KR870007149A - 하이드록시아세트산 유도체의 제조방법 - Google Patents

하이드록시아세트산 유도체의 제조방법 Download PDF

Info

Publication number
KR870007149A
KR870007149A KR870000338A KR870000338A KR870007149A KR 870007149 A KR870007149 A KR 870007149A KR 870000338 A KR870000338 A KR 870000338A KR 870000338 A KR870000338 A KR 870000338A KR 870007149 A KR870007149 A KR 870007149A
Authority
KR
South Korea
Prior art keywords
chloro
fluoro
hydrogen
methyl
bromo
Prior art date
Application number
KR870000338A
Other languages
English (en)
Other versions
KR890004104B1 (ko
Inventor
앤드류 리핀스키 크리스토퍼
Original Assignee
윌리암 데이비스 휸
화이자 인코포레이티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 윌리암 데이비스 휸, 화이자 인코포레이티드 filed Critical 윌리암 데이비스 휸
Publication of KR870007149A publication Critical patent/KR870007149A/ko
Application granted granted Critical
Publication of KR890004104B1 publication Critical patent/KR890004104B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D335/00—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom
    • C07D335/04—Heterocyclic compounds containing six-membered rings having one sulfur atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D335/06—Benzothiopyrans; Hydrogenated benzothiopyrans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/04—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring
    • C07D311/22—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4
    • C07D311/26—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3
    • C07D311/28—Benzo[b]pyrans, not hydrogenated in the carbocyclic ring with oxygen or sulfur atoms directly attached in position 4 with aromatic rings attached in position 2 or 3 with aromatic rings attached in position 2 only
    • C07D311/32—2,3-Dihydro derivatives, e.g. flavanones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/96—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings spiro-condensed with carbocyclic rings or ring systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Diabetes (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)

Abstract

내용 없음

Description

하이드록시아세트산 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (6)

  1. 하기 일반식(Ⅰ)화합물이 라세미체인 경우에는 하기 일반식(Ⅱ)의 상응하는 라세미체 에스테르를 가수분해하거나 ; 일반식(Ⅰ)화합물이 광학적으로 활성인 경우에는 일반식(Ⅰ)의 상응하는 라세미 화합물을 광학적으로 분할함을 특징으로 하여, 하기의 절대 입체화학식(Ⅰ)을 갖는 광학적 활성 화합물 또는 상대 입체화학식(Ⅰ)을 갖는 라세미 화합물, 또는 이의 약제학적으로 허용되는 양이온성 염을 제조하는 방법.
    상기식에서,
    Z는 -O-,-S-,, 또는이고 ;
    R1및 R2는 각각 별도로 R1은 (C1-4)알킬, 트리플루오로메틸 또는 (CH2)nAr 〔여기서, n은 0,1, 또는 2이고, Ar은 페닐, 또는 메톡시, 플루오로, 클로로 또는 브로모에 의해 일치환되거나 동일하거나 상이하게 이치환된 페닐이다〕이며, R2는 수소, 메틸 또는 에틸이거나 ;
    R1및 R2가 함께는 (CH2)4또는 (CH2)5이고 ;
    R3는 수소 또는 메틸이며, 단, Z가 -0-가 아니거나 R1이 메틸, 에틸 또는 트리플루오로메틸이 아닌 경우에 R2및 R3는 모두 수소이고 ;
    X는 수소이거나 6-위치에서의 제 1 치환체로서 플루오로, 클로로, 브로모, 메틸, 니트로, 시아노, 메탄설포닐 또는 벤조일이고, 단, Z가 -0-가 아닌 경우에 X는 수소가 아니며 6-위치에서의 제 1 치환체로서 플루오로, 클로로, 시아노 또는 니트로이며 ;
    X1및 X2는 각각 별도로 X1은 수소이거나 7-위치에서의 제 1 치환체로서 플루오로, 클로로, 브로모, 카복시 또는 메틸이거나, 5-또는 7-위치에서의 제 2 치환체로서 플루오로, 클로로, 브로모, (C1-C3)알킬, (C1-C3)알콕시 또는 벤질옥시이고, X2는 수소이거나 8-위치에서의 제 1 또는 제 2 치환체로서 플루오로, 클로로, 브로모 또는(C1-C3)알킬이거나, X1및 X2는 함께는 7,8-벤조이며 ;
    R은 (C1-C4)알킬, 알릴 또는 페닐이다.
  2. 제 1 항에 있어서, Z가-0-이고 R1이 메틸이며 R2및 R3가 각각 수소인 방법.
  3. 제 2 항에 있어서, X가 6-클로로 또는 6-플루오로이고 X1이 7-브로모, 7-클로로, 7-플루오로 또는 7-메틸이며 X2가 수소인 방법.
  4. 제 3 항에 있어서, 광학적 활성이 있는 방법.
  5. 제 4 항에 있어서 X가 6-플루오로이고 X1이 7-클로로인 방법.
  6. 제 4 항에 있어서, X1이 6-클로로이고 X2가 7-클로로인 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019870000338A 1986-01-17 1987-01-17 하이드록시아세트산 유도체 KR890004104B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US8600091 1986-01-17
PCT/US1986/000091 WO1987004344A1 (en) 1986-01-17 1986-01-17 Hydroxyacetic acid derivatives for the treatment of diabetic complications
USPCT/US86/00091 1986-01-17

