DE10042058A1 - Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung - Google Patents
Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer HerstellungInfo
- Publication number
- DE10042058A1 DE10042058A1 DE10042058A DE10042058A DE10042058A1 DE 10042058 A1 DE10042058 A1 DE 10042058A1 DE 10042058 A DE10042058 A DE 10042058A DE 10042058 A DE10042058 A DE 10042058A DE 10042058 A1 DE10042058 A1 DE 10042058A1
- Authority
- DE
- Germany
- Prior art keywords
- amino
- phenyl
- quinazoline
- chloro
- fluoro
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/16—Otologicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Urology & Nephrology (AREA)
- Dermatology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Priority Applications (34)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10042058A DE10042058A1 (de) | 2000-08-26 | 2000-08-26 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
CA002417897A CA2417897C (en) | 2000-08-26 | 2001-08-18 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
BR0113519-8A BR0113519A (pt) | 2000-08-26 | 2001-08-18 | Heterociclos bicìclicos, composições farmacêuticas contendo esses compostos, seu uso e processos para sua preparação |
MEP-587/08A MEP58708A (en) | 2000-08-26 | 2001-08-18 | Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof |
EEP200300077A EE05269B1 (et) | 2000-08-26 | 2001-08-18 | Bitsüklilised heterotsüklilised ühendid, neid ühendeid sisaldavad ravimid, nende kasutamine ja meetodid nende valmistamiseks |
CNB01814635XA CN100404517C (zh) | 2000-08-26 | 2001-08-18 | 双环杂环、含这些化合物的药物组合物,其用途及制备方法 |
PCT/EP2001/009532 WO2002018351A1 (de) | 2000-08-26 | 2001-08-18 | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und vefahren zu ihrer herstellung |
YU14003A RS52279B (en) | 2000-08-26 | 2001-08-18 | BICYCLIC HETEROCYCLIC COMPOUNDS, THE MEDICINAL PRODUCTS CONTAINING THESE COMPOUNDS, THEIR USE AND THE PROCEDURE FOR OBTAINING THEM |
IL15460201A IL154602A0 (en) | 2000-08-26 | 2001-08-18 | Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof |
CZ20030870A CZ302567B6 (cs) | 2000-08-26 | 2001-08-18 | Aminochinazoliny, farmaceutický prostredek obsahující tyto slouceniny, jejich použití a zpusob jejich výroby |
JP2002523469A JP4834282B2 (ja) | 2000-08-26 | 2001-08-18 | 二環式複素環、それを含む医薬組成物、その使用及びその製造方法 |
KR1020037002744A KR100862873B1 (ko) | 2000-08-26 | 2001-08-18 | 이환식 헤테로사이클, 당해 화합물을 함유하는 약제 및 이의 제조방법 |
SK231-2003A SK287747B6 (sk) | 2000-08-26 | 2001-08-18 | 4-Aminochinazolíny, spôsob ich výroby a farmaceutický prostriedok s ich obsahom |
EA200300219A EA005679B1 (ru) | 2000-08-26 | 2001-08-18 | Бициклические гетероциклы, содержащие эти соединения лекарственные средства, их применение и способ их получения |
NZ524668A NZ524668A (en) | 2000-08-26 | 2001-08-18 | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use, and processes for preparing them. |
AU8769401A AU8769401A (en) | 2000-08-26 | 2001-08-18 | Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof |
PL36024801A PL360248A1 (en) | 2000-08-26 | 2001-08-18 | Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof |
AU2001287694A AU2001287694B2 (en) | 2000-08-26 | 2001-08-18 | Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof |
HU0300819A HUP0300819A3 (en) | 2000-08-26 | 2001-08-18 | Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof |
EP01967285A EP1315705A1 (de) | 2000-08-26 | 2001-08-18 | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und vefahren zu ihrer herstellung |
UA2003032533A UA73004C2 (uk) | 2000-08-26 | 2001-08-18 | Біциклічні гетероцикли та лікувальний засіб на їх основі |
MXPA03001483A MXPA03001483A (es) | 2000-08-26 | 2001-08-18 | Heterociclos biciclicos medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparacion. |
US09/934,772 US6656946B2 (en) | 2000-08-26 | 2001-08-22 | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
