CY1121099T1 - Βιοτεχνολογικα θειωμενη θειικη χονδροϊτινη στη θεση 4 ή 6 στην ιδια αλυσιδα πολυσακχαριτη, και μεθοδος για την παρασκευη αυτης - Google Patents
Βιοτεχνολογικα θειωμενη θειικη χονδροϊτινη στη θεση 4 ή 6 στην ιδια αλυσιδα πολυσακχαριτη, και μεθοδος για την παρασκευη αυτηςInfo
- Publication number
- CY1121099T1 CY1121099T1 CY191100014T CY191100014T CY1121099T1 CY 1121099 T1 CY1121099 T1 CY 1121099T1 CY 191100014 T CY191100014 T CY 191100014T CY 191100014 T CY191100014 T CY 191100014T CY 1121099 T1 CY1121099 T1 CY 1121099T1
- Authority
- CY
- Cyprus
- Prior art keywords
- sulfation
- chain
- same
- sultified
- polysacharine
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/006—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
- C08B37/0063—Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
- C08B37/0069—Chondroitin-4-sulfate, i.e. chondroitin sulfate A; Dermatan sulfate, i.e. chondroitin sulfate B or beta-heparin; Chondroitin-6-sulfate, i.e. chondroitin sulfate C; Derivatives thereof
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08B—POLYSACCHARIDES; DERIVATIVES THEREOF
- C08B37/00—Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
- C08B37/0006—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid
- C08B37/0024—Homoglycans, i.e. polysaccharides having a main chain consisting of one single sugar, e.g. colominic acid beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof
- C08B37/0027—2-Acetamido-2-deoxy-beta-glucans; Derivatives thereof
- C08B37/003—Chitin, i.e. 2-acetamido-2-deoxy-(beta-1,4)-D-glucan or N-acetyl-beta-1,4-D-glucosamine; Chitosan, i.e. deacetylated product of chitin or (beta-1,4)-D-glucosamine; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/737—Sulfated polysaccharides, e.g. chondroitin sulfate, dermatan sulfate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
- A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
- C08L5/08—Chitin; Chondroitin sulfate; Hyaluronic acid; Derivatives thereof
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Rheumatology (AREA)
- Materials Engineering (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Pain & Pain Management (AREA)
- Immunology (AREA)
- Communicable Diseases (AREA)
- Psychiatry (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
Η παρούσα εφεύρεση αποκαλύπτει μία μέθοδο για την παραγωγή θειικής χονδροϊτίνης με ένα μέσο μοριακό βάρος (Mw) 10-30 kDa δια χημικής θείωσης ξεκινώντας από έναν μη θειωμένο σκελετό χονδροϊτίνης που λαμβάνεται με τη σειρά του δια υδρόλυσης οξέος πολυσακχαρίτη κάψας Κ4 που διεξάγεται απευθείας από Ε. coli στέλεχος 05:Κ4:Η4 ή παράγεται άμεσα από ένα γενετικά τροποποιημένο στέλεχος Ε. coli. Η θείωση του υπολοίπου Ν-ακετυλ-D-γαλακτοζαμίνης στη θέση 4 ή διεξάγεται συγχρόνως στην ίδια αλυσίδα πολυσακχαρίτη, προσομοιάζοντας στο σχέδιο θείωσης το οποίο παρατηρείται στη φυσική θειική χονδροϊτίνη αντίθετα προς τη θείωση η οποία λαμβάνεται με τις μεθόδους σύνθεσης οι οποίες περιγράφονται έως σήμερον.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT000829A ITMI20110829A1 (it) | 2011-05-12 | 2011-05-12 | Condroitin solfato biotecnologico solfatato in posizione 4 o 6 sulla stessa catena polisaccaridica e procedimento per la sua preparazione |
