DD207379A5 - Verfahren zur herstellung 1,1-alkandioldicarboxylatverknuepfter antibakterieller mittel - Google Patents

Verfahren zur herstellung 1,1-alkandioldicarboxylatverknuepfter antibakterieller mittel Download PDF

Info

Publication number
DD207379A5
DD207379A5 DD82246325A DD24632582A DD207379A5 DD 207379 A5 DD207379 A5 DD 207379A5 DD 82246325 A DD82246325 A DD 82246325A DD 24632582 A DD24632582 A DD 24632582A DD 207379 A5 DD207379 A5 DD 207379A5
Authority
DD
German Democratic Republic
Prior art keywords
ethyl acetate
mixture
added
sodium
formula
Prior art date
Application number
DD82246325A
Other languages
German (de)
English (en)
Inventor
Vytautas J Jasys
Michael St Kellogg
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DD207379A5 publication Critical patent/DD207379A5/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C07D499/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
DD82246325A 1981-12-22 1982-12-21 Verfahren zur herstellung 1,1-alkandioldicarboxylatverknuepfter antibakterieller mittel DD207379A5 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33402281A 1981-12-22 1981-12-22
US06/429,915 US4457924A (en) 1981-12-22 1982-09-30 1,1-Alkanediol dicarboxylate linked antibacterial agents

Publications (1)

Publication Number Publication Date
DD207379A5 true DD207379A5 (de) 1984-02-29

Family

ID=26989011

Family Applications (1)

Application Number Title Priority Date Filing Date
DD82246325A DD207379A5 (de) 1981-12-22 1982-12-21 Verfahren zur herstellung 1,1-alkandioldicarboxylatverknuepfter antibakterieller mittel

Country Status (25)

Country Link
US (1) US4457924A (da)
EP (1) EP0083484B1 (da)
JP (1) JPH02270881A (da)
KR (1) KR860001370B1 (da)
AU (1) AU537214B2 (da)
BG (4) BG50162A3 (da)
CA (1) CA1213582A (da)
DD (1) DD207379A5 (da)
DE (1) DE3269267D1 (da)
DK (3) DK565482A (da)
ES (3) ES8402310A1 (da)
FI (1) FI80039C (da)
GR (1) GR77066B (da)
GT (1) GT198200058A (da)
HU (1) HU187737B (da)
IE (1) IE54333B1 (da)
IL (1) IL67530A (da)
NO (1) NO824305L (da)
NZ (1) NZ202670A (da)
PH (1) PH18311A (da)
PL (3) PL141306B1 (da)
PT (1) PT76012B (da)
RO (2) RO87709A (da)
SU (1) SU1405704A3 (da)
YU (2) YU43111B (da)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675186A (en) 1985-04-18 1987-06-23 Pfizer Inc. 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives
LU87821A1 (fr) * 1990-10-12 1992-05-25 Cird Galderma Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique
ATE115114T1 (de) * 1991-03-11 1994-12-15 Schweizerhall Saeurefab Verfahren zur herstellung von chlorierten carbonsäureestern.
EP0508943B1 (de) * 1991-03-11 1994-12-14 Säurefabrik Schweizerhall Verfahren zur Herstellung von halogenierten Carbonsäureestern
WO2004035540A1 (ja) * 2002-10-18 2004-04-29 Meiji Seika Kaisha, Ltd. マロン酸モノエステルおよびその製造方法
KR101746250B1 (ko) * 2009-12-01 2017-06-12 스미또모 가가꾸 가부시키가이샤 시클로알칸디카르복실산 모노에스테르의 제조 방법
US7973194B1 (en) 2010-03-18 2011-07-05 Eastman Chemical Company High solvating cyclohexane dicarboxylate diesters plasticizers
CN115385934A (zh) * 2022-10-26 2022-11-25 北京纳百生物科技有限公司 一种舒巴坦半抗原及其合成方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985648A (en) * 1958-10-06 1961-05-23 Doyle Frank Peter Alpha-aminobenzylpenicillins
NL299897A (da) * 1962-11-02
US3520876A (en) * 1967-11-01 1970-07-21 American Home Prod Process for the preparation of 6-(alpha-aminoacylamino)penicillanic acids
ES436565A1 (es) * 1974-06-05 1977-04-01 Bristol Myers Co Un procedimiento para la preparacion de acidos acetamidope- nicilanicos.
FR2290443A1 (fr) * 1974-11-06 1976-06-04 Aries Robert Nouveaux esters bispenicillaniques
FR2309570A1 (fr) * 1975-04-29 1976-11-26 Aries Robert Derives polymeriques des penicillines et cephalosporines
GB1569421A (en) * 1976-06-11 1980-06-18 Beecham Group Ltd Penicillin compositions
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
IE49881B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4309347A (en) * 1979-05-16 1982-01-05 Pfizer Inc. Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide

Also Published As

Publication number Publication date
BG48694A3 (en) 1991-04-15
YU43111B (en) 1989-02-28
KR840002840A (ko) 1984-07-21
FI80039B (fi) 1989-12-29
PL140291B1 (en) 1987-04-30
BG50160A3 (en) 1992-05-15
GR77066B (da) 1984-04-05
PT76012A (en) 1983-01-01
FI80039C (fi) 1990-04-10
YU43992B (en) 1990-02-28
IL67530A0 (en) 1983-05-15
RO84911B (ro) 1984-09-30
FI824409L (fi) 1983-06-23
RO87709B (ro) 1985-10-01
FI824409A0 (fi) 1982-12-21
IE823034L (en) 1983-06-22
YU284482A (en) 1985-03-20
RO84911A (ro) 1984-08-17
ES524894A0 (es) 1985-02-01
ES518425A0 (es) 1984-02-01
SU1405704A3 (ru) 1988-06-23
NO824305L (no) 1983-06-23
CA1213582A (en) 1986-11-04
PL239651A1 (en) 1985-01-16
NZ202670A (en) 1985-12-13
PL248637A1 (en) 1985-02-27
ES524895A0 (es) 1985-02-01
PT76012B (en) 1985-12-13
IL67530A (en) 1986-02-28
PH18311A (en) 1985-05-29
DK565482A (da) 1983-06-23
YU183084A (en) 1986-10-31
AU9172182A (en) 1983-06-30
JPH02270881A (ja) 1990-11-05
BG50162A3 (en) 1992-05-15
AU537214B2 (en) 1984-06-14
BG50161A3 (en) 1992-05-15
RO87709A (ro) 1985-10-31
EP0083484B1 (en) 1986-02-19
IE54333B1 (en) 1989-08-30
DK69092A (da) 1992-05-26
HU187737B (en) 1986-02-28
DK69192A (da) 1992-05-26
EP0083484A1 (en) 1983-07-13
KR860001370B1 (ko) 1986-09-17
US4457924A (en) 1984-07-03
ES8402310A1 (es) 1984-02-01
DK69192D0 (da) 1992-05-26
ES8530002A1 (es) 1985-02-01
DE3269267D1 (en) 1986-03-27
DK69092D0 (da) 1992-05-26
GT198200058A (es) 1984-06-09
PL141306B1 (en) 1987-07-31
ES8503001A1 (es) 1985-02-01
PL145927B1 (en) 1988-11-30

