DK3325514T3 - Her2-bindende proteiner baseret på di-ubiquitin-muteiner - Google Patents
Her2-bindende proteiner baseret på di-ubiquitin-muteiner Download PDFInfo
- Publication number
- DK3325514T3 DK3325514T3 DK16741919.1T DK16741919T DK3325514T3 DK 3325514 T3 DK3325514 T3 DK 3325514T3 DK 16741919 T DK16741919 T DK 16741919T DK 3325514 T3 DK3325514 T3 DK 3325514T3
- Authority
- DK
- Denmark
- Prior art keywords
- binding proteins
- proteins based
- her2 binding
- ubiquitin muteins
- muteins
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2318/00—Antibody mimetics or scaffolds
- C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP15177548 | 2015-07-20 | ||
| PCT/EP2016/067207 WO2017013129A1 (en) | 2015-07-20 | 2016-07-19 | Her2 binding proteins based on di-ubiquitin muteins |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3325514T3 true DK3325514T3 (da) | 2019-12-16 |
Family
ID=53776345
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK16741919.1T DK3325514T3 (da) | 2015-07-20 | 2016-07-19 | Her2-bindende proteiner baseret på di-ubiquitin-muteiner |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20180273636A1 (da) |
| JP (1) | JP6881760B2 (da) |
| CN (1) | CN107849147B (da) |
| AU (1) | AU2016295024B2 (da) |
| CA (1) | CA2991814A1 (da) |
| DK (1) | DK3325514T3 (da) |
| WO (1) | WO2017013129A1 (da) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3253785B1 (en) | 2015-02-06 | 2019-04-10 | Navigo Proteins Gmbh | Novel egfr binding proteins |
| ES2916101T3 (es) | 2015-07-16 | 2022-06-28 | Navigo Proteins Gmbh | Nuevas proteínas de unión a inmunoglobulina y su uso en la purificación por afinidad |
| WO2017013136A1 (en) | 2015-07-20 | 2017-01-26 | Scil Proteins Gmbh | Novel binding proteins based on di-ubiquitin muteins and methods for generation |
| US11813336B2 (en) | 2016-05-04 | 2023-11-14 | Navigo Proteins Gmbh | Targeted compounds for the site-specific coupling of chemical moieties comprising a peptide linker |
| EP3497117B1 (en) | 2016-08-11 | 2024-01-24 | Navigo Proteins GmbH | Novel alkaline stable immunoglobulin-binding proteins |
| US11414466B2 (en) | 2017-11-07 | 2022-08-16 | Navigo Proteins Gmbh | Fusion proteins with specificity for ED-B and long serum half-life for diagnosis or treatment of cancer |
| CA3123986A1 (en) * | 2018-12-18 | 2020-06-25 | Navigo Proteins Gmbh | Novel folr1 specific binding proteins for cancer diagnosis and treatment |
| KR20210150535A (ko) * | 2019-04-10 | 2021-12-10 | 나피고 프로타인스 게엠베하 | 암 진단 및 치료를 위한 새로운 psma 특이적 결합 단백질 |
| WO2021122729A1 (en) * | 2019-12-18 | 2021-06-24 | Bracco Imaging Spa | Anti-her2 polypeptides derivatives as new diagnostic molecular probes |
| EP4077367A1 (en) * | 2019-12-18 | 2022-10-26 | Bracco Imaging SPA | Anti-her2 polypeptides derivatives as new diagnostic molecular probes |
| JP2023533531A (ja) * | 2020-07-16 | 2023-08-03 | ナフィゴ プロテインズ ゲゼルシャフト ミット ベシュレンクテル ハフツング | セラノスティック適用のための血清に安定なヒトｈｅｒ２結合タンパク質 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10324447A1 (de) * | 2003-05-28 | 2004-12-30 | Scil Proteins Gmbh | Generierung künstlicher Bindungsproteine auf der Grundlage von Ubiquitin |
| WO2011073209A1 (en) * | 2009-12-14 | 2011-06-23 | Scil Proteins Gmbh | Modified ubiquitin proteins having a specific binding activity for the extradomain b of fibronectin |
| EP2738180A1 (en) * | 2012-11-30 | 2014-06-04 | Molecular Partners AG | Binding proteins comprising at least two binding domains against HER2. |
| WO2014094799A1 (en) * | 2012-12-19 | 2014-06-26 | Scil-Proteins-Gmbh | Ubiquitin moieties as a means for prolonging serum half-life |
| DK3253795T3 (da) * | 2015-02-06 | 2019-07-29 | Navigo Proteins Gmbh | Hidtil ukendte bindende proteiner, der omfatter et ubiquitin-mutein, og antistoffer eller antistoffragmenter |
-
2016
- 2016-07-19 DK DK16741919.1T patent/DK3325514T3/da active
- 2016-07-19 CA CA2991814A patent/CA2991814A1/en active Pending
- 2016-07-19 US US15/744,053 patent/US20180273636A1/en not_active Abandoned
- 2016-07-19 AU AU2016295024A patent/AU2016295024B2/en active Active
- 2016-07-19 WO PCT/EP2016/067207 patent/WO2017013129A1/en active Application Filing
- 2016-07-19 JP JP2017567102A patent/JP6881760B2/ja active Active
- 2016-07-19 CN CN201680041297.3A patent/CN107849147B/zh active Active
Also Published As
| Publication number | Publication date |
|---|---|
| JP6881760B2 (ja) | 2021-06-02 |
| JP2018529310A (ja) | 2018-10-11 |
| WO2017013129A1 (en) | 2017-01-26 |
| US20180273636A1 (en) | 2018-09-27 |
| AU2016295024A1 (en) | 2018-02-15 |
| CN107849147A (zh) | 2018-03-27 |
| AU2016295024B2 (en) | 2018-12-20 |
| CA2991814A1 (en) | 2017-01-26 |
| CN107849147B (zh) | 2021-09-17 |
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