DE124777T1 - Derivate des 1,4-dihydropyridins. - Google Patents
Derivate des 1,4-dihydropyridins.Info
- Publication number
- DE124777T1 DE124777T1 DE198484103803T DE84103803T DE124777T1 DE 124777 T1 DE124777 T1 DE 124777T1 DE 198484103803 T DE198484103803 T DE 198484103803T DE 84103803 T DE84103803 T DE 84103803T DE 124777 T1 DE124777 T1 DE 124777T1
- Authority
- DE
- Germany
- Prior art keywords
- furoyl
- nitrophenyl
- dihydropyridine
- compound
- dimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- YNGDWRXWKFWCJY-UHFFFAOYSA-N 1,4-Dihydropyridine Chemical class C1C=CNC=C1 YNGDWRXWKFWCJY-UHFFFAOYSA-N 0.000 title 1
- -1 2-furoyl Chemical group 0.000 claims 8
- 150000001875 compounds Chemical class 0.000 claims 5
- 238000000034 method Methods 0.000 claims 4
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 claims 3
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
- 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 3
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000010992 reflux Methods 0.000 claims 2
- 239000003085 diluting agent Substances 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- QZWGOMGZVJHRGW-UHFFFAOYSA-N ethyl 5-(furan-2-carbonyl)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3-carboxylate Chemical compound CCOC(=O)C1=C(C)NC(C)=C(C(=O)C=2OC=CC=2)C1C1=CC=CC=C1[N+]([O-])=O QZWGOMGZVJHRGW-UHFFFAOYSA-N 0.000 claims 1
- 239000012442 inert solvent Substances 0.000 claims 1
- SYZMOVBYGJLHNJ-UHFFFAOYSA-N methyl 5-(furan-2-carbonyl)-2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3-carboxylate Chemical compound COC(=O)C1=C(C)NC(C)=C(C(=O)C=2OC=CC=2)C1C1=CC=CC=C1[N+]([O-])=O SYZMOVBYGJLHNJ-UHFFFAOYSA-N 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/06—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
- A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Diabetes (AREA)
- Rheumatology (AREA)
- Endocrinology (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Hydrogenated Pyridines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Furan Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB8309284 | 1983-04-06 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE124777T1 true DE124777T1 (de) | 1985-06-05 |
Family
ID=10540692
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE198484103803T Pending DE124777T1 (de) | 1983-04-06 | 1984-04-05 | Derivate des 1,4-dihydropyridins. |
| DE8484103803T Expired DE3461086D1 (en) | 1983-04-06 | 1984-04-05 | 1,4-dihydropyridine derivatives |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8484103803T Expired DE3461086D1 (en) | 1983-04-06 | 1984-04-05 | 1,4-dihydropyridine derivatives |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US4529733A (OSRAM) |
| EP (1) | EP0124777B1 (OSRAM) |
| JP (1) | JPS59193884A (OSRAM) |
| KR (1) | KR880002510B1 (OSRAM) |
| AR (1) | AR245941A1 (OSRAM) |
| AT (1) | ATE23151T1 (OSRAM) |
| AU (1) | AU557521B2 (OSRAM) |
| CA (1) | CA1262906C (OSRAM) |
| DE (2) | DE124777T1 (OSRAM) |
| DK (1) | DK162442C (OSRAM) |
| ES (1) | ES531254A0 (OSRAM) |
| GR (1) | GR81903B (OSRAM) |
| IE (1) | IE57182B1 (OSRAM) |
| IL (1) | IL71432A (OSRAM) |
| NO (1) | NO157575C (OSRAM) |
| NZ (1) | NZ207716A (OSRAM) |
| PH (1) | PH19451A (OSRAM) |
| PT (1) | PT78370B (OSRAM) |
| ZA (1) | ZA842456B (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NO883326L (no) * | 1987-08-11 | 1989-02-13 | Bayer Ag | Dhp-retard-tilberedning. |
