CZ297382B6 - Rychle se dispergující orální pevná dávková formafarmaceutického prostredku pro lécení Parkinsonovy nemoci - Google Patents
Rychle se dispergující orální pevná dávková formafarmaceutického prostredku pro lécení Parkinsonovy nemoci Download PDFInfo
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- CZ297382B6 CZ297382B6 CZ0270597A CZ270597A CZ297382B6 CZ 297382 B6 CZ297382 B6 CZ 297382B6 CZ 0270597 A CZ0270597 A CZ 0270597A CZ 270597 A CZ270597 A CZ 270597A CZ 297382 B6 CZ297382 B6 CZ 297382B6
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- selegiline
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- CJRQAPHWCGEATR-UHFFFAOYSA-N n-methyl-n-prop-2-ynylbutan-2-amine Chemical compound CCC(C)N(C)CC#C CJRQAPHWCGEATR-UHFFFAOYSA-N 0.000 description 1
- BSNWMBHBPLPDNI-UHFFFAOYSA-N n-methyl-n-prop-2-ynylpentan-2-amine Chemical compound CCCC(C)N(C)CC#C BSNWMBHBPLPDNI-UHFFFAOYSA-N 0.000 description 1
- RUOKEQAAGRXIBM-UHFFFAOYSA-N n-prop-2-ynyl-2,3-dihydro-1h-inden-1-amine Chemical compound C1=CC=C2C(NCC#C)CCC2=C1 RUOKEQAAGRXIBM-UHFFFAOYSA-N 0.000 description 1
- 208000015122 neurodegenerative disease Diseases 0.000 description 1
- 229910052757 nitrogen Inorganic materials 0.000 description 1
- SFLSHLFXELFNJZ-UHFFFAOYSA-N norepinephrine Natural products NCC(O)C1=CC=C(O)C(O)=C1 SFLSHLFXELFNJZ-UHFFFAOYSA-N 0.000 description 1
- 229960002748 norepinephrine Drugs 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 229920001277 pectin Polymers 0.000 description 1
- 239000001814 pectin Substances 0.000 description 1
- 235000010987 pectin Nutrition 0.000 description 1
- 230000000144 pharmacologic effect Effects 0.000 description 1
- 210000003800 pharynx Anatomy 0.000 description 1
- 229960005190 phenylalanine Drugs 0.000 description 1
- 235000021118 plant-derived protein Nutrition 0.000 description 1
- 229920001184 polypeptide Polymers 0.000 description 1
- 239000005033 polyvinylidene chloride Substances 0.000 description 1
- 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
- 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
- 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 108090000765 processed proteins & peptides Proteins 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000011321 prophylaxis Methods 0.000 description 1
- 229960005359 propylparaben sodium Drugs 0.000 description 1
- 229940070687 psyllium Drugs 0.000 description 1
- RUOKEQAAGRXIBM-GFCCVEGCSA-N rasagiline Chemical compound C1=CC=C2[C@H](NCC#C)CCC2=C1 RUOKEQAAGRXIBM-GFCCVEGCSA-N 0.000 description 1
- 229960000245 rasagiline Drugs 0.000 description 1
- 150000003839 salts Chemical class 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
- MEZLKOACVSPNER-UHFFFAOYSA-N selegiline Chemical compound C#CCN(C)C(C)CC1=CC=CC=C1 MEZLKOACVSPNER-UHFFFAOYSA-N 0.000 description 1
- 210000000813 small intestine Anatomy 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- PESXGULMKCKJCC-UHFFFAOYSA-M sodium;4-methoxycarbonylphenolate Chemical compound [Na+].COC(=O)C1=CC=C([O-])C=C1 PESXGULMKCKJCC-UHFFFAOYSA-M 0.000 description 1
- IXMINYBUNCWGER-UHFFFAOYSA-M sodium;4-propoxycarbonylphenolate Chemical compound [Na+].CCCOC(=O)C1=CC=C([O-])C=C1 IXMINYBUNCWGER-UHFFFAOYSA-M 0.000 description 1
- 239000007909 solid dosage form Substances 0.000 description 1
- 239000008247 solid mixture Substances 0.000 description 1
- 238000007711 solidification Methods 0.000 description 1
- 230000008023 solidification Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 208000024891 symptom Diseases 0.000 description 1
- 229920001059 synthetic polymer Polymers 0.000 description 1
- 239000006188 syrup Substances 0.000 description 1
- 235000020357 syrup Nutrition 0.000 description 1
- 230000009885 systemic effect Effects 0.000 description 1
- 239000000892 thaumatin Substances 0.000 description 1
