ZA887900B - Therapeutic heterocyclic compounds - Google Patents
Therapeutic heterocyclic compoundsInfo
- Publication number
- ZA887900B ZA887900B ZA887900A ZA887900A ZA887900B ZA 887900 B ZA887900 B ZA 887900B ZA 887900 A ZA887900 A ZA 887900A ZA 887900 A ZA887900 A ZA 887900A ZA 887900 B ZA887900 B ZA 887900B
- Authority
- ZA
- South Africa
- Prior art keywords
- aryl
- alkyl
- group
- benzyl
- independently selected
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
- C07D209/16—Tryptamines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pain & Pain Management (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Fats And Perfumes (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Indole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878724912A GB8724912D0 (en) | 1987-10-23 | 1987-10-23 | Indole derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ZA887900B true ZA887900B (en) | 1990-06-27 |
Family
ID=10625806
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ZA887900A ZA887900B (en) | 1987-10-23 | 1988-10-21 | Therapeutic heterocyclic compounds |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0313397B1 (de) |
| JP (1) | JP2501631B2 (de) |
| CN (1) | CN1035113A (de) |
| AT (1) | ATE90089T1 (de) |
| AU (1) | AU604165B2 (de) |
| DD (1) | DD283140A5 (de) |
| DE (1) | DE3881472T2 (de) |
| DK (1) | DK586588A (de) |
| ES (1) | ES2054825T3 (de) |
| FI (1) | FI884879A (de) |
| GB (1) | GB8724912D0 (de) |
| HU (1) | HU202230B (de) |
| IL (1) | IL88122A0 (de) |
| MC (1) | MC1983A1 (de) |
| NZ (1) | NZ226671A (de) |
| PL (1) | PL158305B1 (de) |
| PT (1) | PT88829B (de) |
| ZA (1) | ZA887900B (de) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT95899A (pt) * | 1989-11-17 | 1991-09-13 | Glaxo Group Ltd | Processo para a preparacao de derivados indole |
| IL96891A0 (en) * | 1990-01-17 | 1992-03-29 | Merck Sharp & Dohme | Indole-substituted five-membered heteroaromatic compounds,their preparation and pharmaceutical compositions containing them |
| DE4010797A1 (de) * | 1990-04-04 | 1991-10-10 | Hoechst Ag | Substituierte azole, verfahren zu deren herstellung, diese enthaltende mittel und deren verwendung |
| MC2210A1 (fr) * | 1990-06-07 | 1992-11-26 | Wellcome Found | Composes heterocycliques therapeutiques,leur utilisation et procede pour les preparer |
| EP0494774A1 (de) * | 1991-01-11 | 1992-07-15 | MERCK SHARP & DOHME LTD. | Indazol-substituierte 5-Kettenglieder heteroaromatische Verbindungen |
| US5317103A (en) * | 1991-01-15 | 1994-05-31 | Merck Sharp & Dohme Limited | Indole-substituted five-membered heteroaromatic compounds as 5-HT1 agonists |
| CZ283018B6 (cs) * | 1991-02-01 | 1997-12-17 | Merck Sharp And Dohme Limited | Deriváty imidazolu, triazolu a tetrazolu a farmaceutické přípravky na jejich bázi |
| TW263508B (de) * | 1991-02-12 | 1995-11-21 | Pfizer | |
