CY1117975T1 - Σταθεροποιημενες συνθεσεις πεδιων ινωδονεκτινης, μεθοδοι και χρησεις - Google Patents

Σταθεροποιημενες συνθεσεις πεδιων ινωδονεκτινης, μεθοδοι και χρησεις

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Publication number
CY1117975T1
CY1117975T1 CY20161100884T CY161100884T CY1117975T1 CY 1117975 T1 CY1117975 T1 CY 1117975T1 CY 20161100884 T CY20161100884 T CY 20161100884T CY 161100884 T CY161100884 T CY 161100884T CY 1117975 T1 CY1117975 T1 CY 1117975T1
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Cyprus
Prior art keywords
fields
methods
fibrinonectin
proteins
human
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Application number
CY20161100884T
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English (en)
Inventor
Steven Jacobs
Original Assignee
Janssen Biotech, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Janssen Biotech, Inc. filed Critical Janssen Biotech, Inc.
Publication of CY1117975T1 publication Critical patent/CY1117975T1/el

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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1044—Preparation or screening of libraries displayed on scaffold proteins
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/78—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin or cold insoluble globulin [CIG]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K2318/00—Antibody mimetics or scaffolds
    • C07K2318/20—Antigen-binding scaffold molecules wherein the scaffold is not an immunoglobulin variable region or antibody mimetics
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
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  • Medicinal Chemistry (AREA)
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  • Animal Behavior & Ethology (AREA)
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Abstract

Μία πρωτεΐνη ικρίωμα βασιζόμενη σε μία συναινετική αλληλουχία πρωτεϊνών ινωδονεκτίνης τύπου III (FN3) , όπως η δέκατη FN3 επανάληψη από ανθρώπινη ινωδονεκτίνη (ανθρώπινη Τενασκίνη), συμπεριλαμβανομένων νουκλεϊνικών οξέων που κωδικοποιούν μία πρωτεΐνη ικρίωμα, φορέων, κυττάρων ξενιστών και μεθόδων παρασκευής και χρήσης αυτών. Τα μόρια πρωτεΐνης ικριώματος της παρούσας εφεύρεσης εμφανίζουν ενισχυμένη θερμική και χημική σταθερότητα, ενώ παρουσιάζουν έξι τροποποιήσιμα πεδία βρόχων τα οποία μπορούν να μηχανικευθούν για να σχηματίσουν έναν εταίρο πρόσδεσης ικανό για πρόσδεση ενός στόχου για εφαρμογές σε διαγνωστικές και/ή θεραπευτικές συνθέσεις, μεθόδους και συσκευές, βρόχους.
CY20161100884T 2010-04-30 2016-09-07 Σταθεροποιημενες συνθεσεις πεδιων ινωδονεκτινης, μεθοδοι και χρησεις CY1117975T1 (el)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US32998010P 2010-04-30 2010-04-30
PCT/US2011/034512 WO2011137319A2 (en) 2010-04-30 2011-04-29 Stabilized fibronectin domain compositions, methods and uses

Publications (1)

Publication Number Publication Date
CY1117975T1 true CY1117975T1 (el) 2017-05-17

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Country Status (22)

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US (3) US8569227B2 (el)
EP (4) EP4115911A1 (el)
JP (5) JP5997134B2 (el)
KR (1) KR101863033B1 (el)
CN (1) CN103002923B (el)
AU (1) AU2011245225B2 (el)
BR (1) BR112012027863B1 (el)
CA (1) CA2797274C (el)
CY (1) CY1117975T1 (el)
DK (2) DK3103478T3 (el)
ES (3) ES2923567T3 (el)
HR (1) HRP20161117T1 (el)
HU (1) HUE029622T2 (el)
IL (1) IL222573B (el)
MX (1) MX339126B (el)
PL (1) PL2571531T3 (el)
PT (3) PT2571531T (el)
RS (1) RS55163B1 (el)
RU (2) RU2603272C2 (el)
SI (1) SI2571531T1 (el)
SM (1) SMT201600309B (el)
WO (1) WO2011137319A2 (el)

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