SG100789A1 - Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives - Google Patents

Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Info

Publication number
SG100789A1
SG100789A1 SG200202485A SG200202485A SG100789A1 SG 100789 A1 SG100789 A1 SG 100789A1 SG 200202485 A SG200202485 A SG 200202485A SG 200202485 A SG200202485 A SG 200202485A SG 100789 A1 SG100789 A1 SG 100789A1
Authority
SG
Singapore
Prior art keywords
homoerythromycin
deoxo
aza
derivatives
substituted
Prior art date
Application number
SG200202485A
Other languages
English (en)
Inventor
Sklavounos Constantine
Lloyd Tucker John
Wei Lulin
Peter Mahon Kerry Jr
Dietrich Hammen Philip
Teresa Negri Joanna
Shelton Lehner Richard
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of SG100789A1 publication Critical patent/SG100789A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
SG200202485A 2001-04-27 2002-04-24 Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives SG100789A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US28720301P 2001-04-27 2001-04-27

Publications (1)

Publication Number Publication Date
SG100789A1 true SG100789A1 (en) 2003-12-26

Family

ID=23101880

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200202485A SG100789A1 (en) 2001-04-27 2002-04-24 Process for preparing 4"-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives

Country Status (22)

Country Link
US (1) US6825327B2 (forum.php)
EP (2) EP1383780A1 (forum.php)
JP (3) JP4104463B2 (forum.php)
KR (1) KR100474225B1 (forum.php)
CN (4) CN1297564C (forum.php)
AR (1) AR035871A1 (forum.php)
AU (1) AU784362B2 (forum.php)
BR (2) BR0209241A (forum.php)
CA (2) CA2445306C (forum.php)
CZ (1) CZ303716B6 (forum.php)
DK (1) DK1253153T3 (forum.php)
ES (1) ES2608848T3 (forum.php)
HU (1) HU230717B1 (forum.php)
IL (3) IL158059A0 (forum.php)
MX (2) MXPA03009786A (forum.php)
PL (2) PL371766A1 (forum.php)
PT (1) PT1253153T (forum.php)
RU (2) RU2263117C2 (forum.php)
SG (1) SG100789A1 (forum.php)
WO (1) WO2002088158A1 (forum.php)
YU (1) YU29502A (forum.php)
ZA (2) ZA200203252B (forum.php)

