CZ303716B6 - Zpusob výroby 4"-substituovaných derivátu 9-deoxo-9a-aza-9a-homoerythromycinu - Google Patents

Zpusob výroby 4"-substituovaných derivátu 9-deoxo-9a-aza-9a-homoerythromycinu Download PDF

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Publication number
CZ303716B6
CZ303716B6 CZ20021417A CZ20021417A CZ303716B6 CZ 303716 B6 CZ303716 B6 CZ 303716B6 CZ 20021417 A CZ20021417 A CZ 20021417A CZ 20021417 A CZ20021417 A CZ 20021417A CZ 303716 B6 CZ303716 B6 CZ 303716B6
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CZ
Czechia
Prior art keywords
formula
compound
reaction
compounds
salt
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CZ20021417A
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Czech (cs)
English (en)
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CZ20021417A3 (cs
Inventor
Sklavounos@Constantine
Lloyd Tucker@John
Wei@Lulin
Peter Mahon@Kerry
Dietrich Hammen@Philip
Teresa Negri@Joanna
Shelton Lehner@Richard
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Pfizer Products Inc.
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Publication of CZ20021417A3 publication Critical patent/CZ20021417A3/cs
Publication of CZ303716B6 publication Critical patent/CZ303716B6/cs

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
CZ20021417A 2001-04-27 2002-04-23 Zpusob výroby 4"-substituovaných derivátu 9-deoxo-9a-aza-9a-homoerythromycinu CZ303716B6 (cs)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28720301P 2001-04-27 2001-04-27

Publications (2)

Publication Number Publication Date
CZ20021417A3 CZ20021417A3 (cs) 2003-05-14
CZ303716B6 true CZ303716B6 (cs) 2013-04-03

Family

ID=23101880

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ20021417A CZ303716B6 (cs) 2001-04-27 2002-04-23 Zpusob výroby 4"-substituovaných derivátu 9-deoxo-9a-aza-9a-homoerythromycinu

Country Status (22)

Country Link
US (1) US6825327B2 (forum.php)
EP (2) EP1383780A1 (forum.php)
JP (3) JP4104463B2 (forum.php)
KR (1) KR100474225B1 (forum.php)
CN (4) CN1297564C (forum.php)
AR (1) AR035871A1 (forum.php)
AU (1) AU784362B2 (forum.php)
BR (2) BR0209241A (forum.php)
CA (2) CA2445306C (forum.php)
CZ (1) CZ303716B6 (forum.php)
DK (1) DK1253153T3 (forum.php)
ES (1) ES2608848T3 (forum.php)
HU (1) HU230717B1 (forum.php)
IL (3) IL158059A0 (forum.php)
MX (2) MXPA03009786A (forum.php)
PL (2) PL371766A1 (forum.php)
PT (1) PT1253153T (forum.php)
RU (2) RU2263117C2 (forum.php)
SG (1) SG100789A1 (forum.php)
WO (1) WO2002088158A1 (forum.php)
YU (1) YU29502A (forum.php)
ZA (2) ZA200203252B (forum.php)

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US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US7468428B2 (en) 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
CN102499928A (zh) * 2004-08-13 2012-06-20 先灵-普劳有限公司 包含抗菌素、三唑和皮质类固醇的药物制剂
CN101065352A (zh) 2004-09-23 2007-10-31 先灵-普劳有限公司 使用新的三氟甲磺酰苯胺肟醚衍生物控制动物中的寄生虫
US7705038B2 (en) 2004-11-19 2010-04-27 Intervet, Inc. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1H-pyrrol-2-yl)acrylonitrile derivatives
JP2008526948A (ja) * 2005-01-14 2008-07-24 グラクソスミスクライン・イストラジヴァッキ・センタル・ザグレブ・ドルズバ・ゼー・オメイェノ・オドゴヴォルノスティオ 抗マラリア活性を有する９ａ−カルバモイルおよびチオカルバモイルアザライド
JP2008545788A (ja) * 2005-06-09 2008-12-18 シェーリング−プラウ・リミテッド Ｎ−［（フェニルオキシ）フェニル］−１，１，１−トリフルオロメタンスルホンアミドおよびｎ−［（フェニルスルファニル）フェニル）］−１，１，１−トリフルオロメタンスルホンアミド誘導体による動物中の寄生生物の制御
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
EP2102154A1 (en) * 2006-12-13 2009-09-23 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
MX2009006282A (es) * 2006-12-13 2009-06-23 Schering Plough Ltd Profarmacos solubles en agua de florfenicol y sus analogos.
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
ES2549731T3 (es) 2007-06-27 2015-11-02 E. I. Du Pont De Nemours And Company Método para el control de plagas en animales
TWI401023B (zh) 2008-02-06 2013-07-11 Du Pont 中離子農藥
US8314252B2 (en) * 2008-07-30 2012-11-20 Intervet Inc. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
WO2010086351A1 (en) * 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 3'-n-substituted 9-deoxo-9a-methyl-9a-aza-homoerythromycin having antimalarial activity
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
WO2011017347A2 (en) 2009-08-05 2011-02-10 E. I. Du Pont De Nemours And Company Mesoionic pesticides
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
WO2011017334A2 (en) 2009-08-05 2011-02-10 E. I. Du Pont De Nemours And Company Mesoionic pesticides
MX2012013758A (es) 2010-05-27 2013-01-24 Du Pont Forma cristalina de 4-[5-[3-cloro-5-trifluorometil)fenil]-4,5-dihi dro-5-(trifluorometil)-3-isoxazolil]-n-[2-oxo-2-[(2,2,2-trifluoro etil)amino]etil]-1-naftalenocarboxamida.
US20130102551A1 (en) * 2010-07-01 2013-04-25 Andreas Hotte Antibiotic compositions
ES2532455T3 (es) * 2010-09-20 2015-03-27 Novartis Tiergesundheit Ag Nuevo procedimiento de preparación de 9-desoxo-9a-aza-9a-homoeritromicina modificada en el C-4'' del anillo de cladinosa por un grupo epóxido
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
CN102295672B (zh) * 2011-07-13 2014-06-04 武汉回盛生物科技有限公司 一种泰拉菌素的合成方法
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
EP2736915A1 (en) * 2011-07-27 2014-06-04 Farma GRS, d.o.o. New crystalline forms of tulathromycin
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN103965273B (zh) 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
EP3406619B1 (en) * 2016-01-18 2020-11-25 Zhejiang Hisun Pharmaceutical Co., Ltd. Method and intermediate for preparing tulathromycin
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN106434797A (zh) * 2016-08-25 2017-02-22 艾美科健（中国）生物医药有限公司 一种酶法合成泰拉霉素的工艺
CN106939029B (zh) * 2017-04-28 2020-10-13 艾美科健（中国）生物医药有限公司 一种泰拉霉素的制备方法
CN107400152B (zh) * 2017-08-29 2019-10-15 博瑞生物医药（苏州）股份有限公司 泰拉菌素草酸盐
CN107556351B (zh) * 2017-08-29 2019-10-18 博瑞生物医药（苏州）股份有限公司 一种泰拉菌素的制备方法
CN109535210A (zh) * 2018-12-19 2019-03-29 江苏威凌生化科技有限公司 一种合成纯化泰拉霉素杂质e的方法
CN114007625A (zh) 2019-04-18 2022-02-01 阿祖拉眼科有限公司 用于治疗眼病的化合物和方法
CN111072730B (zh) * 2019-12-16 2021-01-12 浙江国邦药业有限公司 一种泰拉霉素中间体盐的制备方法及应用
CN112225769A (zh) * 2020-09-21 2021-01-15 江苏威凌生化科技有限公司 一种合成纯化泰拉霉素杂质e的方法
CN113493483A (zh) * 2021-07-05 2021-10-12 上海应用技术大学 一种泰拉霉素的合成方法

