DD300406A5 - Verwendung von 10-Amino-5,6-Dihydro 11h-Dibenzo (B,e) Azepin-6,11-dion und Derivaten als Arzneimittel zur Behandlung von Inkontinenz - Google Patents
Verwendung von 10-Amino-5,6-Dihydro 11h-Dibenzo (B,e) Azepin-6,11-dion und Derivaten als Arzneimittel zur Behandlung von Inkontinenz Download PDFInfo
- Publication number
- DD300406A5 DD300406A5 DD342732A DD34273290A DD300406A5 DD 300406 A5 DD300406 A5 DD 300406A5 DD 342732 A DD342732 A DD 342732A DD 34273290 A DD34273290 A DD 34273290A DD 300406 A5 DD300406 A5 DD 300406A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- dihydro
- dibenzo
- azepine
- amino
- dione
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title claims abstract description 10
- 239000003814 drug Substances 0.000 title claims abstract description 5
- BUGOBKVCGVQZLK-UHFFFAOYSA-N 10-amino-5h-benzo[c][1]benzazepine-6,11-dione Chemical compound O=C1C2=CC=CC=C2NC(=O)C2=C1C(N)=CC=C2 BUGOBKVCGVQZLK-UHFFFAOYSA-N 0.000 title claims description 6
- 206010021639 Incontinence Diseases 0.000 title 1
- 229940079593 drug Drugs 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims abstract description 19
- 206010046543 Urinary incontinence Diseases 0.000 claims abstract description 9
- 150000003839 salts Chemical class 0.000 claims abstract description 8
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 4
- 238000004519 manufacturing process Methods 0.000 claims abstract description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 3
- 238000002360 preparation method Methods 0.000 claims description 8
- 239000004480 active ingredient Substances 0.000 claims description 5
- 239000013543 active substance Substances 0.000 claims description 5
- 239000000825 pharmaceutical preparation Substances 0.000 claims description 3
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims description 3
- GXFTXBYRXGCULK-UHFFFAOYSA-N 10-amino-5-methylbenzo[c][1]benzazepine-6,11-dione Chemical group O=C1N(C)C2=CC=CC=C2C(=O)C2=C(N)C=CC=C21 GXFTXBYRXGCULK-UHFFFAOYSA-N 0.000 claims description 2
- KLSKLNWJEDXFSD-UHFFFAOYSA-N adosopine Chemical compound O=C1C2=CC=CC=C2N(C)C(=O)C2=C1C(NC(=O)C)=CC=C2 KLSKLNWJEDXFSD-UHFFFAOYSA-N 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 1
- DTDCRVOAOCSQPA-UHFFFAOYSA-N n-(6,11-dioxo-5h-benzo[c][1]benzazepin-10-yl)acetamide Chemical group O=C1C2=CC=CC=C2NC(=O)C2=C1C(NC(=O)C)=CC=C2 DTDCRVOAOCSQPA-UHFFFAOYSA-N 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 abstract description 3
- 230000001773 anti-convulsant effect Effects 0.000 abstract description 2
- 239000001961 anticonvulsive agent Substances 0.000 abstract description 2
- 229960003965 antiepileptics Drugs 0.000 abstract description 2
- 230000001624 sedative effect Effects 0.000 abstract description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 7
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 6
- 239000002775 capsule Substances 0.000 description 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 238000002844 melting Methods 0.000 description 4
- 230000008018 melting Effects 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- DIVDFFZHCJEHGG-UHFFFAOYSA-N oxidopamine Chemical compound NCCC1=CC(O)=C(O)C=C1O DIVDFFZHCJEHGG-UHFFFAOYSA-N 0.000 description 4
- 229910001220 stainless steel Inorganic materials 0.000 description 4
- 239000010935 stainless steel Substances 0.000 description 4
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 3
- 239000001828 Gelatine Substances 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 3
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 3
- 229920000159 gelatin Polymers 0.000 description 3
- 235000019322 gelatine Nutrition 0.000 description 3
- 239000008187 granular material Substances 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 230000011514 reflex Effects 0.000 description 3