- 235000010436 thaumatin Nutrition 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- 230000002485 urinary effect Effects 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 239000003643 water by type Substances 0.000 description 1
- 235000010493 xanthan gum Nutrition 0.000 description 1
- 239000000230 xanthan gum Substances 0.000 description 1
- 229920001285 xanthan gum Polymers 0.000 description 1
- 229940082509 xanthan gum Drugs 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
- A61K31/136—Amines having aromatic rings, e.g. ketamine, nortriptyline having the amino group directly attached to the aromatic ring, e.g. benzeneamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Zoology (AREA)
- Psychiatry (AREA)
- Emergency Medicine (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9504235.4A GB9504235D0 (en) | 1995-03-02 | 1995-03-02 | Pharmaceutical compositon |
GBGB9517063.5A GB9517063D0 (en) | 1995-03-02 | 1995-08-18 | Pharmaceutical composition |
Publications (2)
Publication Number | Publication Date |
---|---|
CZ270597A3 CZ270597A3 (cs) | 1998-01-14 |
CZ297382B6 true CZ297382B6 (cs) | 2006-11-15 |
Family
ID=26306612
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CZ0270597A CZ297382B6 (cs) | 1995-03-02 | 1996-03-01 | Rychle se dispergující orální pevná dávková formafarmaceutického prostredku pro lécení Parkinsonovy nemoci |
Country Status (26)
Country | Link |
---|---|
US (3) | US20010021722A1 (fr) |
EP (1) | EP0814789B2 (fr) |
JP (1) | JP3273141B2 (fr) |
CN (1) | CN1171586C (fr) |
AT (1) | ATE241346T1 (fr) |
AU (1) | AU702161B2 (fr) |
BG (1) | BG63862B1 (fr) |
BR (1) | BR9607057A (fr) |
CA (1) | CA2214026C (fr) |
CZ (1) | CZ297382B6 (fr) |
DE (1) | DE69628415T3 (fr) |
DK (1) | DK0814789T4 (fr) |
EE (1) | EE04039B1 (fr) |
ES (1) | ES2199283T5 (fr) |
GE (1) | GEP20012374B (fr) |
HU (1) | HU228852B1 (fr) |
IS (1) | IS2789B (fr) |
MX (1) | MX9706647A (fr) |
NO (1) | NO316804B1 (fr) |
NZ (2) | NZ302723A (fr) |
PL (1) | PL183266B1 (fr) |
PT (1) | PT814789E (fr) |
SI (1) | SI0814789T2 (fr) |
SK (1) | SK284383B6 (fr) |
TR (1) | TR199700878T1 (fr) |
WO (1) | WO1996026720A1 (fr) |
Families Citing this family (23)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5744500A (en) | 1990-01-03 | 1998-04-28 | Teva Pharmaceutical Industries, Ltd. | Use of R-enantiomer of N-propargyl-1-aminoindan, salts, and compositions thereof |
US5844003A (en) * | 1991-04-04 | 1998-12-01 | Innovations Foundation | Use of deprenyl compounds to maintain, prevent loss, or recover nerve cell function |
AU723047B2 (en) | 1995-02-10 | 2000-08-17 | University Of Toronto Innovations Foundation, The | Deprenyl compounds for treatment of glaucoma |
IL115357A (en) * | 1995-09-20 | 2000-01-31 | Teva Pharma | Stable compositions containing N-propargyl-1-aminoindan and polyhydric alcohols |
WO1997017067A1 (fr) * | 1995-11-06 | 1997-05-15 | Somerset Pharmaceuticals, Inc. | Administration sublinguale et buccale de selegiline |
GB9715082D0 (en) * | 1997-07-17 | 1997-09-24 | Scherer Ltd R P | Treatment of attention deficit hyperactivity disorder and narcolepsy |
GB9717770D0 (en) * | 1997-08-21 | 1997-10-29 | Scherer Ltd R P | Pharmaceutical composition |
GB9802088D0 (en) * | 1998-01-30 | 1998-03-25 | Scherer Ltd R P | Pharmaceutical products |
CN1251695C (zh) * | 1999-04-21 | 2006-04-19 | 株式会社柳柳 | 用于治疗痴呆的含有司来吉兰和银杏提取物的药物组合物 |
US20050089502A1 (en) * | 2003-08-21 | 2005-04-28 | Todd Schansberg | Effervescent delivery system |
CN101098685A (zh) * | 2004-11-24 | 2008-01-02 | 特瓦制药工业有限公司 | 雷沙吉兰经口崩解组合物 |
AU2005309817B2 (en) * | 2004-11-24 | 2011-08-18 | Teva Pharmaceutical Industries, Ltd. | Rasagiline orally disintegrating compositions |
CA2616918A1 (fr) | 2005-07-01 | 2007-01-11 | Jenrin Discovery | Inhibiteurs mao-b utiles dans le traitement de l'obesite |