Citations (2)

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Publication number Priority date Publication date Assignee Title
WO1998056802A1 (en) * 1997-06-11 1998-12-17 Pfizer Products Inc. 4'-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
WO2000031097A1 (en) * 1998-11-20 2000-06-02 Pfizer Products Inc. 13-membered azalides and their use as antibiotic agents

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WO1998056802A1 (en) * 1997-06-11 1998-12-17 Pfizer Products Inc. 4'-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
WO2000031097A1 (en) * 1998-11-20 2000-06-02 Pfizer Products Inc. 13-membered azalides and their use as antibiotic agents

Also Published As

Publication number Publication date
HU0201385D0 (forum.php) 2002-06-29
ZA200203252B (en) 2003-10-24
CN1384108A (zh) 2002-12-11
JP2007091754A (ja) 2007-04-12
KR20020083474A (ko) 2002-11-02
CN100413879C (zh) 2008-08-27
CN1715289A (zh) 2006-01-04
MXPA02004231A (es) 2002-11-13
ZA200307506B (en) 2005-01-26
PL213731B1 (pl) 2013-04-30
CN1295240C (zh) 2007-01-17
CN1167708C (zh) 2004-09-22
HU230717B1 (hu) 2017-11-28
AU784362B2 (en) 2006-03-16
JP2004528353A (ja) 2004-09-16
DK1253153T3 (da) 2017-01-02
US6825327B2 (en) 2004-11-30
IL158059A0 (en) 2004-03-28
BR0209241A (pt) 2004-06-15
EP1253153A1 (en) 2002-10-30
KR100474225B1 (ko) 2005-03-08
IL182418A0 (en) 2008-01-06
IL149226A (en) 2008-06-05
CZ20021417A3 (cs) 2003-05-14
IL149226A0 (en) 2002-11-10
WO2002088158A1 (en) 2002-11-07
JP4100955B2 (ja) 2008-06-11
CA2383409C (en) 2007-01-02
ES2608848T3 (es) 2017-04-17
SG100789A1 (en) 2003-12-26
US20030064939A1 (en) 2003-04-03
IL182418A (en) 2012-07-31
CN1297564C (zh) 2007-01-31
CN1503804A (zh) 2004-06-09
HK1065803A1 (en) 2005-03-04
PL371766A1 (en) 2005-06-27
PT1253153T (pt) 2016-12-29
CA2383409A1 (en) 2002-10-27
BR0201437A (pt) 2003-06-10
MXPA03009786A (es) 2004-01-29
JP4104463B2 (ja) 2008-06-18
EP1383780A1 (en) 2004-01-28
RU2263117C2 (ru) 2005-10-27
RU2003131351A (ru) 2005-02-27
YU29502A (sh) 2005-03-15
HUP0201385A2 (hu) 2003-12-29
CA2445306A1 (en) 2002-11-07
CN1530370A (zh) 2004-09-22
CA2445306C (en) 2008-02-12
BRPI0201437B8 (pt) 2021-05-25
AU3563002A (en) 2002-10-31
RU2233287C2 (ru) 2004-07-27
PL353633A1 (en) 2002-11-04
HK1050370A1 (en) 2003-06-20
AR035871A1 (es) 2004-07-21
EP1253153B1 (en) 2016-11-02
BRPI0201437B1 (pt) 2017-11-28
JP2002326998A (ja) 2002-11-15

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