- 150000004671 saturated fatty acids Chemical class 0.000 description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 2
- PXIPVTKHYLBLMZ-UHFFFAOYSA-N Sodium azide Chemical compound [Na+].[N-]=[N+]=[N-] PXIPVTKHYLBLMZ-UHFFFAOYSA-N 0.000 description 2
- 229920002472 Starch Polymers 0.000 description 2
- 239000001913 cellulose Substances 0.000 description 2
- 229920002678 cellulose Polymers 0.000 description 2
- -1 defoamers Substances 0.000 description 2
- 125000005456 glyceride group Chemical group 0.000 description 2
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 2
- 239000008101 lactose Substances 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 210000003205 muscle Anatomy 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- 235000003441 saturated fatty acids Nutrition 0.000 description 2
- 239000008107 starch Substances 0.000 description 2
- 235000019698 starch Nutrition 0.000 description 2
- 238000003756 stirring Methods 0.000 description 2
- KHUFHLFHOQVFGB-UHFFFAOYSA-N 1-aminoanthracene-9,10-dione Chemical compound O=C1C2=CC=CC=C2C(=O)C2=C1C=CC=C2N KHUFHLFHOQVFGB-UHFFFAOYSA-N 0.000 description 1
- JLPULHDHAOZNQI-ZTIMHPMXSA-N 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCCCCCC\C=C/C\C=C/CCCCC JLPULHDHAOZNQI-ZTIMHPMXSA-N 0.000 description 1
- USJALFVAJSYMSN-UHFFFAOYSA-N 5h-benzo[c][1]benzazepine-6,11-dione Chemical compound O=C1NC2=CC=CC=C2C(=O)C2=CC=CC=C12 USJALFVAJSYMSN-UHFFFAOYSA-N 0.000 description 1
- 208000000187 Abnormal Reflex Diseases 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 1
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 1
- 239000002253 acid Substances 0.000 description 1
- 230000002378 acidificating effect Effects 0.000 description 1
- 230000029936 alkylation Effects 0.000 description 1
- 238000005804 alkylation reaction Methods 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 125000003277 amino group Chemical group 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- QAYPFHIZJSDUSF-UHFFFAOYSA-N azepin-3-one Chemical class O=C1C=CC=CN=C1 QAYPFHIZJSDUSF-UHFFFAOYSA-N 0.000 description 1
- 230000004071 biological effect Effects 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 230000002490 cerebral effect Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 239000000084 colloidal system Substances 0.000 description 1
- 239000003086 colorant Substances 0.000 description 1
- 239000012043 crude product Substances 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 239000002270 dispersing agent Substances 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000013355 food flavoring agent Nutrition 0.000 description 1
- 239000003349 gelling agent Substances 0.000 description 1
- 206010020718 hyperplasia Diseases 0.000 description 1
- 230000035859 hyperreflexia Effects 0.000 description 1
- 206010020745 hyperreflexia Diseases 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 239000002480 mineral oil Substances 0.000 description 1
- 235000010446 mineral oil Nutrition 0.000 description 1
- 229940124531 pharmaceutical excipient Drugs 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 229910000104 sodium hydride Inorganic materials 0.000 description 1
- 239000012312 sodium hydride Substances 0.000 description 1
- HSFQBFMEWSTNOW-UHFFFAOYSA-N sodium;carbanide Chemical group [CH3-].[Na+] HSFQBFMEWSTNOW-UHFFFAOYSA-N 0.000 description 1
- 239000007787 solid Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 229940083466 soybean lecithin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000000829 suppository Substances 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S128/00—Surgery
- Y10S128/25—Artificial sphincters and devices for controlling urinary incontinence