CN1911211B (zh) * | 2006-08-25 | 2010-04-14 | 重庆医药工业研究院有限责任公司 | 雷沙吉兰口服固体制剂 |
EP1897543A1 (fr) | 2006-08-30 | 2008-03-12 | Euro-Celtique S.A. | Gaufre de buprénorphine pour la thérapie de substitution |
US20070190187A1 (en) * | 2006-09-07 | 2007-08-16 | Kneller Bruce W | Formulation for enhanced delivery of phenethylamine |
EP2053033A1 (fr) | 2007-10-26 | 2009-04-29 | Bayer Schering Pharma AG | Composants à utiliser dans l'imagerie, le diagnostic et/ou le traitement des maladies du système nerveux central ou des tumeurs |
CA2761538A1 (fr) * | 2009-05-20 | 2010-12-23 | Lingual Consegna Pty Ltd | Formulations therapeutiques ameliorees |
US8475832B2 (en) | 2009-08-07 | 2013-07-02 | Rb Pharmaceuticals Limited | Sublingual and buccal film compositions |
CN102048717B (zh) † | 2009-10-29 | 2014-02-19 | 重庆医药工业研究院有限责任公司 | 一种稳定的雷沙吉兰组合物 |
EP2450332A1 (fr) * | 2010-10-22 | 2012-05-09 | Bayer Pharma Aktiengesellschaft | Composants à utiliser dans l'imagerie, le diagnostic et/ou le traitement des maladies du système nerveux central (F-D2-déprényle) |
WO2013175493A1 (fr) | 2012-04-09 | 2013-11-28 | Cadila Healthcare Limited | Compositions pharmaceutiques orales stables |
EP3432931A1 (fr) | 2016-03-26 | 2019-01-30 | Dr. Reddy's Laboratories Ltd. | Compositions pharmaceutiques pour un dérivé de n-propargylamine |
Citations (8)
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GB1153578A (en) * | 1962-03-30 | 1969-05-29 | Chinoin Gyogyszer Es Vegyeszet | Phenyl-Isopropylamine Derivatives |
EP0067105A2 (fr) * | 1981-06-01 | 1982-12-15 | Merrell Dow France Et Cie | Inhibiteurs de MAO du type allylamine |
EP0252290A2 (fr) * | 1986-06-10 | 1988-01-13 | CHIESI FARMACEUTICI S.p.A. | Compositions pharmaceutiques contenant le lévodopa méthyl ester, leur préparation et leurs applications thérapeutiques |
WO1988004552A1 (fr) * | 1986-12-19 | 1988-06-30 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. | Composition servant a traiter le mal de mer |
WO1990001928A1 (fr) * | 1988-08-17 | 1990-03-08 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. | Composition servant a traiter la schizophrenie |
EP0436492A2 (fr) * | 1990-01-03 | 1991-07-10 | Teva Pharmaceutical Industries Limited | R-Enantiomère de N-propargyl-1-aminoindane, son préparation et composition pharmaceutique le contenant |
WO1992002224A1 (fr) * | 1990-08-10 | 1992-02-20 | Farmitalia Carlo Erba S.R.L. | Inhibiteur reversible antiparkinsonien a monoamine-oxydase |
WO1995011016A1 (fr) * | 1993-10-18 | 1995-04-27 | Teva Pharmaceutical Industries Ltd. | R-enantiomere de n-propargyl-1-amino-indane, sels, compositions et utilisation de ce compose |
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GB1548022A (en) * | 1976-10-06 | 1979-07-04 | Wyeth John & Brother Ltd | Pharmaceutial dosage forms |
CA1097233A (fr) * | 1977-07-20 | 1981-03-10 | George K. E. Gregory | Emballages |
IE53696B1 (en) * | 1981-12-02 | 1989-01-18 | Wyeth John & Brother Ltd | Solid shaped articles |
JP2660419B2 (ja) * | 1988-04-02 | 1997-10-08 | 旭電化工業株式会社 | 安定化された合成樹脂組成物 |
US4866046A (en) * | 1988-05-31 | 1989-09-12 | Top Laboratories, Inc. | Low-dosage sublingual aspirin |
US5055303A (en) * | 1989-01-31 | 1991-10-08 | Kv Pharmaceutical Company | Solid controlled release bioadherent emulsions |
US5079018A (en) * | 1989-08-14 | 1992-01-07 | Neophore Technologies, Inc. | Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs |
US5192550A (en) † | 1990-05-07 | 1993-03-09 | Alza Corporation | Dosage form for treating central nervous system disorders |
AU666509B2 (en) † | 1991-12-24 | 1996-02-15 | Yamanouchi Pharmaceutical Co., Ltd. | Intrabuccally disintegrating preparation and production thereof |
US5298261A (en) * | 1992-04-20 | 1994-03-29 | Oregon Freeze Dry, Inc. | Rapidly distintegrating tablet |
AU4534593A (en) † | 1992-06-12 | 1994-01-04 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
