DE10324447A1 - Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin - Google Patents
Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin Download PDFInfo
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- DE10324447A1 DE10324447A1 DE10324447A DE10324447A DE10324447A1 DE 10324447 A1 DE10324447 A1 DE 10324447A1 DE 10324447 A DE10324447 A DE 10324447A DE 10324447 A DE10324447 A DE 10324447A DE 10324447 A1 DE10324447 A1 DE 10324447A1
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C40B40/00—Libraries per se, e.g. arrays, mixtures
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Priority Applications (20)
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| DE10324447A DE10324447A1 (de) | 2003-05-28 | 2003-05-28 | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| EP09176574A EP2163559A1 (de) | 2003-05-28 | 2004-05-27 | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin-Proteinen |
| JP2006529936A JP4803817B2 (ja) | 2003-05-28 | 2004-05-27 | ユビキチンタンパク質に基づく人工結合タンパク質の生成 |
| EP04735010A EP1626985B1 (de) | 2003-05-28 | 2004-05-27 | Generierung künstlicher bindungsproteine auf der grundlage von ubiquitin-proteinen |
| EP20100181802 EP2295446A1 (de) | 2003-05-28 | 2004-05-27 | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin-Proteinen |
| PCT/EP2004/005730 WO2004106368A1 (de) | 2003-05-28 | 2004-05-27 | Generierung künstlicher bindungsproteine auf der grundlage von ubiquitin-proteinen |
| AT04735010T ATE499382T1 (de) | 2003-05-28 | 2004-05-27 | Generierung künstlicher bindungsproteine auf der grundlage von ubiquitin-proteinen |
| CA2524899A CA2524899C (en) | 2003-05-28 | 2004-05-27 | Generation of artificial binding proteins based on ubiquitin proteins |
| CNA2004800146101A CN1956996A (zh) | 2003-05-28 | 2004-05-27 | 基于泛素蛋白的人工结合蛋白的生产 |
| CN201310381691.XA CN103539851B (zh) | 2003-05-28 | 2004-05-27 | 基于泛素蛋白的人工结合蛋白的生产 |
| DK04735010.3T DK1626985T3 (da) | 2003-05-28 | 2004-05-27 | Generering af kunstige bindingsproteiner på basis af ubiquitin proteiner |
| PL04735010T PL1626985T3 (pl) | 2003-05-28 | 2004-05-27 | Generowanie sztucznych białek wiążących na bazie białek ubikwitynowych |
| AU2004242851A AU2004242851B2 (en) | 2003-05-28 | 2004-05-27 | Generation of artificial binding proteins based on ubiquitin proteins |
| PT04735010T PT1626985E (pt) | 2003-05-28 | 2004-05-27 | Gera??o de prote?nas de liga??o artificiais ? base da prote?na ubiquitina |
| ES04735010T ES2361409T3 (es) | 2003-05-28 | 2004-05-27 | Generación de proteinas de unión sintéticas basadas en proteinas de ubiquitina. |
| DE502004012225T DE502004012225D1 (de) | 2003-05-28 | 2004-05-27 | Generierung künstlicher bindungsproteine auf der grundlage von ubiquitin-proteinen |
| US11/283,332 US8790895B2 (en) | 2003-05-28 | 2005-11-18 | Generation of artificial binding proteins on the basis of ubiquitin proteins |
| US12/072,959 US8791238B2 (en) | 2003-05-28 | 2008-02-29 | Artificial binding proteins based on ubiquitin |
| JP2010226505A JP2011046722A (ja) | 2003-05-28 | 2010-10-06 | ユビキチンタンパク質に基づく人工結合タンパク質の生成 |
| JP2011104112A JP5372992B2 (ja) | 2003-05-28 | 2011-05-09 | ユビキチンタンパク質に基づく人工結合タンパク質の生成 |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
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| DE10324447A DE10324447A1 (de) | 2003-05-28 | 2003-05-28 | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
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| DE10324447A1 true DE10324447A1 (de) | 2004-12-30 |
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| DE502004012225T Expired - Lifetime DE502004012225D1 (de) | 2003-05-28 | 2004-05-27 | Generierung künstlicher bindungsproteine auf der grundlage von ubiquitin-proteinen |
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| EP (3) | EP2295446A1 (https=) |
| JP (3) | JP4803817B2 (https=) |
| CN (2) | CN103539851B (https=) |
| AT (1) | ATE499382T1 (https=) |
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| CA (1) | CA2524899C (https=) |
| DE (2) | DE10324447A1 (https=) |
