DD140562A5 - Verfahren zur herstellung von peptiden - Google Patents
Verfahren zur herstellung von peptiden Download PDFInfo
- Publication number
- DD140562A5 DD140562A5 DD78209811A DD20981178A DD140562A5 DD 140562 A5 DD140562 A5 DD 140562A5 DD 78209811 A DD78209811 A DD 78209811A DD 20981178 A DD20981178 A DD 20981178A DD 140562 A5 DD140562 A5 DD 140562A5
- Authority
- DD
- German Democratic Republic
- Prior art keywords
- gly
- compound
- hydrogen
- formula
- tyr
- Prior art date
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- 238000007918 intramuscular administration Methods 0.000 description 1
- FBAFATDZDUQKNH-UHFFFAOYSA-N iron;hydrochloride Chemical compound Cl.[Fe] FBAFATDZDUQKNH-UHFFFAOYSA-N 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 230000008018 melting Effects 0.000 description 1
- 238000002844 melting Methods 0.000 description 1
- UZKWTJUDCOPSNM-UHFFFAOYSA-N methoxybenzene Substances CCCCOC=C UZKWTJUDCOPSNM-UHFFFAOYSA-N 0.000 description 1
- 125000004458 methylaminocarbonyl group Chemical group [H]N(C(*)=O)C([H])([H])[H] 0.000 description 1
- 229960005181 morphine Drugs 0.000 description 1
- BDERNNFJNOPAEC-UHFFFAOYSA-N n-propyl alcohol Natural products CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- 239000012299 nitrogen atmosphere Substances 0.000 description 1
- 239000012044 organic layer Substances 0.000 description 1
- 229910052763 palladium Inorganic materials 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
- 238000010647 peptide synthesis reaction Methods 0.000 description 1
- 239000008194 pharmaceutical composition Substances 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 239000012071 phase Substances 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- UYWQUFXKFGHYNT-UHFFFAOYSA-N phenylmethyl ester of formic acid Natural products O=COCC1=CC=CC=C1 UYWQUFXKFGHYNT-UHFFFAOYSA-N 0.000 description 1
- 235000021317 phosphate Nutrition 0.000 description 1
- 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- JUJWROOIHBZHMG-UHFFFAOYSA-O pyridinium Chemical compound C1=CC=[NH+]C=C1 JUJWROOIHBZHMG-UHFFFAOYSA-O 0.000 description 1
- 238000010791 quenching Methods 0.000 description 1
- 150000003254 radicals Chemical class 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 230000009467 reduction Effects 0.000 description 1
- 230000004044 response Effects 0.000 description 1
- 238000013207 serial dilution Methods 0.000 description 1
- 229910052938 sodium sulfate Inorganic materials 0.000 description 1
- 235000011152 sodium sulphate Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 150000003462 sulfoxides Chemical class 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- LMBFAGIMSUYTBN-MPZNNTNKSA-N teixobactin Chemical compound C([C@H](C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H](CCC(N)=O)C(=O)N[C@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CO)C(=O)N[C@H]1C(N[C@@H](C)C(=O)N[C@@H](C[C@@H]2NC(=N)NC2)C(=O)N[C@H](C(=O)O[C@H]1C)[C@@H](C)CC)=O)NC)C1=CC=CC=C1 LMBFAGIMSUYTBN-MPZNNTNKSA-N 0.000 description 1
- 238000010998 test method Methods 0.000 description 1
- WYURNTSHIVDZCO-UHFFFAOYSA-N tetrahydrofuran Substances C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 238000001665 trituration Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/665—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans derived from pro-opiomelanocortin, pro-enkephalin or pro-dynorphin
- C07K14/70—Enkephalins
- C07K14/702—Enkephalins with at least 1 amino acid in D-form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/04—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms
- C07C275/06—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton
- C07C275/14—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to acyclic carbon atoms of an acyclic and saturated carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1002—Tetrapeptides with the first amino acid being neutral
- C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Toxicology (AREA)
- Neurosurgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Pain & Pain Management (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB5223777 | 1977-12-15 | ||
| GB1384578 | 1978-04-08 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DD140562A5 true DD140562A5 (de) | 1980-03-12 |
Family
ID=26250049
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DD78209811A DD140562A5 (de) | 1977-12-15 | 1978-12-15 | Verfahren zur herstellung von peptiden |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US4178371A (cs) |
| JP (1) | JPS5490142A (cs) |
| AT (1) | AT363198B (cs) |
| AU (1) | AU523732B2 (cs) |
| CA (1) | CA1145330A (cs) |
| CH (1) | CH638177A5 (cs) |
| CS (1) | CS210679B2 (cs) |
| DD (1) | DD140562A5 (cs) |
| DE (1) | DE2854105A1 (cs) |
| DK (1) | DK540678A (cs) |
| ES (1) | ES475997A1 (cs) |
| FI (1) | FI783751A7 (cs) |
| FR (1) | FR2411829A1 (cs) |
| GR (1) | GR72716B (cs) |
| IE (1) | IE47764B1 (cs) |
| IL (1) | IL56181A (cs) |
| IT (1) | IT7869853A0 (cs) |
| LU (1) | LU80654A1 (cs) |
| NL (1) | NL7812166A (cs) |
| NZ (1) | NZ189047A (cs) |
| PL (1) | PL114981B1 (cs) |
| PT (1) | PT68900A (cs) |
| SE (1) | SE7812720L (cs) |
| SU (1) | SU793386A3 (cs) |
| ZA (1) | ZA786966B (cs) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4259234A (en) * | 1976-09-27 | 1981-03-31 | Eli Lilly And Company | Analgesic compounds |
| US4322342A (en) * | 1977-06-20 | 1982-03-30 | Eli Lilly And Company | Analgesic compounds |
| US4254024A (en) * | 1979-10-16 | 1981-03-03 | Pennwalt Corporation | Tetrapeptides and derivatives having opiate activity |
| JPS5692846A (en) * | 1979-12-27 | 1981-07-27 | Takeda Chem Ind Ltd | Tetrapeptide derivative and its preparation |
| HU181013B (en) * | 1980-01-25 | 1983-05-30 | Gyogyszerkutato Intezet | Process for preparing new enkephalin analogues |
| WO1982000640A1 (fr) * | 1980-08-18 | 1982-03-04 | Akita T | Derives de tripeptides alkylamide |
| US4316892A (en) * | 1980-11-03 | 1982-02-23 | G. D. Searle & Co. | 2,6-C-Dimethyltyrosine1 -D-amino acid2 -ε-amino caproic and γ aminobutyric acid5 derivatives of methionine enkephalin |
| ATE16495T1 (de) * | 1981-06-22 | 1985-11-15 | Ici Plc | Peptide und pseudopeptide, die zwei substituenten am n-terminus aufweisen. |
| US4533657A (en) * | 1981-07-24 | 1985-08-06 | Sterling Drug Inc. | Analgesic dipeptide amides and method of use and composition thereof |
| US4454120A (en) * | 1981-07-24 | 1984-06-12 | Sterling Drug Inc. | Analgesic dipeptide amides and method of use and compositions thereof |
| US4450155A (en) * | 1981-07-24 | 1984-05-22 | Sterling Drug Inc. | Analgesic dipeptide amides and method of use and compositions thereof |
| US4658013A (en) * | 1981-07-28 | 1987-04-14 | Sterling Drug Inc. | Analgesic and/or opiate antagonist tripeptide amides and processes for preparation and compositions thereof |
| US4407746A (en) * | 1981-12-14 | 1983-10-04 | G. D. Searle & Co. | Cyclohexyl and phenyl substituted enkephalins |
| AU566643B2 (en) * | 1982-02-05 | 1987-10-29 | Wellcome Foundation Limited, The | Pentapeptides as analgesics |
| US4430327A (en) | 1982-05-18 | 1984-02-07 | Eli Lilly And Company | Method for treating pregnant females for pain and anxiety |
| GB8314646D0 (en) * | 1983-05-26 | 1983-06-29 | Wellcome Found | Pharmaceutical amides |