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US7384921B2 (en) * 2004-02-20 2008-06-10 Enanta Pharmaceuticals, Inc. Polymorphic forms of 6-11 bicyclic ketolide derivatives
US7468428B2 (en) * 2004-03-17 2008-12-23 App Pharmaceuticals, Llc Lyophilized azithromycin formulation
MY145148A (en) * 2004-08-13 2011-12-30 Schering Plough Ltd Pharmaceutical formulation comprising an antibiotic, a triazole and a carticosteroid
ATE406348T1 (de) 2004-09-23 2008-09-15 Schering Plough Ltd Bekämpfung von parasiten in tieren durch verwendung neuer trifluormethansulfonanilidoximetherderivate
WO2006055565A2 (en) 2004-11-19 2006-05-26 Schering-Plough Ltd. Control of parasites in animals by the use of parasiticidal 2-phenyl-3-(1h-pyrrol-2-yl) acrylonitrile derivatives
ES2326002T3 (es) * 2005-01-14 2009-09-28 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 9a-carbamoil y tiocarbamoil azalidos con actividad antipaludica.
PE20070108A1 (es) * 2005-06-09 2007-02-09 Schering Plough Ltd Control de parasitos en animales con derivados de n-[(feniloxi)fenil]-1,1,1-trifluorometansulfonamida y de n-[(fenilsulfanil)fenil]-1,1,1-trifluorometansulfonamida
US20070238700A1 (en) * 2006-04-10 2007-10-11 Winzenberg Kevin N N-phenyl-1,1,1-trifluoromethanesulfonamide hydrazone derivative compounds and their usage in controlling parasites
WO2008076256A1 (en) * 2006-12-13 2008-06-26 Schering-Plough Ltd. Water-soluble prodrugs of chloramphenicol, thiamphenicol, and analogs thereof
EP2091909A1 (en) * 2006-12-13 2009-08-26 Schering-Plough Ltd. Water-soluble prodrugs of florfenicol and its analogs
TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
MX361762B (es) 2007-06-27 2018-12-17 Du Pont Metodo de control de plagas en animales.
TWI468407B (zh) 2008-02-06 2015-01-11 Du Pont 中離子農藥
CA2732017A1 (en) * 2008-07-30 2010-02-04 Intervet International B.V. Process for preparing oxazoline-protected aminodiol compounds useful as intermediates to florfenicol
WO2010086351A1 (en) * 2009-01-30 2010-08-05 Glaxosmithkline Istrazivacki Centar Zagreb D.O.O. 3'-n-substituted 9-deoxo-9a-methyl-9a-aza-homoerythromycin having antimalarial activity
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
UA107804C2 (en) 2009-08-05 2015-02-25 Du Pont Mixtures of pesticides mezoionnyh
CN102574815A (zh) 2009-08-05 2012-07-11 杜邦公司 介离子杀虫剂
MX2012001651A (es) 2009-08-05 2012-03-16 Du Pont Pesticidas mesoionicos.
KR20170015549A (ko) 2010-05-27 2017-02-08 이 아이 듀폰 디 네모아 앤드 캄파니 4-[5-[3-클로로-5-(트라이플루오로메틸)페닐]-4,5-다이하이드로-5-(트라이플루오로메틸)-3-아이속사졸릴]-n-[2-옥소-2-[(2,2,2-트라이플루오로에틸)아미노]에틸]-1-나프탈렌카르복스아미드의 결정 형태
WO2012001089A1 (en) * 2010-07-01 2012-01-05 Novartis Ag Antibiotic compositions
JP5908479B2 (ja) * 2010-09-20 2016-04-26 ノバルティス ティーアゲズントハイト アーゲー クラジノース環のＣ−４”をエポキシド基で修飾した９−デオキソ−９ａ−アザ−９ａ−ホモエリスロマイシンＡの新規製造方法
WO2012087630A1 (en) 2010-12-20 2012-06-28 E.I. Du Pont De Nemours And Company Pyridine and pyrimidine compounds for controlling invertebrate
CN102295672B (zh) * 2011-07-13 2014-06-04 武汉回盛生物科技有限公司 一种泰拉菌素的合成方法
CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
EP2736915A1 (en) * 2011-07-27 2014-06-04 Farma GRS, d.o.o. New crystalline forms of tulathromycin
WO2013158422A1 (en) 2012-04-17 2013-10-24 E. I. Du Pont De Nemours And Company Heterocyclic compounds for controlling invertebrate pests
CN103965273B (zh) 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN103497227B (zh) * 2013-09-13 2015-09-30 青岛科技大学 一种泰拉菌素中间体的制备方法
US10414746B2 (en) 2016-01-18 2019-09-17 Zhejiang Hisun Pharmaceutical Co., Ltd. Method and intermediate for preparing tulathromycin
CN106046077B (zh) * 2016-08-04 2019-07-26 湖北美天生物科技股份有限公司 一种泰拉霉素a的合成方法
CN106434797A (zh) * 2016-08-25 2017-02-22 艾美科健（中国）生物医药有限公司 一种酶法合成泰拉霉素的工艺
CN106939029B (zh) * 2017-04-28 2020-10-13 艾美科健（中国）生物医药有限公司 一种泰拉霉素的制备方法
CN107556351B (zh) * 2017-08-29 2019-10-18 博瑞生物医药（苏州）股份有限公司 一种泰拉菌素的制备方法
CN107400152B (zh) * 2017-08-29 2019-10-15 博瑞生物医药（苏州）股份有限公司 泰拉菌素草酸盐
CN109535210A (zh) * 2018-12-19 2019-03-29 江苏威凌生化科技有限公司 一种合成纯化泰拉霉素杂质e的方法
JP2022529315A (ja) 2019-04-18 2022-06-21 アズーラ オフサルミックス エルティーディー． 眼障害を処置するための化合物および方法
CN111072730B (zh) * 2019-12-16 2021-01-12 浙江国邦药业有限公司 一种泰拉霉素中间体盐的制备方法及应用
CN112225769A (zh) * 2020-09-21 2021-01-15 江苏威凌生化科技有限公司 一种合成纯化泰拉霉素杂质e的方法
CN113493483A (zh) * 2021-07-05 2021-10-12 上海应用技术大学 一种泰拉霉素的合成方法

