DE1442197A1 - Verfahren zur fermentativen L-Glutaminsaeureherstellung - Google Patents
Verfahren zur fermentativen L-GlutaminsaeureherstellungInfo
- Publication number
- DE1442197A1 DE1442197A1 DE19631442197 DE1442197A DE1442197A1 DE 1442197 A1 DE1442197 A1 DE 1442197A1 DE 19631442197 DE19631442197 DE 19631442197 DE 1442197 A DE1442197 A DE 1442197A DE 1442197 A1 DE1442197 A1 DE 1442197A1
- Authority
- DE
- Germany
- Prior art keywords
- medium
- fermentation
- glutamic acid
- media
- basic
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 title claims description 36
- 229960002989 glutamic acid Drugs 0.000 title claims description 25
- 238000000034 method Methods 0.000 title claims description 12
- 238000012262 fermentative production Methods 0.000 title description 2
- 238000000855 fermentation Methods 0.000 claims description 86
- 230000004151 fermentation Effects 0.000 claims description 86
- 239000002609 medium Substances 0.000 claims description 84
- 239000001963 growth medium Substances 0.000 claims description 16
- 238000011534 incubation Methods 0.000 claims description 16
- 239000002253 acid Substances 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 14
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 12
- 239000004220 glutamic acid Substances 0.000 claims description 12
- 235000013922 glutamic acid Nutrition 0.000 claims description 11
- 230000012010 growth Effects 0.000 claims description 9
- 235000015097 nutrients Nutrition 0.000 claims description 9
- 239000013589 supplement Substances 0.000 claims description 7
- 241000894006 Bacteria Species 0.000 claims description 6
- 230000001502 supplementing effect Effects 0.000 claims 1
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 36
- 229960002685 biotin Drugs 0.000 description 18
- 235000020958 biotin Nutrition 0.000 description 18
- 239000011616 biotin Substances 0.000 description 18
- 235000013372 meat Nutrition 0.000 description 9
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 7
- 239000008103 glucose Substances 0.000 description 7
- 230000032258 transport Effects 0.000 description 6
- 108010073771 Soybean Proteins Proteins 0.000 description 4
- XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 description 4
- 239000004202 carbamide Substances 0.000 description 4
- 238000011109 contamination Methods 0.000 description 4
- 235000019710 soybean protein Nutrition 0.000 description 4
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 3
- 230000001580 bacterial effect Effects 0.000 description 3
- 239000012535 impurity Substances 0.000 description 3
- 150000002500 ions Chemical class 0.000 description 3
- 239000003531 protein hydrolysate Substances 0.000 description 3
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 2
- 241000186146 Brevibacterium Species 0.000 description 2
- 241000186226 Corynebacterium glutamicum Species 0.000 description 2
- 229930003270 Vitamin B Natural products 0.000 description 2
- 230000001133 acceleration Effects 0.000 description 2
- 230000015572 biosynthetic process Effects 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
- 238000011835 investigation Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 235000019156 vitamin B Nutrition 0.000 description 2
- 239000011720 vitamin B Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 241000628997 Flos Species 0.000 description 1
- 229930182816 L-glutamine Natural products 0.000 description 1
- 235000016496 Panda oleosa Nutrition 0.000 description 1
- 240000000220 Panda oleosa Species 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 238000005273 aeration Methods 0.000 description 1
- 239000007640 basal medium Substances 0.000 description 1
- 238000010009 beating Methods 0.000 description 1
- 230000010261 cell growth Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 235000009508 confectionery Nutrition 0.000 description 1
- 238000010924 continuous production Methods 0.000 description 1
- 239000002781 deodorant agent Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000011049 filling Methods 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000001404 mediated effect Effects 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 238000004904 shortening Methods 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 230000009469 supplementation Effects 0.000 description 1
- 238000011282 treatment Methods 0.000 description 1
- 150000003672 ureas Chemical class 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P13/00—Preparation of nitrogen-containing organic compounds
- C12P13/04—Alpha- or beta- amino acids
- C12P13/14—Glutamic acid; Glutamine
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- General Chemical & Material Sciences (AREA)
- Biotechnology (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP5731862 | 1962-12-18 | ||
| JP5731762 | 1962-12-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE1442197A1 true DE1442197A1 (de) | 1968-11-07 |