| US7150616B2 (en) * | 2003-12-22 | 2006-12-19 | Kimberly-Clark Worldwide, Inc | Die for producing meltblown multicomponent fibers and meltblown nonwoven fabrics |
| CN114149360B (zh) * | 2021-11-25 | 2024-03-01 | 天津太平洋化学制药有限公司 | 一种高纯度尼群地平原料药的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1670827C3 (de) * | 1967-03-20 | 1974-10-24 | Bayer Ag, 5090 Leverkusen | 4-(2'-Nitrophenyl)-2,6-dimethyl-3,5-dicarbmethoxy-1,4-dihydropyridin |
| ZA7152B (en) * | 1970-01-24 | 1971-10-27 | Bayer Ag | New pharmaceutically active 1,4-dihydropyridines |
| DE2117573C3 (de) * | 1971-04-10 | 1978-07-27 | Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von unsymmetrischen l,4-Dihydropyridin-3,5dicarbonsäureestern, sowie ihre Verwendung als Arzneimittel |
| DE3033919A1 (de) * | 1980-09-09 | 1982-04-22 | Bayer Ag, 5090 Leverkusen | Feste arzneizubereitungen enthaltend nifedipin und verfahren zu ihrer herstellung |
-
1984
- 1984-03-22 US US06/592,184 patent/US4529733A/en not_active Expired - Lifetime
- 1984-04-02 ZA ZA842456A patent/ZA842456B/xx unknown
- 1984-04-02 AR AR84296185A patent/AR245941A1/es active
- 1984-04-02 CA CA451112A patent/CA1262906C/en not_active Expired
- 1984-04-02 NZ NZ207716A patent/NZ207716A/en unknown
- 1984-04-03 IL IL71432A patent/IL71432A/xx not_active IP Right Cessation
- 1984-04-03 AU AU26375/84A patent/AU557521B2/en not_active Ceased
- 1984-04-03 ES ES531254A patent/ES531254A0/es active Granted
- 1984-04-04 PT PT78370A patent/PT78370B/pt not_active IP Right Cessation
- 1984-04-04 GR GR74306A patent/GR81903B/el unknown
- 1984-04-04 IE IE831/84A patent/IE57182B1/en not_active IP Right Cessation
- 1984-04-05 DK DK179984A patent/DK162442C/da not_active IP Right Cessation
- 1984-04-05 JP JP59066848A patent/JPS59193884A/ja active Granted
- 1984-04-05 DE DE198484103803T patent/DE124777T1/de active Pending
- 1984-04-05 AT AT84103803T patent/ATE23151T1/de not_active IP Right Cessation
- 1984-04-05 EP EP84103803A patent/EP0124777B1/en not_active Expired
- 1984-04-05 NO NO841341A patent/NO157575C/no unknown
- 1984-04-05 DE DE8484103803T patent/DE3461086D1/de not_active Expired
- 1984-04-06 PH PH30511A patent/PH19451A/en unknown
- 1984-04-06 KR KR1019840001814A patent/KR880002510B1/ko not_active Expired
Also Published As
| Publication number | Publication date |
|---|---|
| ATE23151T1 (de) | 1986-11-15 |
| DE3461086D1 (en) | 1986-12-04 |
| IL71432A (en) | 1988-03-31 |
| PT78370B (en) | 1986-05-28 |
| AU2637584A (en) | 1984-10-11 |
| KR840009105A (ko) | 1984-12-24 |
| NZ207716A (en) | 1986-09-10 |
| ZA842456B (en) | 1984-11-28 |
| DK179984D0 (da) | 1984-04-05 |
| AR245941A1 (es) | 1994-03-30 |
| EP0124777A1 (en) | 1984-11-14 |
| GR81903B (OSRAM) | 1984-12-12 |
| JPS59193884A (ja) | 1984-11-02 |
| US4529733A (en) | 1985-07-16 |
| IE57182B1 (en) | 1992-05-20 |
| PT78370A (en) | 1984-05-01 |
| CA1262906A (en) | 1989-11-14 |
| ES8505363A1 (es) | 1985-05-16 |
| NO841341L (no) | 1984-10-08 |
| DK179984A (da) | 1984-10-07 |
| PH19451A (en) | 1986-04-18 |
| JPH0465073B2 (OSRAM) | 1992-10-16 |
| IL71432A0 (en) | 1984-07-31 |
| ES531254A0 (es) | 1985-05-16 |
| EP0124777B1 (en) | 1986-10-29 |
| NO157575B (no) | 1988-01-04 |
| DK162442B (da) | 1991-10-28 |
| DK162442C (da) | 1992-03-23 |
| CA1262906C (en) | 1989-11-14 |
| NO157575C (no) | 1988-04-13 |
| KR880002510B1 (ko) | 1988-11-26 |
| IE840831L (en) | 1984-10-06 |
| AU557521B2 (en) | 1986-12-24 |
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