DD286359A5 - Verfahren zur herstellung von 7-oxabicycloheptyl-substituierten heterocycloamid-prostaglandinanalogen - Google Patents

Verfahren zur herstellung von 7-oxabicycloheptyl-substituierten heterocycloamid-prostaglandinanalogen Download PDF

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Publication number
DD286359A5
DD286359A5 DD89336462A DD33646289A DD286359A5 DD 286359 A5 DD286359 A5 DD 286359A5 DD 89336462 A DD89336462 A DD 89336462A DD 33646289 A DD33646289 A DD 33646289A DD 286359 A5 DD286359 A5 DD 286359A5
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DD
German Democratic Republic
Prior art keywords
formula
acid
hept
alkyl
carbonyl
Prior art date
Application number
DD89336462A
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German (de)
English (en)
Inventor
Philip M Sher
Philip D Stein
David Floyd
Steven E Hall
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Publication of DD286359A5 publication Critical patent/DD286359A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
    • C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
    • C07D493/08—Bridged systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/27—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation
    • C07C45/29—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation of hydroxy groups

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pulmonology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DD89336462A 1988-12-23 1989-12-27 Verfahren zur herstellung von 7-oxabicycloheptyl-substituierten heterocycloamid-prostaglandinanalogen DD286359A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28882688A 1988-12-23 1988-12-23

Publications (1)

Publication Number Publication Date
DD286359A5 true DD286359A5 (de) 1991-01-24

Family

ID=23108806

Family Applications (1)

Application Number Title Priority Date Filing Date
DD89336462A DD286359A5 (de) 1988-12-23 1989-12-27 Verfahren zur herstellung von 7-oxabicycloheptyl-substituierten heterocycloamid-prostaglandinanalogen

Country Status (18)

Country Link
EP (1) EP0374952A3 (fi)
JP (1) JPH02221278A (fi)
KR (1) KR900009639A (fi)
CN (1) CN1031059C (fi)
AU (1) AU617569B2 (fi)
CA (1) CA2006355A1 (fi)
DD (1) DD286359A5 (fi)
DK (1) DK172411B1 (fi)
FI (1) FI97230C (fi)
HU (1) HUT54161A (fi)
IL (1) IL92837A (fi)
MX (1) MX18879A (fi)
NO (1) NO175258C (fi)
NZ (1) NZ231962A (fi)
PH (1) PH27413A (fi)
PL (2) PL165147B1 (fi)
PT (1) PT92768B (fi)
ZA (1) ZA899868B (fi)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ232897A (en) * 1989-04-03 1992-12-23 Squibb & Sons Inc Interphenylene 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogues, preparation and pharmaceutical compositions thereof
DE4035851A1 (de) * 1990-11-10 1992-05-14 Bayer Ag Substituierte aminosaeureamid-derivate deren herstellung und verwendung
NZ233600A (en) * 1989-06-12 1992-10-28 Squibb & Sons Inc 7-oxabicyclo(2.2.1)heptane imidazole prostaglandin analogs and pharmaceutical compositions
US4977174A (en) * 1989-06-12 1990-12-11 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane imidazole prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US5290799A (en) * 1990-09-19 1994-03-01 E. R. Squibb & Sons, Inc. 7-oxabicycloheptyl substituted heterocyclic thioamide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US5550248A (en) * 1990-11-29 1996-08-27 E.R. Squibb & Sons, Inc. Substituted stryl heterocyclic amido prostaglandin analogs
DE4102042A1 (de) * 1991-01-24 1992-07-30 Bayer Ag Substituierte aminosaeureamid-derivate deren herstellung und verwendung als fungizide
US5135939A (en) * 1991-01-28 1992-08-04 E. R. Squibb & Sons, Inc. Heterocyclic ketone prostaglandin analogs
US5238951A (en) * 1991-02-01 1993-08-24 E. R. Squibb & Sons, Inc. Heterocyclic amido prostaglandin analogs
IE920039A1 (en) * 1991-02-01 1992-08-12 Squibb & Sons Inc Heterocyclic amido prostaglandin analogs
US5158967A (en) * 1991-06-12 1992-10-27 E. R. Squibb & Sons, Inc. 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US5162352A (en) * 1991-08-22 1992-11-10 E. R. Squibb & Sons, Inc. 7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs
US5280034A (en) * 1991-08-23 1994-01-18 E. R. Squibb & Sons, Inc. Bis-heterocyclic prostaglandin analogs
CA2081679A1 (en) * 1991-11-27 1993-05-28 Raj N. Misra Gem-dialkyl-7-oxabicycloheptyl substituted heterocyclic amide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
US5399725A (en) * 1993-05-27 1995-03-21 Bristol-Myers Squibb Co. 7-oxabicycloheptane carboxylic acid prostaglandin analog intermediates useful in the preparation of anti-thrombotic and anti-vasospastic compounds and method for preparing same
US5849766A (en) * 1996-05-31 1998-12-15 Eli Lilly And Company Carbamoyl substituted heterocycles
US5849922A (en) * 1996-05-31 1998-12-15 Eli Lilly And Company Preparation of substituted alkenoic acids
US5856584A (en) * 1997-08-06 1999-01-05 The Nutrasweet Company Preparation of 3,3-dimethylbutyraldehyde by oxidation of 3, 3-dimethylbutanol
US5905175A (en) * 1998-05-20 1999-05-18 The Nutrasweet Company Synthesis and purification of 3,3-dimethylbutyraldehyde via oxidation of 1-chloro-3,3-dimethylbutane with dimethyl sulfoxide
CN113912619B (zh) * 2021-11-26 2022-12-06 沈阳药科大学 五味子中提取分离的倍半萜化合物及其方法和应用

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4456617A (en) * 1983-01-12 1984-06-26 E. R. Squibb & Sons, Inc. 7-Oxabicycloheptane substituted amino prostaglandin analogs and their use in inhibiting platelet aggregation and bronchoconstriction
US4663337A (en) * 1986-04-18 1987-05-05 E. R. Squibb & Sons, Inc. 7-oxabicycloheptane substituted amides useful in the treatment of thrombotic disease

Also Published As

Publication number Publication date
FI97230B (fi) 1996-07-31
DK663189A (da) 1990-06-24
PL165147B1 (pl) 1994-11-30
PT92768B (pt) 1995-12-29
CN1043716A (zh) 1990-07-11
FI97230C (fi) 1996-11-11
JPH02221278A (ja) 1990-09-04
IL92837A (en) 1994-06-24
HU8906777D0 (fi) 1990-03-28
HUT54161A (en) 1991-01-28
PL164552B1 (pl) 1994-08-31
ZA899868B (en) 1990-09-26
NO175258B (no) 1994-06-13
NO895170L (no) 1990-06-25
MX18879A (es) 1994-01-31
CA2006355A1 (en) 1990-06-23
IL92837A0 (en) 1990-09-17
FI896249A0 (fi) 1989-12-22
NZ231962A (en) 1992-10-28
DK663189D0 (da) 1989-12-22
AU4729089A (en) 1990-06-28
AU617569B2 (en) 1991-11-28
CN1031059C (zh) 1996-02-21
KR900009639A (ko) 1990-07-05
EP0374952A3 (en) 1991-03-27
EP0374952A2 (en) 1990-06-27
NO895170D0 (no) 1989-12-21
PT92768A (pt) 1990-06-29
PH27413A (en) 1993-06-21
NO175258C (no) 1994-09-21
DK172411B1 (da) 1998-05-25

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