DD298406A5 - Verfahren zur herstellung von antiviralen, gut wasserloeslichen, stabilen, kristallinen salzen von 2',3'-dideoxyinosin-monohydrat, 2',3'-dideoxy-2',3'-didehydrothymidin-monohydrat und 2',3'-dideoxy-2'-fluorinosin-hemihydrat - Google Patents
Verfahren zur herstellung von antiviralen, gut wasserloeslichen, stabilen, kristallinen salzen von 2',3'-dideoxyinosin-monohydrat, 2',3'-dideoxy-2',3'-didehydrothymidin-monohydrat und 2',3'-dideoxy-2'-fluorinosin-hemihydrat Download PDFInfo
- Publication number
- DD298406A5 DD298406A5 DD90340679A DD34067990A DD298406A5 DD 298406 A5 DD298406 A5 DD 298406A5 DD 90340679 A DD90340679 A DD 90340679A DD 34067990 A DD34067990 A DD 34067990A DD 298406 A5 DD298406 A5 DD 298406A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- dideoxy
- monohydrate
- soluble
- dideoxyinosine
- water
- Prior art date
Links
- 230000000840 anti-viral effect Effects 0.000 title claims abstract description 14
- 238000004519 manufacturing process Methods 0.000 title claims abstract 3
- SLWSQPYUSBXANQ-BAJZRUMYSA-N 9-[(2r,3r,5s)-3-fluoro-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one Chemical compound O1[C@H](CO)C[C@@H](F)[C@@H]1N1C(NC=NC2=O)=C2N=C1 SLWSQPYUSBXANQ-BAJZRUMYSA-N 0.000 title claims description 6
- TYOLIMOHEMBOPU-UOERWJHTSA-N 9-[(2r,5s)-5-(hydroxymethyl)oxolan-2-yl]-3h-purin-6-one;hydrate Chemical class O.O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 TYOLIMOHEMBOPU-UOERWJHTSA-N 0.000 title 1
- 150000003839 salts Chemical class 0.000 claims abstract description 27
- 238000000034 method Methods 0.000 claims abstract description 17
- BXZVVICBKDXVGW-NKWVEPMBSA-N Didanosine Chemical compound O1[C@H](CO)CC[C@@H]1N1C(NC=NC2=O)=C2N=C1 BXZVVICBKDXVGW-NKWVEPMBSA-N 0.000 claims abstract description 14
- 150000002892 organic cations Chemical class 0.000 claims abstract description 7
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- RWQNBRDOKXIBIV-UHFFFAOYSA-N thymine Chemical compound CC1=CNC(=O)NC1=O RWQNBRDOKXIBIV-UHFFFAOYSA-N 0.000 description 2
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- 206010038997 Retroviral infections Diseases 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
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- 238000007918 intramuscular administration Methods 0.000 description 1
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- 238000010253 intravenous injection Methods 0.000 description 1
- 239000008101 lactose Substances 0.000 description 1
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- 229910052749 magnesium Inorganic materials 0.000 description 1
- 235000019359 magnesium stearate Nutrition 0.000 description 1
- 229910000000 metal hydroxide Inorganic materials 0.000 description 1
- 150000004692 metal hydroxides Chemical class 0.000 description 1
- 229910021645 metal ion Inorganic materials 0.000 description 1
- 150000004682 monohydrates Chemical class 0.000 description 1
- 229940127073 nucleoside analogue Drugs 0.000 description 1
- 125000003835 nucleoside group Chemical group 0.000 description 1
- 239000006186 oral dosage form Substances 0.000 description 1
- 150000007530 organic bases Chemical class 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
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- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 229910052700 potassium Inorganic materials 0.000 description 1
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- 229940002612 prodrug Drugs 0.000 description 1
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- 230000000750 progressive effect Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
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- IGFXRKMLLMBKSA-UHFFFAOYSA-N purine Chemical compound N1=C[N]C2=NC=NC2=C1 IGFXRKMLLMBKSA-UHFFFAOYSA-N 0.000 description 1
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- 230000001177 retroviral effect Effects 0.000 description 1
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- 150000005846 sugar alcohols Polymers 0.000 description 1
