DD266735A5 - Verfahren zur herstellung einer racemischen verbindung - Google Patents

Verfahren zur herstellung einer racemischen verbindung Download PDF

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Publication number
DD266735A5
DD266735A5 DD87299297A DD29929787A DD266735A5 DD 266735 A5 DD266735 A5 DD 266735A5 DD 87299297 A DD87299297 A DD 87299297A DD 29929787 A DD29929787 A DD 29929787A DD 266735 A5 DD266735 A5 DD 266735A5
Authority
DD
German Democratic Republic
Prior art keywords
hydroxy
product
fluoro
added
water
Prior art date
Application number
DD87299297A
Other languages
German (de)
English (en)
Inventor
Christopher A Lipinski
Original Assignee
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Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by ������@���Kk�� filed Critical ������@���Kk��
Publication of DD266735A5 publication Critical patent/DD266735A5/de

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
DD87299297A 1986-01-17 1987-01-16 Verfahren zur herstellung einer racemischen verbindung DD266735A5 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US1986/000091 WO1987004344A1 (fr) 1986-01-17 1986-01-17 Derives de l'acide hydroxyacetique pour le traitement de complications diabetiques

Publications (1)

Publication Number Publication Date
DD266735A5 true DD266735A5 (de) 1989-04-12

Family

ID=22195340

Family Applications (1)

Application Number Title Priority Date Filing Date
DD87299297A DD266735A5 (de) 1986-01-17 1987-01-16 Verfahren zur herstellung einer racemischen verbindung

Country Status (26)

Country Link
US (1) US4853410A (fr)
EP (1) EP0230379B1 (fr)
JP (1) JPS62169775A (fr)
KR (1) KR890004104B1 (fr)
CN (1) CN1015545B (fr)
AT (1) ATE62237T1 (fr)
AU (1) AU574001B2 (fr)
CA (1) CA1283119C (fr)
DD (1) DD266735A5 (fr)
DE (1) DE3768966D1 (fr)
DK (1) DK21687A (fr)
EG (1) EG18353A (fr)
ES (1) ES2022319B3 (fr)
FI (1) FI94636C (fr)
GR (1) GR3001863T3 (fr)
HU (1) HU206618B (fr)
IE (1) IE59450B1 (fr)
IL (1) IL81261A (fr)
NO (1) NO171411C (fr)
NZ (1) NZ218970A (fr)
PH (2) PH22231A (fr)
PL (1) PL148082B1 (fr)
PT (1) PT84107B (fr)
WO (1) WO1987004344A1 (fr)
YU (1) YU46042B (fr)
ZA (1) ZA87309B (fr)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT84806B (pt) * 1986-05-03 1989-12-29 Beecham Group Plc Processo para a preparacao de benzopiranos
AU2440599A (en) * 1998-02-25 1999-09-15 Shionogi & Co., Ltd. Therapeutic agent for complication of diabetes
AT502844B1 (de) * 2005-12-12 2007-08-15 Fronius Int Gmbh Schweissbrenner und endstück sowie kontaktrohr für einen schweissbrenner
BRPI0919578A2 (pt) * 2008-10-02 2018-10-09 Cambrex Karlskoga Ab produto, composto, e processos para o isolamento de um composto e para a preparação de dronedarona ou um sal do mesmo, de uma formulação farmacêutica compreendendo dronedarona ou um sinal do mesmo e de um intermediário de dronedarona ou um sal do mesmo
CN105924425B (zh) * 2016-04-29 2018-06-05 浙江师范大学 一种制备二氢硫色满衍生物的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3359161A (en) * 1963-08-29 1967-12-19 Kefalas As Thiaxanthenols, process of producing and anti-tussive compositions thereof
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
US4117230A (en) * 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
US4210663A (en) * 1978-11-08 1980-07-01 Pfizer Inc. Halogen substituted benzopyran- and benzothiopyran-4-carboxylic acids
US4286098A (en) * 1980-03-28 1981-08-25 Pfizer Inc. Process for the preparation of chiral hydantoins
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
US4305955A (en) * 1980-10-21 1981-12-15 Pfizer Inc. Carboxylic acid therapeutic agents
ATE11781T1 (de) * 1981-05-13 1985-02-15 Imperial Chemical Industries Plc Pharmazeutische zubereitungen, die spirosuccinimidderivate enthalten.
US4486428A (en) * 1982-03-16 1984-12-04 Pfizer Inc. Bicyclic benzo fused compounds

Also Published As

Publication number Publication date
AU574001B2 (en) 1988-06-23
YU5787A (en) 1988-04-30
PL263678A1 (en) 1988-04-14
FI94636C (fi) 1995-10-10
PT84107B (pt) 1989-07-31
YU46042B (sh) 1992-12-21
PT84107A (en) 1987-02-01
KR870007149A (ko) 1987-08-17
WO1987004344A1 (fr) 1987-07-30
NO873854D0 (no) 1987-09-15
NO171411C (no) 1993-03-10
FI873843A0 (fi) 1987-09-04
NO171411B (no) 1992-11-30
AU6764187A (en) 1987-07-30
IL81261A (en) 1992-05-25
IL81261A0 (en) 1987-08-31
PH24703A (en) 1990-10-01
FI94636B (fi) 1995-06-30
DK21687A (da) 1987-07-18
HUT48230A (en) 1989-05-29
EG18353A (en) 1993-02-28
JPH0586952B2 (fr) 1993-12-14
HU206618B (en) 1992-12-28
CN87100191A (zh) 1987-09-09
DE3768966D1 (de) 1991-05-08
GR3001863T3 (en) 1992-11-23
CN1015545B (zh) 1992-02-19
JPS62169775A (ja) 1987-07-25
DK21687D0 (da) 1987-01-16
EP0230379B1 (fr) 1991-04-03
PL148082B1 (en) 1989-09-30
FI873843A (fi) 1987-09-04
KR890004104B1 (ko) 1989-10-20
EP0230379A2 (fr) 1987-07-29
PH22231A (en) 1988-07-01
ZA87309B (fr) 1988-07-18
CA1283119C (fr) 1991-04-16
NO873854L (no) 1987-09-15
ES2022319B3 (es) 1991-12-01
ATE62237T1 (de) 1991-04-15
NZ218970A (en) 1988-11-29
IE59450B1 (en) 1994-02-23
US4853410A (en) 1989-08-01
IE870131L (en) 1987-07-17
EP0230379A3 (en) 1988-10-05

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