| GB9104136D0 (en) * | 1991-02-27 | 1991-04-17 | Merck Sharp & Dohme | Therapeutic agents |
| ES2143992T3 (es) * | 1991-11-25 | 2000-06-01 | Pfizer | Derivados de 5-(hetero- o carbociclilamino)-indol, su preparacion y uso como 5-ht1 agonistas. |
| CA2083891A1 (en) * | 1991-12-03 | 1993-06-04 | Angus Murray Macleod | Heterocyclic compounds, compositions containing them and their use in therapy |
| US5409941A (en) * | 1992-02-03 | 1995-04-25 | Pfizer Inc. | 5-heteroyl indole derivatives |
| TW288010B (de) * | 1992-03-05 | 1996-10-11 | Pfizer | |
| JP3309982B2 (ja) * | 1992-03-13 | 2002-07-29 | メルク シヤープ エンド ドーム リミテツド | イミダゾール，トリアゾールおよびテトラゾール誘導体 |
| GB9207396D0 (en) * | 1992-04-03 | 1992-05-13 | Merck Sharp & Dohme | Therapeutic agents |
| US6380233B1 (en) | 1992-04-07 | 2002-04-30 | Pfizer Inc | Indole derivatives as 5-HT1 agonists |
| UA27467C2 (uk) | 1992-04-07 | 2000-09-15 | Пфайзер Інк. | ПОХІДНІ ІНДОЛУ ЯК 5-НТ<sub>1</sub> АГОНІСТИ ТА ПРОМІЖНІ СПОЛУКИ |
| GB9207930D0 (en) * | 1992-04-10 | 1992-05-27 | Pfizer Ltd | Indoles |
| AU670270B2 (en) * | 1992-04-10 | 1996-07-11 | Pfizer Inc. | Acylaminoindole derivatives as 5-HT1 agonists |
| GB9208463D0 (en) * | 1992-04-16 | 1992-06-03 | Merck Sharp & Dohme | Therapeutic agents |
| GB9210400D0 (en) * | 1992-05-15 | 1992-07-01 | Merck Sharp & Dohme | Therapeutic agents |
| GB9211277D0 (en) | 1992-05-28 | 1992-07-15 | Glaxo Group Inc | Pharmaceutical compositions |
| UA27908C2 (uk) * | 1992-06-05 | 2000-10-16 | Мерк Шарп Енд Дом Лімітед | Сульфатна сіль n,n-диметил-2-[5-(1,2,4-триазол-1ілметил)-1н-індол-3-іл]етиламіну та/або її сольвати, фармацевтична композиція на її основі, спосіб одержання фармацевтичної композиції і спосіб лікування |
| GB9215526D0 (en) * | 1992-07-22 | 1992-09-02 | Merck Sharp & Dohme | Chemical process |
| JPH07509452A (ja) * | 1992-07-24 | 1995-10-19 | メルク シヤープ エンド ドーム リミテツド | イミダゾール，トリアゾール及びテトラゾール誘導体 |
| IL106445A (en) * | 1992-07-30 | 1998-01-04 | Merck Sharp & Dohme | History of 1,2,4-Trans-Triazole 4-Transform, Preparation and Pharmaceutical Preparations Containing Them |
| TW251284B (de) * | 1992-11-02 | 1995-07-11 | Pfizer | |
| GB9226537D0 (en) * | 1992-12-21 | 1993-02-17 | Smithkline Beecham Plc | Compounds |
| LT3594B (en) | 1993-07-29 | 1995-12-27 | Merck Sharp & Dohme | Imidazole,triazole and tetrazole derivatives |
| ES2070087B1 (es) * | 1993-08-13 | 1996-02-16 | Pfizer | Derivados de indol |
| US6423731B2 (en) | 1994-01-06 | 2002-07-23 | Zeneca Limited | Indole derivatives as prodrugs of 5-HT1-like receptor agonists |
| GB9401436D0 (en) * | 1994-01-26 | 1994-03-23 | Wellcome Found | Therapeutic heterocyclic compounds |
| GB9407447D0 (en) * | 1994-04-14 | 1994-06-08 | Glaxo Group Ltd | Chemical compounds |
| ES2161892T3 (es) * | 1994-06-01 | 2001-12-16 | Astrazeneca Ab | Derivados de indol como profarmacos de agonistas de los receptores afines a 5-ht1. |
