CZ292335B6 - Tetrahydropyridoethery, jejich použití a farmaceutický prostředek - Google Patents
Tetrahydropyridoethery, jejich použití a farmaceutický prostředek Download PDFInfo
- Publication number
- CZ292335B6 CZ292335B6 CZ20011082A CZ20011082A CZ292335B6 CZ 292335 B6 CZ292335 B6 CZ 292335B6 CZ 20011082 A CZ20011082 A CZ 20011082A CZ 20011082 A CZ20011082 A CZ 20011082A CZ 292335 B6 CZ292335 B6 CZ 292335B6
- Authority
- CZ
- Czechia
- Prior art keywords
- och
- hydroxy
- methoxyethoxy
- dimethyl
- methoxy
- Prior art date
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- 239000000825 pharmaceutical preparation Substances 0.000 title 1
- -1 methoxy, ethoxy, isopropoxy, methoxyethoxy Chemical group 0.000 claims abstract description 66
- 150000003839 salts Chemical class 0.000 claims abstract description 47
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract description 42
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims abstract description 20
- 125000001424 substituent group Chemical group 0.000 claims abstract description 17
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 12
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims abstract description 8
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- 239000001257 hydrogen Substances 0.000 claims description 27
- 229910052739 hydrogen Inorganic materials 0.000 claims description 27
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 16
- FLBAYUMRQUHISI-UHFFFAOYSA-N 1,8-naphthyridine Chemical compound N1=CC=CC2=CC=CN=C21 FLBAYUMRQUHISI-UHFFFAOYSA-N 0.000 claims description 12
- 239000008194 pharmaceutical composition Substances 0.000 claims description 10
- MXBVNILGVJVVMH-UHFFFAOYSA-N 1,7-naphthyridine Chemical compound C1=NC=CC2=CC=CN=C21 MXBVNILGVJVVMH-UHFFFAOYSA-N 0.000 claims description 5
- 239000004480 active ingredient Substances 0.000 claims description 5
- 238000011282 treatment Methods 0.000 claims description 5
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- VRRUMDUOYBYQPW-UHFFFAOYSA-N n-(2,3-dimethylimidazo[1,2-a]pyridin-8-yl)-2,2-dimethylpropanamide Chemical compound CC(C)(C)C(=O)NC1=CC=CN2C(C)=C(C)N=C21 VRRUMDUOYBYQPW-UHFFFAOYSA-N 0.000 description 1
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- 238000011321 prophylaxis Methods 0.000 description 1
- 210000001187 pylorus Anatomy 0.000 description 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
- VMXUWOKSQNHOCA-LCYFTJDESA-N ranitidine Chemical compound [O-][N+](=O)/C=C(/NC)NCCSCC1=CC=C(CN(C)C)O1 VMXUWOKSQNHOCA-LCYFTJDESA-N 0.000 description 1
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- BZGIPVGCJGXQTA-UHFFFAOYSA-N s-[2-(diethylamino)ethyl] n,n-diphenylcarbamothioate Chemical compound C=1C=CC=CC=1N(C(=O)SCCN(CC)CC)C1=CC=CC=C1 BZGIPVGCJGXQTA-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
- C07D471/14—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pyridine Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19843504 | 1998-09-23 | ||
| EP98117988 | 1998-09-23 |
Publications (2)
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|---|---|
| CZ20011082A3 CZ20011082A3 (cs) | 2001-09-12 |
| CZ292335B6 true CZ292335B6 (cs) | 2003-09-17 |
