DE1283834B - Verfahren zur Herstellung von 11 alpha-Halogen-6-desoxy-6-desmethyl-6-methylen-tetracyclinen bzw. ihren Salzen - Google Patents

Verfahren zur Herstellung von 11 alpha-Halogen-6-desoxy-6-desmethyl-6-methylen-tetracyclinen bzw. ihren Salzen

Info

Publication number
DE1283834B
DE1283834B DE1961P0031281 DEP0031281A DE1283834B DE 1283834 B DE1283834 B DE 1283834B DE 1961P0031281 DE1961P0031281 DE 1961P0031281 DE P0031281 A DEP0031281 A DE P0031281A DE 1283834 B DE1283834 B DE 1283834B
Authority
DE
Germany
Prior art keywords
acid
tetracycline
product
hemiketal
desmethyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DE1961P0031281
Other languages
German (de)
English (en)
Inventor
Rennhard Hans Heinrich
Beereboom John Joseph
Blackwood Robert Keith
Stephens Jun Charles Robert
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27567787&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE1283834(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from US76441A external-priority patent/US2984686A/en
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of DE1283834B publication Critical patent/DE1283834B/de
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29D—PRODUCING PARTICULAR ARTICLES FROM PLASTICS OR FROM SUBSTANCES IN A PLASTIC STATE
    • B29D23/00—Producing tubular articles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D33/00—Details of, or accessories for, sacks or bags
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • F—MECHANICAL ENGINEERING; LIGHTING; HEATING; WEAPONS; BLASTING
    • F16—ENGINEERING ELEMENTS AND UNITS; GENERAL MEASURES FOR PRODUCING AND MAINTAINING EFFECTIVE FUNCTIONING OF MACHINES OR INSTALLATIONS; THERMAL INSULATION IN GENERAL
    • F16L—PIPES; JOINTS OR FITTINGS FOR PIPES; SUPPORTS FOR PIPES, CABLES OR PROTECTIVE TUBING; MEANS FOR THERMAL INSULATION IN GENERAL
    • F16L11/00—Hoses, i.e. flexible pipes
    • F16L11/04—Hoses, i.e. flexible pipes made of rubber or flexible plastics

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Mechanical Engineering (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE1961P0031281 1960-05-23 1961-05-19 Verfahren zur Herstellung von 11 alpha-Halogen-6-desoxy-6-desmethyl-6-methylen-tetracyclinen bzw. ihren Salzen Pending DE1283834B (de)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US3123660A 1960-05-23 1960-05-23
US3841460A 1960-06-29 1960-06-29
US7287560A 1960-12-01 1960-12-01
US7285760A 1960-12-01 1960-12-01
US76441A US2984686A (en) 1960-12-19 1960-12-19 6-deoxy-6-demethyl-6-methylene-5-oxytetracyclines
US8705961A 1961-02-06 1961-02-06
US106146A US3200149A (en) 1960-05-23 1961-05-05 alpha-6-deoxytetracycline derivatives and process

Publications (1)

Publication Number Publication Date
DE1283834B true DE1283834B (de) 1968-11-28

Family

ID=27567787

Family Applications (3)

Application Number Title Priority Date Filing Date
DEP27184A Pending DE1300934B (de) 1960-05-23 1961-05-19 Verfahren zur Herstellung von 6-Desoxy-6-desmethyl-6-methylen-tetracyclinen bzw. ihren Salzen mit Saeuren oder Basen
DE1961P0031281 Pending DE1283834B (de) 1960-05-23 1961-05-19 Verfahren zur Herstellung von 11 alpha-Halogen-6-desoxy-6-desmethyl-6-methylen-tetracyclinen bzw. ihren Salzen
DEP27203A Pending DE1298522B (de) 1960-05-23 1961-05-23 Verfahren zur Herstellung von 6-Desoxy- und 6-Epi-6-desoxytetracyclinen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DEP27184A Pending DE1300934B (de) 1960-05-23 1961-05-19 Verfahren zur Herstellung von 6-Desoxy-6-desmethyl-6-methylen-tetracyclinen bzw. ihren Salzen mit Saeuren oder Basen