UY26903A UY26903A1 (es) | 2000-08-26 | 2001-08-23 | Heterociclos bicíclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparación |
MYPI20013985A MY126132A (en) | 2000-08-26 | 2001-08-24 | Aminoquinazolines which inhibit signal transduction mediated by tyrosine kinases |
TW090120905A TWI294422B (en) | 2000-08-26 | 2001-08-24 | Bicyclic heteocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
ARP010104041A AR033562A1 (es) | 2000-08-26 | 2001-08-24 | Heterociclos biciclicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparacion |
EC2003004464A ECSP034464A (es) | 2000-08-26 | 2003-02-03 | Heterociclicos bicilcicos, medicamentos que contienen estos compuestos, su empleo y procedimientos para su preparacion |
ZA200300991A ZA200300991B (en) | 2000-08-26 | 2003-02-05 | Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof. |
BG107559A BG107559A (bg) | 2000-08-26 | 2003-02-14 | Бициклени хетероцикли, лекарствени средства съдържащи тези съединения, приложението им и метод за тяхното получаване |
HR20030138A HRP20030138A2 (en) | 2000-08-26 | 2003-02-24 | Bicyclic heterocycles, medicaments containing these compound, their use, and methods for the production thereof |
IL154602A IL154602A (en) | 2000-08-26 | 2003-02-24 | Aminoquinazolines inhibit signaling mediated by tyrosine kinases |
NO20030870A NO324866B1 (no) | 2000-08-26 | 2003-02-25 | Bicykliske heterocykler, medikamenter inneholdende disse, deres anvendelse for fremstilling av legemidler for behandling av sykdommer og fremgangsmater for fremstilling derav |
HK04100462A HK1057557A1 (en) | 2000-08-26 | 2004-01-21 | Bicyclic heterocycles, medicaments containing these compounds, their use, and methods for the production thereof |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10042058A DE10042058A1 (de) | 2000-08-26 | 2000-08-26 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
Publications (1)
Publication Number | Publication Date |
---|---|
DE10042058A1 true DE10042058A1 (de) | 2002-03-07 |
Family
ID=7653945
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE10042058A Ceased DE10042058A1 (de) | 2000-08-26 | 2000-08-26 | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
Country Status (31)
Country | Link |
---|---|
EP (1) | EP1315705A1 (uk) |
JP (1) | JP4834282B2 (uk) |
KR (1) | KR100862873B1 (uk) |
CN (1) | CN100404517C (uk) |
AR (1) | AR033562A1 (uk) |
AU (2) | AU2001287694B2 (uk) |
BG (1) | BG107559A (uk) |
BR (1) | BR0113519A (uk) |
CA (1) | CA2417897C (uk) |
CZ (1) | CZ302567B6 (uk) |
DE (1) | DE10042058A1 (uk) |
EA (1) | EA005679B1 (uk) |
EC (1) | ECSP034464A (uk) |
EE (1) | EE05269B1 (uk) |
HK (1) | HK1057557A1 (uk) |
HR (1) | HRP20030138A2 (uk) |
HU (1) | HUP0300819A3 (uk) |
IL (2) | IL154602A0 (uk) |
ME (1) | MEP58708A (uk) |
MX (1) | MXPA03001483A (uk) |
MY (1) | MY126132A (uk) |
NO (1) | NO324866B1 (uk) |
NZ (1) | NZ524668A (uk) |
PL (1) | PL360248A1 (uk) |
RS (1) | RS52279B (uk) |
SK (1) | SK287747B6 (uk) |
TW (1) | TWI294422B (uk) |
UA (1) | UA73004C2 (uk) |
UY (1) | UY26903A1 (uk) |
WO (1) | WO2002018351A1 (uk) |
ZA (1) | ZA200300991B (uk) |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2005011701A1 (de) * | 2003-07-28 | 2005-02-10 | Boehringer Ingelheim International Gmbh | Verwendung von chinazolin tyrosinkinase-inhibitoren zur behandlung inflammatorischer prozesse |
WO2005041973A1 (de) * | 2003-10-30 | 2005-05-12 | Boehringer Ingelheim International Gmbh | Verwendung von tyrosinkinase-inhibitoren zur behandlung inflammatorischer prozesse |
WO2007023073A2 (de) * | 2005-08-22 | 2007-03-01 | Boehringer Ingelheim International Gmbh | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
US7998949B2 (en) | 2007-02-06 | 2011-08-16 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof |
US8399461B2 (en) | 2006-11-10 | 2013-03-19 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing said compounds, use thereof, and method for production of same |
