DD222015A5 - Verfahren zur herstellung von 1-substituierten azetidin-3-ol-derivaten - Google Patents
Verfahren zur herstellung von 1-substituierten azetidin-3-ol-derivaten Download PDFInfo
- Publication number
- DD222015A5 DD222015A5 DD84262630A DD26263084A DD222015A5 DD 222015 A5 DD222015 A5 DD 222015A5 DD 84262630 A DD84262630 A DD 84262630A DD 26263084 A DD26263084 A DD 26263084A DD 222015 A5 DD222015 A5 DD 222015A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- formula
- derivatives
- acid halide
- hal
- aqueous medium
- Prior art date
Links
- -1 1-SUBSTITUTED AZETIDINE-3-OL Chemical class 0.000 title claims abstract description 13
- 238000004519 manufacturing process Methods 0.000 title abstract 2
- 150000004820 halides Chemical class 0.000 claims abstract description 12
- 239000002253 acid Substances 0.000 claims abstract description 11
- 239000012736 aqueous medium Substances 0.000 claims abstract description 7
- 238000002360 preparation method Methods 0.000 claims abstract description 7
- 125000000217 alkyl group Chemical group 0.000 claims abstract description 5
- 150000001875 compounds Chemical class 0.000 claims abstract description 5
- 125000005843 halogen group Chemical group 0.000 claims abstract description 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 4
- 150000002440 hydroxy compounds Chemical class 0.000 claims abstract description 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract description 3
- 125000003118 aryl group Chemical group 0.000 claims abstract description 3
- 125000002924 primary amino group Chemical class [H]N([H])* 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims description 14
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 11
- 238000007363 ring formation reaction Methods 0.000 claims description 7
- 239000003960 organic solvent Substances 0.000 claims description 6
- 238000006243 chemical reaction Methods 0.000 claims description 5
- 239000000203 mixture Substances 0.000 claims description 5
- 239000002585 base Substances 0.000 claims description 3
- 150000008044 alkali metal hydroxides Chemical class 0.000 claims description 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 2
- 238000009835 boiling Methods 0.000 claims description 2
- 125000004432 carbon atom Chemical group C* 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- 125000001309 chloro group Chemical group Cl* 0.000 claims description 2
- 150000002148 esters Chemical class 0.000 claims description 2
- 150000005826 halohydrocarbons Chemical class 0.000 claims description 2
- 150000002576 ketones Chemical class 0.000 claims description 2
- 150000002828 nitro derivatives Chemical class 0.000 claims description 2
- 238000010992 reflux Methods 0.000 claims description 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 1
- 239000000543 intermediate Substances 0.000 abstract description 4
- 125000005002 aryl methyl group Chemical group 0.000 abstract description 2
- GFZWHAAOIVMHOI-UHFFFAOYSA-N azetidine-3-carboxylic acid Chemical class OC(=O)C1CNC1 GFZWHAAOIVMHOI-UHFFFAOYSA-N 0.000 abstract description 2
- 230000008635 plant growth Effects 0.000 abstract description 2
- 239000004593 Epoxy Substances 0.000 abstract 1
- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 12
- YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 12
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 6
- LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 6
- WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 6
- 239000000047 product Substances 0.000 description 5
- QPFMBZIOSGYJDE-UHFFFAOYSA-N 1,1,2,2-tetrachloroethane Chemical compound ClC(Cl)C(Cl)Cl QPFMBZIOSGYJDE-UHFFFAOYSA-N 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- LQNUZADURLCDLV-UHFFFAOYSA-N nitrobenzene Chemical compound [O-][N+](=O)C1=CC=CC=C1 LQNUZADURLCDLV-UHFFFAOYSA-N 0.000 description 4
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 3
- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 3
