CY1124933T1 - Κυτταροτοξικες και αντι-μιτωτικες ενωσεις και μεθοδοι χρησης αυτων - Google Patents

Κυτταροτοξικες και αντι-μιτωτικες ενωσεις και μεθοδοι χρησης αυτων

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Publication number
CY1124933T1
CY1124933T1 CY20221100080T CY221100080T CY1124933T1 CY 1124933 T1 CY1124933 T1 CY 1124933T1 CY 20221100080 T CY20221100080 T CY 20221100080T CY 221100080 T CY221100080 T CY 221100080T CY 1124933 T1 CY1124933 T1 CY 1124933T1
Authority
CY
Cyprus
Prior art keywords
cytotoxic
compounds
methods
disclosed
mitotic compounds
Prior art date
Application number
CY20221100080T
Other languages
English (en)
Inventor
Geoffrey C. Winters
James R. RICH
Graham Albert Edwin GARNETT
Alexander Laurence MANDEL
Tom Han Hsiao HSIEH
Elyse Marie Josee Bourque
Stuart Daniel Barnscher
Original Assignee
Zymeworks Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zymeworks Inc. filed Critical Zymeworks Inc.
Publication of CY1124933T1 publication Critical patent/CY1124933T1/el

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/05—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • H01—ELECTRIC ELEMENTS
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Abstract

Αποκαλύπτονται ενώσεις οι οποίες έχουν κυτταροτοξική και/ή αντιμιτωτική δράση. Αποκαλύπτονται επίσης μέθοδοι που σχετίζονται με την παρασκευή και χρήση τέτοιων ενώσεων, καθώς και φαρμακευτικές συνθέσεις που περιλαμβάνουν τέτοιες ενώσεις. Αποκαλύπτονται επίσης συνθέσεις που έχουν τη δομή: (T)-(L)-(D), όπου το (Τ) είναι ένα τμήμα στόχευσης, το (L) είναι ένας προαιρετικός συνδέτης και το (D) είναι μία ένωση η οποία έχει κυτταροτοξική και/ή αντι-μιτωτική δραστικότητα.
CY20221100080T 2014-09-17 2022-02-01 Κυτταροτοξικες και αντι-μιτωτικες ενωσεις και μεθοδοι χρησης αυτων CY1124933T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462051883P 2014-09-17 2014-09-17
PCT/CA2015/050910 WO2016041082A1 (en) 2014-09-17 2015-09-17 Cytotoxic and anti-mitotic compounds, and methods of using the same

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AU2015318556C1 (en) 2021-01-07
KR20230020018A (ko) 2023-02-09
CN107001415A (zh) 2017-08-01
US10414822B2 (en) 2019-09-17

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