LT3250208T - 7-benzil-4-(4-(trifluormetil)benzil)-1,2,6,7,8,9-heksahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(4h)-onas ir jo druskos, ir jų naudojimas terapijoje - Google Patents

7-benzil-4-(4-(trifluormetil)benzil)-1,2,6,7,8,9-heksahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(4h)-onas ir jo druskos, ir jų naudojimas terapijoje

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Publication number
LT3250208T
LT3250208T LTEP16744237.5T LT16744237T LT3250208T LT 3250208 T LT3250208 T LT 3250208T LT 16744237 T LT16744237 T LT 16744237T LT 3250208 T LT3250208 T LT 3250208T
Authority
LT
Lithuania
Prior art keywords
benzyl
hexahydroimidazo
pyrido
pyrimidin
trifluoromethyl
Prior art date
Application number
LTEP16744237.5T
Other languages
English (en)
Lithuanian (lt)
Inventor
Martin Stogniew
Joshua E. Allen
Richard S. Pottorf
Bhaskara Rao Nallaganchu
Gary L. Olson
Yanjun Sun
Original Assignee
Oncoceutics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncoceutics, Inc. filed Critical Oncoceutics, Inc.
Publication of LT3250208T publication Critical patent/LT3250208T/lt

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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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LTEP16744237.5T 2015-01-30 2016-01-29 7-benzil-4-(4-(trifluormetil)benzil)-1,2,6,7,8,9-heksahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(4h)-onas ir jo druskos, ir jų naudojimas terapijoje LT3250208T (lt)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201562109737P 2015-01-30 2015-01-30
US201562148844P 2015-04-17 2015-04-17
US201562233757P 2015-09-28 2015-09-28
PCT/US2016/015817 WO2016123571A1 (en) 2015-01-30 2016-01-29 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs and salts thereof and their use in therapy

Publications (1)

Publication Number Publication Date
LT3250208T true LT3250208T (lt) 2021-01-25

Family

ID=56544438

Family Applications (2)

Application Number Title Priority Date Filing Date
LTEP16744237.5T LT3250208T (lt) 2015-01-30 2016-01-29 7-benzil-4-(4-(trifluormetil)benzil)-1,2,6,7,8,9-heksahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(4h)-onas ir jo druskos, ir jų naudojimas terapijoje
LTEP20198062.0T LT3805222T (lt) 2015-01-30 2016-01-29 7-benzil-4-(2-metilbenzil)-2,4,6,7,8,9-heksahidroimidazo[1,2-a]pirido[3,4-e]pirimidino-5(1h)-ono dariniai, jų druskos ir jų naudojimas terapijai

Family Applications After (1)

Application Number Title Priority Date Filing Date
LTEP20198062.0T LT3805222T (lt) 2015-01-30 2016-01-29 7-benzil-4-(2-metilbenzil)-2,4,6,7,8,9-heksahidroimidazo[1,2-a]pirido[3,4-e]pirimidino-5(1h)-ono dariniai, jų druskos ir jų naudojimas terapijai

Country Status (27)

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US (6) US9845324B2 (enExample)
EP (4) EP3250208B1 (enExample)
JP (3) JP6802172B2 (enExample)
KR (3) KR20250134216A (enExample)
CN (2) CN113149985B (enExample)
AU (4) AU2016211243B2 (enExample)
BR (1) BR112017016487B1 (enExample)
CA (3) CA3209519A1 (enExample)
CY (1) CY1123616T1 (enExample)
DK (2) DK3250208T3 (enExample)
EA (1) EA037552B1 (enExample)
ES (2) ES3009132T3 (enExample)
FI (1) FI3805222T3 (enExample)
HR (2) HRP20201949T1 (enExample)
HU (2) HUE052821T2 (enExample)
IL (5) IL295286B2 (enExample)
LT (2) LT3250208T (enExample)
MA (2) MA55402B1 (enExample)
MD (2) MD3805222T2 (enExample)
MX (3) MX2021001096A (enExample)
PL (2) PL3805222T3 (enExample)
PT (2) PT3805222T (enExample)
RS (2) RS61243B1 (enExample)
SG (2) SG10201803508WA (enExample)
SI (2) SI3805222T1 (enExample)
SM (2) SMT202500087T1 (enExample)
WO (1) WO2016123571A1 (enExample)

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IL295286B2 (en) 2015-01-30 2024-10-01 Oncoceutics Inc 7-benzyl-4-(2-methylbenzyl)-2,4,6,7,8,9-hexahydroimidazo [1,2-a]pyrido[3,4-e]pyrimidin-5(1h)-one, analogs thereof, and salts thereof and methods for their use in therapy
CN104860948B (zh) 2015-05-15 2017-09-26 南京盖特医药技术有限公司 咪唑并嘧啶酮类化合物及其制备方法和应用
EP3408298B1 (en) * 2016-01-29 2024-11-20 Oncoceutics, Inc. G protein-coupled receptor (gpcr) modulation by imipridones
AU2017228329B2 (en) 2016-03-01 2021-03-11 Corcept Therapeutics, Inc. The use of glucocorticoid receptor modulators to potentiate checkpoint inhibitors
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
WO2018031987A1 (en) 2016-08-12 2018-02-15 Nanjing Gator Meditech Company, Ltd. Protein kinase regulators
US10172862B2 (en) * 2017-01-30 2019-01-08 Oncoceutics, Inc. Imipridones for gliomas
WO2018169994A1 (en) * 2017-03-13 2018-09-20 City Of Hope m6A mRNA MODIFICATION IN CANCER TREATMENT
WO2019197024A1 (en) * 2018-04-11 2019-10-17 Chemestmed Ltd. A method of modulating the rna methylation
TW202102251A (zh) 2019-03-26 2021-01-16 日商富士軟片股份有限公司 抑制ｂ型肝炎病毒蛋白質產生的醫藥組成物、用以處理ｂ型肝炎的醫藥組成物及篩選方法
IL294862A (en) * 2020-01-29 2022-09-01 Corcept Therapeutics Inc Treatment of adrenocortical carcinoma with selective glucocorticoid receptor modulators (sgrms) and antibody checkpoint inhibitors
KR20230106583A (ko) * 2020-08-06 2023-07-13 에오토보스 로란드 투도만예게템 신규한 이미프리돈 유도체의 합성 및 이들의 항암 활성에 대한 평가
EP4223876A4 (en) 2020-09-30 2025-12-10 Fujifilm Corp DOUBLE-STRANDED RNA THAT INHIBITS THE PRODUCTION OF A HEPATITIS B VIRUS PROTEIN, AND PHARMACEUTICAL COMPOSITION
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