Publications (2)

Publication Number Publication Date
KR870007149A true KR870007149A (ko) 1987-08-17
KR890004104B1 KR890004104B1 (ko) 1989-10-20

Family

ID=22195340

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019870000338A KR890004104B1 (ko) 1986-01-17 1987-01-17 하이드록시아세트산 유도체

Country Status (26)

Country Link
US (1) US4853410A (ko)
EP (1) EP0230379B1 (ko)
JP (1) JPS62169775A (ko)
KR (1) KR890004104B1 (ko)
CN (1) CN1015545B (ko)
AT (1) ATE62237T1 (ko)
AU (1) AU574001B2 (ko)
CA (1) CA1283119C (ko)
DD (1) DD266735A5 (ko)
DE (1) DE3768966D1 (ko)
DK (1) DK21687A (ko)
EG (1) EG18353A (ko)
ES (1) ES2022319B3 (ko)
FI (1) FI94636C (ko)
GR (1) GR3001863T3 (ko)
HU (1) HU206618B (ko)
IE (1) IE59450B1 (ko)
IL (1) IL81261A (ko)
NO (1) NO171411C (ko)
NZ (1) NZ218970A (ko)
PH (2) PH22231A (ko)
PL (1) PL148082B1 (ko)
PT (1) PT84107B (ko)
WO (1) WO1987004344A1 (ko)
YU (1) YU46042B (ko)
ZA (1) ZA87309B (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT84806B (pt) * 1986-05-03 1989-12-29 Beecham Group Plc Processo para a preparacao de benzopiranos
WO1999043315A1 (fr) * 1998-02-25 1999-09-02 Shionogi & Co., Ltd. Agent therapeutique utilisable en cas de complication de diabetes
AT502844B1 (de) * 2005-12-12 2007-08-15 Fronius Int Gmbh Schweissbrenner und endstück sowie kontaktrohr für einen schweissbrenner
CN102171200B (zh) * 2008-10-02 2015-09-30 坎布雷卡尔斯库加公司 用于制备二酮类和药物的方法
CN105924425B (zh) * 2016-04-29 2018-06-05 浙江师范大学 一种制备二氢硫色满衍生物的方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3359161A (en) * 1963-08-29 1967-12-19 Kefalas As Thiaxanthenols, process of producing and anti-tussive compositions thereof
US3821383A (en) * 1972-07-10 1974-06-28 Ayerst Mckenna & Harrison Compositions for and a method of treating diabetic complications
US4117230A (en) * 1976-10-18 1978-09-26 Pfizer Inc. Hydantoin derivatives as therapeutic agents
US4130714A (en) * 1977-05-23 1978-12-19 Pfizer Inc. Hydantoin therapeutic agents
US4200642A (en) * 1978-08-21 1980-04-29 Pfizer Inc. Spiro-oxazolidindiones
US4210663A (en) * 1978-11-08 1980-07-01 Pfizer Inc. Halogen substituted benzopyran- and benzothiopyran-4-carboxylic acids
US4286098A (en) * 1980-03-28 1981-08-25 Pfizer Inc. Process for the preparation of chiral hydantoins
JPS5745185A (en) * 1980-07-21 1982-03-13 Eisai Co Ltd Hydantoin derivative and its preparation
US4305955A (en) * 1980-10-21 1981-12-15 Pfizer Inc. Carboxylic acid therapeutic agents
ATE11781T1 (de) * 1981-05-13 1985-02-15 Imperial Chemical Industries Plc Pharmazeutische zubereitungen, die spirosuccinimidderivate enthalten.
US4486428A (en) * 1982-03-16 1984-12-04 Pfizer Inc. Bicyclic benzo fused compounds

