DD283140A5 - Verfahren zur herstellung von therapeutischen heterozyclischen verbindungen - Google Patents
Verfahren zur herstellung von therapeutischen heterozyclischen verbindungen Download PDFInfo
- Publication number
- DD283140A5 DD283140A5 DD88320940A DD32094088A DD283140A5 DD 283140 A5 DD283140 A5 DD 283140A5 DD 88320940 A DD88320940 A DD 88320940A DD 32094088 A DD32094088 A DD 32094088A DD 283140 A5 DD283140 A5 DD 283140A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- formula
- compound
- group
- defined above
- aryl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878724912A GB8724912D0 (en) | 1987-10-23 | 1987-10-23 | Indole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD283140A5 true DD283140A5 (de) | 1990-10-03 |
Family
ID=10625806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD88320940A DD283140A5 (de) | 1987-10-23 | 1988-10-21 | Verfahren zur herstellung von therapeutischen heterozyclischen verbindungen |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0313397B1 (hu) |
| JP (1) | JP2501631B2 (hu) |
| CN (1) | CN1035113A (hu) |
| AT (1) | ATE90089T1 (hu) |
| AU (1) | AU604165B2 (hu) |
| DD (1) | DD283140A5 (hu) |
| DE (1) | DE3881472T2 (hu) |
| DK (1) | DK586588A (hu) |
| ES (1) | ES2054825T3 (hu) |
| FI (1) | FI884879A (hu) |
| GB (1) | GB8724912D0 (hu) |
| HU (1) | HU202230B (hu) |
| IL (1) | IL88122A0 (hu) |
| MC (1) | MC1983A1 (hu) |
| NZ (1) | NZ226671A (hu) |
| PL (1) | PL158305B1 (hu) |
| PT (1) | PT88829B (hu) |
| ZA (1) | ZA887900B (hu) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT95899A (pt) * | 1989-11-17 | 1991-09-13 | Glaxo Group Ltd | Processo para a preparacao de derivados indole |
| IL96891A0 (en) * | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
| DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
| PL166214B1 (pl) * | 1990-06-07 | 1995-04-28 | Wellcome Found | Sposób wytwarzania nowych pochodnych indolu PL PL PL PL PL PL PL |
| EP0494774A1 (en) * | 1991-01-11 | 1992-07-15 | MERCK SHARP & DOHME LTD. | Indazole-substituted fivemembered heteroaromatic compounds |
| US5317103A (en) * | 1991-01-15 | 1994-05-31 | Merck Sharp & Dohme Limited | Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists |
| SK278998B6 (sk) * | 1991-02-01 | 1998-05-06 | Merck Sharp & Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu, spôsob i |
| TW263508B (hu) * | 1991-02-12 | 1995-11-21 | Pfizer | |
| GB9104136D0 (en) * | 1991-02-27 | 1991-04-17 | Merck Sharp & Dohme | Therapeutic agents |
| ATE190608T1 (de) * | 1991-11-25 | 2000-04-15 | Pfizer | 5-(hetero- oder carbocyclylamino)-indol derivate, deren herstellung und deren verwendung als 5-ht1 agonisten |
| EP0545478A1 (en) * | 1991-12-03 | 1993-06-09 | MERCK SHARP & DOHME LTD. | Heterocyclic compounds as tachykinin antagonists |
| US5409941A (en) * | 1992-02-03 | 1995-04-25 | Pfizer Inc. | 5-heteroyl indole derivatives |
| TW288010B (hu) * | 1992-03-05 | 1996-10-11 | Pfizer | |
| JP3309982B2 (ja) * | 1992-03-13 | 2002-07-29 | メルク シヤープ エンド ドーム リミテツド | イミダゾール，トリアゾールおよびテトラゾール誘導体 |
| GB9207396D0 (en) * | 1992-04-03 | 1992-05-13 | Merck Sharp & Dohme | Therapeutic agents |
| US6380233B1 (en) | 1992-04-07 | 2002-04-30 | Pfizer Inc | Indole derivatives as 5-HT1 agonists |
| BR9306201A (pt) | 1992-04-07 | 1998-06-23 | Pfizer | Derivados de indol como agonistas 5-ht1 |
| GB9207930D0 (en) * | 1992-04-10 | 1992-05-27 | Pfizer Ltd | Indoles |
| BR9306221A (pt) * | 1992-04-10 | 1998-06-30 | Pfizer | Derivados do acilaminoindol como agonistas 5-htl |
| GB9208463D0 (en) * | 1992-04-16 | 1992-06-03 | Merck Sharp & Dohme | Therapeutic agents |
| GB9210400D0 (en) * | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
| GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
| CZ282060B6 (cs) * | 1992-06-05 | 1997-05-14 | Merck Sharp And Dohme Limited | Sulfátová sůl substituovaného triazolu, způsob její výroby, farmaceutický prostředek s jejím obsahem a způsob jeho výroby |
