RO84910B - Procedeu pentru prepararea unor derivati 1, 1-dioxizi ai acidului 6-aminoalchilpenicilanic - Google Patents

Procedeu pentru prepararea unor derivati 1, 1-dioxizi ai acidului 6-aminoalchilpenicilanic

Info

Publication number
RO84910B
RO84910B RO109609A RO10960983A RO84910B RO 84910 B RO84910 B RO 84910B RO 109609 A RO109609 A RO 109609A RO 10960983 A RO10960983 A RO 10960983A RO 84910 B RO84910 B RO 84910B
Authority
RO
Romania
Prior art keywords
preparation
hydrogen
acid
alkylpenicillanic
amino
Prior art date
Application number
RO109609A
Other languages
English (en)
Other versions
RO84910A (ro
Inventor
Wayne Ernest Barth
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/388,323 external-priority patent/US4427678A/en
Priority claimed from US06/434,371 external-priority patent/US4452796A/en
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of RO84910A publication Critical patent/RO84910A/ro
Publication of RO84910B publication Critical patent/RO84910B/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor derivati 1,1-dioxizi ai acidului 6-aminopenicilanic, cu activitate antibacteriana, cu formula stereochimica generala Ia sau Ib; (vezi formula) în care R este hidrogen sau metil si cînd n este 2, R este -CH2- iar cînd n este 1, R1 este hidrogen, un radical ce formeaza un ester hidrolizabil în conditii fiziologice ales dintre pivaloiloximetil si acetoximetil, o grupa 1,1-dioxopenicilanoiloximetil sau o grupa cu formula: (vezi formula) în care Y este hidrogen, hidroxi, alcanoiloxi cu 2...7 atomi de carbon, alcoxicarboniloxi cu 2...7 atomi de carbon, benzoiloxi sau benzoiloxi monosubstituit cu alchil cu 1...4 atomi de carbon, alcoxi cu 1...4 atomi de carbon sau halogen.
RO109609A 1982-01-11 1983-01-04 Procedeu pentru prepararea unor derivati 1, 1-dioxizi ai acidului 6-aminoalchilpenicilanic RO84910B (ro)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33879782A 1982-01-11 1982-01-11
US38832482A 1982-06-14 1982-06-14
US06/388,323 US4427678A (en) 1982-01-11 1982-06-14 6-Aminomethylpenicillanic acid 1,1-dioxide derivatives as beta-lactamase inhibitors
US06/434,371 US4452796A (en) 1982-06-14 1982-10-21 6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors

Publications (2)

Publication Number Publication Date
RO84910A RO84910A (ro) 1984-08-17
RO84910B true RO84910B (ro) 1984-09-30

Family

ID=27502592

Family Applications (2)

Application Number Title Priority Date Filing Date
RO109609A RO84910B (ro) 1982-01-11 1983-01-04 Procedeu pentru prepararea unor derivati 1, 1-dioxizi ai acidului 6-aminoalchilpenicilanic
RO83113375A RO87705A (ro) 1982-01-11 1983-01-04 Procedeu pentru prepararea unor derivati ai acidului 6-aminoalchilpenicilanic 1,1-dioxid

Family Applications After (1)

Application Number Title Priority Date Filing Date
RO83113375A RO87705A (ro) 1982-01-11 1983-01-04 Procedeu pentru prepararea unor derivati ai acidului 6-aminoalchilpenicilanic 1,1-dioxid

Country Status (20)

Country Link
EP (1) EP0084925B1 (ro)
JP (1) JPH0689005B2 (ro)
AU (1) AU538468B2 (ro)
BG (1) BG42676A3 (ro)
CA (1) CA1190921A (ro)
DD (2) DD209462A5 (ro)
DE (1) DE3362826D1 (ro)
DK (1) DK166883B1 (ro)
ES (2) ES518912A0 (ro)
FI (1) FI79112C (ro)
GR (1) GR77152B (ro)
HU (1) HU189211B (ro)
IE (1) IE54390B1 (ro)
IL (1) IL67647A (ro)
NO (6) NO830046L (ro)
NZ (1) NZ202982A (ro)
PL (1) PL142315B1 (ro)
PT (1) PT76077B (ro)
RO (2) RO84910B (ro)
YU (1) YU43646B (ro)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499017A (en) * 1983-06-06 1985-02-12 Pfizer Inc. Beta-lactamase inhibiting 6-(alkoxyamino-methyl) penicillanic acid 1,1-dioxide and derivatives
US4502990A (en) * 1983-06-06 1985-03-05 Pfizer Inc. Process for 6-(aminomethyl)penicillanic acid 1,1-dioxide and derivatives thereof
JPS60239489A (ja) * 1984-05-15 1985-11-28 Meiji Seika Kaisha Ltd ６−エピペニシリンスルホン化合物及びその製造方法
GB2206579B (en) * 1987-07-10 1991-05-29 Erba Farmitalia 6a and 6b-(substituted methyl)-penicillanic acid derivatives
US8415339B2 (en) * 2007-05-21 2013-04-09 Hans Rudolf Pfaendler Bactericidal anti-MRSA active pharmaceutical composition containing carbapenems

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237051A (en) * 1979-04-19 1980-12-02 Schering Corporation Stereospecific production of 6- or 7-carbon-substituted-β-lactams
DE2927004A1 (de) * 1979-07-04 1981-05-27 Bayer Ag, 5090 Leverkusen Penicillansaeure-1,1-dioxide, ihre herstellung und ihre verwendung als arzneimittel als arzneimittel
US4287181A (en) * 1979-10-22 1981-09-01 Pfizer Inc. Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors

Also Published As

Publication number Publication date
RO84910A (ro) 1984-08-17
ES8403489A1 (es) 1984-03-16
PL142315B1 (en) 1987-10-31
FI830081A0 (fi) 1983-01-10
NO841069L (no) 1983-07-12
ES518912A0 (es) 1984-03-16
HU189211B (en) 1986-06-30
NZ202982A (en) 1986-04-11
NO841068L (no) 1983-07-12
JPH0689005B2 (ja) 1994-11-09
IE54390B1 (en) 1989-09-13
DD209462A5 (de) 1984-05-09
FI830081L (fi) 1983-07-12
YU43646B (en) 1989-10-31
EP0084925A1 (en) 1983-08-03
IE830042L (en) 1983-07-11
ES525238A0 (es) 1985-08-16
ES8507147A1 (es) 1985-08-16
JPS58126889A (ja) 1983-07-28
CA1190921A (en) 1985-07-23
FI79112C (fi) 1989-11-10
DK7483A (da) 1983-07-12
AU538468B2 (en) 1984-08-16
RO87705A (ro) 1985-10-31
PT76077A (en) 1983-02-01
DD218365A5 (de) 1985-02-06
NO830046L (no) 1983-07-12
DE3362826D1 (en) 1986-05-15
DK7483D0 (da) 1983-01-10
FI79112B (fi) 1989-07-31
AU1023283A (en) 1983-07-21
PL240108A1 (en) 1985-08-13
EP0084925B1 (en) 1986-04-09
DK166883B1 (da) 1993-07-26
NO841070L (no) 1983-07-12
IL67647A0 (en) 1983-05-15
RO87705B (ro) 1985-10-01
BG42676A3 (en) 1988-01-15
NO833416L (no) 1983-07-12
NO833415L (no) 1983-07-12
IL67647A (en) 1986-08-31
PT76077B (en) 1986-01-09
YU4483A (en) 1986-02-28
GR77152B (ro) 1984-09-07

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