren Herstellung

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE19661593110 Pending DE1593110A1 (de) 1965-11-15 1966-11-14 Ribofuranosen und Verfahren zu deren Herstellung

Country Status (5)

Country Link
CH (1) CH490367A (enrdf_load_stackoverflow)
DE (2) DE1768470A1 (enrdf_load_stackoverflow)
FR (1) FR1498856A (enrdf_load_stackoverflow)
GB (1) GB1163102A (enrdf_load_stackoverflow)
NL (1) NL6616102A (enrdf_load_stackoverflow)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MY164523A (en) 2000-05-23 2017-12-29 Univ Degli Studi Cagliari Methods and compositions for treating hepatitis c virus
CA2410579C (en) 2000-05-26 2010-04-20 Jean-Pierre Sommadossi Methods and compositions for treating flaviviruses and pestiviruses
WO2003026589A2 (en) 2001-09-28 2003-04-03 Idenix (Cayman) Limited Methods and compositions for treating hepatitis c virus using 4'-modified nucleosides
US7608600B2 (en) 2002-06-28 2009-10-27 Idenix Pharmaceuticals, Inc. Modified 2′ and 3′-nucleoside prodrugs for treating Flaviviridae infections
BR0312278A (pt) 2002-06-28 2007-06-19 Idenix Cayman Ltd éster 2'-c-metil-3'-o-l-valina de ribofuranosil citidina para tratamento de infecções por flaviviridae
JP5087211B2 (ja) * 2002-06-28 2012-12-05 イデニクス（ケイマン）リミテツド フラビウィルス感染治療のための２′および３′−ヌクレオシドプロドラッグ
NZ537662A (en) 2002-06-28 2007-10-26 Idenix Cayman Ltd 2'-C-methyl-3'-O-L-valine ester ribofuranosyl cytidine for treatment of flaviviridae infections
RU2005118421A (ru) 2002-11-15 2006-01-20 Айденикс (Кайман) Лимитед (Ky) 2'-разветвленные нуклеозиды и мутация flaviviridae
MXPA05006230A (es) 2002-12-12 2005-09-20 Idenix Cayman Ltd Proceso para la produccion de nucleosidos ramificados-2'.
WO2007075876A2 (en) 2005-12-23 2007-07-05 Idenix Pharmaceuticals, Inc. Process for preparing a synthetic intermediate for preparation of branched nucleosides

Also Published As

Publication number Publication date
GB1163102A (en) 1969-09-04
NL6616102A (enrdf_load_stackoverflow) 1967-05-16
FR1498856A (enrdf_load_stackoverflow) 1968-01-10
DE1593110A1 (de) 1970-07-16
CH490367A (de) 1970-05-15

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