| DK (1) | DK1626985T3 (https=) |
| ES (1) | ES2361409T3 (https=) |
| PL (1) | PL1626985T3 (https=) |
| PT (1) | PT1626985E (https=) |
| WO (1) | WO2004106368A1 (https=) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| DE102004049479A1 (de) * | 2004-10-11 | 2006-04-13 | Scil Proteins Gmbh | Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| DE19932688B4 (de) | 1999-07-13 | 2009-10-08 | Scil Proteins Gmbh | Design von Beta-Faltblatt-Proteinen des gamma-II-kristallins antikörperähnlichen |
| DE10324447A1 (de) | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| EP1925664A1 (en) * | 2006-11-15 | 2008-05-28 | Scil proteins GmbH | Artificial binding proteins based on a modified alpha helical region of ubiquitin |
| EP1955712A1 (en) * | 2007-02-09 | 2008-08-13 | Scil proteins GmbH | Multimeric conjugate |
| TWI489993B (zh) | 2007-10-12 | 2015-07-01 | Novartis Ag | 骨硬化素（ｓｃｌｅｒｏｓｔｉｎ）抗體組合物及使用方法 |
| PY09026846A (es) | 2008-08-05 | 2015-09-01 | Novartis Ag | Composiciones y métodos para anticuerpos que se dirigen a la proteína de complemento c5 |
| US20110275535A1 (en) | 2008-12-16 | 2011-11-10 | Novartis Ag | Yeast Display Systems |
| EP2424894A1 (en) | 2009-04-27 | 2012-03-07 | Novartis AG | Composition and methods of use for therapeutic antibodies specific for the il-12 receptore betal subunit |
| JP5766179B2 (ja) | 2009-04-27 | 2015-08-19 | ノバルティス アーゲー | 筋肉増殖を増加させるための組成物および方法 |
| EP2464657B1 (en) | 2009-08-10 | 2015-04-01 | MorphoSys AG | Novel screening strategies for the identification of antibodies or fragments thereof which bind an antigen that has an enzymatic activity |
| WO2011029823A1 (en) | 2009-09-09 | 2011-03-17 | Novartis Ag | Monoclonal antibody reactive with cd63 when expressed at the surface of degranulated mast cells |
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| JP5677453B2 (ja) * | 2009-12-11 | 2015-02-25 | グワンジュ・インスティテュート・オブ・サイエンス・アンド・テクノロジー | Ｂｐｂベースのカーゴ運搬システム |
| AU2010332932B2 (en) * | 2009-12-14 | 2013-01-17 | Navigo Proteins Gmbh | Modified ubiquitin proteins having a specific binding activity for the extradomain B of fibronectin |
| JP5665110B2 (ja) * | 2009-12-18 | 2015-02-04 | 独立行政法人農業生物資源研究所 | 外来ＤＮＡ断片由来の逆方向反復配列を含むＤＮＡ断片の調製方法及びＤＮＡ型ＲＮＡｉライブラリの調製方法 |
| KR20130066631A (ko) | 2010-05-06 | 2013-06-20 | 노파르티스 아게 | 치료적 저밀도 지단백질-관련 단백질 ６ （ｌｒｐ６） 다가 항체에 대한 조성물 및 사용 방법 |
| EP4234698A3 (en) | 2010-05-06 | 2023-11-08 | Novartis AG | Compositions and methods of use for therapeutic low density lipoprotein-related protein 6 (lrp6) antibodies |
| CA2807774C (en) | 2010-08-10 | 2020-10-27 | The Governing Council Of The University Of Toronto | Specific active site inhibitors of enzymes or substrate binding partners and methods of producing same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102004049479A1 (de) * | 2004-10-11 | 2006-04-13 | Scil Proteins Gmbh | Proteinkonjugate zur Verwendung in Therapie, Diagnose und Chromatographie |
Also Published As
| Publication number | Publication date |
|---|---|
| JP5372992B2 (ja) | 2013-12-18 |
| EP2295446A1 (de) | 2011-03-16 |
| CN1956996A (zh) | 2007-05-02 |
| ATE499382T1 (de) | 2011-03-15 |
| EP1626985A1 (de) | 2006-02-22 |
| EP2163559A1 (de) | 2010-03-17 |
| DE502004012225D1 (de) | 2011-04-07 |
| US20060099686A1 (en) | 2006-05-11 |
| AU2004242851A1 (en) | 2004-12-09 |
| JP2008500953A (ja) | 2008-01-17 |
| DK1626985T3 (da) | 2011-06-14 |
| PT1626985E (pt) | 2011-05-25 |
| CA2524899A1 (en) | 2004-12-09 |
| US20080171851A1 (en) | 2008-07-17 |
| US8790895B2 (en) | 2014-07-29 |
| CN103539851A (zh) | 2014-01-29 |
| JP4803817B2 (ja) | 2011-10-26 |
| CN103539851B (zh) | 2016-12-28 |
| US8791238B2 (en) | 2014-07-29 |
| JP2011201893A (ja) | 2011-10-13 |
| EP1626985B1 (de) | 2011-02-23 |
| WO2004106368A1 (de) | 2004-12-09 |
| CA2524899C (en) | 2012-02-07 |
| ES2361409T3 (es) | 2011-06-16 |
| AU2004242851B2 (en) | 2011-03-10 |
| PL1626985T3 (pl) | 2011-07-29 |
| JP2011046722A (ja) | 2011-03-10 |
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