HUE070309T2 - 7-Benzil-4-(2-metilbenzil)-2,4,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4--E]pirimidin-5(1H)-on származékok, sóik és terápiás alkalmazásuk - Google Patents

7-Benzil-4-(2-metilbenzil)-2,4,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4--E]pirimidin-5(1H)-on származékok, sóik és terápiás alkalmazásuk

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Publication number
HUE070309T2
HUE070309T2 HUE20198062A HUE20198062A HUE070309T2 HU E070309 T2 HUE070309 T2 HU E070309T2 HU E20198062 A HUE20198062 A HU E20198062A HU E20198062 A HUE20198062 A HU E20198062A HU E070309 T2 HUE070309 T2 HU E070309T2
Authority
HU
Hungary
Prior art keywords
hexahydroimidazo
pyrido
methylbenzyl
pyrimidin
benzyl
Prior art date
Application number
HUE20198062A
Other languages
English (en)
Hungarian (hu)
Inventor
Martin Stogniew
Joshua E Allen
Richard S Pottorf
Bhaskara Rao Nallaganchu
Gary L Olson
Yanjun Sun
Original Assignee
Oncoceutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncoceutics Inc filed Critical Oncoceutics Inc
Publication of HUE070309T2 publication Critical patent/HUE070309T2/hu

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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
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HUE20198062A 2015-01-30 2016-01-29 7-Benzil-4-(2-metilbenzil)-2,4,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4--E]pirimidin-5(1H)-on származékok, sóik és terápiás alkalmazásuk HUE070309T2 (hu)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562109737P 2015-01-30 2015-01-30
US201562148844P 2015-04-17 2015-04-17
US201562233757P 2015-09-28 2015-09-28

Publications (1)

Publication Number Publication Date
HUE070309T2 true HUE070309T2 (hu) 2025-05-28

Family

ID=56544438

Family Applications (2)

Application Number Title Priority Date Filing Date
HUE20198062A HUE070309T2 (hu) 2015-01-30 2016-01-29 7-Benzil-4-(2-metilbenzil)-2,4,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4--E]pirimidin-5(1H)-on származékok, sóik és terápiás alkalmazásuk
HUE16744237A HUE052821T2 (hu) 2015-01-30 2016-01-29 7-benzil-4-(4-trifluormetil)benzil-1,2,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(4H)-on és sói és azok terápiában történõ alkalmazása

Family Applications After (1)

Application Number Title Priority Date Filing Date
HUE16744237A HUE052821T2 (hu) 2015-01-30 2016-01-29 7-benzil-4-(4-trifluormetil)benzil-1,2,6,7,8,9-hexahidroimidazo[1,2-a]pirido[3,4-e]pirimidin-5(4H)-on és sói és azok terápiában történõ alkalmazása

Country Status (27)

Country Link
US (6) US9845324B2 (enExample)
EP (4) EP3805222B1 (enExample)
JP (3) JP6802172B2 (enExample)
KR (3) KR20250134216A (enExample)
CN (2) CN107427516B8 (enExample)
AU (4) AU2016211243B2 (enExample)
BR (1) BR112017016487B1 (enExample)
CA (3) CA2975476C (enExample)
CY (1) CY1123616T1 (enExample)
DK (2) DK3805222T3 (enExample)
EA (1) EA037552B1 (enExample)
ES (2) ES3009132T3 (enExample)
FI (1) FI3805222T3 (enExample)
HR (2) HRP20201949T1 (enExample)
HU (2) HUE070309T2 (enExample)
IL (5) IL288525B (enExample)
LT (2) LT3250208T (enExample)
MA (2) MA55402B1 (enExample)
MD (2) MD3250208T2 (enExample)
MX (3) MX379425B (enExample)
PL (2) PL3805222T3 (enExample)
PT (2) PT3250208T (enExample)
RS (2) RS66551B1 (enExample)
SG (2) SG10201803508WA (enExample)
SI (2) SI3250208T1 (enExample)
SM (2) SMT202000696T1 (enExample)
WO (1) WO2016123571A1 (enExample)

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CN107427516B8 (zh) * 2015-01-30 2021-04-09 昂克希尔迪克斯有限公司 7-苄基-4-(2-甲基苄基)-2,4,6,7,8,9-六氢咪唑并[1,2-a]吡啶并[3,4-e]嘧啶-5(1h)-酮、其类似物、及其盐、以及它们用于治疗的方法
CN104860948B (zh) 2015-05-15 2017-09-26 南京盖特医药技术有限公司 咪唑并嘧啶酮类化合物及其制备方法和应用
HRP20250207T1 (hr) * 2016-01-29 2025-04-11 Oncoceutics, Inc. Modulacija g protein-spregnutog receptora (gpcr) pomoću imipridona
IL297201A (en) 2016-03-01 2022-12-01 Corcept Therapeutics Inc Use of glucocorticoid receptor modulators to increase the activity of checkpoint inhibitors
TWI794171B (zh) 2016-05-11 2023-03-01 美商滬亞生物國際有限公司 Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療
TWI808055B (zh) 2016-05-11 2023-07-11 美商滬亞生物國際有限公司 Hdac 抑制劑與 pd-1 抑制劑之組合治療
EP3496724B8 (en) * 2016-08-12 2021-11-17 Madera Therapeutics, LLC Protein kinase regulators
US10172862B2 (en) * 2017-01-30 2019-01-08 Oncoceutics, Inc. Imipridones for gliomas
WO2018169994A1 (en) * 2017-03-13 2018-09-20 City Of Hope m6A mRNA MODIFICATION IN CANCER TREATMENT
EP3589745A1 (en) * 2018-04-11 2020-01-08 Chemestmed Ltd. A method of modulating the rna methylation
WO2020196738A1 (ja) 2019-03-26 2020-10-01 富士フイルム株式会社 Ｂ型肝炎ウイルスタンパク質の産生を阻害する医薬組成物、ｂ型肝炎を処置するための医薬組成物およびスクリーニング方法
WO2021154750A1 (en) * 2020-01-29 2021-08-05 Corcept Therapeutics Incorporated TREATMENT OF ADRENOCORTICAL CARCINOMA WITH SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS (SGRMs) AND ANTIBODY CHECKPOINT INHIBITORS
CA3190787A1 (en) * 2020-08-06 2022-02-10 Eotvos Lorand Tudomanyegyetem Synthesis of novel imipridone derivatives and their evaluation for their anticancer activity
JP7644136B2 (ja) 2020-09-30 2025-03-11 富士フイルム株式会社 Ｂ型肝炎ウイルスタンパク質の産生を阻害する二本鎖ｒｎａ、及び医薬組成物
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