| IT000136A ITMI20120136A1 (it) | 2012-02-02 | 2012-02-02 | Condroitin solfato biotecnologico a basso peso molecolare solfatato in posizione 4 o 6 sulla stessa catena polisaccaridica dotato di attivita' antiinfiammatoria e antiartritica e procedimento per la sua preparazione |
| PCT/EP2012/058654 WO2012152872A1 (en) | 2011-05-12 | 2012-05-10 | "biotechnological sulphated chondroitin sulphate at position 4 or 6 on the same polysaccharide chain, and process for the preparation thereof" |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1121099T1 true CY1121099T1 (el) | 2019-12-11 |
Family
ID=46208441
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY191100014T CY1121099T1 (el) | 2011-05-12 | 2019-01-07 | Βιοτεχνολογικα θειωμενη θειικη χονδροϊτινη στη θεση 4 ή 6 στην ιδια αλυσιδα πολυσακχαριτη, και μεθοδος για την παρασκευη αυτης |
Country Status (25)
| Country | Link |
|---|---|
| US (2) | US20140315854A1 (el) |
| EP (1) | EP2707396B1 (el) |
| JP (1) | JP6205350B2 (el) |
| KR (1) | KR101883910B1 (el) |
| CN (1) | CN103582653B (el) |
| AU (1) | AU2012252415B2 (el) |
| BR (1) | BR112013027389B1 (el) |
| CA (1) | CA2835498C (el) |
| CY (1) | CY1121099T1 (el) |
| DK (1) | DK2707396T3 (el) |
| EA (1) | EA023849B1 (el) |
| ES (1) | ES2705734T3 (el) |
| GE (1) | GEP201606591B (el) |
| HR (1) | HRP20190183T1 (el) |
| HU (1) | HUE042378T2 (el) |
| IL (1) | IL229367A (el) |
| LT (1) | LT2707396T (el) |
| MX (1) | MX351660B (el) |
| PL (1) | PL2707396T3 (el) |
| PT (1) | PT2707396T (el) |
| RS (1) | RS58293B1 (el) |
| SG (1) | SG194898A1 (el) |
| SI (1) | SI2707396T1 (el) |
| WO (1) | WO2012152872A1 (el) |
| ZA (1) | ZA201308458B (el) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ITMI20130117A1 (it) | 2013-01-25 | 2014-07-26 | Gnosis Spa | Composizioni comprendenti condroitin solfato, enzimi proteolitici e composti sulfidrilati capaci di migliorare la biodisponibilita' del condroitin solfato |
| CZ2014451A3 (cs) * | 2014-06-30 | 2016-01-13 | Contipro Pharma A.S. | Protinádorová kompozice na bázi kyseliny hyaluronové a anorganických nanočástic, způsob její přípravy a použití |
| CN111662394B (zh) * | 2019-03-05 | 2022-11-04 | 中国医学科学院药物研究所 | 硫酸软骨素多糖半合成制备方法和应用 |
| IT202000013633A1 (it) | 2020-06-08 | 2021-12-08 | Vivatis Pharma Gmbh | Processo di estrazione di una condroitina solfato da un fungo, una condroitina solfato di origine vegetale e suo uso |
| IT202000013618A1 (it) | 2020-06-08 | 2021-12-08 | Vivatis Pharma Gmbh | Processo di estrazione di un acido ialuronico da un fungo, un acido ialuronico di origine vegetale e suo uso |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3405120A (en) * | 1966-01-27 | 1968-10-08 | Green Cross Corp | Low molecular chondroitin sulfate and method for manufacturing the same |
| US4704356A (en) * | 1984-03-27 | 1987-11-03 | Rush-Presbyterian-St. Luke's Medical Center | Method of diagnosing cartilage tissue abnormalities |
| JPS6144822A (ja) * | 1984-08-09 | 1986-03-04 | Seikagaku Kogyo Co Ltd | コンドロイチン硫酸含有抗疲労剤 |
| JPH0699485B2 (ja) * | 1984-08-14 | 1994-12-07 | 生化学工業株式会社 | 合成コンドロイチン多硫酸の製造法 |
| US5856174A (en) | 1995-06-29 | 1999-01-05 | Affymetrix, Inc. | Integrated nucleic acid diagnostic device |
