DE3881472D1 - Heterocyclische verbindungen mit therapeutischer wirkung. - Google Patents
Heterocyclische verbindungen mit therapeutischer wirkung.Info
- Publication number
- DE3881472D1 DE3881472D1 DE8888309943T DE3881472T DE3881472D1 DE 3881472 D1 DE3881472 D1 DE 3881472D1 DE 8888309943 T DE8888309943 T DE 8888309943T DE 3881472 T DE3881472 T DE 3881472T DE 3881472 D1 DE3881472 D1 DE 3881472D1
- Authority
- DE
- Germany
- Prior art keywords
- aryl
- alkyl
- group
- benzyl
- independently selected
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB878724912A GB8724912D0 (en) | 1987-10-23 | 1987-10-23 | Indole derivatives |
Publications (2)
Publication Number | Publication Date |
---|---|
DE3881472D1 true DE3881472D1 (de) | 1993-07-08 |
DE3881472T2 DE3881472T2 (de) | 1993-12-16 |
Family
ID=10625806
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE88309943T Expired - Fee Related DE3881472T2 (de) | 1987-10-23 | 1988-10-21 | Heterocyclische Verbindungen mit therapeutischer Wirkung. |
Country Status (18)
Country | Link |
---|---|
EP (1) | EP0313397B1 (de) |
JP (1) | JP2501631B2 (de) |
CN (1) | CN1035113A (de) |
AT (1) | ATE90089T1 (de) |
AU (1) | AU604165B2 (de) |
DD (1) | DD283140A5 (de) |
DE (1) | DE3881472T2 (de) |
DK (1) | DK586588A (de) |
ES (1) | ES2054825T3 (de) |
FI (1) | FI884879A (de) |
GB (1) | GB8724912D0 (de) |
HU (1) | HU202230B (de) |
IL (1) | IL88122A0 (de) |
MC (1) | MC1983A1 (de) |
NZ (1) | NZ226671A (de) |
PL (1) | PL158305B1 (de) |
PT (1) | PT88829B (de) |
ZA (1) | ZA887900B (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
PT95899A (pt) * | 1989-11-17 | 1991-09-13 | Glaxo Group Ltd | Processo para a preparacao de derivados indole |
IL96891A0 (en) * | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
IL114690A (en) * | 1990-06-07 | 1997-02-18 | Wellcome Found | Antimigraine oxazolidinone substituted indole derivatives |
EP0494774A1 (de) * | 1991-01-11 | 1992-07-15 | MERCK SHARP & DOHME LTD. | Indazol-substituierte 5-Kettenglieder heteroaromatische Verbindungen |
US5317103A (en) * | 1991-01-15 | 1994-05-31 | Merck Sharp & Dohme Limited | Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists |
CZ283018B6 (cs) * | 1991-02-01 | 1997-12-17 | Merck Sharp And Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi |
TW263508B (de) * | 1991-02-12 | 1995-11-21 | Pfizer | |
GB9104136D0 (en) * | 1991-02-27 | 1991-04-17 | Merck Sharp & Dohme | Therapeutic agents |
ES2143992T3 (es) * | 1991-11-25 | 2000-06-01 | Pfizer | Derivados de 5-(hetero- o carbociclilamino)-indol, su preparacion y uso como 5-ht1 agonistas. |
EP0545478A1 (de) * | 1991-12-03 | 1993-06-09 | MERCK SHARP & DOHME LTD. | Heterocyclische Verbindungen als Tachykininantagoniste |
US5409941A (en) * | 1992-02-03 | 1995-04-25 | Pfizer Inc. | 5-heteroyl indole derivatives |
TW288010B (de) * | 1992-03-05 | 1996-10-11 | Pfizer | |
WO1993018029A1 (en) * | 1992-03-13 | 1993-09-16 | Merck Sharp & Dohme Limited | Imidazole, triazole and tetrazole derivatives |