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| CZ20011082A CZ292335B6 (cs) | 1998-09-23 | 1999-09-17 | Tetrahydropyridoethery, jejich použití a farmaceutický prostředek |
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| AT (1) | ATE231862T1 (https=) |
| AU (1) | AU763463B2 (https=) |
| BG (1) | BG65195B1 (https=) |
| BR (1) | BR9914044A (https=) |
| CA (1) | CA2344251A1 (https=) |
| CZ (1) | CZ292335B6 (https=) |
| DE (1) | DE69905178T2 (https=) |
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| EA (1) | EA005377B1 (https=) |
| EE (1) | EE04677B1 (https=) |
| ES (1) | ES2191464T3 (https=) |
| GE (1) | GEP20032926B (https=) |
| HK (1) | HK1038360B (https=) |
| HR (1) | HRP20010224A2 (https=) |
| HU (1) | HUP0102990A3 (https=) |
| ID (1) | ID28896A (https=) |
| IL (2) | IL142063A0 (https=) |
| NO (1) | NO317304B1 (https=) |
| NZ (1) | NZ510610A (https=) |
| PL (1) | PL193616B1 (https=) |
| PT (1) | PT1115725E (https=) |
| RS (1) | RS50145B (https=) |
| SI (1) | SI1115725T1 (https=) |
| SK (1) | SK285165B6 (https=) |
| TR (1) | TR200100805T2 (https=) |
| WO (1) | WO2000017200A1 (https=) |
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| EE04677B1 (et) | 1998-09-23 | 2006-08-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Tetrahdropridoeetrid, nende kasutamine ja ravim |
| JP2002542248A (ja) * | 1999-04-17 | 2002-12-10 | ビイク グルデン ロンベルク ヒエーミツシエ フアブリーク ゲゼルシヤフト ミツト ベシユレンクテル ハフツング | ハロアルコキシイミダゾナフチリジン |
| CA2721484A1 (en) * | 1999-05-12 | 2000-11-12 | President And Fellows Of Harvard College | Dopamine transporter imaging agents |
| MXPA02009549A (es) * | 2000-03-29 | 2004-05-14 | Altana Pharma Ag | Imidazopiridinas triciclicas. |
| KR100860627B1 (ko) * | 2000-03-29 | 2008-09-29 | 니코메드 게엠베하 | 이미다조피리딘 유도체의 프로드러그 |
| PL360412A1 (en) * | 2000-10-25 | 2004-09-06 | Altana Pharma Ag | Polysubstituted imidazopyridines as gastric secretion inhibitors |
| UA80393C2 (uk) | 2000-12-07 | 2007-09-25 | Алтана Фарма Аг | Фармацевтична композиція, яка містить інгібітор фде 4, диспергований в матриці |
| EP1370261A2 (en) * | 2001-03-08 | 2003-12-17 | AstraZeneca AB | New use |
| US6927292B2 (en) | 2001-08-02 | 2005-08-09 | Altana Pharma Ag | Tricyclic epoxides |
| NZ531433A (en) * | 2001-08-03 | 2005-09-30 | Altana Pharma Ag | Alkyl-substituted imidazopyridines for the treatment of gastrointestinal disorders |
| WO2003014120A1 (en) * | 2001-08-03 | 2003-02-20 | Altana Pharma Ag | Amino-substituted imidazopyridines for the treatment of gastrointestinal diseases |
| HRP20040834A2 (en) | 2002-02-15 | 2005-06-30 | Altana Pharma Ag | Tricyclic n-acyl compounds |
| MY140561A (en) | 2002-02-20 | 2009-12-31 | Nycomed Gmbh | Dosage form containing pde 4 inhibitor as active ingredient |
| EP1506016A2 (en) * | 2002-05-07 | 2005-02-16 | ALTANA Pharma AG | New combination of reversible proton pump inhibitors and airway therapeutics for treating airway disorders |
| CA2506027A1 (en) | 2002-11-19 | 2004-06-03 | Altana Pharma Ag | 8-substituted imidazopyridines |
| ES2312844T3 (es) | 2002-12-12 | 2009-03-01 | Nycomed Gmbh | Medicamento de combinacion de r, r-formoterol y ciclesonida. |
| BR0316752A (pt) * | 2002-12-20 | 2005-10-25 | Altana Pharma Ag | Silil éteres |
