CY1123616T1 - 7-βενζυλ-4-(4-(τριφθορομεθυλ)βενζυλ)-1,2,6,7,8,9-εξαϋδροϊμιδαζο[1,2-α]πυριδο[3,4-ε]πυριμιδιν-5(4η)-ονη, και αλατα αυτης και χρηση αυτων στη θεραπεια - Google Patents

7-βενζυλ-4-(4-(τριφθορομεθυλ)βενζυλ)-1,2,6,7,8,9-εξαϋδροϊμιδαζο[1,2-α]πυριδο[3,4-ε]πυριμιδιν-5(4η)-ονη, και αλατα αυτης και χρηση αυτων στη θεραπεια

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Publication number
CY1123616T1
CY1123616T1 CY20201101158T CY201101158T CY1123616T1 CY 1123616 T1 CY1123616 T1 CY 1123616T1 CY 20201101158 T CY20201101158 T CY 20201101158T CY 201101158 T CY201101158 T CY 201101158T CY 1123616 T1 CY1123616 T1 CY 1123616T1
Authority
CY
Cyprus
Prior art keywords
benzyl
salts
hexahydroimidazo
oni
pyrido
Prior art date
Application number
CY20201101158T
Other languages
Greek (el)
English (en)
Inventor
Martin Stogniew
Joshua E. ALLEN
Richard S. Pottorf
Bhaskara Rao Nallaganchu
Gary L. Olson
Yanjun Sun
Original Assignee
Oncoceutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncoceutics, Inc. filed Critical Oncoceutics, Inc.
Publication of CY1123616T1 publication Critical patent/CY1123616T1/el

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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CY20201101158T 2015-01-30 2020-12-07 7-βενζυλ-4-(4-(τριφθορομεθυλ)βενζυλ)-1,2,6,7,8,9-εξαϋδροϊμιδαζο[1,2-α]πυριδο[3,4-ε]πυριμιδιν-5(4η)-ονη, και αλατα αυτης και χρηση αυτων στη θεραπεια CY1123616T1 (el)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562109737P 2015-01-30 2015-01-30
US201562148844P 2015-04-17 2015-04-17
US201562233757P 2015-09-28 2015-09-28
PCT/US2016/015817 WO2016123571A1 (en) 2015-01-30 2016-01-29 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs and salts thereof and their use in therapy

Publications (1)

Publication Number Publication Date
CY1123616T1 true CY1123616T1 (el) 2022-03-24

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CY20201101158T CY1123616T1 (el) 2015-01-30 2020-12-07 7-βενζυλ-4-(4-(τριφθορομεθυλ)βενζυλ)-1,2,6,7,8,9-εξαϋδροϊμιδαζο[1,2-α]πυριδο[3,4-ε]πυριμιδιν-5(4η)-ονη, και αλατα αυτης και χρηση αυτων στη θεραπεια

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US (6) US9845324B2 (enExample)
EP (4) EP4512483A3 (enExample)
JP (4) JP6802172B2 (enExample)
KR (3) KR102618971B1 (enExample)
CN (2) CN113149985B (enExample)
AU (5) AU2016211243B2 (enExample)
BR (1) BR112017016487B1 (enExample)
CA (3) CA2975476C (enExample)
CY (1) CY1123616T1 (enExample)
DK (2) DK3805222T3 (enExample)
EA (1) EA037552B1 (enExample)
ES (2) ES3009132T3 (enExample)
FI (1) FI3805222T3 (enExample)
HR (2) HRP20201949T1 (enExample)
HU (2) HUE070309T2 (enExample)
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PT (2) PT3250208T (enExample)
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SG (2) SG11201706062TA (enExample)
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SM (2) SMT202500087T1 (enExample)
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CN104860948B (zh) 2015-05-15 2017-09-26 南京盖特医药技术有限公司 咪唑并嘧啶酮类化合物及其制备方法和应用
WO2017132661A2 (en) * 2016-01-29 2017-08-03 Oncoceutics, Inc. G protein-coupled receptor (gpcr) modulation by imipridones
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TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
US11091483B2 (en) * 2016-08-12 2021-08-17 Madera Therapeutics, LLC Protein kinase regulators
US10172862B2 (en) * 2017-01-30 2019-01-08 Oncoceutics, Inc. Imipridones for gliomas
WO2018169994A1 (en) * 2017-03-13 2018-09-20 City Of Hope m6A mRNA MODIFICATION IN CANCER TREATMENT
EP3589745A1 (en) * 2018-04-11 2020-01-08 Chemestmed Ltd. A method of modulating the rna methylation
EP3949992A4 (en) 2019-03-26 2022-09-14 FUJIFILM Corporation PHARMACEUTICAL COMPOSITION FOR INHIBITING THE PRODUCTION OF HEPATITIS B VIRUS PROTEIN, PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF HEPATITIS B AND SCREENING METHOD
US12636293B2 (en) 2019-04-04 2026-05-26 Cmtx Biotech Inc. Methods of treating charcot-marie-tooth disease
AU2021214938B2 (en) 2020-01-29 2024-02-08 Corcept Therapeutics Incorporated Treatment of adrenocortical carcinoma with selective glucocorticoid receptor modulators (SGRMs) and antibody checkpoint inhibitors
BR112023002082A2 (pt) * 2020-08-06 2023-05-09 Eoetvoes Lorand Tudomanyegyetem Síntese de derivados de imipridona e sua avaliação para sua atividade anticancerígena
CN116249538A (zh) 2020-09-30 2023-06-09 富士胶片株式会社 抑制乙型肝炎病毒蛋白质的产生的双链rna及药物组合物
KR20230118855A (ko) * 2020-11-13 2023-08-14 더 리전츠 오브 더 유니버시티 오브 캘리포니아 IRE1α 억제제 및 이의 용도
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