Family
ID=26398341
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE19631442197 Pending DE1442197A1 (de) | 1962-12-18 | 1963-12-17 | Verfahren zur fermentativen L-Glutaminsaeureherstellung |
Country Status (3)
| Country | Link |
|---|---|
| DE (1) | DE1442197A1 (https=) |
| GB (1) | GB1009370A (https=) |
| NL (1) | NL301993A (https=) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6562601B2 (en) | 2000-08-31 | 2003-05-13 | Degussa Ag | Fermentation process for the preparation of L-threonine |
| CN1318574C (zh) * | 2000-08-31 | 2007-05-30 | 德古萨股份公司 | 发酵制备l－苏氨酸的方法 |
| KR100547882B1 (ko) | 2002-02-26 | 2006-02-01 | 삼성전자주식회사 | 안테나 선택 다이버시티를 지원하는 이동통신시스템에서순방향 채널 상태 정보를 송수신하는 방법 및 장치 |
| DE102005048818A1 (de) | 2005-10-10 | 2007-04-12 | Degussa Ag | Mikrobiologische Herstellung von 3-Hydroxypropionsäure |
| DE102006039203B4 (de) | 2006-08-22 | 2014-06-18 | Evonik Degussa Gmbh | Verfahren zur Herstellung von durch Kristallisation gereinigter Acrylsäure aus Hydroxypropionsäure sowie Vorrichtung dazu |
| DE102007015583A1 (de) | 2007-03-29 | 2008-10-02 | Albert-Ludwigs-Universität Freiburg | Ein Enzym zur Herstellung von Methylmalonyl-Coenzym A oder Ethylmalonyl-Coenzym A sowie dessen Verwendung |
| DE102007027006A1 (de) | 2007-06-08 | 2008-12-11 | Evonik Degussa Gmbh | Mikrobiologische Herstellung von Aldehyden, insbesondere von 3-Hydroxypropionaldehyd |
| DE102007041862A1 (de) | 2007-09-03 | 2009-03-19 | Evonik Degussa Gmbh | Mikrobiologische Herstellung von Isoprenoiden |
| DE102007059248A1 (de) | 2007-12-07 | 2009-06-10 | Albert-Ludwigs-Universität Freiburg | Zelle, welche in der Lage ist, CO2 zu fixieren |
| DE102007060705A1 (de) | 2007-12-17 | 2009-06-18 | Evonik Degussa Gmbh | ω-Aminocarbonsäuren oder ihre Lactame, herstellende, rekombinante Zellen |
| DE102008001581A1 (de) | 2008-05-06 | 2009-11-12 | Evonik Degussa Gmbh | Ein Verfahren zur Herstellung von Dihydroxyaceton |
| DE102008002715A1 (de) | 2008-06-27 | 2009-12-31 | Evonik Röhm Gmbh | 2-Hydroxyisobuttersäure produzierende rekombinante Zelle |
| DE102008041299A1 (de) | 2008-08-18 | 2010-02-25 | Evonik Degussa Gmbh | Neuartiges, universell einsetzbares addiction-System |
| DE102008042144A1 (de) | 2008-09-17 | 2010-03-18 | Evonik Degussa Gmbh | Verfahren zur Herstellung von Silbenoiden |
| DE102009002583A1 (de) | 2009-04-23 | 2010-10-28 | Evonik Degussa Gmbh | Zellen und Verfahren zur Herstellung von Aceton |
| DE102010014680A1 (de) | 2009-11-18 | 2011-08-18 | Evonik Degussa GmbH, 45128 | Zellen, Nukleinsäuren, Enzyme und deren Verwendung sowie Verfahren zur Herstellung von Sophorolipiden |
| DE102010019059A1 (de) | 2010-05-03 | 2011-11-03 | Forschungszentrum Jülich GmbH | Sensoren zur intrazellulären Metabolit-Detektion |
| DE102010029973A1 (de) | 2010-06-11 | 2011-12-15 | Evonik Degussa Gmbh | Mikrobiologische Herstellung von C4-Körpern aus Saccharose und Kohlendioxid |
| DE102010032484A1 (de) | 2010-07-28 | 2012-02-02 | Evonik Goldschmidt Gmbh | Zellen und Verfahren zur Herstellung von Rhamnolipiden |
| DE102011110945A1 (de) | 2011-08-15 | 2013-02-21 | Evonik Degussa Gmbh | Biotechnologisches Syntheseverfahren von organischen Verbindungen mit alkIL-Genprodukt |
| DE102011110946A1 (de) | 2011-08-15 | 2016-01-21 | Evonik Degussa Gmbh | Biotechnologisches Syntheseverfahren von omegafunktionalisierten Carbonsäuren und Carbonsäure-Estern aus einfachen Kohlenstoffquellen |
| DE102012201360A1 (de) | 2012-01-31 | 2013-08-01 | Evonik Industries Ag | Zellen und Verfahren zur Herstellung von Rhamnolipiden |
| EP2944697A1 (en) | 2014-05-13 | 2015-11-18 | Evonik Degussa GmbH | Method of producing nylon |
| EP2949214A1 (en) | 2014-05-26 | 2015-12-02 | Evonik Degussa GmbH | Methods of producing rhamnolipids |
| CN107208123A (zh) | 2015-02-19 | 2017-09-26 | 赢创德固赛有限公司 | 鼠李糖脂合成 |
| EP3072971B1 (en) | 2015-03-25 | 2019-08-28 | SenseUp GmbH | Sensors for detection and quantification of microbiological protein secretion |
| ES2803208T3 (es) | 2015-12-17 | 2021-01-25 | Evonik Operations Gmbh | Una célula acetogénica genéticamente modificada |
| JP2019523271A (ja) | 2016-07-27 | 2019-08-22 | エボニック デグサ ゲーエムベーハーＥｖｏｎｉｋ Ｄｅｇｕｓｓａ ＧｍｂＨ | Ｎ−アセチルホモセリン |
| CN109863166A (zh) | 2016-10-24 | 2019-06-07 | 赢创德固赛有限公司 | 具有降低的葡萄糖脱氢酶活性的产生鼠李糖脂的细胞 |
| WO2018077701A1 (en) | 2016-10-24 | 2018-05-03 | Evonik Degussa Gmbh | Cells and method for producing rhamnolipids using alternative glucose transporters |
| US11236372B2 (en) | 2018-02-09 | 2022-02-01 | Evonik Operations Gmbh | Lipid production |
| WO2024231217A1 (en) | 2023-05-11 | 2024-11-14 | Evonik Operations Gmbh | Glucolipid production |
-
0
- NL NL301993D patent/NL301993A/xx unknown
-
1963
- 1963-12-11 GB GB4897263A patent/GB1009370A/en not_active Expired
- 1963-12-17 DE DE19631442197 patent/DE1442197A1/de active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NL301993A (https=) | |
| GB1009370A (en) | 1965-11-10 |
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