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8909484A IT1233715B (it) | 1989-07-14 | 1989-07-14 | Uso in terapia della 10-ammino-5,6diidro-11h= dibenzo (b,e) azepina-6,11-dione e derivati, quali farmaci utili per il trattamento dell'incontinenza urinaria |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD300406A5 true DD300406A5 (de) | 1992-06-11 |
Family
ID=11130831
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD342732A DD300406A5 (de) | 1989-07-14 | 1990-07-12 | Verwendung von 10-Amino-5,6-Dihydro 11h-Dibenzo (B,e) Azepin-6,11-dion und Derivaten als Arzneimittel zur Behandlung von Inkontinenz |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US5080905A (cs) |
| EP (1) | EP0408525A3 (cs) |
| JP (1) | JPH0352813A (cs) |
| AU (1) | AU5903690A (cs) |
| CA (1) | CA2021142A1 (cs) |
| CS (1) | CS276842B6 (cs) |
| DD (1) | DD300406A5 (cs) |
| HU (1) | HUT54498A (cs) |
| IE (1) | IE902517A1 (cs) |
| IT (1) | IT1233715B (cs) |
| PT (1) | PT94691A (cs) |
| ZA (1) | ZA905220B (cs) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3348230B2 (ja) | 1995-03-03 | 2002-11-20 | アルゴス ファーマシューティカル コーポレーション | 尿失禁の治療用のデキシトルメトルファン又はデキシトルオルファンの使用 |
| US5998459A (en) * | 1995-06-07 | 1999-12-07 | Nippon Shinyaku Co Ltd | Pyrrole derivatives and medicinal composition |
| JP4873378B2 (ja) | 2008-04-21 | 2012-02-08 | 株式会社デンソー | 吸入空気量センサの異常診断装置 |
| WO2016100711A1 (en) * | 2014-12-18 | 2016-06-23 | The Broad Institute, Inc. | Modulators of hepatic lipoprotein metabolism |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3646616A (en) * | 1969-07-23 | 1972-03-07 | Jesse G Keshin | Prosthesis for implanting around a body duct such as the urethra and method of treating urinary incontinence |
| DE2361467A1 (de) * | 1973-12-10 | 1975-06-19 | Thiemann Chem Pharm Fab | 1-amino-5,6-dihydro-morphanthridin5,11-dion-verbindungen und solche verbindungen enthaltende arzneimittel |
| US4011319A (en) * | 1975-07-02 | 1977-03-08 | Smithkline Corporation | Pharmaceutical compositions and methods involving benzazepine derivatives |
| IT1207417B (it) * | 1982-03-15 | 1989-05-17 | Menarini Sas | Azepina-6-one ad attivita'composti triciclici derivati dalla farmacologica, e procedimenti di 5,6-diidro-11h-dibenzo (b,e)fabbricazione relativi |
| GB8623020D0 (en) * | 1986-09-24 | 1986-10-29 | Young D E | Incontinence diagnostic & treatment device |
| JPH0637389B2 (ja) * | 1986-12-26 | 1994-05-18 | 北陸製薬株式会社 | 頻尿治療剤 |
-
1989
- 1989-07-14 IT IT8909484A patent/IT1233715B/it active
-
1990
- 1990-07-04 ZA ZA905220A patent/ZA905220B/xx unknown
- 1990-07-10 IE IE251790A patent/IE902517A1/en unknown
- 1990-07-11 CS CS903434A patent/CS276842B6/cs unknown
- 1990-07-11 EP EP19900830319 patent/EP0408525A3/en not_active Withdrawn
- 1990-07-12 PT PT94691A patent/PT94691A/pt not_active Application Discontinuation
- 1990-07-12 DD DD342732A patent/DD300406A5/de unknown
- 1990-07-12 US US07/552,786 patent/US5080905A/en not_active Expired - Fee Related
- 1990-07-13 AU AU59036/90A patent/AU5903690A/en not_active Abandoned
- 1990-07-13 CA CA002021142A patent/CA2021142A1/en not_active Abandoned
- 1990-07-13 HU HU904211A patent/HUT54498A/hu unknown
- 1990-07-13 JP JP2184396A patent/JPH0352813A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| US5080905A (en) | 1992-01-14 |
| HUT54498A (en) | 1991-03-28 |
| PT94691A (pt) | 1991-03-20 |
| IT1233715B (it) | 1992-04-14 |
| CA2021142A1 (en) | 1991-01-15 |
| JPH0352813A (ja) | 1991-03-07 |
| EP0408525A2 (en) | 1991-01-16 |
| EP0408525A3 (en) | 1992-03-04 |
| IE902517A1 (en) | 1991-02-13 |
| IT8909484A0 (it) | 1989-07-14 |
| CS343490A3 (en) | 1992-01-15 |
| ZA905220B (en) | 1991-04-24 |
| CS276842B6 (en) | 1992-08-12 |
| AU5903690A (en) | 1991-01-17 |
| HU904211D0 (en) | 1990-12-28 |
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