| US4603121A (en) * | 1983-10-06 | 1986-07-29 | G. D. Searle & Co. | Enkephalin analogs |
| US4495178A (en) * | 1983-10-06 | 1985-01-22 | G. D. Searle & Co. | Enkephalin analogs |
| AU5122196A (en) * | 1995-03-31 | 1996-10-16 | Takeda Chemical Industries Ltd. | Cysteine protease inhibitor |
| FR2788518B1 (fr) * | 1999-01-14 | 2001-03-02 | Centre Nat Rech Scient | Nouveaux carbamates actives stables, leur procede de preparation et leur utilisation pour la preparation d'urees |
| US7777030B2 (en) | 2005-12-29 | 2010-08-17 | Centre National de la Recherge Scientifique (CNRS) | Compositions and methods for the treatment and prevention of disease |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2702711A1 (de) * | 1976-02-02 | 1977-08-04 | Sandoz Ag | Neue organische verbindungen, ihre herstellung und verwendung |
| NZ183712A (en) * | 1976-04-08 | 1979-10-25 | Ici Ltd | Polypeptide analogues of enkephalins, and pharmaceutical compositions |
-
1978
- 1978-11-27 US US05/964,074 patent/US4178371A/en not_active Expired - Lifetime
- 1978-11-29 NZ NZ189047A patent/NZ189047A/xx unknown
- 1978-11-30 CA CA000317174A patent/CA1145330A/en not_active Expired
- 1978-11-30 DK DK540678A patent/DK540678A/da not_active Application Discontinuation
- 1978-12-05 AU AU42199/78A patent/AU523732B2/en not_active Expired
- 1978-12-07 FI FI783751A patent/FI783751A7/fi unknown
- 1978-12-07 GR GR57817A patent/GR72716B/el unknown
- 1978-12-11 IL IL56181A patent/IL56181A/xx unknown
- 1978-12-11 SE SE7812720A patent/SE7812720L/xx unknown
- 1978-12-12 PT PT68900A patent/PT68900A/pt unknown
- 1978-12-12 ZA ZA786966A patent/ZA786966B/xx unknown
- 1978-12-13 PL PL1978211703A patent/PL114981B1/pl unknown
- 1978-12-14 CS CS788343A patent/CS210679B2/cs unknown
- 1978-12-14 LU LU80654A patent/LU80654A1/xx unknown
- 1978-12-14 CH CH1273578A patent/CH638177A5/fr not_active IP Right Cessation
- 1978-12-14 IT IT7869853A patent/IT7869853A0/it unknown
- 1978-12-14 FR FR7835251A patent/FR2411829A1/fr active Granted
- 1978-12-14 IE IE2475/78A patent/IE47764B1/en unknown
- 1978-12-14 DE DE19782854105 patent/DE2854105A1/de not_active Withdrawn
- 1978-12-14 SU SU782699407A patent/SU793386A3/ru active
- 1978-12-14 NL NL7812166A patent/NL7812166A/xx not_active Application Discontinuation
- 1978-12-14 ES ES475997A patent/ES475997A1/es not_active Expired
- 1978-12-15 DD DD78209811A patent/DD140562A5/de unknown
- 1978-12-15 JP JP15570978A patent/JPS5490142A/ja active Pending
- 1978-12-15 AT AT0899878A patent/AT363198B/de not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| DK540678A (da) | 1979-07-06 |
| LU80654A1 (fr) | 1980-07-21 |
| NL7812166A (nl) | 1979-06-19 |
| PT68900A (en) | 1979-01-01 |
| AU523732B2 (en) | 1982-08-12 |
| SE7812720L (sv) | 1979-06-16 |
| SU793386A3 (ru) | 1980-12-30 |
| CA1145330A (en) | 1983-04-26 |
| CH638177A5 (fr) | 1983-09-15 |
| AU4219978A (en) | 1979-06-21 |
| US4178371A (en) | 1979-12-11 |
| GR72716B (cs) | 1983-12-01 |
| FI783751A7 (fi) | 1979-06-16 |
| IL56181A (en) | 1982-05-31 |
| ZA786966B (en) | 1980-11-26 |
| PL114981B1 (en) | 1981-03-31 |
| CS210679B2 (en) | 1982-01-29 |
| PL211703A1 (pl) | 1979-08-13 |
| DE2854105A1 (de) | 1979-06-21 |
| IE47764B1 (en) | 1984-06-13 |
| ES475997A1 (es) | 1979-11-01 |
| IL56181A0 (en) | 1979-03-12 |
| FR2411829B1 (cs) | 1983-11-18 |
| FR2411829A1 (fr) | 1979-07-13 |
| JPS5490142A (en) | 1979-07-17 |
| ATA899878A (de) | 1980-12-15 |
| IT7869853A0 (it) | 1978-12-14 |
| IE782475L (en) | 1979-06-15 |
| AT363198B (de) | 1981-07-10 |
| NZ189047A (en) | 1981-12-15 |
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