ES3009132T3 - 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one derivatives, salts thereof and their use in therapy - Google Patents

7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one derivatives, salts thereof and their use in therapy Download PDF

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Publication number
ES3009132T3
ES3009132T3 ES20198062T ES20198062T ES3009132T3 ES 3009132 T3 ES3009132 T3 ES 3009132T3 ES 20198062 T ES20198062 T ES 20198062T ES 20198062 T ES20198062 T ES 20198062T ES 3009132 T3 ES3009132 T3 ES 3009132T3
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compound
cancer
treatment
group
therapeutic agent
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Spanish (es)
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Martin Stogniew
Joshua E Allen
Richard S Pottorf
Bhaskara Rao Nallaganchu
Gary L Olson
Yanjun Sun
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Oncoceutics Inc
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Oncoceutics Inc
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
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ES20198062T 2015-01-30 2016-01-29 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one derivatives, salts thereof and their use in therapy Active ES3009132T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562109737P 2015-01-30 2015-01-30
US201562148844P 2015-04-17 2015-04-17
US201562233757P 2015-09-28 2015-09-28

Publications (1)

Publication Number Publication Date
ES3009132T3 true ES3009132T3 (en) 2025-03-26

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Application Number Title Priority Date Filing Date
ES20198062T Active ES3009132T3 (en) 2015-01-30 2016-01-29 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo[1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one derivatives, salts thereof and their use in therapy
ES16744237T Active ES2839401T3 (es) 2015-01-30 2016-01-29 7-Bencil-4-(4-trifluorometil)bencil)-1,2,4,6,7,8,9-hexahidroimidazo[1,2-A]pirido[3,4-E]pirimidin-5(4H)-ona y sales del mismo y su uso en terapia

Family Applications After (1)

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ES16744237T Active ES2839401T3 (es) 2015-01-30 2016-01-29 7-Bencil-4-(4-trifluorometil)bencil)-1,2,4,6,7,8,9-hexahidroimidazo[1,2-A]pirido[3,4-E]pirimidin-5(4H)-ona y sales del mismo y su uso en terapia

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US (6) US9845324B2 (enExample)
EP (4) EP4516359A3 (enExample)
JP (3) JP6802172B2 (enExample)
KR (3) KR102618971B1 (enExample)
CN (2) CN107427516B8 (enExample)
AU (4) AU2016211243B2 (enExample)
BR (1) BR112017016487B1 (enExample)
CA (3) CA3209519A1 (enExample)
CY (1) CY1123616T1 (enExample)
DK (2) DK3805222T3 (enExample)
EA (1) EA037552B1 (enExample)
ES (2) ES3009132T3 (enExample)
FI (1) FI3805222T3 (enExample)
HR (2) HRP20201949T1 (enExample)
HU (2) HUE052821T2 (enExample)
IL (5) IL288525B (enExample)
LT (2) LT3805222T (enExample)
MA (2) MA55402B1 (enExample)
MD (2) MD3250208T2 (enExample)
MX (3) MX379425B (enExample)
PL (2) PL3250208T3 (enExample)
PT (2) PT3250208T (enExample)
RS (2) RS61243B1 (enExample)
SG (2) SG10201803508WA (enExample)
SI (2) SI3250208T1 (enExample)
SM (2) SMT202500087T1 (enExample)
WO (1) WO2016123571A1 (enExample)

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SMT202500087T1 (it) * 2015-01-30 2025-03-12 Oncoceutics Inc Derivati di 7-benzil-4-(2-metilbenzil)-2,4,6,7,8,9-esaidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(1h)-one, loro sali e loro uso in terapia
CN104860948B (zh) 2015-05-15 2017-09-26 南京盖特医药技术有限公司 咪唑并嘧啶酮类化合物及其制备方法和应用
BR112018015590A2 (pt) * 2016-01-29 2019-10-01 Oncoceutics Inc modulação de receptor acoplado à proteína g (gpcr) por imipridonas
SG11201807421TA (en) 2016-03-01 2018-09-27 Corcept Therapeutics Inc The use of glucocorticoid receptor modulators to potentiate checkpoint inhibitors
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
WO2018031987A1 (en) 2016-08-12 2018-02-15 Nanjing Gator Meditech Company, Ltd. Protein kinase regulators
US10172862B2 (en) * 2017-01-30 2019-01-08 Oncoceutics, Inc. Imipridones for gliomas
US20200129596A1 (en) * 2017-03-13 2020-04-30 City Of Hope m6A mRNA MODIFICATION IN CANCER TREATMENT
WO2019197024A1 (en) * 2018-04-11 2019-10-17 Chemestmed Ltd. A method of modulating the rna methylation
CN113631192B (zh) 2019-03-26 2023-07-21 富士胶片株式会社 抑制乙型肝炎病毒蛋白产生的医药组合物、用于处置乙型肝炎的医药组合物及筛选方法
EP4096663A4 (en) * 2020-01-29 2023-10-25 Corcept Therapeutics Incorporated TREATMENT OF CORTICOSADRENAL CARCINOMA USING SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS (SGRM) AND ANTIBODY CHECKPOINT INHIBITORS
EP4192467A1 (en) * 2020-08-06 2023-06-14 Eötvös Loránd Tudományegyetem Synthesis of novel imipridone derivatives and their evaluation for their anticancer activity
JP7644136B2 (ja) 2020-09-30 2025-03-11 富士フイルム株式会社 Ｂ型肝炎ウイルスタンパク質の産生を阻害する二本鎖ｒｎａ、及び医薬組成物
EP4243815A4 (en) * 2020-11-13 2024-10-02 The Regents of the University of California IRE1ALPHA INHIBITORS AND USES THEREOF
CN113100233B (zh) * 2021-04-19 2022-02-08 中国农业科学院植物保护研究所 芳甲羟肟酸及其衍生物作为几丁质脱乙酰基酶抑制剂及植物抗真菌剂的应用
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