Family Applications After (1)

Application Number Title Priority Date Filing Date
DEP27203A Pending DE1298522B (de) 1960-05-23 1961-05-23 Verfahren zur Herstellung von 6-Desoxy- und 6-Epi-6-desoxytetracyclinen

Country Status (10)

Country Link
US (1) US3200149A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH (3) CH434238A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CY (4) CY366A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE (3) DE1300934B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FI (1) FI40534B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
FR (1) FR1430859A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
GB (4) GB998294A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
MY (4) MY6700048A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
OA (1) OA00136A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
SE (1) SE302119B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659515A (en) * 1983-09-02 1987-04-21 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt Process for the preparation of 6-demethyl-6-deoxy-6-methylene-5-oxytetracyclin and the 11A-chloro-derivative thereof

Families Citing this family (53)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3444198A (en) * 1967-02-13 1969-05-13 Pfizer & Co C Process for producing alpha-6-deoxytetracyclines
US4089900A (en) * 1967-09-13 1978-05-16 Pfizer Inc. Antimicrobial agents
DE1767891C3 (de) * 1968-06-28 1980-10-30 Pfizer Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat
BR6915425D0 (pt) * 1969-06-27 1973-01-16 Farmaceutici Italia Preparacao de cloro-metileno-tetraciclina
BE754596A (fr) * 1969-08-08 1971-02-08 Farmaceutici Italia Esters de la methylenetetracycline et procede de leur fabrication
BE755678R (fr) * 1969-09-04 1971-03-03 Farmaceutici Italia Esters de la methylenetetracycline et procede de leur fabrication
DK153393C (da) * 1970-07-03 1988-11-28 Ivan Villax Fremgangsmaade til fremstilling af metacyklin ved dehalogenering af et syreadditionssalt af 11a-klor-6-desoxy-6-demetyl-6-metylen-5-hydroxytetracyklin
US3795707A (en) * 1970-12-28 1974-03-05 Rachelle Labor Italia Spa Manufacture of alpha-6-deoxytetracyclines
GB1418137A (en) * 1972-02-24 1975-12-17 Ankerfarm Spa Process for the preparation of alpha-6-deoxytetracyclines
US3954862A (en) * 1973-04-20 1976-05-04 Pfizer Inc. Process for producing α-6-deoxytetracyclines
GB1459861A (en) * 1973-06-21 1976-12-31 Pfizer Process for 11a-dehalogenation of 11a-halotetracyclines
US3907890A (en) * 1974-05-28 1975-09-23 Pfizer Preparation of alpha-6-deoxy-5-hydroxytetracycline
US4001321A (en) * 1975-06-26 1977-01-04 Pfizer Inc. Preparation of α-6-deoxytetracyclines
YU41480B (en) * 1979-03-12 1987-08-31 Pliva Pharm & Chem Works Process for obtaining alpha-6-deoxy-5-hydroxytetracycline
DK386784A (da) * 1983-08-17 1985-02-18 Hovione Int Ltd Fremgangsmaade til fremstilling af alfa-6-desoxy-tetracykliner
US4973719A (en) * 1988-10-28 1990-11-27 Ranbaxy Laboratories Limited Process for the production of alpha-6-deoxytetracyclines
US4987242A (en) * 1988-10-28 1991-01-22 Jagmohan Khanna Hydrogenation catalyst useful in the production of alpha-6-deoxytetracyclines
US5049683A (en) * 1989-01-04 1991-09-17 Houba, Inc. Process for the production of alpha-6-deoxytetracyclines
ES2019267T3 (es) * 1989-04-03 1993-09-16 Ranbaxy Laboratories, Ltd. Un procedimiento para la preparacion de alfa-6-desoxitetraciclinas.
US5494903A (en) 1991-10-04 1996-02-27 American Cyanamid Company 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5281628A (en) * 1991-10-04 1994-01-25 American Cyanamid Company 9-amino-7-(substituted)-6-demethyl-6-deoxytetracyclines