| BRPI0407541A (pt) * | 2003-02-17 | 2006-02-14 | Altana Pharma Ag | combinações e uso de compostos farmaceuticamente ativos selecionados |
| PT1606261E (pt) | 2003-03-10 | 2010-01-11 | Nycomed Gmbh | Novo processo para a preparação de roflumilast |
| TW200503783A (en) * | 2003-04-11 | 2005-02-01 | Altana Pharma Ag | Oral pharmaceutical preparation for proton pump antagonists |
| SA04250092B1 (ar) * | 2003-05-14 | 2008-05-04 | التانا فاروا ايه جي | مركب وسيط جديد لتحضير مركبات إيميدازوبيريدين imidazopyridines فعالة علاجياً |
| JP2006528231A (ja) * | 2003-05-27 | 2006-12-14 | アルタナ ファルマ アクチエンゲゼルシャフト | プロトンポンプ阻害剤と胃腸運動性を変更する化合物との医薬品組合せ物 |
| BRPI0414046A (pt) * | 2003-08-29 | 2006-10-24 | Dynogen Pharmaceuticals Inc | método de tratamento de um distúrbio de motilidade gastrintestinal, de tratamento de "gerd", de "gerd" noturno, composição farmacêutica, kit que compreende um composto e método para aumentar a motilidade esofágica em um paciente |
| AU2004271744B2 (en) | 2003-09-16 | 2010-07-29 | Covis Pharma B.V. | Use of ciclesonide for the treatment of respiratory diseases |
| EP1682133A1 (en) * | 2003-11-03 | 2006-07-26 | AstraZeneca AB | Imidazo 1,2-a pyridine derivatives for the treatment of silent gastro-esophageal reflux |
| EP1697358A1 (en) | 2003-12-19 | 2006-09-06 | Altana Pharma AG | Intermediates for the preparation of tricyclic dihydropyrano -imidazo -pyridines derivatives |
| NZ549011A (en) * | 2004-02-17 | 2009-04-30 | Altana Pharma Ag | Tricyclic imidazopyridines and intermediates for the synthesis thereof |
| MX2007002214A (es) | 2004-09-03 | 2007-05-07 | Yuhan Corp | Derivados de pirrolo[3,2-c]piridina y procesos para su preparacion. |
| KR100958828B1 (ko) | 2004-09-03 | 2010-05-24 | 주식회사유한양행 | 피롤로[3,2-ｂ]피리딘 유도체 및 그의 제조방법 |
| DK1784404T3 (da) | 2004-09-03 | 2012-02-13 | Yuhan Corp | Pyrrolo[2,3-c]pyridinderivater samt fremgangsmåder til deres fremstilling |
| US8663694B2 (en) * | 2005-03-16 | 2014-03-04 | Takeda Gmbh | Taste masked dosage form containing roflumilast |
| EP2080513A1 (en) | 2008-01-16 | 2009-07-22 | Schraermeyer, Ulrich, Prof. Dr. rer. nat | Tetrahydropyridoethers for treatment of AMD |
| EP2452680B1 (en) | 2009-07-09 | 2019-12-18 | RaQualia Pharma Inc. | Acid pump antagonist for the treatment of diseases involved in abnormal gastrointestinal motility |
| WO2012027240A1 (en) * | 2010-08-23 | 2012-03-01 | Schering Corporation | Fused tricyclic inhibitors of mammalian target of rapamycin |
| WO2013187727A1 (en) * | 2012-06-15 | 2013-12-19 | Bio-Pharm Solutions Co., Ltd. | Phenylalkyl sulfamate compound and muscle relaxant composition comprising the same |
| EP3054949A1 (en) | 2013-10-08 | 2016-08-17 | Katairo GmbH | Tetrahydropyridoethers for the treatment of stargardt's disease |
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| US4468400A (en) * | 1982-12-20 | 1984-08-28 | Schering Corporation | Antiulcer tricyclic imidazo [1,2-a]pyridines |
| KR890701585A (ko) * | 1987-07-16 | 1989-12-21 | 헤르베르크 슈키·울리히 볼프 | 새로운 디아졸 |
| SE9401197D0 (sv) * | 1994-04-11 | 1994-04-11 | Astra Ab | Active compounds |
| NZ290819A (en) * | 1994-07-28 | 1998-06-26 | Byk Gulden Lomberg Chem Fab | Acyl 8-benzyloxy- or 8-benzylaminoimidazopyridines |