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- GMWFCJXSQQHBPI-UHFFFAOYSA-N azetidin-3-ol Chemical class OC1CNC1 GMWFCJXSQQHBPI-UHFFFAOYSA-N 0.000 description 3
- 239000007787 solid Substances 0.000 description 3
- RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 2
- XNPBVLLNKJHQAO-UHFFFAOYSA-N 1-(benzylamino)-3-chloropropan-2-ol Chemical compound ClCC(O)CNCC1=CC=CC=C1 XNPBVLLNKJHQAO-UHFFFAOYSA-N 0.000 description 2
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 2
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 2
- HEDRZPFGACZZDS-MICDWDOJSA-N Trichloro(2H)methane Chemical compound [2H]C(Cl)(Cl)Cl HEDRZPFGACZZDS-MICDWDOJSA-N 0.000 description 2
- 238000004587 chromatography analysis Methods 0.000 description 2
- 229930195733 hydrocarbon Natural products 0.000 description 2
- 150000002430 hydrocarbons Chemical class 0.000 description 2
- 150000003141 primary amines Chemical class 0.000 description 2
- 239000011541 reaction mixture Substances 0.000 description 2
- 238000001953 recrystallisation Methods 0.000 description 2
- 239000002904 solvent Substances 0.000 description 2
- VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 239000004215 Carbon black (E152) Substances 0.000 description 1
- 241000736839 Chara Species 0.000 description 1
- 241000251730 Chondrichthyes Species 0.000 description 1
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 1
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 1
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 1
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- 150000001412 amines Chemical class 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 239000012431 aqueous reaction media Substances 0.000 description 1
- 239000007864 aqueous solution Substances 0.000 description 1
- HONIICLYMWZJFZ-UHFFFAOYSA-N azetidine Chemical compound C1CNC1 HONIICLYMWZJFZ-UHFFFAOYSA-N 0.000 description 1
- PBIUUJCEMUAWJJ-UHFFFAOYSA-N azetidine-3-carbonitrile Chemical class N#CC1CNC1 PBIUUJCEMUAWJJ-UHFFFAOYSA-N 0.000 description 1
- 150000001539 azetidines Chemical class 0.000 description 1
- 150000001540 azides Chemical class 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 230000000052 comparative effect Effects 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- MGHPNCMVUAKAIE-UHFFFAOYSA-N diphenylmethanamine Chemical compound C=1C=CC=CC=1C(N)C1=CC=CC=C1 MGHPNCMVUAKAIE-UHFFFAOYSA-N 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 229910052739 hydrogen Inorganic materials 0.000 description 1
- 238000010348 incorporation Methods 0.000 description 1
- 239000002198 insoluble material Substances 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002156 mixing Methods 0.000 description 1
- 150000002894 organic compounds Chemical class 0.000 description 1
- 150000002924 oxiranes Chemical class 0.000 description 1
- QARVLSVVCXYDNA-UHFFFAOYSA-N phenyl bromide Natural products BrC1=CC=CC=C1 QARVLSVVCXYDNA-UHFFFAOYSA-N 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 125000006239 protecting group Chemical group 0.000 description 1
- 230000009993 protective function Effects 0.000 description 1
- 239000000376 reactant Substances 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 239000000741 silica gel Substances 0.000 description 1
- 229910002027 silica gel Inorganic materials 0.000 description 1
- 230000001954 sterilising effect Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D205/00—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom
- C07D205/02—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D205/04—Heterocyclic compounds containing four-membered rings with one nitrogen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Epoxy Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB838312104A GB8312104D0 (en) | 1983-05-04 | 1983-05-04 | Preparation of 1-substituted azetidin-3-ol derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD222015A5 true DD222015A5 (de) | 1985-05-08 |
Family
ID=10542093