GB9207396D0 (en) * | 1992-04-03 | 1992-05-13 | Merck Sharp & Dohme | Therapeutic agents |
US6380233B1 (en) | 1992-04-07 | 2002-04-30 | Pfizer Inc | Indole derivatives as 5-HT1 agonists |
KR0179072B1 (ko) * | 1992-04-07 | 1999-03-20 | 알렌 제이. 스피겔 | 5-ht1 작동약으로서의 인돌 유도체 |
KR0179074B1 (ko) * | 1992-04-10 | 1999-03-20 | 알렌 제이. 스피겔 | 5-ht1 작용물질로서의 아실아미노인돌 유도체 |
GB9207930D0 (en) * | 1992-04-10 | 1992-05-27 | Pfizer Ltd | Indoles |
GB9208463D0 (en) * | 1992-04-16 | 1992-06-03 | Merck Sharp & Dohme | Therapeutic agents |
GB9210400D0 (en) * | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
CZ282060B6 (cs) * | 1992-06-05 | 1997-05-14 | Merck Sharp And Dohme Limited | Sulfátová sůl substituovaného triazolu, způsob její výroby, farmaceutický prostředek s jejím obsahem a způsob jeho výroby |
GB9215526D0 (en) * | 1992-07-22 | 1992-09-02 | Merck Sharp & Dohme | Chemical process |
CA2138649A1 (en) * | 1992-07-24 | 1994-02-03 | Raymond Baker | Imidazole, triazole and tetrazole derivatives |
IL106445A (en) * | 1992-07-30 | 1998-01-04 | Merck Sharp & Dohme | History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them |
TW251284B (de) * | 1992-11-02 | 1995-07-11 | Pfizer | |
GB9226537D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
LT3594B (en) | 1993-07-29 | 1995-12-27 | Merck Sharp & Dohme | Imidazole,triazole and tetrazole derivatives |
ES2070087B1 (es) * | 1993-08-13 | 1996-02-16 | Pfizer | Derivados de indol |
US6423731B2 (en) | 1994-01-06 | 2002-07-23 | Zeneca Limited | Indole derivatives as prodrugs of 5-HT1-like receptor agonists |
GB9401436D0 (en) * | 1994-01-26 | 1994-03-23 | Wellcome Found | Therapeutic heterocyclic compounds |
GB9407447D0 (en) * | 1994-04-14 | 1994-06-08 | Glaxo Group Ltd | Chemical compounds |
PT765322E (pt) * | 1994-06-01 | 2002-01-30 | Astrazeneca Ab | Derivados indole pro-farmacos de agonistas de receptores tipo 5-ht1 |
JP3155008B2 (ja) * | 1994-07-26 | 2001-04-09 | ファイザー・インコーポレーテッド | セロトニンアゴニストおよびアンタゴニストとしての4−インドール誘導体 |
AU699281B2 (en) * | 1994-12-06 | 1998-11-26 | Merck Sharp & Dohme Limited | Azetidine, pyrrolidine and piperidine derivatives as 5HT1 receptor agonists |
GB9516143D0 (en) | 1995-08-07 | 1995-10-04 | Wellcome Found | Improved chemical synthesis |
GB9516145D0 (en) * | 1995-08-07 | 1995-10-04 | Wellcome Found | Improved chemical synthesis |
US6909005B1 (en) | 1995-08-07 | 2005-06-21 | Astrazeneca Uk Limited | One post synthesis of 2-oxazolidinone derivatives |
US5998438A (en) * | 1996-11-26 | 1999-12-07 | Allelix Biopharmaceuticals, Inc. | 5-cyclo indole compounds |
US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
WO2000000490A2 (en) * | 1998-06-26 | 2000-01-06 | Eli Lilly And Company | 5-ht1f agonists |
CN100378108C (zh) | 2002-06-21 | 2008-04-02 | 苏文生命科学有限公司 | 对血清素受体具有亲和力、可用作治疗剂的新型四环芳基磺酰吲哚、其制备方法及其药物组合物 |
RU2320663C2 (ru) | 2002-06-21 | 2008-03-27 | Сувен Лайф Сайенсиз Лимитед | Новые арилалкилиндолы с аффинностью к серотониновым рецепторам, пригодные в качестве лекарственных средств, способ их получения и содержащие их фармацевтические композиции |