USRE40183E1 (en) 1991-10-04 2008-03-25 Wyeth Holdings Corporation 7-Substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines
US5328902A (en) * 1992-08-13 1994-07-12 American Cyanamid Co. 7-(substituted)-9-[(substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5442059A (en) * 1992-08-13 1995-08-15 American Cyanamid Company 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines
SG47520A1 (en) * 1992-08-13 1998-04-17 American Cyanamid Co New method for the production of 9-amino-6-demethyl-6-deoxytetracycline
US5284963A (en) * 1992-08-13 1994-02-08 American Cyanamid Company Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines
US5420272A (en) * 1992-08-13 1995-05-30 American Cyanamid Company 7-(substituted)-8-(substituted)-9-](substituted glycyl)amido]-6-demethyl-6-deoxytetracyclines
US5371076A (en) * 1993-04-02 1994-12-06 American Cyanamid Company 9-[(substituted glycyl)amido]-6-(substituted)-5-hydroxy-6-deoxytetracyclines
US5538954A (en) * 1994-06-24 1996-07-23 A/S Dumex (Dumex Ltd.) Salts of tetracyclines
WO1999037307A1 (en) * 1998-01-23 1999-07-29 Trustees Of Tufts College Pharmaceutically active compounds and methods of use thereof
CN1399627A (zh) * 1999-09-14 2003-02-26 塔夫茨大学信托人 用基于过渡金属的化学制备取代四环素的方法
US8106225B2 (en) * 1999-09-14 2012-01-31 Trustees Of Tufts College Methods of preparing substituted tetracyclines with transition metal-based chemistries
US20020132798A1 (en) 2000-06-16 2002-09-19 Nelson Mark L. 7-phenyl-substituted tetracycline compounds
EP2995610A1 (en) * 2002-01-08 2016-03-16 Paratek Pharmaceuticals, Inc. 4-dedimethylamino tetracycline compounds
WO2003079984A2 (en) 2002-03-21 2003-10-02 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
EP2250887B1 (en) * 2002-03-29 2013-04-24 The Research Foundation Of The State University Of New York Use of non-antibacterial tetracycline analog CMT-1002 and formulations thereof for the treatment of bacterial exotoxins
EP2319828A3 (en) 2003-07-09 2011-07-06 Paratek Pharmaceuticals, Inc. Substituted tetracycline compounds
US20060287283A1 (en) * 2003-07-09 2006-12-21 Paratek Pharmaceuticals, Inc. Prodrugs of 9-aminomethyl tetracycline compounds
UA83266C2 (en) * 2003-12-08 2008-06-25 Уайет Oxazole derivatives of tetracyclines
CN101119964A (zh) 2005-02-15 2008-02-06 惠氏公司 9-经取代四环素
AR057324A1 (es) * 2005-05-27 2007-11-28 Wyeth Corp Tigeciclina y metodos para preparar 9-aminominociclina
AR057032A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos de preparacion
AR057033A1 (es) * 2005-05-27 2007-11-14 Wyeth Corp Tigeciclina y metodos para preparar 9-nitrominociclina
KR20080041722A (ko) * 2005-08-31 2008-05-13 와이어쓰 글리실사이클린의 9-아미노카르보닐 치환된 유도체
AU2008231033B2 (en) * 2007-03-23 2012-08-30 Molecular Research Center, Inc. Anti-inflammatory compositions comprising tetracyclines and use thereof in therapy
PT2271348T (pt) * 2008-03-28 2018-04-16 Paratek Pharm Innc Formulação de comprimido oral de composto de tetraciclina
TW202436282A (zh) * 2008-05-19 2024-09-16 美商Ｐｒｔｋ Ｓｐｖ２公司 四環素化合物之甲苯磺酸鹽及同素異形體
PL2568987T3 (pl) 2010-05-12 2017-06-30 Rempex Pharmaceuticals, Inc. Kompozycje tetracyklinowe
CN101967108B (zh) * 2010-09-13 2013-06-19 苏春华 一种美他环素的衍生物
CN102086165B (zh) * 2010-12-29 2013-06-19 开封制药(集团)有限公司 Pd催化剂在生产强力霉素氢化工艺中的应用
PT108978B (pt) 2015-11-24 2020-03-09 Hovione Farm S A Sais de tetraciclinas
CN111732522B (zh) * 2020-07-21 2022-10-18 山东国邦药业有限公司 一种脱氧土霉素的制备方法
US20250269350A1 (en) * 2022-04-22 2025-08-28 Benjamin V. Mork Compositions and methods for remediation using dithionite and activated carbons

