DD292383A5 - Verfahren zur herstellung eines transdermalen systems zur gesteuerten, abgestuften verabreichung von wirkstoffen - Google Patents
Verfahren zur herstellung eines transdermalen systems zur gesteuerten, abgestuften verabreichung von wirkstoffen Download PDFInfo
- Publication number
- DD292383A5 DD292383A5 DD90338650A DD33865090A DD292383A5 DD 292383 A5 DD292383 A5 DD 292383A5 DD 90338650 A DD90338650 A DD 90338650A DD 33865090 A DD33865090 A DD 33865090A DD 292383 A5 DD292383 A5 DD 292383A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- reservoir
- membrane
- skin
- release
- drug
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims abstract description 12
- 229940100640 transdermal system Drugs 0.000 title claims abstract description 10
- 238000004519 manufacturing process Methods 0.000 title claims abstract description 6
- 239000013543 active substance Substances 0.000 title claims description 20
- 239000012528 membrane Substances 0.000 claims abstract description 81
- 239000003814 drug Substances 0.000 claims abstract description 28
- 229940079593 drug Drugs 0.000 claims abstract description 27
- 239000004480 active ingredient Substances 0.000 claims abstract description 26
- 239000010410 layer Substances 0.000 claims abstract description 21
- 238000012423 maintenance Methods 0.000 claims abstract description 10
- 239000004820 Pressure-sensitive adhesive Substances 0.000 claims abstract description 8
- 239000011241 protective layer Substances 0.000 claims abstract description 4
- 230000009885 systemic effect Effects 0.000 claims abstract description 4
- 230000002500 effect on skin Effects 0.000 claims abstract description 3
- 238000001647 drug administration Methods 0.000 claims abstract 2
- 230000035699 permeability Effects 0.000 claims description 14
- 239000000126 substance Substances 0.000 claims description 11
- 239000000203 mixture Substances 0.000 claims description 7
- 239000002537 cosmetic Substances 0.000 claims description 2
- 239000011505 plaster Substances 0.000 abstract description 3
- 239000011159 matrix material Substances 0.000 description 11
- 239000003795 chemical substances by application Substances 0.000 description 7
- 229920000642 polymer Polymers 0.000 description 7
- 239000000853 adhesive Substances 0.000 description 6
- 238000012377 drug delivery Methods 0.000 description 6
- 239000000463 material Substances 0.000 description 6
- -1 polyethylene Polymers 0.000 description 6
- 229930000680 A04AD01 - Scopolamine Natural products 0.000 description 5
- STECJAGHUSJQJN-GAUPFVANSA-N Hyoscine Natural products C1([C@H](CO)C(=O)OC2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-GAUPFVANSA-N 0.000 description 5
- STECJAGHUSJQJN-UHFFFAOYSA-N N-Methyl-scopolamin Natural products C1C(C2C3O2)N(C)C3CC1OC(=O)C(CO)C1=CC=CC=C1 STECJAGHUSJQJN-UHFFFAOYSA-N 0.000 description 5
- 230000001681 protective effect Effects 0.000 description 5
- STECJAGHUSJQJN-FWXGHANASA-N scopolamine Chemical compound C1([C@@H](CO)C(=O)O[C@H]2C[C@@H]3N([C@H](C2)[C@@H]2[C@H]3O2)C)=CC=CC=C1 STECJAGHUSJQJN-FWXGHANASA-N 0.000 description 5
- 229960002646 scopolamine Drugs 0.000 description 5
- 230000004907 flux Effects 0.000 description 4
- 230000035515 penetration Effects 0.000 description 4
- 230000036470 plasma concentration Effects 0.000 description 4
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 3
- 230000001186 cumulative effect Effects 0.000 description 3
- 239000011888 foil Substances 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- 239000004952 Polyamide Substances 0.000 description 2
- 239000004698 Polyethylene Substances 0.000 description 2
- 229940035676 analgesics Drugs 0.000 description 2
- 239000000730 antalgic agent Substances 0.000 description 2
- 229920001577 copolymer Polymers 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 229920002647 polyamide Polymers 0.000 description 2
- 229920006267 polyester film Polymers 0.000 description 2
- 229920000573 polyethylene Polymers 0.000 description 2
- 229920001296 polysiloxane Polymers 0.000 description 2
- 229920002635 polyurethane Polymers 0.000 description 2
- 239000004814 polyurethane Substances 0.000 description 2
- 229940001470 psychoactive drug Drugs 0.000 description 2
- 239000004089 psychotropic agent Substances 0.000 description 2
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 description 1
- 239000004925 Acrylic resin Substances 0.000 description 1