KR100818508B1 (ko) | 2002-11-28 | 2008-03-31 | 수벤 라이프 사이언시스 리미티드 | 세로토닌 수용체 친화력을 가지는 엔-아릴술포닐-3-치환인돌, 그 제조방법 및 그를 포함하는 약제학적 조성물 |
KR100776118B1 (ko) | 2002-11-28 | 2007-11-15 | 수벤 라이프 사이언시스 리미티드 | 엔-아릴술포닐-3-아미노알콕시인돌 |
NZ540841A (en) | 2002-12-18 | 2008-08-29 | Suven Life Sciences Ltd | Tetracyclic 3-substituted indoles having serotonin receptor affinity |
DE102005018191A1 (de) * | 2005-04-19 | 2006-10-26 | Grünenthal GmbH | Substituierte zyklische Harnstoff-Derivate und deren Verwendung zur Herstellung von Arzneimitteln |
JP7126260B2 (ja) | 2016-01-27 | 2022-08-26 | インスター テクノロジーズ アクチオヴァ スプルチュノスト | 治療処置用の口腔粘膜ナノファイバ担体 |
CN112759550A (zh) * | 2019-11-04 | 2021-05-07 | 上海科技大学 | 一种平滑受体拮抗剂 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3678805D1 (de) | 1985-11-08 | 1991-05-23 | Glaxo Group Ltd | Indolderivate. |
GB8600397D0 (en) | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
-
1987
- 1987-10-23 GB GB878724912A patent/GB8724912D0/en active Pending
-
1988
- 1988-10-21 DK DK586588A patent/DK586588A/da not_active Application Discontinuation
- 1988-10-21 DE DE88309943T patent/DE3881472T2/de not_active Expired - Fee Related
- 1988-10-21 FI FI884879A patent/FI884879A/fi not_active Application Discontinuation
- 1988-10-21 EP EP88309943A patent/EP0313397B1/de not_active Expired - Lifetime
- 1988-10-21 IL IL88122A patent/IL88122A0/xx unknown
- 1988-10-21 DD DD88320940A patent/DD283140A5/de not_active IP Right Cessation
- 1988-10-21 JP JP63265917A patent/JP2501631B2/ja not_active Expired - Lifetime
- 1988-10-21 AT AT88309943T patent/ATE90089T1/de not_active IP Right Cessation
- 1988-10-21 ES ES88309943T patent/ES2054825T3/es not_active Expired - Lifetime
- 1988-10-21 PL PL1988275423A patent/PL158305B1/pl unknown
- 1988-10-21 PT PT88829A patent/PT88829B/pt not_active IP Right Cessation
- 1988-10-21 ZA ZA887900A patent/ZA887900B/xx unknown
- 1988-10-21 CN CN88108816A patent/CN1035113A/zh active Pending
- 1988-10-21 MC MC882012A patent/MC1983A1/xx unknown
- 1988-10-21 NZ NZ226671A patent/NZ226671A/xx unknown
- 1988-10-21 HU HU885431A patent/HU202230B/hu unknown
- 1988-10-24 AU AU24181/88A patent/AU604165B2/en not_active Ceased
Also Published As
Publication number | Publication date |
---|---|
MC1983A1 (fr) | 1989-11-23 |
EP0313397B1 (de) | 1993-06-02 |
ATE90089T1 (de) | 1993-06-15 |
FI884879A0 (fi) | 1988-10-21 |
PT88829B (pt) | 1993-01-29 |
PL275423A1 (en) | 1989-08-07 |
EP0313397A1 (de) | 1989-04-26 |
AU604165B2 (en) | 1990-12-06 |
DE3881472T2 (de) | 1993-12-16 |
ES2054825T3 (es) | 1994-08-16 |
IL88122A0 (en) | 1989-06-30 |
JP2501631B2 (ja) | 1996-05-29 |
ZA887900B (en) | 1990-06-27 |
DK586588A (da) | 1989-04-24 |
HUT50163A (en) | 1989-12-28 |
JPH01146882A (ja) | 1989-06-08 |
HU202230B (en) | 1991-02-28 |
PL158305B1 (en) | 1992-08-31 |
NZ226671A (en) | 1991-09-25 |
FI884879A (fi) | 1989-04-24 |
DK586588D0 (da) | 1988-10-21 |
AU2418188A (en) | 1989-04-27 |
CN1035113A (zh) | 1989-08-30 |
GB8724912D0 (en) | 1987-11-25 |
DD283140A5 (de) | 1990-10-03 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |