RO84911B - Procedeu pentru prepararea unor 1, 1-alcandioli carboxilati - Google Patents

Procedeu pentru prepararea unor 1, 1-alcandioli carboxilati

Info

Publication number
RO84911B
RO84911B RO109396A RO10939682A RO84911B RO 84911 B RO84911 B RO 84911B RO 109396 A RO109396 A RO 109396A RO 10939682 A RO10939682 A RO 10939682A RO 84911 B RO84911 B RO 84911B
Authority
RO
Romania
Prior art keywords
hydrogen
preparation
amino
alkyl
alkanediols
Prior art date
Application number
RO109396A
Other languages
English (en)
Other versions
RO84911A (ro
Inventor
Vytautas Jasys Jasys
Michael Stephen Kellogg
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of RO84911A publication Critical patent/RO84911A/ro
Publication of RO84911B publication Critical patent/RO84911B/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C07D499/32—Esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor 1,1-alcandioli carboxilati cu activitate antibacteriana cu formula generala I: (vezi formula) în care A reprezinta un radical alchilen cu 1...8 atomi de carbon, izopropilen, ciclohexilen sau fenilen, n are valoraea 0 sau 1, R si R1 sunt diferiti si anume cînd n este 0 R reprezinta P sau B si R1 este hidrogen, alchil cu 1...4 atomi de carbon, benzil, clormetil, iodmetil sau tetrabutilamoniu, iar cînd n este 1 unul din R si R1 este P si celalalt este B, P reprezentînd: (vezi formula) în care R2 reprezinta hidrogen (vezi formula) Q1 fiind hidrogen, amino, azido, benziloxicarbonilamino, 4-nitrobenziloxicarbonil-amino sau 1-metil-2-metoxicarbonilvinil-amino si R3 fiind hidrogen, hidroxi, alcanoiloxi cu 2...7 atomi de carbon sau R4C6H4COO, R4 fiind hidrogen, alchil cu 1...4 atomi de carbon, alcoxi cu 1...4 atomi de carbon, halogen sau cian, B reprezentînd: (vezi formula) în care X1...
RO109396A 1981-12-22 1982-12-20 Procedeu pentru prepararea unor 1, 1-alcandioli carboxilati RO84911B (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US33402281A 1981-12-22 1981-12-22
US06/429,915 US4457924A (en) 1981-12-22 1982-09-30 1,1-Alkanediol dicarboxylate linked antibacterial agents

Publications (2)

Publication Number Publication Date
RO84911A RO84911A (ro) 1984-08-17
RO84911B true RO84911B (ro) 1984-09-30

Family

ID=26989011

Family Applications (2)

Application Number Title Priority Date Filing Date
RO82113244A RO87709A (ro) 1981-12-22 1982-12-20 Procedeu pentru prepararea unor 1,1-alcandioli-carboxilati
RO109396A RO84911B (ro) 1981-12-22 1982-12-20 Procedeu pentru prepararea unor 1, 1-alcandioli carboxilati

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RO82113244A RO87709A (ro) 1981-12-22 1982-12-20 Procedeu pentru prepararea unor 1,1-alcandioli-carboxilati

Country Status (25)

Country Link
US (1) US4457924A (ro)
EP (1) EP0083484B1 (ro)
JP (1) JPH02270881A (ro)
KR (1) KR860001370B1 (ro)
AU (1) AU537214B2 (ro)
BG (4) BG50162A3 (ro)
CA (1) CA1213582A (ro)
DD (1) DD207379A5 (ro)
DE (1) DE3269267D1 (ro)
DK (3) DK565482A (ro)
ES (3) ES8402310A1 (ro)
FI (1) FI80039C (ro)
GR (1) GR77066B (ro)
GT (1) GT198200058A (ro)
HU (1) HU187737B (ro)
IE (1) IE54333B1 (ro)
IL (1) IL67530A (ro)
NO (1) NO824305L (ro)
NZ (1) NZ202670A (ro)
PH (1) PH18311A (ro)
PL (3) PL141306B1 (ro)
PT (1) PT76012B (ro)
RO (2) RO87709A (ro)
SU (1) SU1405704A3 (ro)
YU (2) YU43111B (ro)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4675186A (en) 1985-04-18 1987-06-23 Pfizer Inc. 6-(1-acyl-1-hydroxymethyl)penicillanic acid derivatives
LU87821A1 (fr) * 1990-10-12 1992-05-25 Cird Galderma Composes bi-aromatiques,et leur utilisation en medecine humaine et veterinaire et en cosmetique
ATE115114T1 (de) * 1991-03-11 1994-12-15 Schweizerhall Saeurefab Verfahren zur herstellung von chlorierten carbonsäureestern.
EP0508943B1 (de) * 1991-03-11 1994-12-14 Säurefabrik Schweizerhall Verfahren zur Herstellung von halogenierten Carbonsäureestern
WO2004035540A1 (ja) * 2002-10-18 2004-04-29 Meiji Seika Kaisha, Ltd. マロン酸モノエステルおよびその製造方法
KR101746250B1 (ko) * 2009-12-01 2017-06-12 스미또모 가가꾸 가부시키가이샤 시클로알칸디카르복실산 모노에스테르의 제조 방법
US7973194B1 (en) 2010-03-18 2011-07-05 Eastman Chemical Company High solvating cyclohexane dicarboxylate diesters plasticizers
CN115385934A (zh) * 2022-10-26 2022-11-25 北京纳百生物科技有限公司 一种舒巴坦半抗原及其合成方法和应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2985648A (en) * 1958-10-06 1961-05-23 Doyle Frank Peter Alpha-aminobenzylpenicillins
NL299897A (ro) * 1962-11-02
US3520876A (en) * 1967-11-01 1970-07-21 American Home Prod Process for the preparation of 6-(alpha-aminoacylamino)penicillanic acids
ES436565A1 (es) * 1974-06-05 1977-04-01 Bristol Myers Co Un procedimiento para la preparacion de acidos acetamidope- nicilanicos.
FR2290443A1 (fr) * 1974-11-06 1976-06-04 Aries Robert Nouveaux esters bispenicillaniques
FR2309570A1 (fr) * 1975-04-29 1976-11-26 Aries Robert Derives polymeriques des penicillines et cephalosporines
GB1569421A (en) * 1976-06-11 1980-06-18 Beecham Group Ltd Penicillin compositions
US4234579A (en) * 1977-06-07 1980-11-18 Pfizer Inc. Penicillanic acid 1,1-dioxides as β-lactamase inhibitors
IE49881B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
US4309347A (en) * 1979-05-16 1982-01-05 Pfizer Inc. Penicillanoyloxymethyl penicillanate 1,1,1',1'-tetraoxide

Also Published As

Publication number Publication date
BG48694A3 (en) 1991-04-15
YU43111B (en) 1989-02-28
KR840002840A (ko) 1984-07-21
FI80039B (fi) 1989-12-29
PL140291B1 (en) 1987-04-30
BG50160A3 (en) 1992-05-15
GR77066B (ro) 1984-04-05
PT76012A (en) 1983-01-01
FI80039C (fi) 1990-04-10
YU43992B (en) 1990-02-28
IL67530A0 (en) 1983-05-15
FI824409L (fi) 1983-06-23
RO87709B (ro) 1985-10-01
DD207379A5 (de) 1984-02-29
FI824409A0 (fi) 1982-12-21
IE823034L (en) 1983-06-22
YU284482A (en) 1985-03-20
RO84911A (ro) 1984-08-17
ES524894A0 (es) 1985-02-01
ES518425A0 (es) 1984-02-01
SU1405704A3 (ru) 1988-06-23
NO824305L (no) 1983-06-23
CA1213582A (en) 1986-11-04
PL239651A1 (en) 1985-01-16
NZ202670A (en) 1985-12-13
PL248637A1 (en) 1985-02-27
ES524895A0 (es) 1985-02-01
PT76012B (en) 1985-12-13
IL67530A (en) 1986-02-28
PH18311A (en) 1985-05-29
DK565482A (da) 1983-06-23
YU183084A (en) 1986-10-31
AU9172182A (en) 1983-06-30
JPH02270881A (ja) 1990-11-05
BG50162A3 (en) 1992-05-15
AU537214B2 (en) 1984-06-14
BG50161A3 (en) 1992-05-15
RO87709A (ro) 1985-10-31
EP0083484B1 (en) 1986-02-19
IE54333B1 (en) 1989-08-30
DK69092A (da) 1992-05-26
HU187737B (en) 1986-02-28
DK69192A (da) 1992-05-26
EP0083484A1 (en) 1983-07-13
KR860001370B1 (ko) 1986-09-17
US4457924A (en) 1984-07-03
ES8402310A1 (es) 1984-02-01
DK69192D0 (da) 1992-05-26
ES8530002A1 (es) 1985-02-01
DE3269267D1 (en) 1986-03-27
DK69092D0 (da) 1992-05-26
GT198200058A (es) 1984-06-09
PL141306B1 (en) 1987-07-31
ES8503001A1 (es) 1985-02-01
PL145927B1 (en) 1988-11-30

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