| AU740578B2 (en) * | 1997-03-24 | 2001-11-08 | Altana Pharma Ag | Tetrahydropyrido compounds |
| EP0971922B1 (en) * | 1997-03-24 | 2004-04-28 | ALTANA Pharma AG | Tetrahydropyrido compounds |
| EE04677B1 (et) | 1998-09-23 | 2006-08-15 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Tetrahdropridoeetrid, nende kasutamine ja ravim |
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1999
- 1999-09-17 EE EEP200100172A patent/EE04677B1/xx not_active IP Right Cessation
- 1999-09-17 NZ NZ510610A patent/NZ510610A/en unknown
- 1999-09-17 KR KR1020017003553A patent/KR100668400B1/ko not_active Expired - Fee Related
- 1999-09-17 ES ES99948776T patent/ES2191464T3/es not_active Expired - Lifetime
- 1999-09-17 HR HR20010224A patent/HRP20010224A2/hr not_active Application Discontinuation
- 1999-09-17 BR BR9914044-6A patent/BR9914044A/pt not_active Application Discontinuation
- 1999-09-17 SI SI9930207T patent/SI1115725T1/xx unknown
- 1999-09-17 JP JP2000574109A patent/JP4145492B2/ja not_active Expired - Lifetime
- 1999-09-17 CA CA002344251A patent/CA2344251A1/en not_active Abandoned
- 1999-09-17 CN CNB2004100384351A patent/CN100506821C/zh not_active Expired - Fee Related
- 1999-09-17 SK SK399-2001A patent/SK285165B6/sk not_active IP Right Cessation
- 1999-09-17 CN CNB998112992A patent/CN1155598C/zh not_active Expired - Fee Related
- 1999-09-17 HU HU0102990A patent/HUP0102990A3/hu unknown
- 1999-09-17 DK DK99948776T patent/DK1115725T3/da active
- 1999-09-17 EP EP99948776A patent/EP1115725B1/en not_active Expired - Lifetime
- 1999-09-17 RS YUP-214/01A patent/RS50145B/sr unknown
- 1999-09-17 DE DE69905178T patent/DE69905178T2/de not_active Expired - Lifetime
- 1999-09-17 TR TR2001/00805T patent/TR200100805T2/xx unknown
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- 1999-09-17 EA EA200100315A patent/EA005377B1/ru not_active IP Right Cessation
- 1999-09-17 WO PCT/EP1999/006899 patent/WO2000017200A1/en not_active Ceased
- 1999-09-17 PT PT99948776T patent/PT1115725E/pt unknown
- 1999-09-17 AT AT99948776T patent/ATE231862T1/de not_active IP Right Cessation
- 1999-09-17 GE GEAP19995786A patent/GEP20032926B/en unknown
- 1999-09-17 CZ CZ20011082A patent/CZ292335B6/cs not_active IP Right Cessation
- 1999-09-17 US US09/582,212 patent/US6436953B1/en not_active Expired - Lifetime
- 1999-09-17 HK HK02100042.6A patent/HK1038360B/en not_active IP Right Cessation
- 1999-09-17 IL IL14206399A patent/IL142063A0/xx active IP Right Grant
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2001
- 2001-02-19 BG BG105270A patent/BG65195B1/bg unknown
- 2001-03-12 NO NO20011243A patent/NO317304B1/no not_active IP Right Cessation
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2002
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2004
- 2004-02-23 US US10/783,512 patent/US7105676B2/en not_active Expired - Lifetime
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2006
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| Date | Code | Title | Description |
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| MM4A | Patent lapsed due to non-payment of fee |
Effective date: 20090917 |