US8497369B2 (en) | 2008-02-07 | 2013-07-30 | Boehringer Ingelheim International Gmbh | Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production |
US8648191B2 (en) | 2008-08-08 | 2014-02-11 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2375259C (en) | 1999-06-21 | 2009-04-28 | Boehringer Ingelheim Pharma Kg | Bicyclic heterocycles, pharmaceutical compositions containing these compounds, their use and processes for preparing them |
DE10042059A1 (de) * | 2000-08-26 | 2002-03-07 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
US7019012B2 (en) | 2000-12-20 | 2006-03-28 | Boehringer Ingelheim International Pharma Gmbh & Co. Kg | Quinazoline derivatives and pharmaceutical compositions containing them |
TWI324597B (en) * | 2002-03-28 | 2010-05-11 | Astrazeneca Ab | Quinazoline derivatives |
BR0308902A (pt) * | 2002-03-30 | 2005-01-04 | Boehringer Ingelheim Pharma | 4-(n-fenilamino)-quinazolinas/quinolinas como inibidoras da tirosina cinase |
DE10214412A1 (de) * | 2002-03-30 | 2003-10-09 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
US6924285B2 (en) | 2002-03-30 | 2005-08-02 | Boehringer Ingelheim Pharma Gmbh & Co. | Bicyclic heterocyclic compounds, pharmaceutical compositions containing these compounds, their use and process for preparing them |
AU2003249212C1 (en) | 2002-07-15 | 2011-10-27 | Symphony Evolution, Inc. | Receptor-type kinase modulators and methods of use |
DE10326186A1 (de) | 2003-06-06 | 2004-12-23 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
GB0317665D0 (en) | 2003-07-29 | 2003-09-03 | Astrazeneca Ab | Qinazoline derivatives |
RU2370494C2 (ru) | 2003-09-19 | 2009-10-20 | Астразенека Аб | Производные хиназолина |
ES2371383T3 (es) | 2003-09-26 | 2011-12-30 | Exelixis, Inc. | N-[3-fluoro-4-({6-(metiloxi)-7-[(3-morfolin-4-ilpropil)oxi]quinolin-4-il}oxi)fenil]-n'-(4-fluorofenil)ciclopropan-1,1-dicarboxamida para el tratamiento del cáncer. |
US7456189B2 (en) | 2003-09-30 | 2008-11-25 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing these compounds, their use and processes for their preparation |
DE10345875A1 (de) * | 2003-09-30 | 2005-04-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Vewendung und Verfahren zu ihrer Herstellung |
US20060035893A1 (en) | 2004-08-07 | 2006-02-16 | Boehringer Ingelheim International Gmbh | Pharmaceutical compositions for treatment of respiratory and gastrointestinal disorders |
PE20060777A1 (es) | 2004-12-24 | 2006-10-06 | Boehringer Ingelheim Int | Derivados de indolinona para el tratamiento o la prevencion de enfermedades fibroticas |
EP1856095B1 (en) | 2005-02-26 | 2011-08-24 | AstraZeneca AB | Quinazoline derivatives as tyrosine kinase inhibitors |
KR100673775B1 (ko) * | 2005-04-08 | 2007-01-24 | 엘지전자 주식회사 | 냉장고용 홈바 |
US8404697B2 (en) | 2005-11-11 | 2013-03-26 | Boehringer Ingelheim International Gmbh | Quinazoline derivatives for the treatment of cancer diseases |
EP1996561A1 (de) * | 2006-03-09 | 2008-12-03 | Boehringer Ingelheim International GmbH | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
RU2492864C2 (ru) | 2006-09-18 | 2013-09-20 | Бёрингер Ингельхайм Интернациональ Гмбх | Способ лечения рака, несущего мутации egfr |
WO2009138781A1 (en) | 2008-05-13 | 2009-11-19 | Astrazeneca Ab | Fumarate salt of 4- (3-chloro-2-fluoroanilino) -7-methoxy-6- { [1- (n-methylcarbamoylmethyl) piperidin- 4-yl] oxy}quinazoline |
CN110818633A (zh) | 2009-01-16 | 2020-02-21 | 埃克塞里艾克西斯公司 | 一种苹果酸盐及其晶型 |
US9545381B2 (en) | 2009-07-06 | 2017-01-17 | Boehringer Ingelheim International Gmbh | Process for drying of BIBW2992, of its salts and of solid pharmaceutical formulations comprising this active ingredient |
UA108618C2 (uk) | 2009-08-07 | 2015-05-25 | Застосування c-met-модуляторів в комбінації з темозоломідом та/або променевою терапією для лікування раку | |
KR101317809B1 (ko) | 2011-06-07 | 2013-10-16 | 한미약품 주식회사 | 암세포의 성장을 억제하는 아마이드 유도체 및 비금속염 활택제를 포함하는 약학 조성물 |