US5607691A (en) * | 1992-06-12 | 1997-03-04 | Affymax Technologies N.V. | Compositions and methods for enhanced drug delivery |
WO1997017067A1 (fr) * | 1995-11-06 | 1997-05-15 | Somerset Pharmaceuticals, Inc. | Administration sublinguale et buccale de selegiline |
-
1996
- 1996-03-01 JP JP52610896A patent/JP3273141B2/ja not_active Expired - Lifetime
- 1996-03-01 US US08/894,764 patent/US20010021722A1/en not_active Abandoned
- 1996-03-01 AU AU48846/96A patent/AU702161B2/en not_active Expired
- 1996-03-01 CZ CZ0270597A patent/CZ297382B6/cs not_active IP Right Cessation
- 1996-03-01 PL PL96322046A patent/PL183266B1/pl unknown
- 1996-03-01 ES ES96904929T patent/ES2199283T5/es not_active Expired - Lifetime
- 1996-03-01 HU HU9801227A patent/HU228852B1/hu unknown
- 1996-03-01 PT PT96904929T patent/PT814789E/pt unknown
- 1996-03-01 SI SI9630617T patent/SI0814789T2/sl unknown
- 1996-03-01 EP EP96904929A patent/EP0814789B2/fr not_active Expired - Lifetime
- 1996-03-01 BR BR9607057A patent/BR9607057A/pt not_active Application Discontinuation
- 1996-03-01 GE GEAP19963934A patent/GEP20012374B/en unknown
- 1996-03-01 TR TR97/00878T patent/TR199700878T1/xx unknown
- 1996-03-01 EE EE9700187A patent/EE04039B1/xx unknown
- 1996-03-01 CA CA002214026A patent/CA2214026C/fr not_active Expired - Lifetime
- 1996-03-01 DE DE69628415T patent/DE69628415T3/de not_active Expired - Lifetime
- 1996-03-01 SK SK1158-97A patent/SK284383B6/sk not_active IP Right Cessation
- 1996-03-01 AT AT96904929T patent/ATE241346T1/de active
- 1996-03-01 DK DK96904929T patent/DK0814789T4/da active
- 1996-03-01 NZ NZ302723A patent/NZ302723A/en not_active IP Right Cessation
- 1996-03-01 CN CNB961923032A patent/CN1171586C/zh not_active Expired - Lifetime
- 1996-03-01 NZ NZ329471A patent/NZ329471A/en not_active IP Right Cessation
- 1996-03-01 WO PCT/GB1996/000484 patent/WO1996026720A1/fr active IP Right Grant
-
1997
- 1997-08-27 IS IS4553A patent/IS2789B/is unknown
- 1997-09-01 NO NO19974010A patent/NO316804B1/no not_active IP Right Cessation
- 1997-09-02 MX MX9706647A patent/MX9706647A/es unknown
- 1997-10-01 BG BG101937A patent/BG63862B1/bg unknown
-
2003
- 2003-07-01 US US10/610,613 patent/US20040091525A1/en not_active Abandoned
-
2007
- 2007-09-05 US US11/850,141 patent/US20080187573A1/en not_active Abandoned
Patent Citations (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1153578A (en) * | 1962-03-30 | 1969-05-29 | Chinoin Gyogyszer Es Vegyeszet | Phenyl-Isopropylamine Derivatives |
EP0067105A2 (fr) * | 1981-06-01 | 1982-12-15 | Merrell Dow France Et Cie | Inhibiteurs de MAO du type allylamine |
EP0252290A2 (fr) * | 1986-06-10 | 1988-01-13 | CHIESI FARMACEUTICI S.p.A. | Compositions pharmaceutiques contenant le lévodopa méthyl ester, leur préparation et leurs applications thérapeutiques |
WO1988004552A1 (fr) * | 1986-12-19 | 1988-06-30 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. | Composition servant a traiter le mal de mer |
WO1990001928A1 (fr) * | 1988-08-17 | 1990-03-08 | Chinoin Gyógyszer és Vegyészeti Termékek Gyára Rt. | Composition servant a traiter la schizophrenie |
EP0436492A2 (fr) * | 1990-01-03 | 1991-07-10 | Teva Pharmaceutical Industries Limited | R-Enantiomère de N-propargyl-1-aminoindane, son préparation et composition pharmaceutique le contenant |
WO1992002224A1 (fr) * | 1990-08-10 | 1992-02-20 | Farmitalia Carlo Erba S.R.L. | Inhibiteur reversible antiparkinsonien a monoamine-oxydase |
WO1995011016A1 (fr) * | 1993-10-18 | 1995-04-27 | Teva Pharmaceutical Industries Ltd. | R-enantiomere de n-propargyl-1-amino-indane, sels, compositions et utilisation de ce compose |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PD00 | Pending as of 2000-06-30 in czech republic | ||
MK4A | Patent expired |
Effective date: 20160301 |