- 239000003826 tablet Substances 0.000 description 1
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- 229910052623 talc Inorganic materials 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229940124597 therapeutic agent Drugs 0.000 description 1
- 230000004797 therapeutic response Effects 0.000 description 1
- 229940113082 thymine Drugs 0.000 description 1
- QORWJWZARLRLPR-UHFFFAOYSA-H tricalcium bis(phosphate) Chemical compound [Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O QORWJWZARLRLPR-UHFFFAOYSA-H 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- 235000011178 triphosphate Nutrition 0.000 description 1
- UNXRWKVEANCORM-UHFFFAOYSA-N triphosphoric acid Chemical compound OP(O)(=O)OP(O)(=O)OP(O)(O)=O UNXRWKVEANCORM-UHFFFAOYSA-N 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 208000007089 vaccinia Diseases 0.000 description 1
- 239000003981 vehicle Substances 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Landscapes
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US35206589A | 1989-05-15 | 1989-05-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD298406A5 true DD298406A5 (de) | 1992-02-20 |
Family
ID=23383649
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD90340679A DD298406A5 (de) | 1989-05-15 | 1990-05-15 | Verfahren zur herstellung von antiviralen, gut wasserloeslichen, stabilen, kristallinen salzen von 2',3'-dideoxyinosin-monohydrat, 2',3'-dideoxy-2',3'-didehydrothymidin-monohydrat und 2',3'-dideoxy-2'-fluorinosin-hemihydrat |
Country Status (11)
| Country | Link |
|---|---|
| JP (1) | JP2926257B2 (enExample) |
| CA (1) | CA2016765C (enExample) |
| CZ (1) | CZ9602347A3 (enExample) |
| DD (1) | DD298406A5 (enExample) |
| MY (1) | MY116824A (enExample) |
| NZ (1) | NZ233646A (enExample) |
| PL (1) | PL163999B1 (enExample) |
| SK (2) | SK237290A3 (enExample) |
| TW (1) | TW233301B (enExample) |
| YU (1) | YU92890A (enExample) |
| ZA (1) | ZA903662B (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7122207B2 (en) | 1998-05-22 | 2006-10-17 | Bristol-Myers Squibb Company | High drug load acid labile pharmaceutical composition |
| JP4731121B2 (ja) * | 2004-02-02 | 2011-07-20 | 協和発酵キリン株式会社 | キサンチン誘導体水和物 |
| WO2009119785A1 (ja) * | 2008-03-28 | 2009-10-01 | 浜理薬品工業株式会社 | エチニルチミジン化合物の精製方法 |
| US8445669B2 (en) * | 2008-04-10 | 2013-05-21 | Hamari Chemicals, Ltd. | Production process of ethynylthymidine compounds from 5-methyluridine as a starting material |
-
1990
- 1990-05-11 NZ NZ23364690A patent/NZ233646A/xx unknown
- 1990-05-11 YU YU92890A patent/YU92890A/sh unknown
- 1990-05-12 TW TW79103864A patent/TW233301B/zh active
- 1990-05-14 MY MYPI90000768A patent/MY116824A/en unknown
- 1990-05-14 ZA ZA903662A patent/ZA903662B/xx unknown
- 1990-05-14 PL PL28517590A patent/PL163999B1/pl not_active IP Right Cessation
- 1990-05-14 CA CA002016765A patent/CA2016765C/en not_active Expired - Fee Related
- 1990-05-15 DD DD90340679A patent/DD298406A5/de unknown
- 1990-05-15 JP JP12326390A patent/JP2926257B2/ja not_active Expired - Lifetime
- 1990-05-15 SK SK2372-90A patent/SK237290A3/sk unknown
-
1996
- 1996-08-08 CZ CZ19962347A patent/CZ9602347A3/cs not_active IP Right Cessation
-
1997
- 1997-09-19 SK SK1273-97A patent/SK127397A3/sk unknown
Also Published As
| Publication number | Publication date |
|---|---|
| SK279253B6 (sk) | 1998-08-05 |
| JPH035477A (ja) | 1991-01-11 |
| NZ233646A (en) | 1991-10-25 |
| CZ288463B6 (en) | 2001-06-13 |
| JP2926257B2 (ja) | 1999-07-28 |
| MY116824A (en) | 2004-04-30 |
| SK127397A3 (en) | 1998-08-05 |
| SK279130B6 (sk) | 1998-07-08 |
| TW233301B (enExample) | 1994-11-01 |
| PL163999B1 (pl) | 1994-06-30 |
| CA2016765A1 (en) | 1990-11-15 |
| ZA903662B (en) | 1991-01-30 |
| PL285175A1 (en) | 1991-01-14 |
| CZ9602347A3 (en) | 2001-06-13 |
| SK237290A3 (en) | 1998-07-08 |
| YU92890A (sh) | 1992-09-07 |
| CA2016765C (en) | 1997-10-21 |
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| IF04 | In force in the year 2004 |
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