ES8507147A1 - Un procedimiento para la preparacion de derivados del acido penicilanico 6alfa-o-6beta-sustituidos. - Google Patents

Un procedimiento para la preparacion de derivados del acido penicilanico 6alfa-o-6beta-sustituidos.

Info

Publication number
ES8507147A1
ES8507147A1 ES525238A ES525238A ES8507147A1 ES 8507147 A1 ES8507147 A1 ES 8507147A1 ES 525238 A ES525238 A ES 525238A ES 525238 A ES525238 A ES 525238A ES 8507147 A1 ES8507147 A1 ES 8507147A1
Authority
ES
Spain
Prior art keywords
beta
lactamase inhibitors
esters
dioxides
acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES525238A
Other languages
English (en)
Other versions
ES525238A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pfizer Inc
Original Assignee
Pfizer Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US06/388,323 external-priority patent/US4427678A/en
Priority claimed from US06/434,371 external-priority patent/US4452796A/en
Application filed by Pfizer Inc filed Critical Pfizer Inc
Publication of ES525238A0 publication Critical patent/ES525238A0/es
Publication of ES8507147A1 publication Critical patent/ES8507147A1/es
Expired legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/542—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

UN PROCEDIMIENTO PARA LA PREPARACION DE DERIVADOS DEL ACIDO PENICILANICO 6BAB- O 6BBB-SUSTITUIDOS.COMPRENDE: HACER REACCIONAR UN COMPUESTO AMINOMETILICO DE FORMULA II, CON UN ALDEHIDO DE FORMULA; W-CHO, DONDE W ES UN RADICAL SELECCIONADO ENTRE FENILO, ORTO- Y OTROS, EN PRESENCIA DE UN EXCESO DE CIANOBOROHIDRURO SODICO; Y CONVERTIR EL COMPUESTO OBTENIDO EN UNA SAL DE ADICION DE ACIDO FARMACEUTICAMENTE ACEPTABLE DE FORMULA I, EN DONDE Q ES BENCILO, ORTO-, META- U OTROS, R7 ES H O UN RADICAL FORMADOR DE UN ESTER QUE ES HIDROLIZABLE BAJO LAS CONDICIONES FISIOLOGICAS Y LA LINEA ONDULADA SIGNIFICA QUE EL RADICAL Q NH CH2 ESTA POR ENCIMA O POR DEBAJO DEL PLANO DE LA MOLECULA.SE UTILIZAN EN EL TRATAMIENTO DE INFECCIONES BACTERIANAS.
ES525238A 1982-01-11 1983-08-30 Un procedimiento para la preparacion de derivados del acido penicilanico 6alfa-o-6beta-sustituidos. Expired ES8507147A1 (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US33879782A 1982-01-11 1982-01-11
US38832482A 1982-06-14 1982-06-14
US06/388,323 US4427678A (en) 1982-01-11 1982-06-14 6-Aminomethylpenicillanic acid 1,1-dioxide derivatives as beta-lactamase inhibitors
US06/434,371 US4452796A (en) 1982-06-14 1982-10-21 6-Aminoalkylpenicillanic acid 1,1-dioxides as beta-lactamase inhibitors

Publications (2)

Publication Number Publication Date
ES525238A0 ES525238A0 (es) 1985-08-16
ES8507147A1 true ES8507147A1 (es) 1985-08-16

Family

ID=27502592

Family Applications (2)

Application Number Title Priority Date Filing Date
ES518912A Granted ES518912A0 (es) 1982-01-11 1983-01-11 Un procedimiento para la preparacion de derivados del acido penicilanico.
ES525238A Expired ES8507147A1 (es) 1982-01-11 1983-08-30 Un procedimiento para la preparacion de derivados del acido penicilanico 6alfa-o-6beta-sustituidos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES518912A Granted ES518912A0 (es) 1982-01-11 1983-01-11 Un procedimiento para la preparacion de derivados del acido penicilanico.