| GB9215526D0 (en) * | 1992-07-22 | 1992-09-02 | Merck Sharp & Dohme | Chemical process |
| US5567726A (en) * | 1992-07-24 | 1996-10-22 | Merck, Sharp & Dohme Ltd. | Imidazole, Triazole and tetrazole derivatives |
| IL106445A (en) * | 1992-07-30 | 1998-01-04 | Merck Sharp & Dohme | History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them |
| TW251284B (hu) * | 1992-11-02 | 1995-07-11 | Pfizer | |
| GB9226537D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| LT3594B (en) | 1993-07-29 | 1995-12-27 | Merck Sharp & Dohme | Imidazole,triazole and tetrazole derivatives |
| ES2070087B1 (es) * | 1993-08-13 | 1996-02-16 | Pfizer | Derivados de indol |
| US6423731B2 (en) | 1994-01-06 | 2002-07-23 | Zeneca Limited | Indole derivatives as prodrugs of 5-HT1-like receptor agonists |
| US5962486A (en) * | 1994-06-01 | 1999-10-05 | Zeneca Limited | Indole derivatives as prodrugs of 5-HT1 -like receptor agonists |
| GB9401436D0 (en) * | 1994-01-26 | 1994-03-23 | Wellcome Found | Therapeutic heterocyclic compounds |
| GB9407447D0 (en) * | 1994-04-14 | 1994-06-08 | Glaxo Group Ltd | Chemical compounds |
| EP0773942A1 (en) * | 1994-07-26 | 1997-05-21 | Pfizer Inc. | 4-indole derivatives as serotonin agonists and antagonists |
| JPH10509721A (ja) * | 1994-12-06 | 1998-09-22 | メルク シヤープ エンド ドーム リミテツド | ５ｈｔ１レセプターアゴニストとしてのアゼチジン、ピロリジン及びピペリジン誘導体 |
| GB9516143D0 (en) | 1995-08-07 | 1995-10-04 | Wellcome Found | Improved chemical synthesis |
| GB9516145D0 (en) * | 1995-08-07 | 1995-10-04 | Wellcome Found | Improved chemical synthesis |
| US6909005B1 (en) | 1995-08-07 | 2005-06-21 | Astrazeneca Uk Limited | One post synthesis of 2-oxazolidinone derivatives |
| US5998438A (en) * | 1996-11-26 | 1999-12-07 | Allelix Biopharmaceuticals, Inc. | 5-cyclo indole compounds |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| AU4961499A (en) * | 1998-06-26 | 2000-01-17 | Eli Lilly And Company | 5-HT1f agonists |
| ATE377603T1 (de) | 2002-06-21 | 2007-11-15 | Suven Life Sciences Ltd | Tetracyklische arylsulfonylindole mit affinität zum serotonin rezeptor |
| AU2003249584B9 (en) | 2002-06-21 | 2008-05-15 | Suven Life Sciences Limited | Arylalkyl indoles having sertonin receptor affinity useful as therapeutic agents, process for their preparation and pharmaceutical compositions containing them |
| EP1581492B1 (en) | 2002-11-28 | 2008-07-16 | Suven Life Sciences Limited | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them |
| CN1720227A (zh) | 2002-11-28 | 2006-01-11 | 苏文生命科学有限公司 | N－芳基磺酰基－3－氨基烷氧基吲哚 |
| CA2507923C (en) | 2002-12-18 | 2010-02-02 | Suven Life Sciences Limited | Tetracyclic 3-substituted indoles having serotonin receptor affinity |
| DE102005018191A1 (de) * | 2005-04-19 | 2006-10-26 | Grünenthal GmbH | Substituierte zyklische Harnstoff-Derivate und deren Verwendung zur Herstellung von Arzneimitteln |
| US20210069122A1 (en) | 2016-01-27 | 2021-03-11 | Instar Technologies A.S. | Oromucosal nanofiber carriers for therapeutic treatment |
| CN112759550A (zh) * | 2019-11-04 | 2021-05-07 | 上海科技大学 | 一种平滑受体拮抗剂 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4833153A (en) | 1985-11-08 | 1989-05-23 | Glaxo Group Limited | Indole derivatives |
| GB8600397D0 (en) | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
-
1987
- 1987-10-23 GB GB878724912A patent/GB8724912D0/en active Pending
-
1988
- 1988-10-21 AT AT88309943T patent/ATE90089T1/de not_active IP Right Cessation
- 1988-10-21 DD DD88320940A patent/DD283140A5/de not_active IP Right Cessation
- 1988-10-21 MC MC882012A patent/MC1983A1/xx unknown
- 1988-10-21 JP JP63265917A patent/JP2501631B2/ja not_active Expired - Lifetime
- 1988-10-21 NZ NZ226671A patent/NZ226671A/xx unknown
- 1988-10-21 DE DE88309943T patent/DE3881472T2/de not_active Expired - Fee Related
- 1988-10-21 DK DK586588A patent/DK586588A/da not_active Application Discontinuation
- 1988-10-21 ZA ZA887900A patent/ZA887900B/xx unknown
- 1988-10-21 PT PT88829A patent/PT88829B/pt not_active IP Right Cessation
