ES2161892T3 - Derivados de indol como profarmacos de agonistas de los receptores afines a 5-ht1. - Google Patents

Derivados de indol como profarmacos de agonistas de los receptores afines a 5-ht1.

Info

Publication number
ES2161892T3
ES2161892T3 ES95921004T ES95921004T ES2161892T3 ES 2161892 T3 ES2161892 T3 ES 2161892T3 ES 95921004 T ES95921004 T ES 95921004T ES 95921004 T ES95921004 T ES 95921004T ES 2161892 T3 ES2161892 T3 ES 2161892T3
Authority
ES
Spain
Prior art keywords
pct
formula
4alkyl
hydrogen
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES95921004T
Other languages
English (en)
Inventor
Robert John Blade
Yih Sang Pang
David Lawrence Selwood
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca AB
Original Assignee
AstraZeneca AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by AstraZeneca AB filed Critical AstraZeneca AB
Application granted granted Critical
Publication of ES2161892T3 publication Critical patent/ES2161892T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

UN COMPUESTO DE FORMULA (I), DONDE A ES UN ALQUILO C 1-6, -O-ALQUILO C1-6, -O-FENILO O FENILO, OPCIONALMENTE SUSTITUIDO CON HALOGENO O ALQUILO C1-3; N ES UN ENTERO DE 0 A 3; W ES UN GRUPO DE FORMULA (I), (II), O (III), DONDE R ES HIDROGENO, O ALQUILO C1-4, X ES -O-, -S-, -NH- O -CH{SUB,2}-, Y ES OXIGENO O AZUFRE, Y EL CENTRO QUIRAL EN LA FORMULA (I) O (II), ESTA EN SU FORMA (S) O (R), O ES UNA MEZCLA DE LAS MISMAS EN CUALQUIER PROPORCION; Y Z ES UN GRUPO DE FORMULA (IV) -CH2 CH2 NR1 R2-, (V) O (VI), DONDE R1 Y R2, SON SELECCIONADOS INDEPENDIENTEMENTE ENTRE HIDROGENO, Y ALQUILO C1-4, Y R3 ES HIDROGENO O ALQUILO C1-4; ASI COMO LAS SALES, SOLVATOS, Y DERIVADOS FISIOLOGICAMENTE FUNCIONALES DE LOS MISMOS.
ES95921004T 1994-06-01 1995-05-31 Derivados de indol como profarmacos de agonistas de los receptores afines a 5-ht1. Expired - Lifetime ES2161892T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP94303928 1994-06-01

Publications (1)

Publication Number Publication Date
ES2161892T3 true ES2161892T3 (es) 2001-12-16

Family

ID=8217728

Family Applications (1)

Application Number Title Priority Date Filing Date
ES95921004T Expired - Lifetime ES2161892T3 (es) 1994-06-01 1995-05-31 Derivados de indol como profarmacos de agonistas de los receptores afines a 5-ht1.

Country Status (11)

Country Link
US (1) US5962486A (es)
EP (1) EP0765322B1 (es)
JP (1) JP3262800B2 (es)
AT (1) ATE203533T1 (es)
AU (1) AU2621995A (es)
DE (1) DE69521895T2 (es)
DK (1) DK0765322T3 (es)
ES (1) ES2161892T3 (es)
GR (1) GR3036953T3 (es)
PT (1) PT765322E (es)
WO (1) WO1995032966A1 (es)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9515305D0 (en) * 1995-07-26 1995-09-20 Wellcome Found Therapeutic heterocyclic compounds
US6909005B1 (en) * 1995-08-07 2005-06-21 Astrazeneca Uk Limited One post synthesis of 2-oxazolidinone derivatives
ES2212814T3 (es) * 1996-10-31 2004-08-01 Harbor Branch Oceanographic Institution, Inc. Uso de compuestos y composiciones antiinflamatorias neurogenicas.
WO1999042092A2 (en) 1998-02-20 1999-08-26 Harbor Branch Oceanographic Institution, Inc. Compounds and methods of use for treatment of neurogenic inflammation

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8724912D0 (en) * 1987-10-23 1987-11-25 Wellcome Found Indole derivatives
RU2160736C2 (ru) * 1990-06-07 2000-12-20 Зенека Лимитед Производные индола и их физиологически приемлемые соли и сольваты, способы их получения, лекарственное средство для лечения или профилактики клинических состояний, для которых показан прием агониста "5-нт1-подобного" рецептора, и способ его получения
TW263508B (es) * 1991-02-12 1995-11-21 Pfizer
GB9208463D0 (en) * 1992-04-16 1992-06-03 Merck Sharp & Dohme Therapeutic agents
FR2701026B1 (fr) * 1993-02-02 1995-03-31 Adir Nouveaux dérivés de l'indole, de l'indazole et du benzisoxazole, leur procédé de préparation et les compositions pharmaceutiques qui les contiennent.

Also Published As

Publication number Publication date
AU2621995A (en) 1995-12-21
WO1995032966A1 (en) 1995-12-07
JPH10500987A (ja) 1998-01-27
JP3262800B2 (ja) 2002-03-04
DE69521895T2 (de) 2002-04-04
PT765322E (pt) 2002-01-30
DK0765322T3 (da) 2001-10-22
DE69521895D1 (de) 2001-08-30
EP0765322B1 (en) 2001-07-25
US5962486A (en) 1999-10-05
ATE203533T1 (de) 2001-08-15
GR3036953T3 (en) 2002-01-31
EP0765322A1 (en) 1997-04-02

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