- 206010012335 Dependence Diseases 0.000 description 1
- VGGSQFUCUMXWEO-UHFFFAOYSA-N Ethene Chemical compound C=C VGGSQFUCUMXWEO-UHFFFAOYSA-N 0.000 description 1
- 239000005977 Ethylene Substances 0.000 description 1
- 239000004743 Polypropylene Substances 0.000 description 1
- 229920002125 Sokalan® Polymers 0.000 description 1
- 229940124532 absorption promoter Drugs 0.000 description 1
- 230000009471 action Effects 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 230000001070 adhesive effect Effects 0.000 description 1
- 229910052782 aluminium Inorganic materials 0.000 description 1
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
- 238000004873 anchoring Methods 0.000 description 1
- 239000004004 anti-anginal agent Substances 0.000 description 1
- 239000000924 antiasthmatic agent Substances 0.000 description 1
- 239000002830 appetite depressant Substances 0.000 description 1
- 230000008901 benefit Effects 0.000 description 1
- 230000036772 blood pressure Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 238000001035 drying Methods 0.000 description 1
- 229920001971 elastomer Polymers 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 239000004744 fabric Substances 0.000 description 1
- 239000000945 filler Substances 0.000 description 1
- 238000004128 high performance liquid chromatography Methods 0.000 description 1
- 239000003326 hypnotic agent Substances 0.000 description 1
- 230000000147 hypnotic effect Effects 0.000 description 1
- 239000005554 hypnotics and sedatives Substances 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 210000004185 liver Anatomy 0.000 description 1
- 229960002715 nicotine Drugs 0.000 description 1
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 239000004014 plasticizer Substances 0.000 description 1
- 229920001200 poly(ethylene-vinyl acetate) Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 229920000139 polyethylene terephthalate Polymers 0.000 description 1
- 239000005020 polyethylene terephthalate Substances 0.000 description 1
- 239000002861 polymer material Substances 0.000 description 1
- 229920001155 polypropylene Polymers 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 239000000932 sedative agent Substances 0.000 description 1
- 229940125723 sedative agent Drugs 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 239000004753 textile Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7023—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
- A61K9/703—Transdermal patches and similar drug-containing composite devices, e.g. cataplasms characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
- A61K9/7038—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
- A61K9/7046—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds
- A61K9/7053—Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer the adhesive comprising macromolecular compounds obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
- A61K9/7061—Polyacrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dermatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Biomedical Technology (AREA)
- Anesthesiology (AREA)
- Medical Informatics (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Media Introduction/Drainage Providing Device (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- External Artificial Organs (AREA)
- Adhesives Or Adhesive Processes (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE3908431A DE3908431A1 (de) | 1989-03-15 | 1989-03-15 | Transdermales system mit gestufter wirkstoffabgabe und verwendung fuer die lokale oder systemische wirkstoffverabreichung |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD292383A5 true DD292383A5 (de) | 1991-08-01 |
Family
ID=6376396
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD90338650A DD292383A5 (de) | 1989-03-15 | 1990-03-13 | Verfahren zur herstellung eines transdermalen systems zur gesteuerten, abgestuften verabreichung von wirkstoffen |
Country Status (26)
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4341444C2 (de) * | 1993-12-04 | 1996-03-14 | Lohmann Therapie Syst Lts | Wirkstoffhaltiges Pflaster und Verfahren zu seiner Herstellung |
| US5714162A (en) * | 1994-09-16 | 1998-02-03 | Lts Lohmann Therapie-Systeme Gmbh & Co. Kg | Scopolamine patch |
| DE4438989C2 (de) * | 1994-09-16 | 1999-02-25 | Lohmann Therapie Syst Lts | Scopolaminpflaster |
