CZ287531B6 - Process for preparing extremely pure buspirone and hydrochloride thereof - Google Patents

Process for preparing extremely pure buspirone and hydrochloride thereof Download PDF

Info

Publication number
CZ287531B6
CZ287531B6 CZ19941709A CZ170994A CZ287531B6 CZ 287531 B6 CZ287531 B6 CZ 287531B6 CZ 19941709 A CZ19941709 A CZ 19941709A CZ 170994 A CZ170994 A CZ 170994A CZ 287531 B6 CZ287531 B6 CZ 287531B6
Authority
CZ
Czechia
Prior art keywords
decane
pyrimidin
piperazin
dione
spiro
Prior art date
Application number
CZ19941709A
Other languages
Czech (cs)
English (en)
Other versions
CZ170994A3 (en
Inventor
Libor Dr Mezei
Gabor Dr Blaske
Zoltan Dr Budai
Margit Dr Csoergoe
Va Dr Furdyga
Imre Dr Klebovich
Laszle Koncz
Ilona Dr Sztruhar
Attila Dr Mandi
Kalman Dr Nagy
Klara Dr Reiter
Gyula Dr Simig
Judit Dr Szegoe
Gyoengyi Vereczkey
Original Assignee
Egis Gyegyszergyar Rt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Egis Gyegyszergyar Rt filed Critical Egis Gyegyszergyar Rt
Publication of CZ170994A3 publication Critical patent/CZ170994A3/cs
Publication of CZ287531B6 publication Critical patent/CZ287531B6/cs

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Anesthesiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Pyrrole Compounds (AREA)
CZ19941709A 1993-07-16 1994-07-14 Process for preparing extremely pure buspirone and hydrochloride thereof CZ287531B6 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
HU9302040A HU217129B (hu) 1993-07-16 1993-07-16 Eljárás nagy tisztaságú buspiron gyógyászati hatóanyag előállítására

Publications (2)

Publication Number Publication Date
CZ170994A3 CZ170994A3 (en) 1995-04-12
CZ287531B6 true CZ287531B6 (en) 2000-12-13

Family

ID=10983790

Family Applications (1)

Application Number Title Priority Date Filing Date
CZ19941709A CZ287531B6 (en) 1993-07-16 1994-07-14 Process for preparing extremely pure buspirone and hydrochloride thereof

Country Status (20)

Country Link
US (1) US5473072A (fr)
EP (1) EP0634411B1 (fr)
JP (1) JPH07165755A (fr)
KR (1) KR950003287A (fr)
AT (1) ATE180480T1 (fr)
BG (1) BG98904A (fr)
CA (1) CA2128164A1 (fr)
CZ (1) CZ287531B6 (fr)
DE (1) DE59408299D1 (fr)
ES (1) ES2082722B1 (fr)
FR (1) FR2709128B1 (fr)
GB (1) GB2280185B (fr)
HR (1) HRP940408B1 (fr)
HU (1) HU217129B (fr)
IT (1) IT1271677B (fr)
PL (1) PL176708B1 (fr)
RU (1) RU2131875C1 (fr)
SK (1) SK281622B6 (fr)
UA (1) UA44687C2 (fr)
ZA (1) ZA945210B (fr)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2146593A1 (fr) * 1994-05-05 1995-11-06 Jack Melton Procede pour la synthese a grande echelle d'azapirone
US20040127501A1 (en) * 2002-09-24 2004-07-01 Zhengming Chen Therapeutic agents useful for treating pain

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE1943024B2 (de) * 1969-08-23 1972-12-21 Metallgesellschaft Ag, 6000 Frankfurt Vorrichtung zur abdichtung von end-windkaesten von wanderrosten
BE759371A (fr) * 1969-11-24 1971-05-24 Bristol Myers Co Azaspirodecanediones heterocycliques et procedes pour leur preparation
JPS6310760A (ja) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd イミド誘導体の新規製造法
JPS6310786A (ja) * 1986-07-01 1988-01-18 Sumitomo Pharmaceut Co Ltd 新規イミド誘導体およびその製造法
CH677924A5 (fr) * 1987-02-25 1991-07-15 Egyt Gyogyszervegyeszeti Gyar
US4810789A (en) * 1987-08-28 1989-03-07 Bristol-Myers Company Process for buspirone hydrochloride polymorphic crystalline form conversion
US5015646A (en) * 1987-08-28 1991-05-14 Bristol-Myers Squibb Co. Pharmaceutically useful polymorphic modification of buspirone
US5130315A (en) * 1991-01-10 1992-07-14 Raymond R. Wittekind 1-piperazinyl-2-butenes and -2-butynes

Also Published As

Publication number Publication date
HRP940408A2 (en) 1996-10-31
US5473072A (en) 1995-12-05
PL176708B1 (pl) 1999-07-30
EP0634411B1 (fr) 1999-05-26
SK281622B6 (sk) 2001-05-10
BG98904A (bg) 1995-05-31
FR2709128B1 (fr) 1996-02-23
CZ170994A3 (en) 1995-04-12
DE59408299D1 (de) 1999-07-01
GB2280185B (en) 1997-04-16
FR2709128A1 (fr) 1995-02-24
GB9414325D0 (en) 1994-09-07
ZA945210B (en) 1996-01-15
RU2131875C1 (ru) 1999-06-20
HU217129B (hu) 1999-11-29
ATE180480T1 (de) 1999-06-15
EP0634411A1 (fr) 1995-01-18
GB2280185A (en) 1995-01-25
ITMI941492A1 (it) 1996-01-18
PL304313A1 (en) 1995-01-23
IT1271677B (it) 1997-06-04
KR950003287A (ko) 1995-02-16
ES2082722B1 (es) 1996-10-01
UA44687C2 (uk) 2002-03-15
CA2128164A1 (fr) 1995-01-17
SK86194A3 (en) 1995-03-08
HRP940408B1 (en) 2000-02-29
HUT69720A (en) 1995-09-28
ITMI941492A0 (it) 1994-07-18
HU9302040D0 (en) 1993-10-28
RU94026281A (ru) 1996-05-27
JPH07165755A (ja) 1995-06-27
ES2082722A1 (es) 1996-03-16

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Legal Events

Date Code Title Description
PD00 Pending as of 2000-06-30 in czech republic
MM4A Patent lapsed due to non-payment of fee

Effective date: 20100714