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1011417B (de) * 1954-01-15 1957-07-04 Pfizer & Co C Verfahren zur Herstellung von Anhydrodesdimethylaminochlortetracyclin bzw. Anhydrodesdimethylaminotetracyclin
DE1117567B (de) * 1959-02-26 1961-11-23 American Cyanamid Co Verfahren zur Herstellung von 7- bzw. 11ª‡-Halogen- bzw. 7, 11ª‡-Dihalogen-6-desoxytetracyclinen
DE1131608B (de) * 1954-08-19 1962-06-14 Albert Fezer Saugspannvorrichtung fuer Werkstuecke, insbesondere hoelzerne Platten
DE1132918B (de) * 1959-04-16 1962-07-12 Hoechst Ag Verfahren zur Herstellung von 12a-Bromanhydrotetracyclinen

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1073482B (de) * 1960-01-21 American Cyanamid Company New York N Y (V St A) \ertr Dr F Zumstem Dipl Chem Dr rer nat E Assmann und Dipl Chem Dr R Koe nigsberger Pat Anwalte München 2 Verfahren zur Herstellung von Tetracyclmen und ihren 5a Epimeren
BE572584A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) *
BE565025A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) *
BE572236A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) *
BE566456A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) *
DE932670C (de) * 1952-10-23 1955-09-05 Pfizer & Co C Verfahren zur Herstellung von Tetracyclin und seinen Salzen
US2731497A (en) * 1954-05-14 1956-01-17 American Cyanamid Co Production of tetracycline
DE1007775B (de) * 1955-02-12 1957-05-09 Pfizer & Co C Verfahren zur Herstellung von Tetracyclin und seinen Salzen
CH365484A (fr) * 1956-05-28 1962-11-15 American Cyanamid Co Procédé de préparation d'une substance antibiotique
GB845649A (en) * 1957-03-01 1960-08-24 American Cyanamid Co 6-deoxytetracycline and 6-deoxyoxytetracycline
US3005023A (en) * 1957-04-05 1961-10-17 American Cyanamid Co Production of tetracycline
US3036129A (en) * 1959-10-09 1962-05-22 American Cyanamid Co Preparation of 7-halo-6-deoxy-tetracyclines
US3019260A (en) * 1959-05-13 1962-01-30 American Cyanamid Co Process for the catalytic reduction of 6-hydroxy hydronaphthacenes
US2976318A (en) * 1959-05-18 1961-03-21 Pfizer & Co C Tetracycline derivatives and process of producing the same

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1011417B (de) * 1954-01-15 1957-07-04 Pfizer & Co C Verfahren zur Herstellung von Anhydrodesdimethylaminochlortetracyclin bzw. Anhydrodesdimethylaminotetracyclin
DE1131608B (de) * 1954-08-19 1962-06-14 Albert Fezer Saugspannvorrichtung fuer Werkstuecke, insbesondere hoelzerne Platten
DE1117567B (de) * 1959-02-26 1961-11-23 American Cyanamid Co Verfahren zur Herstellung von 7- bzw. 11ª‡-Halogen- bzw. 7, 11ª‡-Dihalogen-6-desoxytetracyclinen
DE1132918B (de) * 1959-04-16 1962-07-12 Hoechst Ag Verfahren zur Herstellung von 12a-Bromanhydrotetracyclinen

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4659515A (en) * 1983-09-02 1987-04-21 Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt Process for the preparation of 6-demethyl-6-deoxy-6-methylene-5-oxytetracyclin and the 11A-chloro-derivative thereof

Also Published As

Publication number Publication date
CY366A (en) 1967-02-02
MY6900209A (en) 1969-12-31
GB995032A (en) 1965-06-10
FI40534B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1968-11-30
US3200149A (en) 1965-08-10
DE1300934B (de) 1969-08-14
CY480A (en) 1969-04-10
OA00136A (fr) 1966-03-15
CH459189A (de) 1968-07-15
SE302119B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1968-07-08
GB998294A (en) 1965-07-14
MY6700048A (en) 1967-12-31
CY365A (en) 1967-02-02
MY6700047A (en) 1967-12-31
CH434238A (de) 1967-04-30
FR1430859A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) 1966-05-25
GB995031A (en)
CH444853A (de) 1967-10-15
DE1298522B (de) 1969-07-03
CY381A (en) 1967-03-08
GB995033A (en) 1965-06-10
MY7400226A (en) 1974-12-31

Similar Documents

Publication Publication Date Title
DE1283834B (de) Verfahren zur Herstellung von 11 alpha-Halogen-6-desoxy-6-desmethyl-6-methylen-tetracyclinen bzw. ihren Salzen
DE2104620C3 (de) Verfahren zur Herstellung von a -L-Aspartyl-Lphenylalanin-und a -L- Aspartyl-L-ryrosin-C,. bis C 3-alkylestern
CH397657A (de) Verfahren zur Herstellung von Tetracyclinverbindungen
DE2846321C2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
CH621554A5 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html)
DE2929058A1 (de) Anorganische salze von trimethylammoniumderivaten der polyenmakrolide, insbesondere anorganische salze von methylestern dieser derivate, und verfahren zu deren herstellung
DE2322655A1 (de) Kristalline prostansaeureester
DE1143817C2 (de) Verfahren zur Herstellung von 6-Phenoxyacylamidopenicillansaeure-derivaten und von nicht giftigen Salzen derselben
DE1768971C (de) 11 a-H alogen-e-desoxy-e-desmethyl-emethylentetracycline und ihre Säureadditionssalze
DE1768971A1 (de) 11a-Halogen-6-desoxy-6-desmethyl-6-methylentetracycline bzw. deren Salze
EP0770083B1 (de) PYRIDO[3,2,1-i,j][3,1]BENZOXAZINDERIVATE
DE2252323A1 (de) Thiazolochinolin-derivate, verfahren zu ihrer herstellung und ihre verwendung als bakterizide
DE1918316C3 (de) Mitomycindenvate und Verfahren zu ihrer Herstellung
DE2060205A1 (de) Antibiotisch wirksame Dibenzofuranderivate und Verfahren zu deren Herstellung
DE1960130A1 (de) Neue Verfahren zur Herstellung von N-(Diaethylaminoaethyl)-4-amino-5-chloro-2-methoxybenzamid
AT236363B (de) Verfahren zur Herstellung von Tetracyano-benzochinon-(1,4)
AT209007B (de) Verfahren zur Herstellung von 9 α-Halogen-4-pregnen-16 α, 17 α,21-triol-3, 11, 20-trionen und ihren Estern
DE865449C (de) Verfahren zur Herstellung von halogenierten substituierten Pteridinen
DE825686C (de) Verfahren zur UEberfuehrung von í¸-20-Cyanpregnenen mit einer oder mehreren kerngebundenen Hydroxylgruppen in 17 alpha-Oxy-20-ketopregnane
AT326638B (de) Verfahren zur herstellung von n(beta-diäthylaminoäthyl) -4-amino-5-chlor-2-methoxybenzamid
DE2161420A1 (de) Penicillinderivate und Verfahren zu deren Herstellung
DE2131945B2 (de) Verfahren zum abtrennen von alpha6-desoxy-5-hydroxy-tetracyclin hoher reinheit aus einem reaktionsgemisch
DE911135C (de) Verfahren zur Herstellung von Pteridinen
AT233174B (de) Verfahren zur Herstellung von 3-Keto-Δ4, 6-10(α)-methylsteroiden
DE893790C (de) Verfahren zur Herstellung von A9,11-12-Ketocyclopentanopoly-hydrophenanthrenen