| MX9700693A (es) * | 1994-07-26 | 1997-04-30 | Pfizer | Derivados del 4-indol. |
| JPH10509721A (ja) * | 1994-12-06 | 1998-09-22 | メルク シヤープ エンド ドーム リミテツド | ５ｈｔ１レセプターアゴニストとしてのアゼチジン、ピロリジン及びピペリジン誘導体 |
| GB9516145D0 (en) * | 1995-08-07 | 1995-10-04 | Wellcome Found | Improved chemical synthesis |
| US6909005B1 (en) | 1995-08-07 | 2005-06-21 | Astrazeneca Uk Limited | One post synthesis of 2-oxazolidinone derivatives |
| GB9516143D0 (en) | 1995-08-07 | 1995-10-04 | Wellcome Found | Improved chemical synthesis |
| US5998438A (en) * | 1996-11-26 | 1999-12-07 | Allelix Biopharmaceuticals, Inc. | 5-cyclo indole compounds |
| US7189753B1 (en) | 1997-11-06 | 2007-03-13 | Cady Roger K | Preemptive prophylaxis of migraine |
| AU4961499A (en) * | 1998-06-26 | 2000-01-17 | Eli Lilly And Company | 5-HT1f agonists |
| DE60329607D1 (de) | 2002-06-21 | 2009-11-19 | Suven Life Sciences Ltd | Sich als therapeutische mittel eignende arylalkylindole mit affinität für den serotoninrezeptor, verfahren zu deren herstellung und pharmazeutische zusammensetzungen, die diese enthalten |
| CN100378108C (zh) | 2002-06-21 | 2008-04-02 | 苏文生命科学有限公司 | 对血清素受体具有亲和力、可用作治疗剂的新型四环芳基磺酰吲哚、其制备方法及其药物组合物 |
| AU2003237599B2 (en) | 2002-11-28 | 2009-06-18 | Suven Life Sciences Limited | N-arylsulfonyl-3-substituted indoles having serotonin receptor affinity, process for their preparation and pharmaceutical composition containing them |
| WO2004048328A2 (en) | 2002-11-28 | 2004-06-10 | Suven Life Sciences Limited | N-arylsulfonyl-3-aminoalkoxyindoles |
| EP1581538B1 (de) | 2002-12-18 | 2007-02-28 | Suven Life Sciences Limited | Tetrazyklische 3-substituierte indole mit serotoninrezeptoraffinität |
| DE102005018191A1 (de) * | 2005-04-19 | 2006-10-26 | Grünenthal GmbH | Substituierte zyklische Harnstoff-Derivate und deren Verwendung zur Herstellung von Arzneimitteln |
| CN108697637A (zh) | 2016-01-27 | 2018-10-23 | 因斯塔尔科技股份公司 | 用于治疗性处理的口腔粘膜纳米纤维载体 |
| CN112759550A (zh) * | 2019-11-04 | 2021-05-07 | 上海科技大学 | 一种平滑受体拮抗剂 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3678805D1 (de) | 1985-11-08 | 1991-05-23 | Glaxo Group Ltd | Indolderivate. |
| GB8600397D0 (en) | 1986-01-08 | 1986-02-12 | Glaxo Group Ltd | Chemical compounds |
-
1987
- 1987-10-23 GB GB878724912A patent/GB8724912D0/en active Pending
-
1988
- 1988-10-21 ZA ZA887900A patent/ZA887900B/xx unknown
- 1988-10-21 AT AT88309943T patent/ATE90089T1/de not_active IP Right Cessation
- 1988-10-21 JP JP63265917A patent/JP2501631B2/ja not_active Expired - Lifetime
- 1988-10-21 PT PT88829A patent/PT88829B/pt not_active IP Right Cessation
- 1988-10-21 FI FI884879A patent/FI884879A/fi not_active Application Discontinuation
- 1988-10-21 DE DE88309943T patent/DE3881472T2/de not_active Expired - Fee Related
- 1988-10-21 DK DK586588A patent/DK586588A/da not_active Application Discontinuation
- 1988-10-21 PL PL1988275423A patent/PL158305B1/pl unknown