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD84262630A DD222015A5 (de) | 1983-05-04 | 1984-05-02 | Verfahren zur herstellung von 1-substituierten azetidin-3-ol-derivaten |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4560507A (cs) |
| EP (1) | EP0125714B1 (cs) |
| JP (1) | JPS59206350A (cs) |
| KR (1) | KR840009086A (cs) |
| AT (1) | ATE30718T1 (cs) |
| AU (1) | AU563050B2 (cs) |
| BR (1) | BR8402056A (cs) |
| CA (1) | CA1240685A (cs) |
| CS (1) | CS244813B2 (cs) |
| DD (1) | DD222015A5 (cs) |
| DE (1) | DE3467345D1 (cs) |
| ES (1) | ES532098A0 (cs) |
| GB (1) | GB8312104D0 (cs) |
| HU (1) | HU191682B (cs) |
| IL (1) | IL71722A (cs) |
| SU (1) | SU1318156A3 (cs) |
| ZA (1) | ZA843258B (cs) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8412814D0 (en) * | 1984-05-18 | 1984-06-27 | Shell Int Research | 1-substituted azetidine-3-ol derivatives |
| GB8419085D0 (en) * | 1984-07-26 | 1984-08-30 | Shell Int Research | Azetidine derivatives |
| GB8627493D0 (en) * | 1986-11-18 | 1986-12-17 | Shell Int Research | Catalytic hydrogenolysis |
| CN1157224C (zh) * | 1999-02-18 | 2004-07-14 | 科研制药株式会社 | 用作生长激素促分泌剂的新酰胺衍生物 |
| CN101911773B (zh) * | 2008-01-16 | 2013-12-04 | 阿尔卡特朗讯美国公司 | 用于有限目的的接入网络 |
| CN115385840B (zh) * | 2022-09-05 | 2024-07-02 | 北京京宇复瑞科技集团有限责任公司 | 制备3-甲氧基氮杂环丁烷盐酸盐的方法 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE934508C (de) * | 1954-04-23 | 1955-10-27 | Dehydag Gmbh | Verfahren zur Herstellung galvanischer Metallueberzuege |
| DE1111638B (de) * | 1956-06-22 | 1961-07-27 | Ernst Schneider Dipl Chem Dr R | Verfahren zur Herstellung von Trimethyleniminverbindungen |
| GB1236078A (en) * | 1968-07-04 | 1971-06-16 | Beecham Group Ltd | Substituted azetidinols |
| US3649618A (en) * | 1970-10-02 | 1972-03-14 | Abbott Lab | Certain 1-aralkyl azetidines |
| US4341887A (en) * | 1980-03-07 | 1982-07-27 | Petrolite Corporation | Azetidinium salts and polymers and copolymers thereof |
-
1983
- 1983-05-04 GB GB838312104A patent/GB8312104D0/en active Pending
-
1984
- 1984-04-10 CA CA000451647A patent/CA1240685A/en not_active Expired
- 1984-04-13 AT AT84200534T patent/ATE30718T1/de not_active IP Right Cessation
- 1984-04-13 DE DE8484200534T patent/DE3467345D1/de not_active Expired
- 1984-04-13 EP EP84200534A patent/EP0125714B1/en not_active Expired
- 1984-04-27 US US06/604,696 patent/US4560507A/en not_active Expired - Fee Related
- 1984-05-02 JP JP59087982A patent/JPS59206350A/ja active Pending
- 1984-05-02 BR BR8402056A patent/BR8402056A/pt not_active IP Right Cessation
- 1984-05-02 KR KR1019840002377A patent/KR840009086A/ko not_active Withdrawn
- 1984-05-02 ZA ZA843258A patent/ZA843258B/xx unknown
- 1984-05-02 CS CS843245A patent/CS244813B2/cs unknown
- 1984-05-02 AU AU27586/84A patent/AU563050B2/en not_active Ceased
- 1984-05-02 DD DD84262630A patent/DD222015A5/de not_active IP Right Cessation
- 1984-05-02 IL IL71722A patent/IL71722A/xx unknown
- 1984-05-02 HU HU841701A patent/HU191682B/hu not_active IP Right Cessation
- 1984-05-02 ES ES532098A patent/ES532098A0/es active Granted
- 1984-05-03 SU SU843735695A patent/SU1318156A3/ru active
Also Published As
| Publication number | Publication date |
|---|---|
| ATE30718T1 (de) | 1987-11-15 |
| US4560507A (en) | 1985-12-24 |
| ZA843258B (en) | 1984-12-24 |
| IL71722A0 (en) | 1984-09-30 |
| CS244813B2 (en) | 1986-08-14 |
| ES8505947A1 (es) | 1985-06-16 |
| KR840009086A (ko) | 1984-12-24 |
| EP0125714A1 (en) | 1984-11-21 |
| CA1240685A (en) | 1988-08-16 |
| AU2758684A (en) | 1984-11-08 |
| EP0125714B1 (en) | 1987-11-11 |
| GB8312104D0 (en) | 1983-06-08 |
| IL71722A (en) | 1987-12-20 |
| HUT34002A (en) | 1985-01-28 |
| AU563050B2 (en) | 1987-06-25 |
| CS324584A2 (en) | 1985-09-17 |
| BR8402056A (pt) | 1984-12-11 |
| HU191682B (en) | 1987-03-30 |
| DE3467345D1 (en) | 1987-12-17 |
| ES532098A0 (es) | 1985-06-16 |
| JPS59206350A (ja) | 1984-11-22 |
| SU1318156A3 (ru) | 1987-06-15 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ENJ | Ceased due to non-payment of renewal fee |