KR20140096571A (ko) | 2013-01-28 | 2014-08-06 | 한미약품 주식회사 | 1-(4-(4-(3,4-디클로로-2-플루오로페닐아미노)-7-메톡시퀴나졸린-6-일옥시)피페리딘-1-일)프로프-2-엔-1-온의 제조방법 |
KR101645112B1 (ko) | 2013-03-06 | 2016-08-02 | 아스트라제네카 아베 | 표피 성장 인자 수용체의 활성화 돌연변이체 형태의 퀴나졸린 억제제 |
US9242965B2 (en) | 2013-12-31 | 2016-01-26 | Boehringer Ingelheim International Gmbh | Process for the manufacture of (E)-4-N,N-dialkylamino crotonic acid in HX salt form and use thereof for synthesis of EGFR tyrosine kinase inhibitors |
DK3126354T3 (da) * | 2014-04-04 | 2020-03-09 | H Lundbeck As | Halogenerede quinazolin-thf-aminer som pde1-inhibitorer |
US20170176028A1 (en) | 2015-12-18 | 2017-06-22 | Lg Electronics Inc. | Air conditioner |
KR20230145496A (ko) | 2016-11-17 | 2023-10-17 | 더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템 | Egfr 또는 her2 엑손 20 돌연변이를 갖는 암 세포에 대한 항종양 활성을 갖는 화합물 |
CN112321814B (zh) * | 2020-12-30 | 2021-03-23 | 广州初曲科技有限公司 | 一种吉非替尼艾地苯醌轭合物的制备及用途 |
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GB9508538D0 (en) * | 1995-04-27 | 1995-06-14 | Zeneca Ltd | Quinazoline derivatives |
GB9624482D0 (en) * | 1995-12-18 | 1997-01-15 | Zeneca Phaema S A | Chemical compounds |
BR9707495A (pt) * | 1996-02-13 | 1999-07-27 | Zeneca Ltd | Derivado de quinazolina processo para a preparação do mesmo composição farmacêutica e processo para a produç o de um efeito antiangiogênico e/ou de redução de permeabilidade vascular em um animal de sangue quente |
GB9603095D0 (en) * | 1996-02-14 | 1996-04-10 | Zeneca Ltd | Quinazoline derivatives |
KR100489174B1 (ko) * | 1996-03-05 | 2005-09-30 | 제네카-파마 소시에떼아노님 | 4-아닐리노퀴나졸린유도체 |
SI0892789T2 (sl) * | 1996-04-12 | 2010-03-31 | Warner Lambert Co | Ireverzibilni inhibitorji tirozin kinaz |
GB9718972D0 (en) * | 1996-09-25 | 1997-11-12 | Zeneca Ltd | Chemical compounds |
DE19911509A1 (de) * | 1999-03-15 | 2000-09-21 | Boehringer Ingelheim Pharma | Bicyclische Heterocyclen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung |
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Cited By (9)
Publication number | Priority date | Publication date | Assignee | Title |
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WO2005011701A1 (de) * | 2003-07-28 | 2005-02-10 | Boehringer Ingelheim International Gmbh | Verwendung von chinazolin tyrosinkinase-inhibitoren zur behandlung inflammatorischer prozesse |
WO2005041973A1 (de) * | 2003-10-30 | 2005-05-12 | Boehringer Ingelheim International Gmbh | Verwendung von tyrosinkinase-inhibitoren zur behandlung inflammatorischer prozesse |
WO2007023073A2 (de) * | 2005-08-22 | 2007-03-01 | Boehringer Ingelheim International Gmbh | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
WO2007023073A3 (de) * | 2005-08-22 | 2007-05-18 | Boehringer Ingelheim Int | Bicyclische heterocyclen, diese verbindungen enthaltende arzneimittel, deren verwendung und verfahren zu ihrer herstellung |
US8399461B2 (en) | 2006-11-10 | 2013-03-19 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, medicaments containing said compounds, use thereof, and method for production of same |
US7998949B2 (en) | 2007-02-06 | 2011-08-16 | Boehringer Ingelheim International Gmbh | Bicyclic heterocycles, drugs containing said compounds, use thereof, and method for production thereof |
US8497369B2 (en) | 2008-02-07 | 2013-07-30 | Boehringer Ingelheim International Gmbh | Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production |
US8772298B2 (en) | 2008-02-07 | 2014-07-08 | Boehringer Ingelheim International Gmbh | Spirocyclic heterocycles medicaments containing said compounds, use thereof and method for their production |
US8648191B2 (en) | 2008-08-08 | 2014-02-11 | Boehringer Ingelheim International Gmbh | Cyclohexyloxy substituted heterocycles, pharmaceutical compositions containing these compounds and processes for preparing them |
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