DD209462A5 - Verfahren zur herstellung von 6-aminoalkylpenicillansaeure-1,1-dioxiden und derivaten als beta-lactamase-inhibitoren - Google Patents

Verfahren zur herstellung von 6-aminoalkylpenicillansaeure-1,1-dioxiden und derivaten als beta-lactamase-inhibitoren Download PDF

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Publication number
DD209462A5
DD209462A5 DD83247166A DD24716683A DD209462A5 DD 209462 A5 DD209462 A5 DD 209462A5 DD 83247166 A DD83247166 A DD 83247166A DD 24716683 A DD24716683 A DD 24716683A DD 209462 A5 DD209462 A5 DD 209462A5
Authority
DD
German Democratic Republic
Prior art keywords
title product
beta
benzyl
acid
ethyl acetate
Prior art date
Application number
DD83247166A
Other languages
German (de)
English (en)
Inventor
Wayne E Barth
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/388,323 external-priority patent/US4427678A/en
Priority claimed from US06/434,371 external-priority patent/US4452796A/en
Application filed by Pfizer filed Critical Pfizer
Publication of DD209462A5 publication Critical patent/DD209462A5/de

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
DD83247166A 1982-01-11 1983-01-11 Verfahren zur herstellung von 6-aminoalkylpenicillansaeure-1,1-dioxiden und derivaten als beta-lactamase-inhibitoren DD209462A5 (de)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33879782A 1982-01-11 1982-01-11
US38832482A 1982-06-14 1982-06-14
US06/388,323 US4427678A (en) 1982-01-11 1982-06-14 6-Aminomethylpenicillanic acid 1,1-dioxide derivatives as beta-lactamase inhibitors
US06/434,371 US4452796A (en) 1982-06-14 1982-10-21 6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors

Publications (1)

Publication Number Publication Date
DD209462A5 true DD209462A5 (de) 1984-05-09

Family

ID=27502592

Family Applications (2)

Application Number Title Priority Date Filing Date
DD83247166A DD209462A5 (de) 1982-01-11 1983-01-11 Verfahren zur herstellung von 6-aminoalkylpenicillansaeure-1,1-dioxiden und derivaten als beta-lactamase-inhibitoren
DD83262053A DD218365A5 (de) 1982-01-11 1983-01-11 Verfahren zur herstellung von 6-aminomethylpenicillansaeure-1,1-dioxid-derivaten als beta-lactamase-inhibitoren

Family Applications After (1)

Application Number Title Priority Date Filing Date
DD83262053A DD218365A5 (de) 1982-01-11 1983-01-11 Verfahren zur herstellung von 6-aminomethylpenicillansaeure-1,1-dioxid-derivaten als beta-lactamase-inhibitoren

Country Status (20)

Country Link
EP (1) EP0084925B1 (es)
JP (1) JPH0689005B2 (es)
AU (1) AU538468B2 (es)
BG (1) BG42676A3 (es)
CA (1) CA1190921A (es)
DD (2) DD209462A5 (es)
DE (1) DE3362826D1 (es)
DK (1) DK166883B1 (es)
ES (2) ES518912A0 (es)
FI (1) FI79112C (es)
GR (1) GR77152B (es)
HU (1) HU189211B (es)
IE (1) IE54390B1 (es)
IL (1) IL67647A (es)
NO (6) NO830046L (es)
NZ (1) NZ202982A (es)
PL (1) PL142315B1 (es)
PT (1) PT76077B (es)
RO (2) RO87705A (es)
YU (1) YU43646B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499017A (en) * 1983-06-06 1985-02-12 Pfizer Inc. Beta-lactamase inhibiting 6-(alkoxyamino-methyl) penicillanic acid 1,1-dioxide and derivatives
US4502990A (en) * 1983-06-06 1985-03-05 Pfizer Inc. Process for 6-(aminomethyl)penicillanic acid 1,1-dioxide and derivatives thereof
JPS60239489A (ja) * 1984-05-15 1985-11-28 Meiji Seika Kaisha Ltd ６−エピペニシリンスルホン化合物及びその製造方法
GB2206579B (en) * 1987-07-10 1991-05-29 Erba Farmitalia 6a and 6b-(substituted methyl)-penicillanic acid derivatives
WO2008141764A1 (en) * 2007-05-21 2008-11-27 Hans Rudolf Pfaendler Bactericidal anti-mrsa active pharmaceutical composition containing carbapenems

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237051A (en) * 1979-04-19 1980-12-02 Schering Corporation Stereospecific production of 6- or 7-carbon-substituted-β-lactams
DE2927004A1 (de) * 1979-07-04 1981-05-27 Bayer Ag, 5090 Leverkusen Penicillansaeure-1,1-dioxide, ihre herstellung und ihre verwendung als arzneimittel als arzneimittel
US4287181A (en) * 1979-10-22 1981-09-01 Pfizer Inc. Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors

Also Published As

Publication number Publication date
NO841068L (no) 1983-07-12
PL142315B1 (en) 1987-10-31
ES525238A0 (es) 1985-08-16
ES8403489A1 (es) 1984-03-16
RO84910B (ro) 1984-09-30
CA1190921A (en) 1985-07-23
PT76077A (en) 1983-02-01
IE54390B1 (en) 1989-09-13
FI830081A0 (fi) 1983-01-10
DE3362826D1 (en) 1986-05-15
RO87705A (ro) 1985-10-31
IL67647A (en) 1986-08-31
NO833415L (no) 1983-07-12
GR77152B (es) 1984-09-07
DK166883B1 (da) 1993-07-26
RO84910A (ro) 1984-08-17
JPS58126889A (ja) 1983-07-28
IL67647A0 (en) 1983-05-15
NZ202982A (en) 1986-04-11
NO830046L (no) 1983-07-12
JPH0689005B2 (ja) 1994-11-09
NO841070L (no) 1983-07-12
PL240108A1 (en) 1985-08-13
BG42676A3 (en) 1988-01-15
AU538468B2 (en) 1984-08-16
EP0084925B1 (en) 1986-04-09
FI79112B (fi) 1989-07-31
RO87705B (ro) 1985-10-01
FI79112C (fi) 1989-11-10
YU43646B (en) 1989-10-31
NO841069L (no) 1983-07-12
FI830081L (fi) 1983-07-12
ES518912A0 (es) 1984-03-16
IE830042L (en) 1983-07-11
AU1023283A (en) 1983-07-21
HU189211B (en) 1986-06-30
YU4483A (en) 1986-02-28
DD218365A5 (de) 1985-02-06
EP0084925A1 (en) 1983-08-03
DK7483D0 (da) 1983-01-10
DK7483A (da) 1983-07-12
PT76077B (en) 1986-01-09
ES8507147A1 (es) 1985-08-16
NO833416L (no) 1983-07-12

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NAH Public notice for inspection of foreign-language patent applications (havanna treaty)
ENJ Ceased due to non-payment of renewal fee