- 1988-10-21 ES ES88309943T patent/ES2054825T3/es not_active Expired - Lifetime
- 1988-10-21 CN CN88108816A patent/CN1035113A/zh active Pending
- 1988-10-21 EP EP88309943A patent/EP0313397B1/en not_active Expired - Lifetime
- 1988-10-21 FI FI884879A patent/FI884879A/fi not_active Application Discontinuation
- 1988-10-21 IL IL88122A patent/IL88122A0/xx unknown
- 1988-10-21 HU HU885431A patent/HU202230B/hu unknown
- 1988-10-21 PL PL1988275423A patent/PL158305B1/pl unknown
- 1988-10-24 AU AU24181/88A patent/AU604165B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| IL88122A0 (en) | 1989-06-30 |
| EP0313397B1 (en) | 1993-06-02 |
| AU2418188A (en) | 1989-04-27 |
| JPH01146882A (ja) | 1989-06-08 |
| DK586588A (da) | 1989-04-24 |
| ZA887900B (en) | 1990-06-27 |
| ATE90089T1 (de) | 1993-06-15 |
| PL158305B1 (en) | 1992-08-31 |
| DE3881472D1 (de) | 1993-07-08 |
| JP2501631B2 (ja) | 1996-05-29 |
| CN1035113A (zh) | 1989-08-30 |
| GB8724912D0 (en) | 1987-11-25 |
| DK586588D0 (da) | 1988-10-21 |
| FI884879A0 (fi) | 1988-10-21 |
| HU202230B (en) | 1991-02-28 |
| FI884879A (fi) | 1989-04-24 |
| MC1983A1 (fr) | 1989-11-23 |
| ES2054825T3 (es) | 1994-08-16 |
| EP0313397A1 (en) | 1989-04-26 |
| AU604165B2 (en) | 1990-12-06 |
| DE3881472T2 (de) | 1993-12-16 |
| HUT50163A (en) | 1989-12-28 |
| NZ226671A (en) | 1991-09-25 |
| PL275423A1 (en) | 1989-08-07 |
| PT88829B (pt) | 1993-01-29 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DD283140A5 (de) | Verfahren zur herstellung von therapeutischen heterozyclischen verbindungen | |
| DE69127260T2 (de) | Therapeutische heterocyclische verbindungen | |
| DE69227458T2 (de) | Tryptamin analoga, ihre herstellung und anwendung als 5-ht1-artige rezeptoren oder 5-ht2 rezeptor agonisten | |
| DE69522718T2 (de) | Substituierte n-(indol-2-carbonyl)-amide und derivate als glycogen phosphorylase inhibitoren | |
| DE3527648C2 (hu) | ||
| DE60002554T2 (de) | Pyrazino(aza)indolderivate | |
| DE69730156T2 (de) | 5-Pyrimidinyl-4-yl-imidazole derivatives useful for the treatment of CSBP/RK/p38 mediated diseases | |
| DE3131748C2 (hu) | ||
| DE69929689T2 (de) | Heterocyclische Verbindungen und Verfahren zur Behandlung von Herzversagen und anderer Erkrankungen | |
| DE69523182T2 (de) | Substituierte n-(indol-2-carbonyl)-glycinamide und derivate als glycogen phosphorylase inhibitoren | |
| DE60211199T2 (de) | 3-substituierte oxindol-beta-3-agonisten | |
| DE60014918T2 (de) | Indol-verbindungen, verfahren zu ihrer herstellung, sie enthaltende pharmazeutische zusammensetzungen und ihre medizinische anwendung | |
| EP0700905B1 (de) | Tricyclische Pyrazol-Derivate | |
| DE3008632A1 (de) | Indol-derivate, verfahren zu ihrer herstellung und ihre verwendung | |
| FR2725986A1 (fr) | Nouveaux derives de piperidine, leur procede de preparation et les compositions pharmaceutiques qui les contiennent | |
| DE60113563T2 (de) | Substituierte 2-phenylaminoimidazolin-phenyl-ketonderivate als ip-antagonisten | |
| DE69016530T2 (de) | 1,3-Dihydro-1-(pyridinylamino)-2H-indol-2-one, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel. | |
| DE69105659T2 (de) | 3-Arylindol- und 3-Arylindazolderivate. | |
| FR2722190A1 (fr) | Derives de 1-benzyl-1,3-dihydro-2h-benzimidazol-2-one, leur preparation, les compositions pharmaceutique en contenant | |
| DE69105135T2 (de) | Piperidyl-substituierte indole. | |
| EP0740658B1 (de) | N-substituierte azabicycloheptan-derivate und ihre verwendung, z.b., als neuroleptika | |
| DE69300373T2 (de) | (1H-Indol-1-yl)-2-(Amino)Acetamide und verwandte (1H-Indol-1-yl)-(Aminoalkyl)Amide, Zwischenprodukte, Verfahren zur Herstellung davon und ihre Verwendung als Arzneimittel. | |
| JPH09510706A (ja) | ドパミン作動性活性を有するベンゾイミダゾール誘導体 | |
| DE3700407A1 (de) | Indolderivate, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische zubereitungen | |
| WO2009118163A1 (de) | (hetero-)aryl-cyclohexan-derivate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ENJ | Ceased due to non-payment of renewal fee |