DD208151A5 - Verfahren zur herstellung neuer pyrimidinone - Google Patents

Verfahren zur herstellung neuer pyrimidinone Download PDF

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Publication number
DD208151A5
DD208151A5 DD81235494A DD23549481A DD208151A5 DD 208151 A5 DD208151 A5 DD 208151A5 DD 81235494 A DD81235494 A DD 81235494A DD 23549481 A DD23549481 A DD 23549481A DD 208151 A5 DD208151 A5 DD 208151A5
Authority
DD
German Democratic Republic
Prior art keywords
group
methyl
phenyl
hydroxy
reaction
Prior art date
Application number
DD81235494A
Other languages
German (de)
English (en)
Inventor
Joachim Heider
Volkhard Austel
Wolfgang Eberlein
Rudolf Kadatz
Christian Lillie
Original Assignee
Thomae Gmbh Dr K
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19803046871 external-priority patent/DE3046871A1/de
Priority claimed from DE19813115447 external-priority patent/DE3115447A1/de
Application filed by Thomae Gmbh Dr K filed Critical Thomae Gmbh Dr K
Publication of DD208151A5 publication Critical patent/DD208151A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/88—Oxygen atoms
    • C07D239/91—Oxygen atoms with aryl or aralkyl radicals attached in position 2 or 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/04—1,3-Oxazines; Hydrogenated 1,3-oxazines
    • C07D265/12—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems
    • C07D265/14—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • C07D265/20—1,3-Oxazines; Hydrogenated 1,3-oxazines condensed with carbocyclic rings or ring systems condensed with one six-membered ring with hetero atoms directly attached in position 4
    • C07D265/22—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Cardiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyridine Compounds (AREA)
DD81235494A 1980-12-12 1981-12-07 Verfahren zur herstellung neuer pyrimidinone DD208151A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19803046871 DE3046871A1 (de) 1980-12-12 1980-12-12 Neue chinazolinone, ihre herstellung und ihre verwendung als arzneimittel
DE19813115447 DE3115447A1 (de) 1981-04-16 1981-04-16 Neue pyrimidinone, ihre herstellung und ihre verwendung als arzneimittel

Publications (1)

Publication Number Publication Date
DD208151A5 true DD208151A5 (de) 1984-03-28

Family

ID=25789685

Family Applications (1)

Application Number Title Priority Date Filing Date
DD81235494A DD208151A5 (de) 1980-12-12 1981-12-07 Verfahren zur herstellung neuer pyrimidinone

Country Status (22)