Similar Documents

Publication Publication Date Title
CH628901A5 (de) Verfahren zur herstellung von cephalosporinantibiotika.
DE2751624A1 (de) 1-carba-2-penem-3-carbonsaeure
EP0571870B1 (de) Cyclopentan- und -penten-beta-Aminosäuren
DE3625870A1 (de) 7-oxabicycloheptansubstituierte amid-thioamid-prostaglandin-analoge
DD207379A5 (de) Verfahren zur herstellung 1,1-alkandioldicarboxylatverknuepfter antibakterieller mittel
DE1966850C3 (de) Penicilline mit einer Sulfogruppe in a-Stellung des Acylrestes und Verfahren zu ihrer Herstellung
US4638012A (en) 7-oxabicycloheptane α-substituted ketone prostaglandin analogs useful in the treatment of thrombotic disease
DE2205144C3 (de) Azetidino [3,2-d] thiazole und Verfahren zu ihrer Herstellung
EP0697405B1 (de) Substituierte-Chinolinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung
DE3911064A1 (de) Substituierte 1,8-naphthyridine
DE2123111A1 (de) Penicillansäure-Derivate
CH644608A5 (de) Verfahren zur herstellung von penicillansaeure-1,1-dioxid und dessen estern sowie zwischenverbindungen zur durchfuehrung des verfahrens.
US4359472A (en) Bis-hydroxymethyl carbonate bridged antibacterial agents
CA2050054A1 (en) 7-oxabicycloheptyl substituted heterocyclic thioamide prostaglandin analogs useful in the treatment of thrombotic and vasospastic disease
DD202163A5 (de) Verfahren und zwischenstufen zur herstellung von 1,1-dixopenicillanoyloxymethyl-6 (2-amino-2-phenylacetamido)penicillanaten
DE2716172C2 (de) Bis(6-[(hexahydro-1H-azepin-1-yl)-methylenamino]-penicillanoyloxy)-methan, seine Herstellung und dieses enthaltendes Arzneimittel
DE2012022C3 (de) Pivaloyloxymethyl- a -amino-phydroxybenzylpenicillinat und Verfahren zu seiner Herstellung
DE2145354C3 (de) Thioester und Verfahren zu ihrer Herstellung
DD209462A5 (de) Verfahren zur herstellung von 6-aminoalkylpenicillansaeure-1,1-dioxiden und derivaten als beta-lactamase-inhibitoren
NZ233600A (en) 7-oxabicyclo(2.2.1)heptane imidazole prostaglandin analogs and pharmaceutical compositions
HU187574B (en) Process for producing antibacterial 6-comma above-square bracket-2-amino-2-bracket-4-acyl-oxy-phenyl-bracket closed-acetamido-square bracket closed-pename-3-carbonyl-oxy-methyl-pename-3-carboxylate-1,1-dioxide compounds
EP0805145A1 (de) Effizientes und hochenantioselektives Verfahren zur Herstellung von enantiomerenreinen Cyclopentan-beta-Aminosäuren
DE2950436A1 (de) 1 alpha -aethyl-1 beta - eckige klammer auf 2'-(methoxycarbonyl)-aethyl eckige klammer zu -9-brom-1,2,3,4,6,7,12,12b -octahydroindolo eckige klammer auf 2,3-a eckige klammer zu chinolizinderivate, verfahren zur herstellung derselben bzw. von 10-bromvincamin und 10-brom-14-epivincamin, erstere enthaltende arzneimittel sowie 1-aethyl-1- eckige klammer auf 2'- (acetoxy)-2'-(methoxycarbonyl)-aethyl eckige klammer zu -9-brom-1,2,3,4,6,7- hexahydro-12h-indolo eckige klammer auf 2,3-a eckige klammer zu chinolizin-5- iumperchlorat und 1-aethyl-1- eckige klammer auf 2'-(hydroxy)-2'-(methoxycarbonyl)- aethyl eckige klammer zu -9-brom-1,2,3,4, 6,7-hexahydro-12h-indolo eckige klammer auf 2,3-a eckige klammer zu chinolizin- 5-iumperchlorat
JPS58116486A (ja) １，１―アルカンジオールジカルボキシラート結合抗菌剤
WO1988005429A1 (en) Process for producing bicyclo [3.3.0]octane-3,7-dione-2 carboxylic acid esters

Legal Events

Date Code Title Description
NPV Change in the person, the name or the address of the representative (addendum to changes before extension act)
ENJ Ceased due to non-payment of renewal fee