| JP4258856B2 (ja) * | 1998-03-06 | 2009-04-30 | ニプロ株式会社 | 抗癌性複合体 |
| ITMI20012200A1 (it) * | 2001-10-22 | 2003-04-22 | Ibsa Inst Biochimique Sa | Processo per la preparazione di condroitin solfati dal polisaccaride k4 e prodotti ottenuti |
| JP2003128705A (ja) * | 2001-10-29 | 2003-05-08 | Kyowa Technos:Kk | 低分子キトサンおよびその製造方法 |
| JP4317350B2 (ja) * | 2002-06-12 | 2009-08-19 | 生化学工業株式会社 | 顆粒球マクロファージコロニー刺激因子分泌促進剤 |
| US8455458B2 (en) * | 2002-10-16 | 2013-06-04 | Arthrodynamic Technologies, Animal Health Division, Inc. | Composition and method for treating connective tissue damage |
| JP4567942B2 (ja) * | 2002-12-27 | 2010-10-27 | 生化学工業株式会社 | 破骨細胞形成抑制剤 |
| JP4914594B2 (ja) * | 2005-09-29 | 2012-04-11 | ユニテックフーズ株式会社 | 関節痛改善用食品組成物 |
| CN1789287A (zh) * | 2005-12-20 | 2006-06-21 | 山东大学 | 一种多硫酸化硫酸软骨素及其制备方法 |
| WO2009044765A1 (ja) * | 2007-10-01 | 2009-04-09 | Seikagaku Corporation | 新規な低分子化コンドロイチン硫酸およびその用途 |
| US8394782B2 (en) * | 2007-11-30 | 2013-03-12 | Allergan, Inc. | Polysaccharide gel formulation having increased longevity |
| US9109243B2 (en) * | 2008-06-04 | 2015-08-18 | Amano Enzyme Usa, Ltd. | Microbial-derived chondroitin sulfate |
| JP5435538B2 (ja) * | 2008-09-25 | 2014-03-05 | 国立大学法人鳥取大学 | コンドロイチン硫酸の低分子化物の製造方法 |
| IT1402871B1 (it) * | 2010-11-11 | 2013-09-27 | Ibsa Inst Biochimique Sa | Processo per ottenere condroitina solfatata in posizione 4 o 6 dei residui di n-acetil-galattosammina |
-
2012
- 2012-05-10 DK DK12725644.4T patent/DK2707396T3/en active
- 2012-05-10 RS RS20190078A patent/RS58293B1/sr unknown
- 2012-05-10 WO PCT/EP2012/058654 patent/WO2012152872A1/en active Application Filing
- 2012-05-10 EA EA201391673A patent/EA023849B1/ru not_active IP Right Cessation
- 2012-05-10 EP EP12725644.4A patent/EP2707396B1/en active Active
- 2012-05-10 PT PT12725644T patent/PT2707396T/pt unknown
- 2012-05-10 MX MX2013013181A patent/MX351660B/es active IP Right Grant
- 2012-05-10 PL PL12725644T patent/PL2707396T3/pl unknown
- 2012-05-10 LT LTEP12725644.4T patent/LT2707396T/lt unknown
- 2012-05-10 HU HUE12725644A patent/HUE042378T2/hu unknown
- 2012-05-10 CA CA2835498A patent/CA2835498C/en active Active
- 2012-05-10 SG SG2013083456A patent/SG194898A1/en unknown
- 2012-05-10 BR BR112013027389-5A patent/BR112013027389B1/pt active IP Right Grant
- 2012-05-10 ES ES12725644T patent/ES2705734T3/es active Active
- 2012-05-10 SI SI201231511T patent/SI2707396T1/sl unknown
- 2012-05-10 KR KR1020137029882A patent/KR101883910B1/ko active IP Right Grant
- 2012-05-10 AU AU2012252415A patent/AU2012252415B2/en active Active
- 2012-05-10 US US14/115,184 patent/US20140315854A1/en not_active Abandoned
- 2012-05-10 GE GEAP201213319A patent/GEP201606591B/en unknown
- 2012-05-10 JP JP2014509734A patent/JP6205350B2/ja not_active Expired - Fee Related
- 2012-05-10 CN CN201280022676.XA patent/CN103582653B/zh active Active
-
2013
- 2013-11-11 IL IL229367A patent/IL229367A/en active IP Right Grant
- 2013-11-11 ZA ZA2013/08458A patent/ZA201308458B/en unknown
-
2015
- 2015-12-21 US US14/977,119 patent/US9908947B2/en active Active
-
2019
- 2019-01-07 CY CY191100014T patent/CY1121099T1/el unknown
- 2019-01-29 HR HRP20190183TT patent/HRP20190183T1/hr unknown
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