DE102004005172A1 - Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase - Google Patents

Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase Download PDF

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Publication number
DE102004005172A1
DE102004005172A1 DE102004005172A DE102004005172A DE102004005172A1 DE 102004005172 A1 DE102004005172 A1 DE 102004005172A1 DE 102004005172 A DE102004005172 A DE 102004005172A DE 102004005172 A DE102004005172 A DE 102004005172A DE 102004005172 A1 DE102004005172 A1 DE 102004005172A1
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Germany
Prior art keywords
compounds
formulas
alkyl
combination
alkylaminocarbonyl
Prior art date
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Application number
DE102004005172A
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German (de)
English (en)
Inventor
Gerhard Dr. Zoller
Stefan Dr. Petry
Günter Dr. Müller
Hubert Dr. Heuer
Karl-Heinz Dr. Baringhaus
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sanofi Aventis Deutschland GmbH
Original Assignee
Aventis Pharma Deutschland GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharma Deutschland GmbH filed Critical Aventis Pharma Deutschland GmbH
Priority to DE102004005172A priority Critical patent/DE102004005172A1/de
Priority to EP05700954A priority patent/EP1713779B1/de
Priority to CNA2005800037984A priority patent/CN1914180A/zh
Priority to BRPI0507370-7A priority patent/BRPI0507370A/pt
Priority to KR1020067015071A priority patent/KR20060128958A/ko
Priority to PCT/EP2005/000365 priority patent/WO2005073199A1/de
Priority to CA002554524A priority patent/CA2554524A1/en
Priority to DE502005011241T priority patent/DE502005011241D1/de
Priority to JP2006549989A priority patent/JP4714158B2/ja
Priority to SG200900705-5A priority patent/SG149891A1/en
Priority to AT05700954T priority patent/ATE505460T1/de
Priority to AU2005209366A priority patent/AU2005209366A1/en
Priority to RU2006131564/04A priority patent/RU2370491C2/ru
Priority to NZ548872A priority patent/NZ548872A/en
Priority to US11/042,565 priority patent/US7528155B2/en
Priority to DO2005000011A priority patent/DOP2005000011A/es
Priority to PE2005000108A priority patent/PE20050690A1/es
Priority to MYPI20050387A priority patent/MY143407A/en
Priority to ARP050100347A priority patent/AR047520A1/es
Priority to TW094102825A priority patent/TW200536535A/zh
Priority to HN2005000039A priority patent/HN2005000039A/es
Priority to UY28735A priority patent/UY28735A1/es
Publication of DE102004005172A1 publication Critical patent/DE102004005172A1/de
Priority to ZA200605311A priority patent/ZA200605311B/en
Priority to CR8487A priority patent/CR8487A/es
Priority to IL176912A priority patent/IL176912A/en
Priority to MA29217A priority patent/MA28338A1/fr
Priority to EC2006006750A priority patent/ECSP066750A/es
Priority to NO20063925A priority patent/NO20063925L/no
Priority to US12/431,010 priority patent/US7968719B2/en
Withdrawn legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P17/00—Drugs for dermatological disorders
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61P3/04—Anorexiants; Antiobesity agents
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C07D231/56—Benzopyrazoles; Hydrogenated benzopyrazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Obesity (AREA)
  • Pulmonology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Psychiatry (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Psychology (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hospice & Palliative Care (AREA)
  • Immunology (AREA)
  • Urology & Nephrology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Vascular Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE102004005172A 2004-02-02 2004-02-02 Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase Withdrawn DE102004005172A1 (de)

Priority Applications (29)

