DE1246728B - Verfahren zur Herstellung von 11-oxygenierten 17alpha-Hydroxy-6, 16alpha-dimethyl-4, 6-pregnadien-bzw. -1, 4, 6-pregnatrien-3, 20-dionen - Google Patents

Verfahren zur Herstellung von 11-oxygenierten 17alpha-Hydroxy-6, 16alpha-dimethyl-4, 6-pregnadien-bzw. -1, 4, 6-pregnatrien-3, 20-dionen

Info

Publication number
DE1246728B
DE1246728B DEM50554A DEM0050554A DE1246728B DE 1246728 B DE1246728 B DE 1246728B DE M50554 A DEM50554 A DE M50554A DE M0050554 A DEM0050554 A DE M0050554A DE 1246728 B DE1246728 B DE 1246728B
Authority
DE
Germany
Prior art keywords
dione
pregnadiene
dimethyl
dehydrated
substituted
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
DEM50554A
Other languages
German (de)
English (en)
Inventor
Glen Edward Arth
John Fried
Lewis Hastings Sarett
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE1246728B publication Critical patent/DE1246728B/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J75/00—Processes for the preparation of steroids in general

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Steroid Compounds (AREA)
DEM50554A 1960-10-19 1961-10-11 Verfahren zur Herstellung von 11-oxygenierten 17alpha-Hydroxy-6, 16alpha-dimethyl-4, 6-pregnadien-bzw. -1, 4, 6-pregnatrien-3, 20-dionen Pending DE1246728B (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US6349760A 1960-10-19 1960-10-19

Publications (1)

Publication Number Publication Date
DE1246728B true DE1246728B (de) 1967-08-10

Family

ID=22049605

Family Applications (1)

Application Number Title Priority Date Filing Date
DEM50554A Pending DE1246728B (de) 1960-10-19 1961-10-11 Verfahren zur Herstellung von 11-oxygenierten 17alpha-Hydroxy-6, 16alpha-dimethyl-4, 6-pregnadien-bzw. -1, 4, 6-pregnatrien-3, 20-dionen

Country Status (8)

Country Link
BE (1) BE609377A (da)
CH (1) CH413832A (da)
DE (1) DE1246728B (da)
DK (2) DK108572C (da)
ES (1) ES272044A1 (da)
FR (1) FR2145M (da)
GB (1) GB1001661A (da)
SE (1) SE302120B (da)

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1033199B (de) * 1955-06-08 1958-07-03 Organon Nv Verfahren zur Darstellung von Dehydrosteroiden
US2891079A (en) * 1959-01-23 1959-06-16 Searle & Co 6-methyl-4, 6-pregnadiene-3, 20-dione and 17alpha-acyloxy derivatives thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1033199B (de) * 1955-06-08 1958-07-03 Organon Nv Verfahren zur Darstellung von Dehydrosteroiden
US2891079A (en) * 1959-01-23 1959-06-16 Searle & Co 6-methyl-4, 6-pregnadiene-3, 20-dione and 17alpha-acyloxy derivatives thereof

Also Published As

Publication number Publication date
FR2145M (fr) 1963-11-18
BE609377A (fr) 1962-02-15
ES272044A1 (es) 1962-03-16
GB1001661A (en) 1965-08-18
DK108572C (da) 1968-01-08
SE302120B (da) 1968-07-08
DK105021C (da) 1966-08-08
CH413832A (de) 1966-05-31

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