Country Status (20)

Country Link
EP (1) EP0084925B1 (es)
JP (1) JPH0689005B2 (es)
AU (1) AU538468B2 (es)
BG (1) BG42676A3 (es)
CA (1) CA1190921A (es)
DD (2) DD209462A5 (es)
DE (1) DE3362826D1 (es)
DK (1) DK166883B1 (es)
ES (2) ES518912A0 (es)
FI (1) FI79112C (es)
GR (1) GR77152B (es)
HU (1) HU189211B (es)
IE (1) IE54390B1 (es)
IL (1) IL67647A (es)
NO (6) NO830046L (es)
NZ (1) NZ202982A (es)
PL (1) PL142315B1 (es)
PT (1) PT76077B (es)
RO (2) RO84910B (es)
YU (1) YU43646B (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4499017A (en) * 1983-06-06 1985-02-12 Pfizer Inc. Beta-lactamase inhibiting 6-(alkoxyamino-methyl) penicillanic acid 1,1-dioxide and derivatives
US4502990A (en) * 1983-06-06 1985-03-05 Pfizer Inc. Process for 6-(aminomethyl)penicillanic acid 1,1-dioxide and derivatives thereof
JPS60239489A (ja) * 1984-05-15 1985-11-28 Meiji Seika Kaisha Ltd ６−エピペニシリンスルホン化合物及びその製造方法
GB2206579B (en) * 1987-07-10 1991-05-29 Erba Farmitalia 6a and 6b-(substituted methyl)-penicillanic acid derivatives
US8415339B2 (en) * 2007-05-21 2013-04-09 Hans Rudolf Pfaendler Bactericidal anti-MRSA active pharmaceutical composition containing carbapenems

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4237051A (en) * 1979-04-19 1980-12-02 Schering Corporation Stereospecific production of 6- or 7-carbon-substituted-β-lactams
DE2927004A1 (de) * 1979-07-04 1981-05-27 Bayer Ag, 5090 Leverkusen Penicillansaeure-1,1-dioxide, ihre herstellung und ihre verwendung als arzneimittel als arzneimittel
US4287181A (en) * 1979-10-22 1981-09-01 Pfizer Inc. Derivatives of 6β-hydroxyalkylpenicillanic acids as β-lactamase inhibitors

Also Published As

Publication number Publication date
RO84910A (ro) 1984-08-17
ES8403489A1 (es) 1984-03-16
PL142315B1 (en) 1987-10-31
FI830081A0 (fi) 1983-01-10
NO841069L (no) 1983-07-12
ES518912A0 (es) 1984-03-16
HU189211B (en) 1986-06-30
NZ202982A (en) 1986-04-11
NO841068L (no) 1983-07-12
JPH0689005B2 (ja) 1994-11-09
IE54390B1 (en) 1989-09-13
DD209462A5 (de) 1984-05-09
RO84910B (ro) 1984-09-30
FI830081L (fi) 1983-07-12
YU43646B (en) 1989-10-31
EP0084925A1 (en) 1983-08-03
IE830042L (en) 1983-07-11
ES525238A0 (es) 1985-08-16
JPS58126889A (ja) 1983-07-28
CA1190921A (en) 1985-07-23
FI79112C (fi) 1989-11-10
DK7483A (da) 1983-07-12
AU538468B2 (en) 1984-08-16
RO87705A (ro) 1985-10-31
PT76077A (en) 1983-02-01
DD218365A5 (de) 1985-02-06
NO830046L (no) 1983-07-12
DE3362826D1 (en) 1986-05-15
DK7483D0 (da) 1983-01-10
FI79112B (fi) 1989-07-31
AU1023283A (en) 1983-07-21
PL240108A1 (en) 1985-08-13
EP0084925B1 (en) 1986-04-09
DK166883B1 (da) 1993-07-26
NO841070L (no) 1983-07-12
IL67647A0 (en) 1983-05-15
RO87705B (ro) 1985-10-01
BG42676A3 (en) 1988-01-15
NO833416L (no) 1983-07-12
NO833415L (no) 1983-07-12
IL67647A (en) 1986-08-31
PT76077B (en) 1986-01-09
YU4483A (en) 1986-02-28
GR77152B (es) 1984-09-07

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19980202