- 1988-10-21 ES ES88309943T patent/ES2054825T3/es not_active Expired - Lifetime
- 1988-10-21 MC MC882012A patent/MC1983A1/xx unknown
- 1988-10-21 DD DD88320940A patent/DD283140A5/de not_active IP Right Cessation
- 1988-10-21 EP EP88309943A patent/EP0313397B1/de not_active Expired - Lifetime
- 1988-10-21 HU HU885431A patent/HU202230B/hu unknown
- 1988-10-21 IL IL88122A patent/IL88122A0/xx unknown
- 1988-10-21 NZ NZ226671A patent/NZ226671A/xx unknown
- 1988-10-21 CN CN88108816A patent/CN1035113A/zh active Pending
- 1988-10-24 AU AU24181/88A patent/AU604165B2/en not_active Ceased
Also Published As
| Publication number | Publication date |
|---|---|
| AU604165B2 (en) | 1990-12-06 |
| HU202230B (en) | 1991-02-28 |
| DD283140A5 (de) | 1990-10-03 |
| FI884879A0 (fi) | 1988-10-21 |
| CN1035113A (zh) | 1989-08-30 |
| ATE90089T1 (de) | 1993-06-15 |
| PT88829B (pt) | 1993-01-29 |
| AU2418188A (en) | 1989-04-27 |
| IL88122A0 (en) | 1989-06-30 |
| PL158305B1 (en) | 1992-08-31 |
| DK586588A (da) | 1989-04-24 |
| DE3881472D1 (de) | 1993-07-08 |
| HUT50163A (en) | 1989-12-28 |
| PL275423A1 (en) | 1989-08-07 |
| JPH01146882A (ja) | 1989-06-08 |
| DK586588D0 (da) | 1988-10-21 |
| EP0313397B1 (de) | 1993-06-02 |
| FI884879A (fi) | 1989-04-24 |
| JP2501631B2 (ja) | 1996-05-29 |
| NZ226671A (en) | 1991-09-25 |
| EP0313397A1 (de) | 1989-04-26 |
| ES2054825T3 (es) | 1994-08-16 |
| DE3881472T2 (de) | 1993-12-16 |
| GB8724912D0 (en) | 1987-11-25 |
| MC1983A1 (fr) | 1989-11-23 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ZA887900B (en) | Therapeutic heterocyclic compounds | |
| CA2282890A1 (en) | Therapeutic heterocyclic compounds | |
| DE10199003I2 (de) | ||
| MA21502A1 (fr) | 4--phenyl-(-piperazinyl)phenols et procedes pour leur preparation . | |
| ATE79376T1 (de) | Dithioacetal-verbindungen, verfahren zu deren herstellung und diese enthaltende pharmazeutische zusammensetzungen. | |
| IL103944A0 (en) | Piperazine derivatives,their preparation and pharmaceutical compositions containing them | |
| MY131193A (en) | 7-(2-aminoethyl)-benzothiazolones | |
| NO163855C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive arylcyklobutylalkylaminer. | |
| SI1216245T1 (en) | Pharmaceutically active sulfonyl hydrazide derivatives | |
| ATE110721T1 (de) | 2-alkyl-3-benzoylbenzofurane und diese enthaltende pharmazeutische zusammensetzungen. | |
| ES8403887A1 (es) | Procedimiento de obtencion de los 2-amino 5- (aralcoil piperidino alcoil) amino 1,4-diazoles | |
| FI853233L (fi) | 1,6-naftyridinderivat, foerfarande foer deras framstaellning och dessa innehaollande farmaceutiska produkter. | |
| AU597923B2 (en) | 5-aminoalkyl-beta-carboline derivatives, their production and their use as drugs | |
| ATE160567T1 (de) | Psoralen-derivate, deren herstellung und verwendung als arzneimittel | |
| TH11701EX (th) | สารประกอบเฮเทโรไซคลิคที่ใช้ในการรักษาโรค |