RO84910B - Procedeu pentru prepararea unor derivati 1, 1-dioxizi ai acidului 6-aminoalchilpenicilanic - Google Patents
Procedeu pentru prepararea unor derivati 1, 1-dioxizi ai acidului 6-aminoalchilpenicilanicInfo
- Publication number
- RO84910B RO84910B RO109609A RO10960983A RO84910B RO 84910 B RO84910 B RO 84910B RO 109609 A RO109609 A RO 109609A RO 10960983 A RO10960983 A RO 10960983A RO 84910 B RO84910 B RO 84910B
- Authority
- RO
- Romania
- Prior art keywords
- preparation
- hydrogen
- acid
- alkylpenicillanic
- amino
- Prior art date
Links
- 239000002253 acid Substances 0.000 title 1
- 229910052739 hydrogen Inorganic materials 0.000 abstract 3
- 239000001257 hydrogen Substances 0.000 abstract 3
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 3
- 125000001231 benzoyloxy group Chemical group C(C1=CC=CC=C1)(=O)O* 0.000 abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 2
- -1 pivaloyloxymethyl Chemical group 0.000 abstract 2
- 125000006795 (C2-C7) alkoxycarbonyloxy group Chemical group 0.000 abstract 1
- NGHVIOIJCVXTGV-ALEPSDHESA-N 6-aminopenicillanic acid Chemical compound [O-]C(=O)[C@H]1C(C)(C)S[C@@H]2[C@H]([NH3+])C(=O)N21 NGHVIOIJCVXTGV-ALEPSDHESA-N 0.000 abstract 1
- NGHVIOIJCVXTGV-UHFFFAOYSA-N 6beta-amino-penicillanic acid Natural products OC(=O)C1C(C)(C)SC2C(N)C(=O)N21 NGHVIOIJCVXTGV-UHFFFAOYSA-N 0.000 abstract 1
- 125000004423 acyloxy group Chemical group 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 125000000217 alkyl group Chemical group 0.000 abstract 1
- 230000000844 anti-bacterial effect Effects 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 230000004962 physiological condition Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
- A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
- A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/429—Thiazoles condensed with heterocyclic ring systems
- A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Inventia se refera la un procedeu pentru prepararea unor derivati 1,1-dioxizi ai acidului 6-aminopenicilanic, cu activitate antibacteriana, cu formula stereochimica generala Ia sau Ib; (vezi formula) în care R este hidrogen sau metil si cînd n este 2, R este -CH2- iar cînd n este 1, R1 este hidrogen, un radical ce formeaza un ester hidrolizabil în conditii fiziologice ales dintre pivaloiloximetil si acetoximetil, o grupa 1,1-dioxopenicilanoiloximetil sau o grupa cu formula: (vezi formula) în care Y este hidrogen, hidroxi, alcanoiloxi cu 2...7 atomi de carbon, alcoxicarboniloxi cu 2...7 atomi de carbon, benzoiloxi sau benzoiloxi monosubstituit cu alchil cu 1...4 atomi de carbon, alcoxi cu 1...4 atomi de carbon sau halogen.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US33879782A | 1982-01-11 | 1982-01-11 | |
| US38832482A | 1982-06-14 | 1982-06-14 | |
| US06/388,323 US4427678A (en) | 1982-01-11 | 1982-06-14 | 6-Aminomethylpenicillanic acid 1,1-dioxide derivatives as beta-lactamase inhibitors |
| US06/434,371 US4452796A (en) | 1982-06-14 | 1982-10-21 | 6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RO84910A RO84910A (ro) | 1984-08-17 |
| RO84910B true RO84910B (ro) | 1984-09-30 |
Family
ID=27502592
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO109609A RO84910B (ro) | 1982-01-11 | 1983-01-04 | Procedeu pentru prepararea unor derivati 1, 1-dioxizi ai acidului 6-aminoalchilpenicilanic |
| RO83113375A RO87705A (ro) | 1982-01-11 | 1983-01-04 | Procedeu pentru prepararea unor derivati ai acidului 6-aminoalchilpenicilanic 1,1-dioxid |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO83113375A RO87705A (ro) | 1982-01-11 | 1983-01-04 | Procedeu pentru prepararea unor derivati ai acidului 6-aminoalchilpenicilanic 1,1-dioxid |