Country Link
US (1) US4379788A (cs)
EP (1) EP0054132B1 (cs)
AR (1) AR227567A1 (cs)
AU (1) AU543568B2 (cs)
CA (1) CA1217767A (cs)
CS (1) CS227024B2 (cs)
DD (1) DD208151A5 (cs)
DE (1) DE3166627D1 (cs)
DK (1) DK525481A (cs)
ES (2) ES507761A0 (cs)
FI (1) FI813971A7 (cs)
GB (1) GB2090249B (cs)
GR (1) GR76952B (cs)
HU (1) HU187384B (cs)
IL (1) IL64504A (cs)
MY (1) MY8700562A (cs)
NO (1) NO814239L (cs)
NZ (1) NZ199254A (cs)
PH (1) PH18930A (cs)
PL (1) PL135330B1 (cs)
PT (1) PT74116B (cs)
SU (1) SU1056900A3 (cs)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4460589A (en) * 1980-10-03 1984-07-17 The Upjohn Company Process for treating hypertension
US4379778A (en) * 1980-10-10 1983-04-12 Air Products And Chemicals, Inc. Hydrogen peroxide synthesis
DE3428476A1 (de) * 1984-08-02 1986-02-13 Basf Ag, 6700 Ludwigshafen 4h-pyrido(2,3-d)(1,3)oxazin-4-on-derivate, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses
DE3631294A1 (de) * 1986-09-13 1988-03-24 Thomae Gmbh Dr K Neue synergistische kombination bestehend aus einem phosphodiesterase-hemmer und einem thromboxan-a(pfeil abwaerts)2(pfeil abwaerts)-antagonisten und deren verwendung bzw. herstellung
US5037980A (en) * 1988-04-18 1991-08-06 American Cyanamid Company Phenyl imidazo[1,2-a]pyrimidines
GB8928346D0 (en) * 1989-12-15 1990-02-21 Smith Kline French Lab Chemical compounds
GB9126260D0 (en) * 1991-12-11 1992-02-12 Pfizer Ltd Therapeutic agents
GB9404485D0 (en) * 1994-03-09 1994-04-20 Cancer Res Campaign Tech Benzamide analogues
SK287161B6 (sk) * 1997-11-12 2010-02-08 Bayer Healthcare Ag 2-Fenylsubstituované imidazotriazinóny, spôsob ich výroby, liečivá obsahujúce tieto látky a ich použitie
RU2207337C2 (ru) * 1998-11-18 2003-06-27 Изаксон Елена Александровна 6-(3-ацетилфенил)аминоурацил
US20040102324A1 (en) 2002-02-28 2004-05-27 Annis Gary David Heterocyclic diamide invertebrate pest control agents
US6642244B2 (en) 2001-03-16 2003-11-04 Bristol-Myers Squibb Co. Pyrazolopyridopyrimidine inhibitors of cGMP phosphodiesterase
US7893071B2 (en) * 2001-04-23 2011-02-22 University Of Virginia Patent Foundation Synthesis and evaluation of novel phthalimide mimics as anti-angiogenic
BR0209541A (pt) * 2001-05-09 2004-04-20 Bayer Healthcare Ag Uso das imidazotriazinonas 2-fenil-substituìdas
DE10232113A1 (de) 2002-07-16 2004-01-29 Bayer Ag Vardenafil Hydrochlorid Trihydrat enthaltende Arzneimittel
CN1893951A (zh) * 2003-12-19 2007-01-10 默克公司 有丝分裂驱动蛋白抑制剂
SE0401345D0 (sv) * 2004-05-25 2004-05-25 Astrazeneca Ab Therapeutic compounds: Pyridine as scaffold
SE0401342D0 (sv) * 2004-05-25 2004-05-25 Astrazeneca Ab Therapeutic compounds
WO2005115993A1 (ja) 2004-05-31 2005-12-08 Banyu Pharmaceutical Co., Ltd. キナゾリン誘導体
DE102005001989A1 (de) * 2005-01-15 2006-07-20 Bayer Healthcare Ag Intravenöse Formulierungen von PDE-Inhibitoren
DE102005009241A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit kontrollierter Bioverfügbarkeit
DE102005009240A1 (de) * 2005-03-01 2006-09-07 Bayer Healthcare Ag Arzneiformen mit verbesserten pharmakokinetischen Eigenschaften
AU2006299232A1 (en) * 2005-09-29 2007-04-12 Bayer Schering Pharma Aktiengesellschaft PDE inhibitors and combinations thereof for the treatment of urological disorders
WO2008041118A2 (en) * 2006-10-04 2008-04-10 Pfizer Products Inc. Pyrido[4,3-d]pyrimidin-4(3h)-one derivatives as calcium receptor antagonists
WO2008151734A1 (en) * 2007-06-13 2008-12-18 Bayer Schering Pharma Aktiengesellschaft Pde inhibitors for the treatment of hearing impairment
CN101531638B (zh) * 2008-03-13 2011-12-28 中国科学院广州生物医药与健康研究院 用作雌激素相关受体调节剂的化合物及其应用
CN102098918A (zh) * 2008-05-13 2011-06-15 帕纳德制药公司 用于治疗癌症和神经退行性疾病的生物活性化合物
CN101628913B (zh) 2008-07-18 2013-01-23 中国科学院广州生物医药与健康研究院 用作雌激素相关受体调节剂的化合物及其应用
BR112015006524A8 (pt) * 2012-09-26 2019-08-20 Merck Patent Gmbh derivados de quinazolinona como inibidores de parp, seu processo de preparação, seu uso, medicamentos e conjunto (kit)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3265697A (en) * 1964-09-04 1966-08-09 Shulton Inc 2-p-dialkylaminoalkoxyphenyl-2, 3-dihydro-4 (1h)-quinazolinones and their derivatives
DE1939109A1 (de) * 1968-08-31 1970-03-05 Troponwerke Dinklage & Co 2-Methyl-3-[2-(2-diaethylaminoaethoxy)-phenyl]-chinazolinon-(4) und Verfahren zu seiner Herstellung
US3862191A (en) * 1972-09-27 1975-01-21 Pfizer Pyrido{8 2,3-d{9 pyrimidin-4(3H)-one

Also Published As

Publication number Publication date
IL64504A0 (en) 1982-03-31
IL64504A (en) 1985-02-28
HU187384B (en) 1985-12-28
CS227024B2 (en) 1984-04-16
PL135330B1 (en) 1985-10-31
DE3166627D1 (en) 1984-11-15
AR227567A1 (es) 1982-11-15
ES8207156A1 (es) 1982-09-01
ES507761A0 (es) 1982-09-01
PT74116A (de) 1982-01-01
AU7847381A (en) 1982-06-17
GB2090249B (en) 1984-08-22
FI813971L (fi) 1982-06-13
FI813971A7 (fi) 1982-06-13
SU1056900A3 (ru) 1983-11-23
ES511835A0 (es) 1983-02-16
GB2090249A (en) 1982-07-07
CA1217767A (en) 1987-02-10
ES8304096A1 (es) 1983-02-16
US4379788A (en) 1983-04-12
DK525481A (da) 1982-06-13
MY8700562A (en) 1987-12-31
PT74116B (de) 1983-12-19
NZ199254A (en) 1985-02-28
NO814239L (no) 1982-06-14
AU543568B2 (en) 1985-04-26
GR76952B (cs) 1984-09-04
PH18930A (en) 1985-11-11
PL234175A1 (cs) 1982-08-16
EP0054132B1 (de) 1984-10-10
EP0054132A1 (de) 1982-06-23

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