Application Number Priority Date Filing Date Title
DE102004005172A DE102004005172A1 (de) 2004-02-02 2004-02-02 Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase
EP05700954A EP1713779B1 (de) 2004-02-02 2005-01-15 Indazolderivate als inhibitoren der hormon-sensitiven lipase
CNA2005800037984A CN1914180A (zh) 2004-02-02 2005-01-15 作为激素敏感性脂肪酶抑制剂的吲唑衍生物
BRPI0507370-7A BRPI0507370A (pt) 2004-02-02 2005-01-15 derivados de indazol como inibidores da lipase sensìvel ao hormÈnio
KR1020067015071A KR20060128958A (ko) 2004-02-02 2005-01-15 호르몬-민감성 리파아제의 억제제로서의 인다졸 유도체
PCT/EP2005/000365 WO2005073199A1 (de) 2004-02-02 2005-01-15 Indazolderivate als inhibitoren der hormon sensitiven lipase
CA002554524A CA2554524A1 (en) 2004-02-02 2005-01-15 Indazole derivatives as inhibitors of hormone-sensitive lipases
DE502005011241T DE502005011241D1 (de) 2004-02-02 2005-01-15 Indazolderivate als inhibitoren der hormon-sensitiven lipase
JP2006549989A JP4714158B2 (ja) 2004-02-02 2005-01-15 ホルモン感受性リパーゼの阻害剤としてのインダゾール誘導体
SG200900705-5A SG149891A1 (en) 2004-02-02 2005-01-15 Indazole derivatives as inhibitors of hormone-sensitive lipases
AT05700954T ATE505460T1 (de) 2004-02-02 2005-01-15 Indazolderivate als inhibitoren der hormon- sensitiven lipase
AU2005209366A AU2005209366A1 (en) 2004-02-02 2005-01-15 Indazole derivatives as inhibitors of hormone-sensitive lipases
RU2006131564/04A RU2370491C2 (ru) 2004-02-02 2005-01-15 Производные индазола как ингибиторы гормончувствительных липаз
NZ548872A NZ548872A (en) 2004-02-02 2005-01-15 Indazole derivatives as inhibitors of hormone-sensitive lipases
US11/042,565 US7528155B2 (en) 2004-02-02 2005-01-25 Indazole derivatives as inhibitors of hormone sensitive lipase
DO2005000011A DOP2005000011A (es) 2004-02-02 2005-01-27 Derivados de indazol como inhibidores de la lipasa sensible a hormonas
PE2005000108A PE20050690A1 (es) 2004-02-02 2005-01-28 Derivados de indazol como inhibidores de la lipasa sensible a hormonas
MYPI20050387A MY143407A (en) 2004-02-02 2005-01-31 Indazole derivatives as inhibitors of hormone sensitive lipase
ARP050100347A AR047520A1 (es) 2004-02-02 2005-01-31 Derivados de indazol como inhibidores de la lipasa sensible a hormonas
TW094102825A TW200536535A (en) 2004-02-02 2005-01-31 Indazole derivatives as inhibitors of hormone sensitive lipase
HN2005000039A HN2005000039A (es) 2004-02-02 2005-02-01 Derivados de indazol como inhibidores de la lipasa sensible a hormonas.
UY28735A UY28735A1 (es) 2004-02-02 2005-02-02 Derivados de indazol como inhibidores de la lipasa sensible a hormonas
ZA200605311A ZA200605311B (en) 2004-02-02 2006-06-27 Indazole derivatives as inhibitors of hormone-sensitive lipases
CR8487A CR8487A (es) 2004-02-02 2006-06-27 Derivados de indazole como inhibidores de una hormona sensitiva a la lipasa
IL176912A IL176912A (en) 2004-02-02 2006-07-17 Indazole derivatives as inhibitors of hormone-sensitive lipases
MA29217A MA28338A1 (fr) 2004-02-02 2006-07-28 Derives d'indazole comme inhibiteurs de lipases sensibles aux hormones
EC2006006750A ECSP066750A (es) 2004-02-02 2006-08-01 Derivados de indazol como inhibidores de lipasas sensibles a hormonas
NO20063925A NO20063925L (no) 2004-02-02 2006-09-01 Indazolderivater som inhibitorer av hormonsensitiv lipase
US12/431,010 US7968719B2 (en) 2004-02-02 2009-04-28 Indazole derivatives as inhibitors of hormone sensitive lipase

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102004005172A DE102004005172A1 (de) 2004-02-02 2004-02-02 Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase

Publications (1)

Publication Number Publication Date
DE102004005172A1 true DE102004005172A1 (de) 2005-08-18

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ID=34801466

Family Applications (2)

Application Number Title Priority Date Filing Date
DE102004005172A Withdrawn DE102004005172A1 (de) 2004-02-02 2004-02-02 Indazolderivate als Inhibitoren der Hormon Sensitiven Lipase
DE502005011241T Active DE502005011241D1 (de) 2004-02-02 2005-01-15 Indazolderivate als inhibitoren der hormon-sensitiven lipase

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE502005011241T Active DE502005011241D1 (de) 2004-02-02 2005-01-15 Indazolderivate als inhibitoren der hormon-sensitiven lipase

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US (2) US7528155B2 (US20070167479A1-20070719-C00034.png)
EP (1) EP1713779B1 (US20070167479A1-20070719-C00034.png)
JP (1) JP4714158B2 (US20070167479A1-20070719-C00034.png)
KR (1) KR20060128958A (US20070167479A1-20070719-C00034.png)
CN (1) CN1914180A (US20070167479A1-20070719-C00034.png)
AR (1) AR047520A1 (US20070167479A1-20070719-C00034.png)
AT (1) ATE505460T1 (US20070167479A1-20070719-C00034.png)
AU (1) AU2005209366A1 (US20070167479A1-20070719-C00034.png)
BR (1) BRPI0507370A (US20070167479A1-20070719-C00034.png)
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