Country Status (20)
| Country | Link |
|---|---|
| EP (1) | EP0084925B1 (ro) |
| JP (1) | JPH0689005B2 (ro) |
| AU (1) | AU538468B2 (ro) |
| BG (1) | BG42676A3 (ro) |
| CA (1) | CA1190921A (ro) |
| DD (2) | DD218365A5 (ro) |
| DE (1) | DE3362826D1 (ro) |
| DK (1) | DK166883B1 (ro) |
| ES (2) | ES8403489A1 (ro) |
| FI (1) | FI79112C (ro) |
| GR (1) | GR77152B (ro) |
| HU (1) | HU189211B (ro) |
| IE (1) | IE54390B1 (ro) |
| IL (1) | IL67647A (ro) |
| NO (6) | NO830046L (ro) |
| NZ (1) | NZ202982A (ro) |
| PL (1) | PL142315B1 (ro) |
| PT (1) | PT76077B (ro) |
| RO (2) | RO84910B (ro) |
| YU (1) | YU43646B (ro) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4502990A (en) * | 1983-06-06 | 1985-03-05 | Pfizer Inc. | Process for 6-(aminomethyl)penicillanic acid 1,1-dioxide and derivatives thereof |
| US4499017A (en) * | 1983-06-06 | 1985-02-12 | Pfizer Inc. | Beta-lactamase inhibiting 6-(alkoxyamino-methyl) penicillanic acid 1,1-dioxide and derivatives |
| JPS60239489A (ja) * | 1984-05-15 | 1985-11-28 | Meiji Seika Kaisha Ltd | ６−エピペニシリンスルホン化合物及びその製造方法 |
| GB2206579B (en) * | 1987-07-10 | 1991-05-29 | Erba Farmitalia | 6a and 6b-(substituted methyl)-penicillanic acid derivatives |
| NZ580178A (en) * | 2007-05-21 | 2011-01-28 | Hans Rudolf Pfaendler | Bactericidal anti-mrsa active pharmaceutical composition containing carbapenems |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4237051A (en) * | 1979-04-19 | 1980-12-02 | Schering Corporation | Stereospecific production of 6- or 7-carbon-substituted-β-lactams |
| DE2927004A1 (de) * | 1979-07-04 | 1981-05-27 | Bayer Ag, 5090 Leverkusen | Penicillansaeure-1,1-dioxide, ihre herstellung und ihre verwendung als arzneimittel als arzneimittel |
| US4287181A (en) * | 1979-10-22 | 1981-09-01 | Pfizer Inc. | Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors |
-
1983
- 1983-01-04 RO RO109609A patent/RO84910B/ro unknown
- 1983-01-04 RO RO83113375A patent/RO87705A/ro unknown
- 1983-01-05 DE DE8383300042T patent/DE3362826D1/de not_active Expired
- 1983-01-05 EP EP83300042A patent/EP0084925B1/en not_active Expired
- 1983-01-07 GR GR70215A patent/GR77152B/el unknown
- 1983-01-07 NO NO830046A patent/NO830046L/no unknown
- 1983-01-10 PT PT76077A patent/PT76077B/pt not_active IP Right Cessation
- 1983-01-10 IL IL67647A patent/IL67647A/xx not_active IP Right Cessation
- 1983-01-10 CA CA000419181A patent/CA1190921A/en not_active Expired
- 1983-01-10 IE IE42/83A patent/IE54390B1/en not_active IP Right Cessation
- 1983-01-10 BG BG059284A patent/BG42676A3/xx unknown
- 1983-01-10 YU YU44/83A patent/YU43646B/xx unknown
- 1983-01-10 FI FI830081A patent/FI79112C/fi not_active IP Right Cessation
- 1983-01-10 NZ NZ202982A patent/NZ202982A/en unknown
- 1983-01-10 DK DK007483A patent/DK166883B1/da active
- 1983-01-10 AU AU10232/83A patent/AU538468B2/en not_active Ceased
- 1983-01-10 HU HU8370A patent/HU189211B/hu not_active IP Right Cessation
- 1983-01-11 ES ES518912A patent/ES8403489A1/es not_active Expired
- 1983-01-11 DD DD83262053A patent/DD218365A5/de not_active IP Right Cessation
- 1983-01-11 JP JP58002768A patent/JPH0689005B2/ja not_active Expired - Lifetime
- 1983-01-11 DD DD83247166A patent/DD209462A5/de not_active IP Right Cessation
- 1983-01-11 PL PL1983240108A patent/PL142315B1/pl unknown
- 1983-08-30 ES ES525238A patent/ES525238A0/es active Granted
- 1983-09-22 NO NO833416A patent/NO833416L/no unknown
- 1983-09-22 NO NO833415A patent/NO833415L/no unknown
-
1984
- 1984-03-20 NO NO841069A patent/NO841069L/no unknown
- 1984-03-20 NO NO841068A patent/NO841068L/no unknown
- 1984-03-20 NO NO841070A patent/NO841070L/no unknown
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