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998056802A1 (en) * 1997-06-11 1998-12-17 Pfizer Products Inc. 4'-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
WO1998056801A1 (en) * 1997-06-11 1998-12-17 Pfizer Products Inc. C-4''-substituted macrolide derivatives
WO2000031097A1 (en) * 1998-11-20 2000-06-02 Pfizer Products Inc. 13-membered azalides and their use as antibiotic agents

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SI8110592A8 (en) 1981-03-06 1996-06-30 Pliva Pharm & Chem Works Process for preparing of n-methyl-11-aza-10-deoxo-10-dihydroerythromycine a and derivatives thereof
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CA2064634C (en) 1991-04-04 1998-08-04 James V. Heck 9-deoxo-8a-aza-8a-homoerythromycin a derivatives modified at the 4"- and8a-positions
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WO1998056802A1 (en) * 1997-06-11 1998-12-17 Pfizer Products Inc. 4'-substituted-9-deoxo-9a-aza-9a-homoerythromycin a derivatives
WO1998056801A1 (en) * 1997-06-11 1998-12-17 Pfizer Products Inc. C-4''-substituted macrolide derivatives
WO2000031097A1 (en) * 1998-11-20 2000-06-02 Pfizer Products Inc. 13-membered azalides and their use as antibiotic agents

Also Published As

Publication number Publication date
RU2233287C2 (ru) 2004-07-27
EP1253153B1 (en) 2016-11-02
CZ20021417A3 (cs) 2003-05-14
IL158059A0 (en) 2004-03-28
CA2445306A1 (en) 2002-11-07
ZA200307506B (en) 2005-01-26
EP1253153A1 (en) 2002-10-30
RU2003131351A (ru) 2005-02-27
PT1253153T (pt) 2016-12-29
CN1297564C (zh) 2007-01-31
CN1503804A (zh) 2004-06-09
IL182418A (en) 2012-07-31
YU29502A (sh) 2005-03-15
JP4100955B2 (ja) 2008-06-11
HU0201385D0 (forum.php) 2002-06-29
ZA200203252B (en) 2003-10-24
IL149226A (en) 2008-06-05
CN100413879C (zh) 2008-08-27
CN1715289A (zh) 2006-01-04
RU2263117C2 (ru) 2005-10-27
JP2002326998A (ja) 2002-11-15
CA2445306C (en) 2008-02-12
IL182418A0 (en) 2008-01-06
CN1530370A (zh) 2004-09-22
KR20020083474A (ko) 2002-11-02
CA2383409C (en) 2007-01-02
HUP0201385A2 (hu) 2003-12-29
ES2608848T3 (es) 2017-04-17
US6825327B2 (en) 2004-11-30
PL213731B1 (pl) 2013-04-30
KR100474225B1 (ko) 2005-03-08
CN1384108A (zh) 2002-12-11
EP1383780A1 (en) 2004-01-28
DK1253153T3 (da) 2017-01-02
JP4104463B2 (ja) 2008-06-18
US20030064939A1 (en) 2003-04-03
BRPI0201437B1 (pt) 2017-11-28
CZ303716B6 (cs) 2013-04-03
IL149226A0 (en) 2002-11-10
AR035871A1 (es) 2004-07-21
BR0209241A (pt) 2004-06-15
HK1050370A1 (en) 2003-06-20
AU784362B2 (en) 2006-03-16
PL353633A1 (en) 2002-11-04
JP2004528353A (ja) 2004-09-16
HU230717B1 (hu) 2017-11-28
AU3563002A (en) 2002-10-31
BRPI0201437B8 (pt) 2021-05-25
MXPA02004231A (es) 2002-11-13
CN1167708C (zh) 2004-09-22
MXPA03009786A (es) 2004-01-29
PL371766A1 (en) 2005-06-27
JP2007091754A (ja) 2007-04-12
CA2383409A1 (en) 2002-10-27
CN1295240C (zh) 2007-01-17
WO2002088158A1 (en) 2002-11-07
HK1065803A1 (en) 2005-03-04
BR0201437A (pt) 2003-06-10

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