Also Published As

Publication number Publication date
EP0230379B1 (en) 1991-04-03
IL81261A (en) 1992-05-25
HUT48230A (en) 1989-05-29
EG18353A (en) 1993-02-28
NO873854D0 (no) 1987-09-15
DD266735A5 (de) 1989-04-12
YU5787A (en) 1988-04-30
DK21687D0 (da) 1987-01-16
FI94636B (fi) 1995-06-30
PT84107B (pt) 1989-07-31
PH24703A (en) 1990-10-01
EP0230379A2 (en) 1987-07-29
DE3768966D1 (de) 1991-05-08
ES2022319B3 (es) 1991-12-01
NO171411B (no) 1992-11-30
FI873843A0 (fi) 1987-09-04
PH22231A (en) 1988-07-01
FI94636C (fi) 1995-10-10
PL263678A1 (en) 1988-04-14
ZA87309B (ko) 1988-07-18
HU206618B (en) 1992-12-28
AU6764187A (en) 1987-07-30
EP0230379A3 (en) 1988-10-05
NO873854L (no) 1987-09-15
PT84107A (en) 1987-02-01
CN87100191A (zh) 1987-09-09
CA1283119C (en) 1991-04-16
NZ218970A (en) 1988-11-29
NO171411C (no) 1993-03-10
US4853410A (en) 1989-08-01
ATE62237T1 (de) 1991-04-15
DK21687A (da) 1987-07-18
CN1015545B (zh) 1992-02-19
JPS62169775A (ja) 1987-07-25
FI873843A (fi) 1987-09-04
PL148082B1 (en) 1989-09-30
JPH0586952B2 (ko) 1993-12-14
YU46042B (sh) 1992-12-21
IE59450B1 (en) 1994-02-23
IL81261A0 (en) 1987-08-31
IE870131L (en) 1987-07-17
GR3001863T3 (en) 1992-11-23
KR890004104B1 (ko) 1989-10-20
AU574001B2 (en) 1988-06-23
WO1987004344A1 (en) 1987-07-30

Similar Documents

Publication Publication Date Title
KR850003890A (ko) 1H-이미다조[4,5c]-퀴놀린-4-아민의 제조방법
KR890006642A (ko) 벤족사진 화합물 및 그의 약제학적 용도
PT92378A (pt) Processo para a preparacao de derivados de cromano, activos sobre o sistema nervoso central
KR930023362A (ko) 술포닐벤질 치환 벤조피리돈 및 피리도피리돈
KR870007149A (ko) 하이드록시아세트산 유도체의 제조방법
KR900006317A (ko) 퀴놀린 유도체 그의 제법 및 치료요법에 있어서의 그의 이용
IE821394L (en) N-(4,5-dihydrothiazol-2-yl)-3-quinoline carboxamide¹derivatives
KR880009958A (ko) 치환된 3,4-디하이드로-2h-벤조피란, 그의 제조방법 및 용도
KR970006302A (ko) 4-아미노-3-아실나프티리딘 유도체
KR920004394A (ko) 티에노디아제핀 이의 제조방법 및 paf-길항 활성을 지닌 약제학적 조성물로서의 이의 용도
AU583375B2 (en) 2,4-diphenyl-1,3-dioxanes
KR910020004A (ko) 이소크로만 유도체
PT97032A (pt) Processo para a preparacao de derivado do acido (benzidriloxi-etilpiperidil)-alifatico utilizaveis como agente anti-histaminicos
KR850007600A (ko) 테트라히드로티에노피리딘의 제조방법
PT878548E (pt) Processo de varias etapas para a producao de (1s,4r)- e/ou (1r.4s)-4-(2-amino-6-cloro-9-h-purin-9-il)-2-ciclopenten-1-metanol
KR880007494A (ko) 5-아릴-3h-1,2,4-트리아졸-3-온 및 진경제로서의 그들의 용도
KR890701095A (ko) 생물학적 활성 화합물
KR880005138A (ko) 신규 화합물들
NO840131L (no) Fremgangsmaate ved fremstilling av nye bicyklo (4.2.0)1,3,5-oktarienderivater
KR880007499A (ko) 광학적으로 활성인 2,3-디하이드로 벤즈옥사진 유도체 및 이의 제조방법
FI955386A (fi) 4-p-fluoribentsoyyli-1-piperidinyyli-propoksi-kromen-4-onijohdannaiset, niiden valmistus ja käyttö psykoosin ja skitsofrenian hoidossa
ES2062223T3 (es) Derivados de imidazol, procedimiento para la preparacion de los mismos y agentes antiulcera que los contienen.
MX9100450A (es) Reduccion de niveles de acido urico en la sangre
DE59010041D1 (de) Herstellung von Dioxolanderivaten
KR930019642A (ko) 치환된 페닐퀴나졸린 유도체

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 19950830

Year of fee payment: 7

LAPS Lapse due to unpaid annual fee