| DE19705138A1 (de) * | 1997-02-11 | 1998-08-13 | Lohmann Therapie Syst Lts | Dehnbares transdermales therapeutisches System |
| DE19733981A1 (de) * | 1997-08-06 | 1999-02-11 | Lohmann Therapie Syst Lts | Transdermales Therapeutisches System (TTS) zur Abgabe von Wirkstoff durch die Haut an einen Organismus und Verfahren zur Applikation auf der Haut |
| DE19738643C2 (de) | 1997-09-04 | 2001-10-04 | Lohmann Therapie Syst Lts | Transdermales therapeutisches System mit dem Wirkstoff Scopolaminbase und Verfahren zu seiner Herstellung |
| DE10056014A1 (de) * | 2000-11-11 | 2002-05-16 | Beiersdorf Ag | Mehrschichtige Trägerkonstruktion für wirkstofhaltige Pflastersyteme |
| DE10056012A1 (de) * | 2000-11-11 | 2002-05-16 | Beiersdorf Ag | Flexible Barrierefolie für ein Trägermaterial für medizinische Zwecke |
| DE102004020463A1 (de) * | 2004-04-26 | 2005-11-10 | Grünenthal GmbH | Wirkstoffabgabesystem aus einem wirkstoffhaltigen Pflaster und mindestens einem Wirkstoffabgaberegulierungsmittel |
| EP2693928B1 (en) | 2011-04-04 | 2018-09-05 | The Procter and Gamble Company | Personal care article |
| EP2744340A2 (en) | 2011-08-15 | 2014-06-25 | The Procter and Gamble Company | Personal care methods |
| US9428719B2 (en) | 2011-08-15 | 2016-08-30 | The Procter & Gamble Company | Personal care articles having multiple zones with compliant personal care compositions |
| CN105307731B (zh) | 2013-06-27 | 2019-09-24 | 宝洁公司 | 防腐性个人护理组合物 |
| DE102018216244A1 (de) | 2018-09-24 | 2020-03-26 | Lts Lohmann Therapie-Systeme Ag | Transdermales therapeutisches System mit Barriereschicht |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5755157A (en) * | 1980-09-19 | 1982-04-01 | Nitto Electric Ind Co | Drug member having transcataneous absorbing property |
| IE53703B1 (en) * | 1982-12-13 | 1989-01-18 | Elan Corp Plc | Drug delivery device |
| US4698062A (en) * | 1985-10-30 | 1987-10-06 | Alza Corporation | Medical device for pulsatile transdermal delivery of biologically active agents |
| US4666441A (en) * | 1985-12-17 | 1987-05-19 | Ciba-Geigy Corporation | Multicompartmentalized transdermal patches |
| DE3634016A1 (de) * | 1986-04-17 | 1987-10-29 | Lohmann Gmbh & Co Kg | Flaechenfoermiges therapeutisches system, verfahren zu seiner herstellung und seine verwendung |
| ATE71287T1 (de) * | 1986-06-13 | 1992-01-15 | Alza Corp | Aktivierung eines transdermalen drogenabgabesystems durch feuchtigkeit. |
| US4781924A (en) * | 1987-11-09 | 1988-11-01 | Alza Corporation | Transdermal drug delivery device |
-
1989
- 1989-03-15 DE DE3908431A patent/DE3908431A1/de active Granted
-
1990
- 1990-03-07 PH PH40155A patent/PH26276A/en unknown
- 1990-03-07 MY MYPI90000358A patent/MY107420A/en unknown
- 1990-03-07 AU AU50765/90A patent/AU625402B2/en not_active Ceased
- 1990-03-08 SK SK1136-90A patent/SK279357B6/sk unknown
- 1990-03-08 ES ES90104406T patent/ES2095216T3/es not_active Expired - Lifetime
- 1990-03-08 DE DE59010514T patent/DE59010514D1/de not_active Expired - Fee Related
- 1990-03-08 DK DK90104406.5T patent/DK0387693T3/da active
- 1990-03-08 EP EP90104406A patent/EP0387693B1/de not_active Expired - Lifetime
- 1990-03-08 AT AT90104406T patent/ATE143276T1/de not_active IP Right Cessation
- 1990-03-08 CZ CS901136A patent/CZ284770B6/cs unknown
- 1990-03-08 IL IL9367890A patent/IL93678A/en not_active IP Right Cessation
- 1990-03-09 NO NO901128A patent/NO300087B1/no not_active IP Right Cessation
- 1990-03-12 JP JP2058241A patent/JPH0693921B2/ja not_active Expired - Fee Related
- 1990-03-13 DD DD90338650A patent/DD292383A5/de unknown
- 1990-03-13 NZ NZ232895A patent/NZ232895A/xx unknown
- 1990-03-13 HU HU901422A patent/HU206991B/hu not_active IP Right Cessation
- 1990-03-14 SI SI9010493A patent/SI9010493B/sl unknown
- 1990-03-14 PT PT93430A patent/PT93430B/pt not_active IP Right Cessation
- 1990-03-14 PL PL28430190A patent/PL162693B1/pl unknown
- 1990-03-14 CA CA002012123A patent/CA2012123C/en not_active Expired - Fee Related
- 1990-03-14 YU YU49390A patent/YU48228B/sh unknown
- 1990-03-14 ZA ZA901941A patent/ZA901941B/xx unknown
- 1990-03-14 KR KR1019900003563A patent/KR960005148B1/ko not_active Expired - Fee Related
- 1990-03-15 FI FI901290A patent/FI901290A7/fi not_active Application Discontinuation
-
1993
- 1993-04-01 HR HR930662A patent/HRP930662A2/hr not_active Application Discontinuation
-
1996
- 1996-12-13 GR GR960403458T patent/GR3022033T3/el unknown
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